Latest news with #Biomolecules
Medscape
7 days ago
- Health
- Medscape
Gut Health in Rosacea: Diet, Probiotics, and the Microbiome
Growing evidence suggested that the skin and gut may be more closely linked than once thought — especially in chronic inflammatory conditions like rosacea. In a comprehensive review recently published in Biomolecules , Marco Manfredini, MD, from the Department of Dermatology at the University of Modena and Reggio Emilia, Modena, Italy, and colleagues explored the evolving science around how diet, gut microbiota, and probiotics may influence rosacea pathogenesis and symptom severity. While more clinical studies are needed, the review highlighted new pathways linking gastrointestinal dysbiosis to cutaneous inflammation. The authors proposed that specific dietary modifications and the use of probiotics could support traditional treatment approaches for certain patients. Pathogenesis of Rosacea: A Multifactorial Inflammatory Process Rosacea arises from a complex interplay of multiple contributing factors. 'The pathogenesis of rosacea continues to be a subject of investigation,' the authors wrote, involving 'dysregulation of the innate immune response and neuropeptide activity, microbial involvement, environmental factors, dietary triggers, and skin barrier dysfunction.' Central to these mechanisms is the innate immune system. In rosacea, elevated levels of kallikrein-5 trigger excessive processing of antimicrobial peptides into proinflammatory fragments such as LL-37. These fragments promote oxidative stress, cytokine release, and blood vessel changes, contributing to the inflammation and vascular symptoms seen in the disease, according to the authors. Neurovascular dysregulation is also a hallmark of the disease. The authors noted, 'activation of TRPV1 [Transient Receptor Potential Cation Channel Subfamily V Member 1] and related channels by environmental triggers like heat and UV [ultraviolet] radiation exacerbate flushing and erythema by promoting vasodilation and neurogenic inflammation.' These channels are hypersensitive in patients with rosacea, contributing to enhanced symptom severity. While the skin microbiome — particularly Demodex folliculorum and its associated Bacillus oleronius — has long been considered a contributing factor, recent attention has turned to the gut. 'Emerging evidence suggests that while microorganisms may not be central causative factors… alterations in the skin microbiome across multiple rosacea subtypes may act as trigger factors or potentiate inflammation,' the review authors wrote. 'Gastrointestinal dysbiosis, including conditions such as Helicobacter pylori infection and small intestinal bacterial overgrowth (SIBO),' they noted, 'has been hypothesized as a potential contributor to rosacea development.' Gut Dysbiosis and the Skin: The Available Evidence The concept of a gut–skin axis describes the bidirectional relationship between intestinal microbiota and skin inflammation. In rosacea, this relationship is supported by associations with conditions like SIBO, H pylori infection, and inflammatory bowel diseases, as highlighted in the Manfredini review. Asked to comment on this emerging topic, Rajani Katta, MD, clinical professor of dermatology at the McGovern Medical School, University of Texas, Houston, noted, 'We have strong evidence linking gut dysbiosis to rosacea, but it is important to note that this applies only to certain patients. In other words, only a subset of patients with rosacea seems to have gut dysbiosis, and in those patients, there appears to be a link.' Rajani Katta, MD Katta added that the most compelling mechanisms relate to inflammation. 'Patients with SIBO may have higher levels of inflammatory mediators, such as tumor necrosis factor alpha. In other studies, gut dysbiosis can lead to the activation of specific inflammatory pathways like the kallikrein-kinin pathway. Activation of these pathways has multiple downstream effects, which may ultimately increase neurogenic inflammation in the skin.' The review by Manfredini and colleagues supported these theories, citing studies that show improvement in rosacea symptoms following SIBO eradication, although the benefit of H pylori treatment is less clear. 'The association between Helicobacter pylori infection and rosacea remains complex and influenced by several confounding factors,' the authors wrote. 'The antibiotic treatment required for H pylori eradication represents an important confounding factor.' The authors caution that without large-scale prospective studies examining the gut microbiome before and after intervention, firm conclusions about causality remain elusive. Dietary Triggers: What the Evidence Supports Dietary factors may influence rosacea by promoting vasodilation, activating sensory receptors, or altering the gut microbiome. Yet, data on specific triggers remain mixed, according to the authors. Asked to comment on dietary triggers in rosacea, Lauren Kole, MD, associate professor of dermatology at the University of Alabama at Birmingham, said that 'the best data for dietary triggers for rosacea are for alcohol and hot beverages. Alcohol may induce peripheral vasodilation, promote inflammation, modulate the immune system, and may trigger histamine release. Hot beverages may cause direct vasodilation and trigger other pathways that lead to flushing, stinging, and sensitive skin.' Katta also noted that alcohol and hot beverages 'are common triggers, likely because they lead to vasodilation, which causes flushing.' She also highlighted spicy foods as a culprit. 'Foods that contain capsaicin may result in vasodilation and thus flare rosacea, so avoiding spicy foods may be helpful.' Another category included foods that contain cinnamaldehyde — a compound found in cinnamon, tomatoes, and citrus —which may trigger flushing in sensitive individuals, according to Katta. Katta recommended a practical approach for patients. 'For most patients, a 6-week trial of eliminating the most commonly reported food triggers in rosacea is a good first step… I tell patients that it can take 6 weeks of avoiding these foods to see if it will be helpful, and I recommend a food diary.' Interestingly, certain foods may offer benefits. Dairy products have been associated with reduced rosacea severity in some populations, potentially because of their anti-inflammatory effects. High-fiber diets may support gut microbial diversity and caffeine — despite its reputation — has been inversely associated with rosacea in large observational studies, cited in the Manfredini review. Probiotics: Potential but Preliminary Probiotics are another area of growing interest. These live microorganisms may influence rosacea by rebalancing the gut microbiome, reducing inflammatory cytokine production, and enhancing skin barrier function, according to the authors. 'Dietary probiotics may help normalize skin dysbiosis in rosacea and may limit substance P-induced skin inflammation,' said Kole. She referenced a study that found improved skin barrier function and reduced sensitivity with oral probiotic use alongside doxycycline therapy. Katta said that she has not used probiotics for rosacea in her practice. 'Preliminary results appear intriguing, but there are still many questions about the optimal strain of probiotics as well as dose and duration,' she told Medscape Medical News . She added that the current evidence is 'too preliminary to recommend specific strains or delivery routes, although some have shown benefit,' referencing studies on strains of Bifidobacterium , Lactobacillus , and Escherichia coli Nissle included in the Manfredini review. Topical formulations are also being explored with promising results, and a product containing Vitreoscilla filiformis has shown reductions in facial erythema and Demodex density while improving transepidermal water loss, according to the review's authors. However, mirroring Katta's sentiment, the authors concluded that 'despite promising results, the evidence supporting the use of probiotics in the treatment of rosacea remains relatively limited. Further clinical trials are necessary to evaluate and compare the effectiveness of various probiotic strains and different methods of delivery, such as oral ingestion and topical use.' Looking Ahead: Clinical Considerations and Research Needs While the current research is promising, more rigorous studies are needed. 'One of the research areas that I'd love to see more of,' Katta said, 'is measuring rates of gut dysbiosis in patients with rosacea, with prospective studies examining gut microbiome composition before and after treatment, and how that correlates to rosacea severity.' For now, clinicians may consider an individualized approach, she said, and asking about gastrointestinal symptoms, evaluating for common dietary triggers, and discussing a food elimination trial can be helpful strategies. Although formal probiotic guidelines for rosacea are lacking, some patients may benefit from a monitored trial of supplementation — particularly if they also have gut-related complaints, she added. 'There are many gaps in our understanding of the gut–skin axis,' Katta emphasized. 'But it's an exciting area of dermatologic research.'
Jordan News
15-04-2025
- Health
- Jordan News
Hyaluronic Acid for Acne Treatment: What It Can Do for Your Skin - Jordan News
If acne is one of your biggest beauty concerns, chances are you've tried everything—from home remedies to conventional treatments—and probably spent a lot on oil-free, non-comedogenic skincare products. But today, the solution might be simpler than ever. Hyaluronic acid, a naturally occurring substance in your skin, is proving to be a direct and effective approach to acne care. اضافة اعلان What Is Hyaluronic Acid? Hyaluronic acid (HA) is a naturally occurring substance found in your skin, connective tissues, and joints. Its main job? Keeping your skin hydrated. HA binds to water molecules and can retain up to 1000 times its weight in water, making it a go-to ingredient in serums, creams, and moisturizers. As you age, the natural levels of HA in your skin decrease, leading to dryness and loss of elasticity. For acne-prone skin, dryness and a compromised skin barrier are common problems—especially because many acne treatments (like benzoyl peroxide, salicylic acid, and retinoids) strip the skin of moisture and oils, often leaving it irritated and overly dry. When this happens, your skin can overcompensate by producing more oil (sebum), leading to clogged pores and more breakouts—a frustrating cycle. Here's How Hyaluronic Acid Can Help: 1. Provides Deep Hydration HA delivers essential hydration without clogging pores. Unlike thick moisturizers that can trap oil and dirt, HA is lightweight—it attracts and retains moisture without leaving a greasy film. It also helps regulate your skin's oil production and maintains a healthy balance—both of which are crucial in preventing breakouts. According to a 2017 study published in the Journal of Investigative Dermatology, proper hydration can help reduce excess sebum and acne formation. 2. Soothes Redness and Irritation For many people with acne, redness and irritation are just as troubling as the breakouts themselves. HA has anti-inflammatory and wound-healing properties that calm the skin and promote a more stable, less reactive environment, as noted in a 2021 study published in Biomolecules. 3. Boosts Absorption of Other Ingredients Properly hydrated skin absorbs active ingredients—like retinoids or salicylic acid—more effectively. When used alongside HA, these treatments are less likely to dry out or irritate the skin, allowing for more targeted and efficient results. 4. Helps Heal Acne Scars HA can also help improve the appearance of acne scars. A 2018 study in Dermatologic Surgery found that HA fillers were effective and safe for treating atrophic acne scars. Hydrated skin heals faster, which means incorporating HA into your routine can help scars fade sooner. Does Hyaluronic Acid Cause Acne? While HA does not cause acne, certain formulations that mix HA with heavy oils or comedogenic agents can trap dirt and bacteria, leading to breakouts. Also, applying HA on dry skin without sealing it with a moisturizer can sometimes draw moisture from deeper layers, causing dryness and increasing oil production—potentially worsening acne for some people. How to Use Hyaluronic Acid for Acne-Prone Skin To get the most out of HA, use it correctly: Apply on Damp Skin: HA draws in moisture, so always apply it to damp (not dry) skin to avoid dehydration. After cleansing, gently pat your face so it remains slightly moist. Use a Serum First: Apply a few drops of an HA-based serum to your damp face. Lock in Moisture: Follow up with a non-comedogenic lightweight moisturizer to trap the hydration inside your skin. Pair with Acne Treatments Carefully: You can use HA before or after acne treatments like benzoyl peroxide or retinoids. If your routine includes multiple actives, apply HA first to create a calming moisture base and reduce irritation. If your skin feels too dry, layer HA on top of your acne treatments to form a protective barrier. Show Related News Show Related News
Yahoo
15-04-2025
- Health
- Yahoo
Anti-aging benefits linked to one surprising health habit
Engaging in a long-term meditation practice could significantly alleviate stress and slow down aging, suggests a new study published in the journal Biomolecules. Researchers from Maharishi International University (MIU), the University of Siegen, and the Uniformed Services University of the Health Sciences studied the effectiveness of transcendental meditation, which is a program where people silently repeat a mantra in their head to achieve deep relaxation. "These results support other studies indicating that the transcendental meditation technique can reverse or remove long-lasting effects of stress," co-author Kenneth Walton, a senior researcher at MIU, told Fox News Digital. Biohacking Revealed: What To Know About The Hip Health Trend Embraced By Brooke Burke, Tom Brady And Others "Lasting effects of stress are now recognized as causing or contributing to all diseases and disorders," he added. The study included two groups of participants — one ranging from 20 to 30 years old and another ranging from 55 to 72. Half of the participants followed transcendental meditation and a control group did not. Read On The Fox News App For each participant, the researchers analyzed the expression of genes linked to inflammation and aging, according to a press release from MIU. Secrets Of Longevity From The World's 'Blue Zones' They found that people who practiced transcendental meditation had lower expression of the genes associated with inflammation and aging. "The lower expression of age-related genes … extend the findings of short-term studies indicating that these practices lead to healthy aging and more resilient adaptation to stress," Walton said in the release. The researchers also analyzed cognitive function via EEG tests. Older practitioners of transcendental meditation were found to have faster processing speeds. That group also received higher scores on the Brain Integration Scale (BIS), which is a comprehensive measure of cognitive performance. "The findings around cognitive function are particularly exciting," said co-author Frederick Travis, PhD, head of faculty at Maharishi International University, in the release. "Both younger and older TM practitioners showed higher scores on the BIS compared to non-meditators, while the older meditators performed on par with young controls," he stated. Common Supplement Could Help You Live Longer, Research Suggests The third area of focus was hair cortisol and cortisone, which are steroid hormones that serve as biomarkers for long-term stress exposure and other health conditions. The amount of active cortisol was higher for those who practiced transcendental meditation, the study found. "Cortisol plays a critical role in the body's response to stress, and chronically high cortisol levels are associated with a host of age-related health issues, in addition to cognitive decline," Walton said. "The reduced cortisol-to-cortisone ratio in meditators suggests they have more adaptive reserve, more resilience, contributing to overall health and longevity." Healthy Eating In Middle Age Has This Key Longevity Benefit The main limitation in the years-long, cohort study was the lack of a placebo control group, according to Walton. "These meditators practiced their techniques twice daily for many years, and the control subjects had no similar activity," he told Fox News Digital. "Also, most subjects spent their years in the same geographical location (Southeast Iowa in the U.S.)." Biohacker Dave Asprey, author of the upcoming book "Heavily Meditated: The Fast Path to Remove Your Triggers, Dissolve Stress, and Activate Inner Peace," has spent 25 years studying meditation with shamans and gurus, and researching neuroscience. He agrees that meditation helps to slow the aging process. "It reduces stress — and the more stress you have that's not useful stress, like going to the gym or working hard, that shrinks your brain and makes you old," Asprey said during an on-camera interview with Fox News Digital. "Meditation has been shown in multiple studies to undo those problems." The biohacker also refers to meditation as "weightlifting for the brain." "Long-term meditators have brains that can make more electricity than someone who doesn't meditate — and their brains are more orderly." Meditation could potentially slow and perhaps prevent some types of dementia, according to Asprey. "There are studies showing that people who meditate are better at excreting toxins," he added. Asprey emphasized that meditation starts not in the mind, but in the body. For those who are just getting started, he recommends trying a body scan to calm the nervous system. "For this, you breathe in deeply for four seconds and breathe out for eight seconds," he said. "Focus on your toes, then your ankles, then your calves, then your knees — and you slowly put all of your awareness in each part of your body." Click Here To Sign Up For Our Health Newsletter "Learning that meditation is an embodied practice versus a mental practice can shift it for everyone when they're just getting going." Some studies have shown that the right form of meditation or breath work can have effects that exceed pharmaceuticals, according to Asprey. "There are profound results that meditation can do much better than antidepressants," he said. "That said, if you're on a medication and you start meditating, you should tell your doctor and probably not go off the drugs without some support." For more Health articles, visit One of the biggest myths is that all meditation is the same or that all meditation is good for everyone, Asprey noted. "The normal meditation that was designed for farmers isn't going to work if you're a warrior — and it's okay if it doesn't work. It doesn't mean there's something wrong with you."Original article source: Anti-aging benefits linked to one surprising health habit
Fox News
15-04-2025
- Health
- Fox News
Anti-aging benefits linked to one surprising health habit
Engaging in a long-term meditation practice could significantly alleviate stress and slow down aging, suggests a new study published in the journal Biomolecules. Researchers from Maharishi International University (MIU), the University of Siegen, and the Uniformed Services University of the Health Sciences studied the effectiveness of transcendental meditation, which is a program where people silently repeat a mantra in their head to achieve deep relaxation. "These results support other studies indicating that the transcendental meditation technique can reverse or remove long-lasting effects of stress," co-author Kenneth Walton, a senior researcher at MIU, told Fox News Digital. "Lasting effects of stress are now recognized as causing or contributing to all diseases and disorders," he added. The study included two groups of participants — one ranging from 20 to 30 years old and another ranging from 55 to 72. Half of the participants followed transcendental meditation and a control group did not. For each participant, the researchers analyzed the expression of genes linked to inflammation and aging, according to a press release from MIU. They found that people who practiced transcendental meditation had lower expression of the genes associated with inflammation and aging. "The lower expression of age-related genes … extend the findings of short-term studies indicating that these practices lead to healthy aging and more resilient adaptation to stress," Walton said in the release. "Lasting effects of stress are now recognized as causing or contributing to all diseases and disorders." The researchers also analyzed cognitive function via EEG tests. Older practitioners of transcendental meditation were found to have faster processing speeds. That group also received higher scores on the Brain Integration Scale (BIS), which is a comprehensive measure of cognitive performance. "The findings around cognitive function are particularly exciting," said co-author Frederick Travis, PhD, head of faculty at Maharishi International University, in the release. "Both younger and older TM practitioners showed higher scores on the BIS compared to non-meditators, while the older meditators performed on par with young controls," he stated. The third area of focus was hair cortisol and cortisone, which are steroid hormones that serve as biomarkers for long-term stress exposure and other health conditions. The amount of active cortisol was higher for those who practiced transcendental meditation, the study found. "Cortisol plays a critical role in the body's response to stress, and chronically high cortisol levels are associated with a host of age-related health issues, in addition to cognitive decline," Walton said. "The reduced cortisol-to-cortisone ratio in meditators suggests they have more adaptive reserve, more resilience, contributing to overall health and longevity." The main limitation in the years-long, cohort study was the lack of a placebo control group, according to Walton. "These meditators practiced their techniques twice daily for many years, and the control subjects had no similar activity," he told Fox News Digital. "Also, most subjects spent their years in the same geographical location (Southeast Iowa in the U.S.)." Biohacker Dave Asprey, author of the upcoming book "Heavily Meditated: The Fast Path to Remove Your Triggers, Dissolve Stress, and Activate Inner Peace," has spent 25 years studying meditation with shamans and gurus, and researching neuroscience. He agrees that meditation helps to slow the aging process. "It reduces stress — and the more stress you have that's not useful stress, like going to the gym or working hard, that shrinks your brain and makes you old," Asprey said during an on-camera interview with Fox News Digital. "Meditation has been shown in multiple studies to undo those problems." The biohacker also refers to meditation as "weightlifting for the brain." "Long-term meditators have brains that can make more electricity than someone who doesn't meditate — and their brains are more orderly." Meditation could potentially slow and perhaps prevent some types of dementia, according to Asprey. "There are studies showing that people who meditate are better at excreting toxins," he added. Asprey emphasized that meditation starts not in the mind, but in the body. "There are profound results showing that meditation can do much better than antidepressants." For those who are just getting started, he recommends trying a body scan to calm the nervous system. "For this, you breathe in deeply for four seconds and breathe out for eight seconds," he said. "Focus on your toes, then your ankles, then your calves, then your knees — and you slowly put all of your awareness in each part of your body." "Learning that meditation is an embodied practice versus a mental practice can shift it for everyone when they're just getting going." Some studies have shown that the right form of meditation or breath work can have effects that exceed pharmaceuticals, according to Asprey. "There are profound results that meditation can do much better than antidepressants," he said. "That said, if you're on a medication and you start meditating, you should tell your doctor and probably not go off the drugs without some support." For more Health articles, visit One of the biggest myths is that all meditation is the same or that all meditation is good for everyone, Asprey noted. "The normal meditation that was designed for farmers isn't going to work if you're a warrior — and it's okay if it doesn't work. It doesn't mean there's something wrong with you."
