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New York Post
5 days ago
- Health
- New York Post
These 2 drugs made mice live 30% longer — why Bryan Johnson has warned of downsides
Biohackers, chew on this. Anti-aging aficionados have tried it all — including taking certain drugs off-label in the hopes they will lead to longer, healthier lives. A new study out of Germany provides fresh evidence that this approach may be worthwhile. Researchers at the Max Planck Institute for Biology of Aging found that a combination of two cancer drugs prolonged the lives of mice by about 30%. 4 Biohackers have tried it all — including taking certain drugs off-label in the hopes they will lead to longer, healthier lives. Prostock-studio – But buyer beware. One of the drugs, rapamycin, has sparked controversy over its safety and effectiveness in humans. Biohacking buff Bryan Johnson, 47, even admitted to dumping it from his regimen. Rapamycin is an immunosuppressant used to prevent organ rejection in transplant patients. The pill was found in the new study to increase mouse lifespan by 15% to 20% on its own. Rapamycin inhibits the mTOR pathway, which regulates major body functions such as protein synthesis, cell growth and the clearing of 'zombie' cells that don't function properly but refuse to die. Because it suppresses the immune system, one major downside of rapamycin is that it increases the risk of infections. Other potential side effects include elevated levels of cholesterol and triglycerides in the blood, gastrointestinal problems, skin issues, headaches, fatigue and drug interactions. 4 Prominent anti-aging enthusiast Bryan Johnson, 47, admitted to recently dumping rapamycin from his regimen. SXSW Conference & Festivals via Getty Images Johnson had experimented with different doses of the drug over five years before he stopped taking it in September. 'Despite the immense potential from pre-clinical trials, my team and I came to the conclusion that the benefits of lifelong dosing of rapamycin do not justify the hefty side effects (intermittent skin/soft tissue infections, lipid abnormalities, glucose elevations, and increased resting heart rate),' Johnson wrote in January. Rapamycin, along with trametinib, worked wonders in the new study. 4 The one-two punch of rapamycin and trametinib influenced gene expression differently than each drug by itself. K. Link / Max Planck Institute for Biology of Ageing Trametinib is used to treat certain types of melanoma and low-grade glioma, among other cancers. It interferes with the signals that tell cancer cells to multiply. Trametinib extended the mouse lives by 5% to 10% alone — and it was even better with rapamycin. 'Trametinib, especially in combination with rapamycin, is a good candidate to be tested in clinical trials as a geroprotector,' study author Sebastian Grönke said. 'We hope that our results will be taken up by others and tested in humans. Our focus is on optimizing the use of trametinib in animal models.' 4 Combination therapy was found to be more successful than the individual drugs. The Washington Post via Getty Images The one-two punch of rapamycin and trametinib influenced gene expression differently than each drug by itself. Researchers found lower amounts of harmful inflammation in the tissue and brain, and cancer didn't develop as fast. The findings were published this week in the journal Nature Aging. 'While we do not expect a similar extension to human lifespans as we found in mice, we hope that the drugs we're investigating could help people to stay healthy and disease-free for longer late in life,' co-senior author Linda Partridge said. 'Further research in humans in years to come will help us to elucidate how these drugs may be useful to people, and who might be able to benefit.'
Miami Herald
22-05-2025
- Business
- Miami Herald
Uber CEO reveals a crucial key to business success
While both the retail and automotive sectors are both grappling with the chaos that's ensured ever since President Donald Trump announced his tariffs plan on April 2, a few select businesses have been lucky enough to be "tariff-proof." One such retailer is TJX Companies, which along with its brands TJ Maxx, Marshall's, and HomeGoods, has been rallying lately despite the trade war. That's because the discount chains buy secondhand goods from other retailers, meaning they do not have to import their products from overseas. Don't miss the move: Subscribe to TheStreet's free daily newsletter Another company that doesn't need to worry is beverage giant Coca-Cola. Thanks to steps the company has taken to hedge against rising aluminum costs, Coca-Cola will not feel the sting the way hundreds of thousands of other businesses will. Certain lucky business models are not affected by tariffs at all. One of those is Uber (UBER) , which relies on its users to supply their own vehicles in order to use the service. Related: Uber shares new budget-friendly pricing model When Uber reported its Q4 earnings on May 7, they looked terrific: its Q1 revenue soared a remarkable 14% year over year at $11.5 billion, with a revenue forecast to grow 12% over the next three years. Uber CEO Dara Khosrowshahi's recent interview with The Verge addressed the rideshare company's future plans, including a new service that sounds a lot like a bus and which Khosrowshahi calls "complementary to public transit." But the CEO also shed some light on a key part of his success strategy with his company, and his advice is well worth checking out. Image source: Burkardt/SXSW Conference & Festivals via Getty Images Early in the interview, The Verge editor-in-chief Nilay Patel asked Khosrowshahi an interesting question: whether he "dogfoods" his own products. Dogfooding is a practice where businesses use their own products in real-world settings. When asked if he uses Uber services, including UberX and Uber Black, Khosrowshahi had some interesting insight to share. "Actually, one of the really important moves I made was starting to deliver," Khosrowshahi revealed. "Most Uber employees use Uber as consumers, but not as many use Uber as earners, as drivers, or as couriers. Early on when I joined, we were building more for the rider or the eater than the earner." Related: Uber takes aim at Tesla with its newest plan Khosrowshahi went on to say that during Covid, he felt he was "going crazy at home." The CEO's solution? To get on his e-bike and start delivering food. "Then, I got a Tesla and I started driving folks around," Khosrowshahi said. "I really do think that it's important to dogfood. You can't do it every single day, because you have a day job. But for one, you learn about your product. Just as importantly, you're setting an example for your employees." Khosrowshahi also added that Uber driving is "a lot harder than it looks." "When I first started driving, I was so nervous," he said. "I didn't want to screw up. I didn't want to take the wrong route. It's actually a lot more challenging than you think it is." The Arena Media Brands, LLC THESTREET is a registered trademark of TheStreet, Inc.
Buzz Feed
03-05-2025
- Entertainment
- Buzz Feed
26 Pairs Of Celebrities Who Look Sooo Much Alike, It's A Little Uncanny
There are so many celebrities who have completely unique looks — once-in-a-lifetime beauties. But every once in awhile, a pair of celebs hit the scene and it's almost impossible to tell them a part. 1. " Margot Robbie and Jaime Pressly." —u/ Haunting_Homework381 2. " Frankie Grande and Ethan Slater." 3. " Timothée Chalamet and Natalia Dyer." —u/ BoolImAGhost 4. "Jeremy Allen White and Gene Wilder." 5. "Charlotte Le Bon and Winona Ryder." —u/ ChileanRidge 6. "Chad Smith from Red Hot Chili Peppers and Will Ferrell." 7. "McKenna Grace and Kiernan Shipka." 8. "Josh Duhamel and Timothy Olyphant." Allen Berezovsky / Getty Images Jeffrey Mayer / WireImage Allen Berezovsky / Getty Images, Jeffrey Mayer / WireImage —u/ kjan1289 9. "Jean Smart and Kim Catrall." Jon Kopaloff / FilmMagic Jim Spellman / WireImage Jon Kopaloff / FilmMagic, Jim Spellman / WireImage —u/ MoonageDaydream24 10. "Kym Whitley and Jackee Harry." Robin L Marshall / Getty Images Robin L Marshall / FilmMagic Robin L Marshall / Getty Images, Robin L Marshall / FilmMagic —u/ the_ecdysiast 11. "Rachel Brosnahan and Evan Rachel Wood." Mindy Small / WireImage Theo Wargo / WireImage Mindy Small / WireImage, Theo Wargo / WireImage —u/ Glass-Coach-2521 12. "Henry Cavill and Matt Bomer." Han Myung-Gu / WireImage JC Olivera / Deadline via Getty Images Han Myung-Gu / WireImage, JC Olivera / Deadline via Getty Images —u/ quiet-panda-360 13. "Lili Reinhart and Brittany Murphy." Gilbert Flores / SXSW Conference & Festivals via Getty Images Jon Kopaloff / FilmMagic Gilbert Flores / SXSW Conference & Festivals via Getty Images, Jon Kopaloff / FilmMagic —u/ romant1cs 14. "Tom Hardy and Logan Marshall-Green." Steve Granitz / WireImage Kevin Winter / Getty Images Steve Granitz / WireImage, Kevin Winter / Getty Images —u/ VinylHiFi1017 15. "Adelaide Clemens and Michelle Williams." Steve Granitz / FilmMagic Yui Mok - PA Images / PA Images via Getty Images Steve Granitz / FilmMagic, Yui Mok - PA Images / PA Images via Getty Images —u/ sabine_strohem_moss 16. "Millie Bobby Brown and Elizabeth Perkins." Matt Winkelmeyer / FilmMagic, —u/ Dapper_Card_1377 Gary Gershoff / Getty Images Matt Winkelmeyer / FilmMagic,, Gary Gershoff / Getty Images 17. "Javier Bardem and Jeffrey Dean Morgan." JB Lacroix / WireImage Jamie McCarthy / Getty Images for AMC JB Lacroix / WireImage, Jamie McCarthy / Getty Images for AMC —u/ groovygyal 18. "Victoria Justice and Nina Dobrev." Maya Dehlin Spach / FilmMagic Robert Smith / Patrick McMullan via Getty Images Maya Dehlin Spach / FilmMagic, Robert Smith / Patrick McMullan via Getty Images —u/ Super_Bad6238 19. "Heath Ledger and Joseph Gordon-Levitt." Bob Riha Jr / WireImage Monica Schipper / FilmMagic Bob Riha Jr / WireImage, Monica Schipper / FilmMagic —u/ Real-Potato-4955 20. "Christopher Knight and Seth McFarland." Gabe Ginsberg / FilmMagic Michael Buckner / Variety via Getty Images Gabe Ginsberg / FilmMagic, Michael Buckner / Variety via Getty Images —u/ 22fitkitty 21. "Stanley Tucci and Mark Strong." Cindy Ord / Getty Images Mike Marsland / WireImage Cindy Ord / Getty Images, Mike Marsland / WireImage —u/ owange_tweleve 22. "Leighton Meester and Minka Kelly." Matt Winkelmeyer / WireImage Jason Mendez / Getty Images Matt Winkelmeyer / WireImage, Jason Mendez / Getty Images –u/ ThatGirl8709 23. "James Brolin and Christian Bale." Peter Bischoff / Getty Images —u/ Sm211 Lester Cohen / WireImage Peter Bischoff / Getty Images, Lester Cohen / WireImage 24. "Haley Lu Richardson and Zoey Deutch." Matt Winkelmeyer / Getty Images Cindy Ord / WireImage Matt Winkelmeyer / Getty Images, Cindy Ord / WireImage —u/ Hefty_Heron3028 25. "Bryce Dallas Howard and Jessica Chastain." Rune Hellestad - Corbis / Corbis via Getty Images Jon Kopaloff / FilmMagic Rune Hellestad - Corbis / Corbis via Getty Images, Jon Kopaloff / FilmMagic —u/ DoNotGoGentle27 26. "Kit Harington and Chris Abbot." Marc Piasecki / WireImage Frazer Harrison / Getty Images Marc Piasecki / WireImage, Frazer Harrison / Getty Images —u/ bistandards What do you think? Any surprises? Or any celebs you think should have been included in this list? Let me know in the comments!
Business Insider
02-05-2025
- Business
- Business Insider
Apple's legal setback could be a big win for the creator economy: 'We are celebrating'
Patreon CEO Jack Conte said the Apple ruling marked a "good day for creative people inarguably." Hutton Supancic/SXSW Conference & Festivals via Getty Images lighning bolt icon An icon in the shape of a lightning bolt. lighning bolt icon An icon in the shape of a lightning bolt. Impact Link This story is available exclusively to Business Insider subscribers. Become an Insider and start reading now. Apple was issued a potentially crushing setback in its ongoing legal battle over App Store fees — but players across the subscription creator economy are cheering it as a win. "This is a huge moment for creators and their businesses," a Patreon spokesperson told Business Insider in a statement. "The iOS app is the No. 1 platform for fan engagement on Patreon, and we believe this ruling allows creators to get paid without giving Apple 30%." Patreon is a platform where creators can build subscription businesses and charge fans for paywalled content, such as podcasts or videos, and other perks. A judge on Wednesday found Apple had violated a 2021 injunction in its legal fight with Epic Games. The dispute started over the 30% fee Apple collects on in-app purchases. The 2021 injunction largely favored Apple, but it said the company needed to let developers inform users in their apps about purchase options outside the Apple App Store. Wednesday's ruling said the company failed to do that. It also said Apple violated the court's order by charging a 27% fee when links guide users to off-app purchases. An Apple spokesperson previously told BI that the company "strongly" disagrees with the court's decision and plans to both comply and appeal — a sentiment echoed by CEO Tim Cook on the company's earnings call. Apple did not respond to a request for further comment. Apps that help creators make money from subscriptions, like Patreon, Passes, Kajabi, and Mighty Networks, rejoiced at the changes. If more subscriptions are transacted outside Apple's ecosystem, it could mean more money for creators and platforms alike. Patreon said it's submitting an app update for review that will enable payment options outside of in-app purchases so creators can keep more money. Last year, the company said it was removing all other billing systems from its iOS app, and advised creators that they could either raise their in-app prices to cover Apple's fees or eat the fees themselves. Subscribers could also avoid the fees by signing up on Patreon's website. While "the dust has yet to settle," given Apple's plans to appeal, "this is a good day for creative people," Patreon CEO Jack Conte said on Instagram. Passes founder and CEO Lucy Guo told BI in a statement that "companies have had to charge more to creators because of these commissions, so this will put more money in creators' pockets." Mighty Networks CEO Gina Bianchini said, "We are celebrating over here at Mighty Networks." 'A more equitable digital marketplace for creators' The ruling could threaten Apple's App Store revenue, which is a major money maker for the company. Related stories Business Insider tells the innovative stories you want to know Business Insider tells the innovative stories you want to know Last quarter, the company's services business, which includes its App Store, accounted for $26.6 billion in net sales. While it's unclear how many prospective subscribers will forego the convenience of in-app purchases, Kajabi CEO Ahad Khan said the ruling points to a shift toward more creator ownership. "Creators have long relied on social platforms and tech giants to earn money, and it cuts into their earnings and even limits how they engage with their audiences," he told BI. "This ruling is another proof point of this shift toward a more equitable digital marketplace for creators."
Black America Web
22-04-2025
- Entertainment
- Black America Web
Michelle Obama's Brother Had Doubts About Her Relationship With Barack
Black America Web Featured Video CLOSE Source: SXSW Conference & Festivals / Getty Before Michelle and Barack Obama became America's favorite power couple, Michelle's older brother, Craig Robinson, had his doubts. Read more about what he shared on the latest episode of their podcast. On the latest episode of IMO with Michelle Obama and Craig Robinson , Craig opened up about meeting Barack for the first time. He shared his very first impression of the man who would eventually become President of the United States. 'Mich starts to date Barack, and we don't know who this guy is. We're just like, 'Barack? Who's got a name like Barack?'' he joked. 'And I'm thinking to myself, it's gonna last like about a month like most of your relationships did.' Michelle, 61, didn't let that slide. 'That's not true,' she fired back. 'I had many a long-term boyfriend.' But her big brother wasn't buying it, and even recalled their mother's reaction to Barack's height, saying, 'At least he's tall.' Despite his early skepticism, Craig admitted he put Barack through a test on the basketball court. Their father once told him you could tell a lot about a man by how he played pickup basketball. 'Aside from the fact that he's left-handed so he couldn't go right at all,' Craig said, 'most importantly, he was a team player. He fit in with the people. So I was able to report back to you, everything was fine. And the rest was history.' Michelle and Barack tied the knot in 1992 and have been married for 32 years, raising daughters Malia, 26, and Sasha, 23. Though he's long retired from pickup games (after needing 30 stitches from a White House game), Barack still keeps the romance alive. This past Valentine's Day, he posted, 'Thirty-two years together and you still take my breath away.' Michelle recently addressed public speculation about her marriage, explaining that her independent choices have been misunderstood. 'People couldn't even fathom that I was making a choice for myself,' she told Sophia Bush on the Work in Progress podcast. 'That they had to assume that my husband and I are divorcing. But that's what society does to us.' From doubtful beginnings to decades of love, Barack and Michelle's love story is still unfolding—despite the haters, skeptics, or even family teasing. Check out IMO with Michelle Obama and Craig Robinson here . SEE ALSO Michelle Obama's Brother Had Doubts About Her Relationship With Barack was originally published on
