Latest news with #DepartmentofMedicalEpidemiologyandBiostatistics
Time of India
3 days ago
- Health
- Time of India
Mirrorlights: Autistic patients at high risk of Parkinson's disease: Study
autism spectrum disorder People with autism could be at a higher risk of developing Parkinson's disease early in life, according to a large-scale study that showed similar underlying biological mechanisms of the from the Karolinska Institutet questioned a possible connection between the neuropsychiatric diagnosis of(ASD), which affects an individual's thought processes, behaviour, and interpersonal communication, and early-onset Parkinson's disease -- a condition that affects locomotion and results, published in JAMA Neurology, show that people with an autism diagnosis were four times more likely to develop Parkinson's disease than people without such a diagnosis.'This indicates that there can be shared biological drivers behind ASD and Parkinson's disease,' said Weiyao Yin, researcher at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet.'One hypothesis is that the brain's dopamine system is affected in both cases, since the neurotransmitter dopamine plays an important part in social behavior and motion control,' Yin study is based on registry data from over two million people born in Sweden between 1974 and 1999, who were followed from the ageof 20 up to the end of is well-known that dopamine-producing neurons are degraded in Parkinson's studies have also shown that dopamine is possibly implicated in autism, but more research needs to be done to confirm this.'We hope that our results will eventually help to bring greater clarity to the underlying causes of both ASD and Parkinson's disease,' Yin for more studies, the researchers urged healthcare services to keep people with ASD -- a vulnerable group with high co-morbidity and high use of psychotropics -- under long-term observation.
India.com
12-05-2025
- Health
- India.com
Pregnant Women With Fatty Liver Face 3X Higher Risk Of Premature Birth, Finds Study
New Delhi: Pregnant women with metabolic dysfunction-associated steatotic liver disease (MASLD) have an increased risk of giving birth prematurely and the risk increase cannot be explained by obesity, according to a new study on Friday. It is estimated that as many as three out of ten people globally have MASLD, previously called non-alcoholic fatty liver disease. Common risk factors are metabolic disorders such as Type 2 diabetes and overweight or obesity. The disease has become increasingly common, including among women of reproductive age. Researchers from Karolinska Institutet in Sweden have now investigated the association between maternal MASLD and pregnancy and neonatal birth outcomes. Their findings, published in the journal eClinicalMedicine, showed that women with MASLD were more than three times more likely to give birth prematurely. The risk did not increase with MASLD severity and the increase in risk persisted even when compared to overweight or obese women without known MASLD. 'This suggests that the association is not only due to a high body mass index (BMI) and that the liver disease itself can have negative effects,' explains lead author Carole A. Marxer, a postdoctoral researcher at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet. The study is based on Swedish registry data and includes a total of 240 births among women with MASLD and 1,140 matched births of women from the general population. Women with MASLD also had a 63 per cent higher risk of caesarean section than the control group. However, this seems to be explained by high BMI as no increase in risk was seen compared to overweight or obese women without fatty liver disease. 'It is important that pregnant women with MASLD are closely monitored during pregnancy to reduce the risk of complications. Consideration should also be given to adding specific recommendations for pregnant women to the clinical guidelines for MASLD,' Marxer said. 'It is also worth noting that we did not find any increased risk in women with MASLD of having children with congenital malformations or of having children who died at birth,' added Jonas F. Ludvigsson, paediatrician at Orebro University Hospital and professor at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet. However, the increased risk may have been influenced by other factors as well, the researchers said.
Hans India
09-05-2025
- Health
- Hans India
Fatty liver in pregnancy may increase risk of preterm birth
New Delhi: Pregnant women with metabolic dysfunction-associated steatotic liver disease (MASLD) have an increased risk of giving birth prematurely and the risk increase cannot be explained by obesity, according to a new study on Friday. It is estimated that as many as three out of ten people globally have MASLD, previously called non-alcoholic fatty liver disease. Common risk factors are metabolic disorders such as Type 2 diabetes and overweight or obesity. The disease has become increasingly common, including among women of reproductive age. Researchers from Karolinska Institutet in Sweden have now investigated the association between maternal MASLD and pregnancy and neonatal birth outcomes. Their findings, published in the journal eClinicalMedicine, showed that women with MASLD were more than three times more likely to give birth prematurely. The risk did not increase with MASLD severity and the increase in risk persisted even when compared to overweight or obese women without known MASLD. 'This suggests that the association is not only due to a high body mass index (BMI) and that the liver disease itself can have negative effects,' explains lead author Carole A. Marxer, a postdoctoral researcher at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet. The study is based on Swedish registry data and includes a total of 240 births among women with MASLD and 1,140 matched births of women from the general population. Women with MASLD also had a 63 per cent higher risk of caesarean section than the control group. However, this seems to be explained by high BMI as no increase in risk was seen compared to overweight or obese women without fatty liver disease. 'It is important that pregnant women with MASLD are closely monitored during pregnancy to reduce the risk of complications. Consideration should also be given to adding specific recommendations for pregnant women to the clinical guidelines for MASLD,' Marxer said. 'It is also worth noting that we did not find any increased risk in women with MASLD of having children with congenital malformations or of having children who died at birth,' added Jonas F. Ludvigsson, paediatrician at Orebro University Hospital and professor at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet. However, the increased risk may have been influenced by other factors as well, the researchers said.
