Latest news with #Cymbalta
Health Line
2 days ago
- Health
- Health Line
Is It Normal to Smell Myself Through My Pants?
While a temporary smell right before it's shower time is common, a lingering smell so strong you can smell it through your pants could indicate an infection or other underlying condition. Your body is full of weird and wonderful surprises. Some of them may be smelly. Keep reading for some of the reasons why you may smell yourself through your pants and ways to treat any underlying condition. What can cause a strong overall odor? Diet Eating some foods can temporarily affect the way your body smells, including the smell of your sweat or urine. For example: asparagus garlic onion chili vinegar marinated fish fermented milk products Sweat Sweating in the groin area can attract fungus and bacteria, leading to an unusual smell. Showering after exercise or vigorous activity — including masturbation or partner sex — can help. Putting on clean, dry clothes after a sweat session can also have a positive impact. Avoid tight-fitting clothes, which will make you sweat more. Medication side effects Some medications may increase the body's likelihood to sweat, such as: duloxetine hydrochloride (Cymbalta) escitalopram oxalate (Lexapro) paroxetine hydrochloride (Paxil) sertraline hydrochloride (Zoloft) Incontinence Accidental leakage can buildup on your underwear or skin, leading to a smelly groin. Good hygiene practices, such as changing soiled underwear as soon as possible and washing with soap and warm water, can help. Yeast infection Yeast infections can cause a bread-like smell in the groin area as well as unusual discharge, itching, redness, and skin irritation. Treatments may include topical antifungal ointments or oral antifungal medications. If you have recurrent infections, consider making an appointment with a healthcare professional to discuss prescription medication. Urinary tract infection (UTI) UTIs occur when excess bacteria invade the urinary tract. In addition to an unusual odor, symptoms can include: frequent urge to urinate painful urination side pain nausea Although over-the-counter medications can help reduce pain, prescription antibiotics are necessary to clear the infection. What can cause a strong vulvar or vaginal odor? Stuck tampon Sometimes, an inserted tampon can turn sideways or the tampon string can move up into the vaginal canal. As a result, you may forget about the tampon or have such difficulty removing it that it remains there for longer than intended. Symptoms of a stuck tampon include: discolored, foul-smelling discharge painful urination swelling around the vaginal opening fever A retained tampon can cause serious complications, including an illness known as toxic shock syndrome. To keep this from happening, remove the tampon with clean hands as quickly as possible. Bacterial vaginosis (BV) BV occurs due to an overgrowth of bacteria. Symptoms include: strong odor that may be described as 'fishy' unusual or excessive gray or white discharge itching and burning Although the condition may clear up on its own for some people, prescription medication can help alleviate symptoms sooner rather than later. Trichomoniasis Trichomoniasis is a common sexually transmitted infection (STI). It's often asymptomatic, meaning many people do not experience symptoms. When symptoms do occur, they can include: unusual or fishy odor frothy, pink discharge painful urination Treatments include antifungal medications, such as metronidazole. Hormonal fluctuations Hormonal changes due to menopause can lead to the thinning of vaginal tissues, which can affect the pH balance in the vagina. This can cause an unusual, acidic smell. While the smell doesn't necessarily require treatment, healthcare professionals can treat menopause-related vaginal atrophy with topical or oral hormones. Rectovaginal fistula A rectovaginal fistula is an abnormal connection between the rectum and vagina that causes stool and other bowel contents to leak into the vaginal canal. The most common cause is trauma related to childbirth that causes a third or fourth degree vaginal tear. However, a history of surgical procedures, Crohn's disease, or cancer can also cause the condition. Symptoms include: smell of intestinal gas coming from the vagina unusual or unexpected bleeding passage of stool through the vagina Treating the underlying condition or surgical correction can help alleviate your symptoms. What can cause a strong penile odor? Smegma Smegma occurs when dead skin cells, fluids, and oils build up around the head of the penis. It's more common in people who have an uncircumcised penis, as the area under the foreskin can trap bacteria and debris. Thoroughly cleaning the area with soap and warm water is usually all that's needed to remove smegma. If left untreated, smegma can lead to balanitis. Balanitis Balanitis is an inflammatory condition that affects the head of the penis. It may result from inadequate hygiene, contact with an irritant, or an infection. Depending on the underlying cause, symptoms may include: foul-smelling discharge tight-appearing foreskin itching pain Treatments for balanitis include topical creams to reduce inflammation and itching, and antibiotics or antifungals to treat an infection.
Yahoo
06-06-2025
- Health
- Yahoo
Denovo Biopharma Announces Formation of Neuroscience Scientific Advisory Board to Advance Precision Medicine in Depression
- Scientific Advisory Board brings together distinguished experts in neuroscience to support Denovo's CNS development programs, including the Phase 3-ready lead program, biomarker-guided DB104 (liafensine) in treatment-resistant depression (TRD) - SAN DIEGO, June 06, 2025 (GLOBE NEWSWIRE) -- Denovo Biopharma LLC, a pioneer in applying precision medicine to development of innovative drugs, today announced the formation of its neuroscience-focused Scientific Advisory Board (SAB) comprised of distinguished experts in the field. The SAB will be chaired by Charles B. Nemeroff, M.D., Ph.D., Chair and Professor of the Department of Psychiatry and Behavioral Sciences at Dell Medical School at The University of Texas at Austin. Dr. Nemeroff served as president of the American College of Psychiatrists and the American College of Neuropsychopharmacology, and is past-president of the Anxiety and Depression Association of America (ADAA). 'We are extremely honored to welcome such a distinguished group of scientific leaders to join our efforts at Denovo Biopharma as we work towards addressing a major unmet need in the psychiatry field with a novel precision medicine,' said Wen Luo, Ph.D., Chief Executive Officer of Denovo Biopharma. 'As we prepare our lead asset, DB104, to enter a biomarker-guided Phase 3 study in TRD, we believe their guidance will be instrumental in shaping both our clinical development strategy and our regulatory path forward. We are thankful for their support and look forward to collaborating as we work to advance a first-in-class, potentially transformative therapy for patients with TRD.' Other members of Denovo's neuroscience Scientific Advisory Board include: Stephen Brannan, M.D., is a neuroscience drug development expert with over 15 years of industry experience. He most recently served as Chief Medical Officer at Karuna Therapeutics, where he was instrumental in the development of CobenfyTM for the treatment of schizophrenia, which was later acquired by Bristol Myers Squibb for $14 billion. Prior to Karuna, Dr. Brannan was the Therapeutic Head of Neuroscience at Takeda and Vice President for Clinical Research and Medical Affairs at Forum Pharmaceuticals. Dr. Brannan has been active in the development of multiple important central nervous system treatments including Cymbalta®, Exelon Patch®, Trintellix®, and Vagal Nerve Stimulation for TRD during his tenures at Forum, Takeda, Novartis, Cyberonics, and Eli Lilly. Sanjay Mathew, M.D., is Professor of Psychiatry and Behavioral Sciences, Director of Mood and Anxiety Disorders Program, and Vice Chair for Research at Baylor College of Medicine. He is currently ADAA's President-Elect and Chief Medical Officer. Dr. Mathew is a leading expert in the areas of experimental therapeutics and pathophysiology of TRD, suicide, and PTSD. About DB104 (biomarker-guided liafensine) Liafensine is a first-in-class triple reuptake inhibitor targeting transporters for serotonin, norepinephrine, and dopamine. It was licensed from Albany Molecular Research, Inc. (now Curia) and was previously developed by Bristol-Myers Squibb (BMS), who had conducted two large Phase 2b clinical trials in non-selected TRD patient population. Denovo's unique artificial intelligence (AI) and whole genome sequencing (WGS)-based Denovo Genomic Marker (DGM™) biomarker platform allowed discovery of a novel genetic biomarker at the ANK3 gene, with a strong correlation of ANK3-positive status with liafensine's efficacy in the BMS studies. Denovo's ENLIGHTEN Phase 2b study results prospectively demonstrated the use of ANK3 as a predictive biomarker for liafensine's efficacy in TRD patients, a first for genetic biomarkers in psychiatry. About Denovo Biopharma Denovo Biopharma LLC is a clinical-stage biopharmaceutical company that uses novel biomarker approaches to execute efficient clinical trials in targeted patient subpopulations to increase the probability of success. Denovo has seven late-stage drugs in its pipeline addressing major unmet medical needs in central nervous system diseases and oncology, most of which are first in class drugs with global rights. Visit for additional information. Investor Contact: Stephen Jasper Gilmartin Group stephen@ in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Time Business News
02-05-2025
- Health
- Time Business News
Ketamine Therapy vs. Antidepressants: Which Is More Effective Long-Term?
Depression affects more than 280 million people globally, and finding the right treatment is often a long, frustrating journey. Traditionally, antidepressants like SSRIs (Selective Serotonin Reuptake Inhibitors) have been the go-to option. However, Ketamine Therapy is emerging as a powerful alternative, offering rapid relief for patients who haven't responded to conventional treatment. So, which option is better for long-term mental health recovery: antidepressants or Ketamine Therapy? If you're considering Ketamine Therapy in Boulder or evaluating your current treatment plan, this guide will help you understand the key differences, effectiveness, risks, and benefits of both. Antidepressants are medications designed to balance brain chemicals like serotonin, dopamine, and norepinephrine. Common types include: SSRIs (e.g., Prozac, Zoloft) (e.g., Prozac, Zoloft) SNRIs (e.g., Effexor, Cymbalta) (e.g., Effexor, Cymbalta) Tricyclics and MAOIs (less commonly prescribed due to side effects) These medications generally take 2–6 weeks to show results and are often used alongside therapy. Ketamine Therapy, particularly in the form of IV infusions or intranasal esketamine (Spravato), targets the glutamate system, promoting neural plasticity and rapid mood improvement. Clinics offering Ketamine Therapy in Boulder report that many patients feel better within hours to days of their first treatment. It's often used for treatment-resistant depression (TRD) and suicidal ideation. Antidepressants increase the availability of serotonin and other neurotransmitters. They aim to regulate mood over time but do not typically address the brain's structural changes linked to long-term depression. Limitations: Slower onset Common side effects (e.g., weight gain, ****** dysfunction, fatigue) Emotional blunting Ketamine works by blocking NMDA receptors, enhancing glutamate activity and promoting synaptogenesis—the creation of new neural connections. Advantages: Fast-acting (within hours) May reverse structural brain damage caused by chronic stress Strong effects on suicidal ideation Recent studies have shown that Ketamine Therapy in Boulder and similar clinics across the U.S. report high success rates, especially for patients who haven't responded to 2+ antidepressants. According to a 2018 meta-analysis in The Lancet , 60% of people experience some improvement with antidepressants, but relapse is common. , 60% of people experience some improvement with antidepressants, but relapse is common. 33% of patients relapse within a year of stopping medication. Many require long-term use, leading to increased risk of side effects and dependency. A 2020 study published in JAMA Psychiatry found that 70% of patients with TRD responded positively to ketamine. found that 70% of patients with TRD responded positively to ketamine. Another study in The American Journal of Psychiatry reported reduced suicidal ideation within 24 hours of treatment. reported reduced suicidal ideation within 24 hours of treatment. Long-term effectiveness depends on maintenance treatments and integration with therapy. Clinics offering Ketamine Therapy in Boulder often combine infusions with psychotherapy to sustain results, significantly reducing relapse rates. Common: Insomnia, fatigue, nausea, ****** side effects Severe (less common): Increased anxiety or suicidal thoughts during initial weeks Long-term: Tolerance, emotional numbness, and withdrawal symptoms Common (short-term): Dissociation, dizziness, nausea, increased blood pressure Rare (long-term): Bladder issues, dependency (in recreational use, not clinical) Safe when administered in a medical setting like a certified Ketamine Therapy clinic in Boulder Generally covered by insurance Low out-of-pocket costs Widely available through primary care or psychiatry Can be more expensive per session (average $400–$800) Spravato (nasal form) often covered by insurance IV infusions may not be fully covered However, many clinics offering Ketamine Therapy in Boulder provide flexible payment plans or work with insurance for partial reimbursement. Require daily medication Often a trial-and-error process Side effects can interfere with daily life Less frequent sessions (typically 6–8 over 2–3 weeks) Immediate symptom relief can improve quality of life quickly Enhanced engagement in therapy due to faster symptom reduction Patients receiving Ketamine Therapy in Boulder frequently report improved motivation, better sleep, and enhanced social interactions after just a few sessions. You're experiencing mild to moderate depression You have not tried any treatment yet You prefer a cost-effective and accessible option You have treatment-resistant depression You need rapid relief from suicidal ideation You're looking for a non-traditional, science-backed alternative Pro Tip: Many mental health professionals now recommend combining both for enhanced, long-term results. For example, ongoing antidepressants with booster ketamine sessions at a Ketamine Therapy clinic in Boulder can provide balanced, sustainable mental health support. Claire, a 36-year-old Boulder resident, struggled with major depression for over a decade. After trying five different antidepressants with minimal success, she discovered Ketamine Therapy in Boulder. 'I felt better within 24 hours of my first session,' Claire shares. 'It gave me the clarity and energy to engage in therapy again. I wish I had tried this sooner.' Her current regimen includes monthly maintenance ketamine infusions and weekly CBT sessions. She reports an 80% reduction in depressive symptoms and is back to working full-time. Both antidepressants and Ketamine Therapy can be effective—depending on the individual. However, for patients with TRD, ketamine offers significant advantages in speed, depth of relief, and neurobiological repair. That said, Ketamine Therapy isn't a standalone cure. It works best when paired with therapy and lifestyle adjustments. Clinics providing Ketamine Therapy in Boulder understand this and often offer integrative care models to support long-term success. TIME BUSINESS NEWS
