Latest news with #BreakthroughPrize
UPI
11 hours ago
- Entertainment
- UPI
Watch: Margot Robbie, Colin Farrell go on 'Big Bold Beautiful Journey'
1 of 4 | Margot Robbie attends the Breakthrough Prize ceremony in 2024. She stars in "A Big Bold Beautiful Journey." File Photo by Jim Ruymen/UPI | License Photo June 3 (UPI) -- Sony Pictures is previewing the film A Big Bold Beautiful Journey, starring Margot Robbie and Colin Farrell. The romantic fantasy film is written by Seth Reiss and directed by Kogonada (Columbus, After Yang). "What if you could open a doorway and walk through it to re-live a defining moment from your past?" the official synopsis reads. That's exactly what Sarah (Robbie) and David (Farrell) do in the preview released Tuesday. After meeting at a wedding and experiencing "a surprising twist of fate," they find themselves staring at a red door standing alone in a forest. "Maybe we should go through it," David says. They find themselves exploring David's high school memories and Sarah's memories with her mother, who seemingly died from an illness. Kevin Kline and Phoebe Waller-Bridge also star. Robbie is well-known for her roles in such films as Suicide Squad and Barbie, while Farrell recently starred in The Penguin and The Batman. A release date has not yet been announced Margot Robbie's career: Barbie, Harley Quinn and more Margot Robbie arrives on the red carpet at the premiere of "The Wolf of Wall Street" at the Ziegfield Theatre in New York City on December 17, 2013. Photo by Dennis Van Tine/UPI | License Photo
The Guardian
22-05-2025
- Health
- The Guardian
The extraordinary promise of gene editing
Biologist whose innovation saved the life of British teenager wins $3m Breakthrough prize US doctors rewrite DNA of infant with severe genetic disorder in medical first Support the Guardian:
Yahoo
15-05-2025
- Health
- Yahoo
Scientists uncover possible missing link between 'mono' virus and multiple sclerosis
When you buy through links on our articles, Future and its syndication partners may earn a commission. For years, scientists have known that the virus behind "mono" dramatically raises the risk of multiple sclerosis (MS), a disease in which the immune system attacks nerve cells. But while most people are exposed to the mono virus by adulthood, only a few develop MS, raising the question of why. Now, researchers have uncovered a possible reason why most people infected with the mono virus never develop MS: a specific immune-system gene may mediate their risk. The mono virus — called Epstein-Barr virus (EBV) — infects more than 90% of people by adulthood, although it usually causes no symptoms. In some people, it can trigger infectious mononucleosis, better known as mono, causing fever, swollen lymph nodes and fatigue. Despite EBV's widespread presence, very few people exposed to the virus go on to develop MS, a chronic condition that affects the brain and spinal cord. Now, scientists have identified a specific genetic variant that may help explain this disparity. They published their results April 7 in the European Journal of Neurology. "The findings … could offer clues as to why only a small fraction of people develop MS despite the fact that over 90% of the global population are infected with EBV," Lisa Kiani, a senior editor of Nature Reviews Neurology, wrote in a summary of the study. Related: $3 million Breakthrough Prize goes to scientists that completely changed our understanding of multiple sclerosis The team found that people who carry a genetic variant called HLA-E*01:01 are more likely to develop MS than people without the variant, but only if they have previously had mono. The gene HLA-E is thought to influence the immune system by interacting with white blood cells, which help defend the body against infections and abnormal cells. A 2023 study published in the journal Cell found that many people with MS have previously been infected with variants of EBV that boost production of the protein that this gene encodes. This molecule can help harmful, self-destructive cells evade detection and destruction by the immune system. For the current study, the researchers examined data from more than 487,000 people from the UK Biobank, a biomedical database and research resource that includes data from 500,000 U.K. adults. They examined whether individuals carried the HLA-E*01:01 gene variant and reviewed their medical histories to see if they had ever been diagnosed with infectious mononucleosis. The group also accounted for other known MS risk factors, like smoking, childhood obesity and other genetic markers. The findings showed that people with the HLA-E*01:01 variant who had previously had mono were much more likely to develop MS than those who carried the variant but never had mono, or those with a different version of the same gene. In other words, the combination of the genetic variant and mono appeared to work together to raise the risk of developing MS. This may be because this specific version of the HLA-E gene may raise the risk of MS by weakening the immune system's ability to control EBV infection. RELATED STORIES —1 gene may explain 30 mysterious medical conditions —People with this rare genetic condition can't repair damage to their DNA —Origins of schizophrenia linked to epigenetics of the placenta For people who carried two copies of the variant — one from each parent — and had a history of mono, these factors accounted for 65% of their risk of MS, lead study author Andrea Nova, a postdoctoral researcher at the University of Pavia, told Nature Reviews Neurology. "This finding further supports the idea that genetic susceptibility is necessary for IM [infectious mononucleosis] to act as a risk factor for MS, and vice versa," Nova said. The findings could play an important role in improving early detection and treatment of MS. In theory, by screening for the HLA-E*01:01 genetic variant, doctors may be able to identify people at higher risk of developing the disease down the line, especially if they've had mono. This could enable earlier diagnosis and prompt treatment, which is key to slowing long-term damage. Early intervention can significantly improve a person's overall health and quality of life.
Newsweek
12-05-2025
- Entertainment
- Newsweek
MrBeast's Fiancée Makes Rare Comment About Him
Based on facts, either observed and verified firsthand by the reporter, or reported and verified from knowledgeable sources. Newsweek AI is in beta. Translations may contain inaccuracies—please refer to the original content. MrBeast's fiancée Thea Booysen made a rare comment about him on social media following their recent trip to Mexico. The Context MrBeast—whose real name is James "Jimmy" Donaldson—is a popular YouTuber with 393 million subscribers on the platform. In addition to YouTube, he also boasts 115.3 million followers on TikTok, 70.1 million followers on Instagram and 32.5 million followers on X, formerly Twitter. In 2022, Forbes reported the 27-year-old could become the world's "first YouTuber billionaire" with an annual income of $54 million and a net worth of $500 million. Donaldson began his content creation career in 2012 by posting gaming videos. Five years later, he went viral for uploading a nearly 24-hour-long clip of himself titled "I Counted To 100,000!" These days, the Kansas native is known for his over-the-top challenges, large giveaways, and philanthropic endeavors. On January 1, Donaldson announced his engagement to Booysen. "So I kinda did a thing..," he wrote at the time, alongside a photo of his proposal and a picture of Booysen's engagement ring. Currently, the post has 63.2 million views. MrBeast and Thea Booysen attend the 11th Breakthrough Prize ceremony at the Barker Hangar on April 5, 2025 in Santa Monica, California. MrBeast and Thea Booysen attend the 11th Breakthrough Prize ceremony at the Barker Hangar on April 5, 2025 in Santa Monica, Breakthrough Prize What To Know On Saturday, Booysen spoke out about Donaldson on social media. "I got to explore Ancient Mayan temples in Mexico with Jimmy! We saw some incredible things," the fellow content creator wrote via Instagram. "Go check out his video." "It was SO fun exploring ancient Mayan ruins in Mexico. Will show some cool stuff I caught on camera next week!" she said in a separate note on X. Donaldson also shared a photo with Booysen from their trip and wrote, "We explored dozens of 2,000 year old ancient temples in the new video to see what's inside. One of my favorite vids :D." Newsweek reached out to Donaldson's representative via email for further comment. The couple explored the country while Donaldson filmed his latest YouTube video: "I Survived 100 Hours In An Ancient Temple." As it stands, the clip already has 43.8 million views on YouTube and is quickly rising. Following its release, Donaldson wrote on X: "I remember when videos used to get 37 views in a day not 37 million. I appreciate everyone that watches the videos and just know I would personally thank each of you if it was physically possible." Prior to Booysen's latest posts, she last posted about Donaldson on Instagram and X on April 7. On Instagram, she shared photos of the pair together at the 2025 Breakthrough Prize ceremony, and on X, she promoted his Beast Philanthropy video, "Rescuing Child Slaves in Africa." What People Are Saying Booysen shared further details about their trip in the comments of her post on X. Referring to the couple's recent trip to Egypt, X user @lordsp asked: "What is the most similar and less similar thing youve seen from being inside those in Egypt and these ones?" In response, Booysen—who has a master's degree in neuropsychology—said, "Most similar: the weird fact that both feel abandoned and modern people in both regions haven't replicated those structures since. Least similar: These temples are filled with paintings and statues, etc. The pyramids were completely empty (likely raided or never had art in it to begin with)." @observadorcity wrote: "What did you have to do to go up? The government has forbidden it since some years. There are videos of tourist going up the Chichén Itzá temple and the Police goes up to bring them down and the people shout and throw stones." Booysen replied, "We didn't go up! It's seen as disrespectful to the locals. Instead we went into the Calakmul temples and some other spots around Mexico." Additionally, Donaldson commented on Booysen's most recent Instagram post: "Cutie," he said. What Happens Next It's unclear if Donaldson and Booysen have set a wedding date yet.
New York Post
08-05-2025
- Entertainment
- New York Post
Messika draws A-list crowd with sparkling statement pieces
From the start, Valérie Messika's designs were edgy and unexpected. Soon after founding her namesake fine jewelry house in 2005, the artistic innovator introduced her hit Move bracelet, featuring three brilliant-cut diamonds that glide up and down gleaming tracks. She followed that with hip pieces like Glam'Azone Double ring and Gatsby multi-hoop earrings and collaborated on capsules with Gigi Hadid. Her downtown diamond aesthetic resonated with tastemakers across the globe. Messika added High Jewelry in 2013 and quickly became an A-list mainstay. The brand's first collaboration with Kate Moss was unveiled in 2020 and stars including Beyoncé, Nicole Kidman, Emma Stone, Selena Gomez, Kerry Washington, Olivia Munn and Serena Williams have all rocked the brand's bold creations on red carpets. Gwyneth Paltrow is a fan of Messika as well. Getty Images for Breakthrough Prize Beyoncé attended the 2020 and 2022 Super Bowls wearing diamond-frosted High Jewelry. In 2023, Rihanna performed at halftime wearing a High Jewelry ear party: the Illusionnistes earring that splits into three parts, the Equilibristes diamond clip, the Magnetic Love earring, the Diamond Illusionnistes clip and part of the Diamond Equalizer earring. Four years ago, Messika held its first High Jewelry runway show in the gardens of the Ritz hotel in Paris. The event celebrated the maison's ongoing collaboration with Moss and highlighted diamond, malachite, turquoise and mother-of-pearl creations, from headpieces and fringed necklaces to supersized earrings. The glittering event is now annual. Last September, Valérie welcomed Cardi B, Natalia Vodianova, Isabelle Adjani, Future, Nina Dobrev, Cole Sprouse, Heidi Klum and the new face of her collection, Lucien Laviscount, to her star-studded front row. 'This show goes beyond jewelry; it embodies the essence of our Maison,' says Messika. 'It is an exceptional moment powered by music and fashion. It reflects our energy and singularity, which drive us to continuously create our High Jewelry pieces as true fashion statements.' She sent out 125 dazzling Midnight Sun Opus II creations, from bib necklaces and cocktail rings to the most modern of accents: lip jewelry, body belts for men and women, headpieces and nail jewels. Most spectacular of all were the Supernature and Fragments of Time diamond rivière necklaces, holding stones measuring up to over 36 carats. This High Jewelry is low-key cool.
