Latest news with #Barratt
Yahoo
26 minutes ago
- Health
- Yahoo
ERA Congress: Long-term data show sustained efficacy and safety of zigakibart in patients with IgA nephropathy
VIENNA, June 4, 2025 /PRNewswire/ -- New 100-week data from the ongoing Phase 1/2 study of zigakibart, an investigational anti-APRIL monoclonal antibody, reinforce its potential as a disease-modifying treatment for IgA nephropathy (IgAN). Findings presented today at the 62nd ERA Congress demonstrate sustained proteinuria remission, stable kidney function, and a reassuring safety profile. IgAN is the most common form of glomerular disease worldwide and a frequent cause of chronic kidney disease. Its pathogenesis is marked by inflammation and progressive kidney damage, which can lead to kidney failure. Many patients are unaware they have the condition until significant kidney damage has occurred, and 50% of IgAN patients will ultimately develop kidney failure. By targeting the APRIL pathway and reducing production of pathogenic galactose-debecause ofgA1), zigakibart addresses a key driver of disease progression. "Zigakibart is designed to intercept the initiating factor in IgAN pathogenesis, offering a new approach that may halt or significantly delay progression", explained lead investigator Professor Jonathan Barratt. The ADU-CL-19 trial included 40 adults with biopsy-confirmed IgAN and persistent proteinuria despite stable supportive therapy. Patients received zigakibart every two weeks via intravenous infusion or subcutaneous injection, in addition to maximally tolerated renin–angiotensin system inhibitors (RASi) unless RASi-intolerant – demonstrating efficacy beyond standard care. At Week 100, proteinuria was reduced by 60% from baseline. Over half of patients (55%) reached <500 mg/24 h, and 31% achieved <300 mg/24 h, indicating deeper remission. Estimated glomerular filtration rate (eGFR) remained stable across subgroups. "The consistency of eGFR stabilisation over 100 weeks, even across proteinuria response groups, is particularly encouraging," said Prof. Barratt. Treatment also led to sustained reductions in serum immunoglobulins, including a 74% drop in IgA and pathogenic Gd-IgA1, consistent with APRIL pathway inhibition. Zigakibart was well tolerated throughout. Most adverse events were mild or moderate, with no treatment-related serious infections or discontinuations. Infections were the most common AEs; the study coincided with a high prevalence of COVID-19. This is the longest duration of eGFR stabilisation reported for an anti-APRIL agent in IgAN. "These long-term results build confidence in zigakibart as a potential cornerstone therapy for IgAN," said Prof. Barratt. "We're excited to see how the upcoming Phase 3 trials will further define its role." The global Phase 3 BEYOND study is now evaluating zigakibart in a broader population, with primary proteinuria endpoints at 40 weeks and long-term kidney function through 104 weeks. View original content: SOURCE ERA Congress Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Cision Canada
30 minutes ago
- Health
- Cision Canada
ERA Congress: Long-term data show sustained efficacy and safety of zigakibart in patients with IgA nephropathy
VIENNA, June 4, 2025 /CNW/ -- New 100-week data from the ongoing Phase 1/2 study of zigakibart, an investigational anti-APRIL monoclonal antibody, reinforce its potential as a disease-modifying treatment for IgA nephropathy (IgAN). Findings presented today at the 62 nd ERA Congress demonstrate sustained proteinuria remission, stable kidney function, and a reassuring safety profile. IgAN is the most common form of glomerular disease worldwide and a frequent cause of chronic kidney disease. Its pathogenesis is marked by inflammation and progressive kidney damage, which can lead to kidney failure. Many patients are unaware they have the condition until significant kidney damage has occurred, and 50% of IgAN patients will ultimately develop kidney failure. By targeting the APRIL pathway and reducing production of pathogenic galactose-debecause ofgA1), zigakibart addresses a key driver of disease progression. "Zigakibart is designed to intercept the initiating factor in IgAN pathogenesis, offering a new approach that may halt or significantly delay progression", explained lead investigator Professor Jonathan Barratt. The ADU-CL-19 trial included 40 adults with biopsy-confirmed IgAN and persistent proteinuria despite stable supportive therapy. Patients received zigakibart every two weeks via intravenous infusion or subcutaneous injection, in addition to maximally tolerated renin–angiotensin system inhibitors (RASi) unless RASi-intolerant – demonstrating efficacy beyond standard care. At Week 100, proteinuria was reduced by 60% from baseline. Over half of patients (55%) reached <500 mg/24 h, and 31% achieved <300 mg/24 h, indicating deeper remission. Estimated glomerular filtration rate (eGFR) remained stable across subgroups. "The consistency of eGFR stabilisation over 100 weeks, even across proteinuria response groups, is particularly encouraging," said Prof. Barratt. Treatment also led to sustained reductions in serum immunoglobulins, including a 74% drop in IgA and pathogenic Gd-IgA1, consistent with APRIL pathway inhibition. Zigakibart was well tolerated throughout. Most adverse events were mild or moderate, with no treatment-related serious infections or discontinuations. Infections were the most common AEs; the study coincided with a high prevalence of COVID-19. This is the longest duration of eGFR stabilisation reported for an anti-APRIL agent in IgAN. "These long-term results build confidence in zigakibart as a potential cornerstone therapy for IgAN," said Prof. Barratt. "We're excited to see how the upcoming Phase 3 trials will further define its role." The global Phase 3 BEYOND study is now evaluating zigakibart in a broader population, with primary proteinuria endpoints at 40 weeks and long-term kidney function through 104 weeks.
Yahoo
3 days ago
- Entertainment
- Yahoo
Breaking Baz: ‘Bring Her Back' Star Billy Barratt Says He Performed Best In The Horror Pic After Being Locked Alone In A Room Without His Phone
EXCLUSIVE: Billy Barratt, star of Danny and Michael Philippou's grippingly intense, dark and twisted Bring Her Back, was able to get into the mood for horror by being locked alone in a room, he reveals. Brit actor Barratt, 17, who also plays Casper Morrow, one of the few humans able to communicate with the alien invaders in the Apple TV+ drama Invasion, tells Deadline: 'There were moments where Danny would basically lock me in a room by myself, and he goes, 'Just try and get in character.' He shut the door, I'm not allowed to leave. I ended up just sitting there with no phone, no nothing — which is great, by the way. I just sat there for ages, and then when I came back outside of that door, back into the scene … you just feel like you are there are in it.' More from Deadline Horror Twins Danny & Michael Philippou On The Evil That Lies Beneath In Their Latest 'Bring Her Back' – Crew Call Podcast 'Bring Her Back' Review: Sally Hawkins Gaslights Kids & Channels Grief Into Terror In The Philippous' Trauma-Soaked Sophomore Feature 'Lilo & Stitch' Still Rich With $60M-$64M Second Weekend, 'Mission Impossible 8' Near $27M, 'Karate Kid: Legends' Looks To Punch $21M+ - Box Office Update It was funny at first, but then he found it freaky and scary. However, he adds, being shut away for half-hour stretches at a time was useful. 'Seeing the effect it had actually helped me so much, not just in the script but in future projects as well. So thank you, Danny,' he says with gratitude. Bring Her Back is a horror film underpinned by a solid tale involving siblings Andy and Piper, who is vision-impaired, played by Barratt and Sora Wong, respectively. Following the death of their father, they're fostered by Laura, a seemingly — at first glance, at least — kindly, grieving mother whose daughter has died, played by two-time Oscar nominee Sally Hawkins. 'It's more emotion than just jump scares and gory things,' Barratt says with a dramatic shiver. This isn't a spoiler, because it's in all the trailers, but Hawkins scares the living daylights out of those kids – and the audience. There's a third kid involved in the story called Oliver, played with macabre relish by Jonah Wren Phillips. I saw the A24 picture on a recent morning at a screening kindly set up by Sony at its HQ in Paddington, London, and it left me shaken for the rest of the day — and night. Hawkins fully immerses herself in her role. Barratt recalls chatting to her at the wrap party. 'She said to me, 'We should meet up in London because I haven't actually got to meet you as me yet properly.' And I was like, 'Oh, OK. Cool. Right. So you were really Laura in that!'' He makes clear that the actress wasn't 'terrifying' the whole time. 'It only clicked for me when she said that. And I was like, 'Oh, so you were fully immersed the whole time?'' It can be 'quite handy' to stay in character all day, he says, and go the full Daniel Day-Lewis. There were three weeks of pre-production in Adelaide, Australia, the Philippous' home state, which he says, 'actors at my level aren't usually involved in.' Ordinarily, 'you just sort of show up on the first day, they've done their pre-production, and then you just start. Here, everyone felt so involved. Me especially. It actually helped me and Sora to have that sort of brother-sister relationship, which is hard to get until you actually hang out with them. Those first three weeks of pre-production were fun for sure, because it felt like the whole thing was a great big icebreaker.' Barratt studied acting and music at Sylvia Young's drama school in London, and he was cast in several TV shows, films and one musical. That was with Kelsey Grammer in the musical Big Fish, which I happened to have caught. His breakthrough came when he was 12 in director Nick Holt and writer Sean Buckley's Responsible Child , the 2019 Kudos and BBC TV drama that won him the International Emmy for Best Actor, followed by two seasons of Invasion. He's already filmed a third season, possibly coming to screens later this year. There's a genuine brother-and-sister warmth between the Andy and Piper characters in Bring Her Back — and plenty of sibling bickering too. He's always holding her hand, and the relationship doesn't seem at all feigned. 'And also the fact that I'm not sure how much she could see,' Barratt tells me, because like Piper, Sora is partially blind, though she could see more than her character. 'Anywhere we'd go,' he gently adds, 'we'd end up just sort of linking arms. And so I explained to her what I could see, what was going on, and just sort of paint an image for her. Andy's whole thing is he wants to make the world look like a better place for his little sister.' Hawkins' Laura does a bunch of things that I can't spoil here, though as we discuss them, the word that Barratt and I kept repeating was 'weird.' I'd go so far to say, wonderfully weird. Maybe terrifyingly weird is more appropriate. And as Barratt points out, 'Piper cannot see what's going on.' It's a whole mind game and such great writing from Danny Philippou and Michael Hinzman, who wrote Talk to Me. Barrett didn't meet with any psychologists or social workers whilst preparing for the film, but he tells me that he was introduced to Miranda Harcourt, the distinguished dramaturg and acting coach who often works with the likes of Nicole Kidman. 'She helped me and Sora … and also just how to approach certain scenes and just gave options and different exercises to do before a scene to get you real wound up,' he explains. He says that the crew 'were also my therapy.' How so, I ask. 'Because anytime that it was like a sad scene or a really happy scene or whatever, they would match the vibe on set all day. And it was just so a 'We are one' sort of thing.'' For instance, if he had to do a really sad scene, 'everyone would be really quiet for the whole day.' Reviewing Barratt's performances from Responsible Child, through two seasons of Invasion and now Bring Her Back, there is a discernible deeper progression in his acting. I mean, he's growing up. He's not a little kid anymore; he's gained confidence in front of the camera as he's gotten older. It's not something that he's noticed himself, though he notes that there's 'definitely a feeling of being more comfortable on set' that first day when you don't know anyone. 'It's nerve-wracking, and all you can really think about is the scene, but then at the same time, are they going to like it? Am I doing the right thing? There's still time to pull me out of the movie. But that's just what goes through my mind, at least.' Reflecting on Invasion, he points out that he's been on the set with his castmates since he was 13, 'and I'm turning 18 next month.' Shaking his head, he adds, 'It's just been a mad trip, a mad drive, especially through Covid and everything.' There were stops and starts during the pandemic, though there was a period where they had to stop shooting 'for ages.' But when they resumed 'we'd all grown up by that point and all the growth spurts had happened.' The plus factor is that he made lifelong friends through his involvement with Invasion. He took Cassius, his younger brother, to the set while shooting the final episode of Season 2. 'He was acting a little bit before this and then stopped. And then when I took him to that set, he was so amazed by all the lights and the lasers. It was a mad thing to see. He was like, 'I want to start acting again.' There's video on YouTube of the 2020 International Emmy ceremony done remotely. Barratt's at home with his family, and when he's announced as the winner, he turns to Cassius, now 13, and says, 'Man, I love you,' rubs his brother's head affectionately and says, 'That'll be you next.' It's a telling moment. Also in Bring Her Back there are aforementioned moments with Wong, and in certain scenes in Invasion, there's a sort of inherent caring gene that he has that comes through the screen. The matter is not something he's, thought about or is aware of, obviously, but Barratt acknowledges there's something in what I'm suggesting. 'I think that's what freaks me out when I'm watching myself back. Is it too much like me or have I actually got the character down or have I just half-assed that? Because I'm seeing parts of me in there. But then I also think on the flip side of that, I think it's quite important to have a little bit of you in there because that's what makes it natural.' During the Bring Her Back shoot, he says that he saw a lot of his brother in Sora because they're a similar age 'and they have fights and that sort of thing.' He adds: 'It's just siblings, there's a real deep love in it. I definitely saw a lot of my brother in Sora's character.' We spent a long time chatting, and it's clear, at least to me, that Barratt's in it for the long haul. 'I'd love to be involved in every aspect of a film from the moment it started right up to when it comes out,' he says. 'I think there's moments that I miss because as an actor it's just not your job to be involved in those certain scenarios. And I wish I could be involved in that. And I look at some really big actors who will sit next to the director and have a say in what happens. And I don't know if that's because they're able to produce as well or whatever. 'I am not like, massive. You say to anyone: 'What's his name?' I dunno,' he shrugs. 'I'm definitely new. I'm definitely starting, even though I've been doing it for about 11 years now, almost. I'm a new actor, I guess.' Every actor arrives in some shape or from, I suggest. Leonardo DiCaprio didn't arrive fully formed, nor did Timothée Chalamet or Tom Cruise. Taking issue, Barratt argues that 'Leonardo DiCaprio did come fully formed. I love him. And I think every single film I've seen him in from when he was younger than me in these films like Basketball Diaries or What's Eating Gilbert Grape he's just incredible in all of it. I just think there's just some people that have just got it straight away, and I don't class myself with one of those people, I'm still learning, for sure. And I think that's what I mean when I say an 'actor at my level' — someone that doesn't understand a lot of it but really wants to. Wants to be involved in all of it.' We order French fries, a Coke for him and more piping-hot tea for me. Making Responsible Child, about a 12-year-old boy accused of helping to kill his abusive stepfather who was tried in court the same as an adult in England and Wales, opened his eyes to the power of film. After it came out, he realized 'how much of an impact' it had had, with changes made in how police and courts handle such cases. He remembers reading about it and thinking: 'Oh, shit! It's not just sitting down and watching something on Netflix. It can change people's lives.' Certainly, Responsible Child hold is one of those films that stay with you. There are a bunch of movies that have stayed with him too. Like David Fincher's Fight Club, Martin Scorsese's Shutter Island and Christopher Nolan's Inception. He's a big fan of Sofia Coppola's Lost in Translation as well. And Michael Curtiz's Casablanca! He likes Francis Coppola's The Godfather, and now — having watched the Paramount+ series The Offer, about producer Albert S. Ruddy's experience of making The Godfather — he wants to see the whole trilogy. He'd like to work with the Philippou brothers again and admires what he calls their 'genius' way of working. They'd work a full day in the studio and then home and be up until the early hours editing the footage of the day and 'be back at 7 in the morning.' They shot with the same crew and used the same studio they filmed Talk to Me in. It was once an insane asylum. The Babadook was shot there. Apparently, he regales, the studio's haunted on one particular floor. 'We went up to have a little look around,' he recalls, 'This one room was so scary, and there was a pile of dead bees. A lot of bees bang in the center of the film. And people had told stories of cleaners quitting and a security guard going up there and in his ear he could hear whispering. He left and never came back. I would never come back. That's terrifying,' he says, pausing to add, 'a great place to shoot a horror movie.' Season 3 of Invasion was shot in Canada, with Barratt's scenes being shot before and after working on Bring Her Back. 'My hair was really long, and then I went to shoot Invasion, they cut my hair really short. And then I went back out to Canada, and my hair was still short. So then they a wig. But the wig, it just didn't look like it did before. I don't blame anyone for that. I just think it just didn't fit me correctly. It just wasn't right. I've actually watched it back on the cameras, and it looked good. But me actually walking around, it just didn't work.' He's not allowed to give anything away about Season 3 of Invasion, but he does let slip that … Oh, no! I realize that it's way too much of a spoiler to impart. Whatever happens to his Casper Morrow in Invasion, Billy Barratt's in for a long and fruitful career. Best of Deadline Sean 'Diddy' Combs Sex-Trafficking Trial Updates: Cassie Ventura's Testimony, $10M Hotel Settlement, Drugs, Violence, & The Feds 'Poker Face' Season 2 Guest Stars: From Katie Holmes To Simon Hellberg 2025-26 Awards Season Calendar: Dates For Tonys, Emmys, Oscars & More
Scotsman
28-05-2025
- Lifestyle
- Scotsman
Expert tips for Scottish homeowners to create impactful interiors
In line with World Interiors Day (31st May), Barratt and David Wilson Homes Scotland has teamed up with Edward Thomas Interiors to provide residents with top tips to get the most out of their homes. From gorgeous Georgian town houses to jaw-dropping penthouses, converted campervans to bargain boltholes. Take a peek at the finest homes across the UK. Sign up Thank you for signing up! Did you know with a Digital Subscription to The Scotsman, you can get unlimited access to the website including our premium content, as well as benefiting from fewer ads, loyalty rewards and much more. Learn More Sorry, there seem to be some issues. Please try again later. Submitting... World Interiors Day is an annual celebration organised by the International Federation of Interior Architects/Designers to highlight the significance of interior design and architecture and its impact on the quality of life. Barratt and David Wilson Homes Scotland, with the help of Estelle Palmer, Head of Design at Edward Thomas Interiors, has put together four top tips for homeowners in Scotland to make the most of their interiors. Advertisement Hide Ad Advertisement Hide Ad Felipe Ferreira, Sales Director at Barratt and David Wilson Homes North Scotland, said: 'Our homes provide the ideal blank canvas for residents to express their own personality. We would like to say a huge thank you to Edward Thomas Interiors for providing our homeowners with some excellent advice. A David Wilson Homes show home kitchen designed by Edward Thomas Interiors 'We recommend anyone interested in moving home to come and visit our show homes where they can see these tips expertly put into place.' Think Vertically! Estelle said: 'If you want to create extra storage space, don't overlook walls or the ceiling. Floating shelves, hooks, picture rails and pegboards are great space savers, or why not wall mount TVs and media units to create more floorspace in living rooms, kitchen diners or children's bedrooms. 'For those with balconies or limited outdoor space, we've seen great examples of doorstep and vertical gardens. Source, or repurpose, rustic plant pots or window boxes and plant climbers, vegetables or wildflowers for an immediate new hobby.' Paint Effects Advertisement Hide Ad Advertisement Hide Ad For an instant impact at low cost, painting (in all its forms) is a straightforward way to revamp a room. Estelle continued: 'Homeowners could try paint blocks or shapes to help 'zone' a room, create a feature wall in one of this year's popular shades like Mocha Mousse, or colour drench. 'Drenching is really on trend right now and includes not just the walls, but the ceiling and any woodwork (skirting boards, window and door frames, and stair spindles) too. It's bold and unapologetic about colour and really makes a statement.' Upcycling Homeowners could take a trip to a charity shop or flea market where they can find an abundance of pre-loved pieces. Advertisement Hide Ad Advertisement Hide Ad Estelle said: 'Unlock your inner creativity by upcycling second-hand or inherited pieces. This can be something as simple as making candles holders from old gin bottles or lampshades from rattan plant pots to more inventive décor. 'We have turned rugs and cricket bats into headboards, old fruit crates into desks and even joined two breadbins together to make a 'breadside' table!' Decals and Murals To really personalise a space, there's the option to add wall decals or a mural. These are instantly transformative and make fantastic focal points for living rooms and bedrooms. These can be found in high-street and online retailers but for the more artistic homeowners, why not hand-paint them? Estelle added: 'Some of our current favourite designs depict cherry blossom, hanging vines, wisteria, and lavender. While these can be really striking, they can just as easily be removed by re-painting or wallpapering.' Advertisement Hide Ad Advertisement Hide Ad
Yahoo
20-05-2025
- Yahoo
Police use HGV tractor unit to spot risky drivers
Traffic police officers have been driving a plain white HGV tractor unit on key routes to spot drivers using mobile phones or breaking seatbelt laws. West Mercia Police borrowed the vehicle from National Highways because it gave them "an elevated position allowing officers to film risky, unlawful behaviour". In a week-long operation, 64 offences were spotted on the M54, M50, M5 and M42 motorways. They included not using seatbelts, using a mobile phone, speeding, and not being in full control of a vehicle. Insp Darren Godsall said it was concerning there were still motorists who were "willing to risk their own and others' safety". He said there was no excuse for drivers not to know what the law states or the penalties they can receive. Police and crime commissioner John Campion said too many people were being killed or seriously injured on roads, adding that it had a "devastating effect" on families and communities. He said that was why road safety was a key part of the West Mercia Safer Communities Plan. In a separate development on Tuesday, West Mercia Police also announced the appointment of a new deputy chief constable, Damian Barratt. Previously assistant chief constable at West Midlands Police, Mr Barratt started his police career with the West Mercia force in 1995. Mr Barratt said he was proud to be returning as a deputy chief constable, adding: "This force has always held a special place in my career, and I'm looking forward to once again serving the communities across Herefordshire, Shropshire and Worcestershire." Follow BBC Hereford & Worcester on BBC Sounds, Facebook, X and Instagram. Hundreds of bad drivers caught with dashcam scheme West Mercia Police
