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Yahoo
14-05-2025
- Business
- Yahoo
Codexis Reports First Quarter 2025 Financial Results
Secured first revenue-generating contract for ECO Synthesis™ manufacturing services Company reiterates full-year financial guidance Six presentations to feature the ECO Synthesis platform at upcoming TIDES USA annual meeting, including three from leading CDMO collaborators REDWOOD CITY, Calif., May 14, 2025 (GLOBE NEWSWIRE) -- Codexis, Inc. (NASDAQ: CDXS), a leading provider of enzymatic solutions for efficient and scalable therapeutics manufacturing, today announced financial results for the first quarter ended March 31, 2025, and provided a business update. 'Codexis finished the first quarter with $60 million in cash, which remains on track to fund the company through cash flow positivity by the end of 2026,' said Stephen Dilly, MBBS, PhD, Chairman and Chief Executive Officer at Codexis. 'Importantly, the Q1 revenue guidance we outlined in February included a $2.5 million one-time payment from a Pharma Biocatalysis customer due in March which was received in April. Since this has no impact on our overall 2025 revenue projections, we are confident in reiterating our 2025 guidance and the current range of published analyst estimates. 'On the commercial front, we have already executed on several key milestones this year, including our first revenue-generating contract for our ECO Synthesis manufacturing services. Our ligase business is also gaining traction, reflected by the delivery of our first order to a large pharma customer, a new order from a second important drug innovator, and three key CDMO collaborators planning to highlight the performance of our ligases in their facilities at the upcoming TIDES USA meeting. Between those positive developments, several recent advancements in the siRNA therapeutic landscape, and the macro trends toward building out U.S.-based manufacturing infrastructures, we believe the broader environment is becoming increasingly favorable for our unique toolbox of enzymatic solutions.' First Quarter and Recent Business Highlights In March 2025, Codexis announced its first revenue-generating contract to manufacture siRNA material in its ECO Synthesis Innovation Lab. The Company also announced that it successfully completed development of the first generation of its core ECO Synthesis enzymes, having met the pre-specified criteria to support scaling to industrial capacity. Since the first of the year, Codexis has appointed Christos Richards and Cynthia Collins to its Board of Directors. Mr. Richards has over 30 years of global executive advisory and search experience in the biopharmaceutical and healthcare sectors. Ms. Collins brings a wealth of knowledge about the contract development and manufacturing organization (CDMO) landscape and currently serves as Chairman and CEO of Nutcracker Therapeutics, a company with a next generation RNA precision manufacturing platform. In February 2025, Codexis appointed Arthur Levin, PhD, to its Strategic Advisory Board. Dr. Levin has three decades of experience developing oligonucleotides and is a founding member of Avidity Biosciences, a biopharmaceutical company committed to delivering a new class of RNA therapeutics called antibody oligonucleotide conjugates. Upcoming Milestones Codexis will host two oral presentations and one poster at the 2025 TIDES USA annual meeting, taking place from May 19-22, 2025, in San Diego, California. In addition, three leading CDMOs are presenting data on their use of Codexis' double-stranded RNA ligases to successfully combine short RNA fragments, including one co-presentation between Codexis and Bachem. The Company expects to achieve pilot scale production of GLP-grade siRNA material using the ECO Synthesis Innovation Lab in 2025. Codexis expects to sign a GMP scale-up partner by the end of 2025 to enable larger scale clinical and commercial siRNA production. First Quarter 2025 Financial Highlights 'We delivered a solid performance this quarter, despite the slip of a $2.5 million customer order from Q1 to Q2,' said Georgia Erbez, Chief Financial Officer of Codexis. 'As we've highlighted in the past, our revenue can be unpredictable as large orders such as this one can be delayed by a customer by only a few weeks. Additionally, when comparing Q1 revenue in 2024 versus 2025, it's important to note that the first quarter of last year was higher than anticipated due to one-time revenue recognition of $6 million related to an agreement with Roche, as well as two sizable customer orders placed that quarter, further demonstrating the variability in our revenue from quarter to quarter. Notwithstanding these dynamics, we are encouraged by our momentum so far this year, remain in a strong cash position, and are confident in reiterating our 2025 guidance range.' Total revenues were $7.5 million for the first quarter of 2025 compared to $17.1 million in the first quarter of 2024. The decrease was primarily due to the recognition of $6.0 million in revenue from a licensing agreement with Roche for an exclusive, global license for our double-stranded DNA ligase, as well as two sizable customer orders placed in the first quarter of 2024. Product gross margin was 55% for the first quarter of 2025 compared to 49% in the first quarter of 2024. The increase in gross margin was largely due to a shift in sales toward more profitable products, and declines in less profitable, legacy products. Research and Development expenses for the first quarter of 2025 were $12.9 million compared to $11.2 million in the first quarter of 2024; the increase was primarily driven by an increase in costs associated with salaries and employee costs, and higher lab supplies expense. Selling, General & Administrative expenses for the first quarter of 2025 were $12.4 million compared to $12.9 million in the first quarter of 2024; the decrease was primarily due to lower legal fees and lower stock-based compensation expense. The net loss for the first quarter of 2025 was $20.7 million, or $0.25 per share, compared to a net loss of $11.5 million, or $0.16 per share, for the first quarter of 2024. As of March 31, 2025, the Company had $59.8 million in cash, cash equivalents and short-term investments. 2025 Financial Guidance Reiterated Codexis reiterated its full-year 2025 financial guidance originally issued on February 27, 2025, as follows: Total revenues are expected to be in the range of $64 million to $68 million. Codexis expects that its existing cash, cash equivalents and short-term investments will be sufficient to fund its planned operations through positive cash flow, expected by the end of 2026. Conference Call and Webcast Codexis will hold a conference call and webcast today beginning at 4:30 pm ET. A live webcast and slide presentation to accompany the conference call will be available on the Investors section of the Company website at The conference call dial-in numbers are 877-705-2976 for domestic callers and 201-689-8798 for international callers. A telephone recording of the call will be available for 48 hours beginning approximately two hours after the completion of the call by dialing 877-660-6853 for domestic callers or 201-612-7415 for international callers. Please use the passcode 13726635 to access the recording. A webcast replay will be available on the Investors section of the Company website for at least 90 days, beginning approximately two hours after the completion of the call. About Codexis Codexis is a leading provider of enzymatic solutions for efficient and scalable therapeutics manufacturing, leveraging its proprietary CodeEvolver® technology platform to discover, develop and enhance novel, high-performance enzymes. Codexis enzymes solve for real-world challenges associated with small molecule pharmaceuticals manufacturing and nucleic acid synthesis. The Company is currently developing its proprietary ECO Synthesis™ manufacturing platform to enable the scaled manufacture of RNAi therapeutics through an enzymatic route. Codexis' unique enzymes can drive improvements such as higher yields, reduced energy usage and waste generation, improved efficiency in manufacturing and greater sensitivity in genomic and diagnostic applications. For more information, visit Forward-Looking Statements This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. In some cases, you can identify forward-looking statements by terminology such as 'aim,' 'anticipate,' 'assume,' 'believe,' 'contemplate,' 'continue,' 'could,' 'design,' 'due,' 'estimate,' 'expect,' 'goal,' 'intend,' 'may,' 'objective,' 'plan,' 'positioned,' 'potential,' 'predict,' 'seek,' 'should,' 'suggest,' 'target,' 'on track,' 'will,' 'would' and other similar expressions that are predictions of or indicate future events and future trends, or the negative of these terms or other comparable terminology. To the extent that statements contained in this press release are not descriptions of historical facts, they are forward-looking statements reflecting the current beliefs and expectations of management, including but not limited to statements regarding anticipated milestones, including product launches, technical milestones, data releases and public announcements related thereto; whether Codexis will be able to, and the timing of it entering into revenue-generating development contracts with customers regarding its ECO Synthesis™ manufacturing platform; its ability to enter into an agreement with a GMP scale-up partner regarding its ECO Synthesis™ manufacturing platform in 2025; Codexis achieving pilot scale production of GLP-grade siRNA material using the ECO Synthesis™ Innovation Lab in 2025; Codexis' expectations regarding 2025 product revenues, R&D revenues and gross margin on product revenue, as well as its ability to fund planned operations through the end of 2026; Codexis' ability to achieve positive cash flow around the end of 2026; potential receipt by Codexis of certain royalty payments pursuant to its recent license agreement with Alphazyme; the potential of the ECO Synthesis™ manufacturing platform, including its ability to be broadly utilized and to enable commercial-scale manufacture of RNAi therapeutics through an enzymatic route; and expectations regarding future demand for dsRNA. You should not place undue reliance on these forward-looking statements because they involve known and unknown risks, uncertainties and other factors that are, in some cases, beyond Codexis' control and that could materially affect actual results. Factors that could materially affect actual results include, among others: Codexis' dependence on its licensees and collaborators; if any of its collaborators terminate their development programs under their respective license agreements with Codexis; Codexis may need additional capital in the future in order to expand its business; if Codexis is unable to successfully develop new technology such as its ECO Synthesis™ manufacturing platform and dsRNA ligase; Codexis' dependence on a limited number of products and customers, and potential adverse effects to Codexis' business if its customers' products are not received well in the markets; if Codexis is unable to develop and commercialize new products for its target markets; if competitors and potential competitors who have greater resources and experience than Codexis develop products and technologies that make Codexis' products and technologies obsolete; Codexis' ability to comply with debt covenants under its loan facility; if Codexis is unable to accurately forecast financial and operational performance; and market, political and economic conditions may negatively impact Codexis business, financial condition and share price. International trade policies, including tariffs, sanctions and trade barriers, may adversely affect our business. Additional information about factors that could materially affect actual results can be found in Codexis' Annual Report on Form 10-K filed with the Securities and Exchange Commission (SEC) on February 27, 2025 and in Codexis' Quarterly Report on Form 10-Q filed with the SEC on or about the date hereof, including under the caption 'Risk Factors,' and in Codexis' other periodic reports filed with the SEC. Codexis expressly disclaims any intent or obligation to update these forward-looking statements, except as required by law. Codexis' results for the year and quarter ended March 31, 2025, are not necessarily indicative of our operating results for any future periods. For More InformationInvestor ContactCarrie McKim(336) 608-9706ir@ Consolidated Statements of Operations(Unaudited)(In Thousands, Except Per Share Amounts) Three Months Ended March 31, 2025 2024 Revenues: Product revenue $ 6,059 $ 9,551 Research and development revenue 1,484 7,522 Total revenues 7,543 17,073 Costs and operating expenses: Cost of product revenue 2,732 4,855 Research and development 12,942 11,246 Selling, general and administrative 12,355 12,860 Total costs and operating expenses 28,029 28,961 Loss from operations (20,486 ) (11,888 ) Interest income 751 909 Interest and other expense, net (942 ) (516 ) Loss before income taxes (20,677 ) (11,495 ) Provision for income taxes 11 10 Net loss $ (20,688 ) $ (11,505 ) Net loss per share, basic and diluted $ (0.25 ) $ (0.16 ) Weighted average common stock shares used in computing net loss per share, basic and diluted 82,410 69,854 Codexis, Consolidated Statements of Comprehensive Loss(Unaudited)(In Thousands) Three Months Ended March 31, 2025 2024 Net loss $ (20,688 ) $ (11,505 ) Other comprehensive loss: Unrealized loss on available-for-sale short-term investments, net of tax (38 ) (16 ) Comprehensive loss $ (20,726 ) $ (11,521 ) Codexis, Consolidated Balance Sheets(Unaudited)(In Thousands) March 31, 2025 December 31, 2024 Assets Current assets: Cash and cash equivalents $ 18,319 $ 19,264 Restricted cash, current 504 503 Short-term investments 41,462 54,194 Financial assets: Accounts receivable 6,442 11,920 Contract assets 1,788 4,375 Unbilled receivables 3,406 2,751 Total financial assets 11,636 19,046 Less: allowances (49 ) (162 ) Total financial assets, net 11,587 18,884 Inventories 1,781 1,799 Prepaid expenses and other current assets 4,155 4,128 Total current assets 77,808 98,772 Restricted cash 1,062 1,062 Investment in non-marketable equity securities 2,798 2,798 Right-of-use assets - Operating leases, net 27,986 28,700 Property and equipment, net 15,803 14,197 Goodwill 2,463 2,463 Other non-current assets 967 1,019 Total assets $ 128,887 $ 149,011 Liabilities and Stockholders' Equity Current liabilities: Accounts payable $ 6,046 $ 2,838 Accrued compensation 6,387 11,410 Other accrued liabilities 5,117 6,223 Current portion of lease obligations - Operating leases 2,913 2,827 Deferred revenue 438 350 Total current liabilities 20,901 23,648 Deferred revenue, net of current portion 490 100 Long-term lease obligations - Operating leases 27,398 28,163 Long-term debt 29,186 28,905 Other long-term liabilities 1,283 1,268 Total liabilities 79,258 82,084 Stockholders' equity: Common stock 8 8 Additional paid-in capital 633,101 629,673 Accumulated other comprehensive income 14 52 Accumulated deficit (583,494 ) (562,806 ) Total stockholders' equity 49,629 66,927 Total liabilities and stockholders' equity $ 128,887 $ 149,011 Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
18-02-2025
- Business
- Yahoo
Codexis to Participate in TD Cowen 45th Annual Health Care Conference
REDWOOD CITY, Calif., Feb. 18, 2025 (GLOBE NEWSWIRE) -- Codexis, Inc. (NASDAQ: CDXS), a leading provider of enzymatic solutions for efficient and scalable therapeutics manufacturing, today announced the Company will attend the TD Cowen 45th Annual Health Care Conference, being held March 3-5, 2025, in Boston, Massachusetts. Management will participate in a fireside chat on Tuesday, March 4, 2025, at 1:10 pm ET. A live webcast of the event will be available in the Investor Relations section of the Company's website, A replay will be archived for 90 days following the event. About Codexis Codexis is a leading provider of enzymatic solutions for efficient and scalable therapeutics manufacturing that leverages its proprietary CodeEvolver® technology platform to discover, develop and enhance novel, high-performance enzymes. Codexis enzymes solve for real-world challenges associated with small molecule pharmaceuticals manufacturing and nucleic acid synthesis. The Company is currently developing its proprietary ECO Synthesis™ manufacturing platform to enable the scaled manufacture of RNAi therapeutics through an enzymatic route. Codexis' unique enzymes can drive improvements such as higher yields, reduced energy usage and waste generation, improved efficiency in manufacturing and greater sensitivity in genomic and diagnostic applications. For more information, visit For More Information Investor ContactCarrie McKim(336) 608-9706ir@ Media ContactLauren Musto(650) 421-8205media@ in to access your portfolio
Yahoo
13-02-2025
- Business
- Yahoo
Codexis to Report Fourth Quarter and Fiscal Year 2024 Financial Results on February 27th
REDWOOD CITY, Calif., Feb. 13, 2025 (GLOBE NEWSWIRE) -- Codexis, Inc. (NASDAQ: CDXS), a leading provider of enzymatic solutions for efficient and scalable therapeutics manufacturing, today announced that it will report its financial results for the fourth quarter and fiscal year 2024 on Thursday, February 27, 2025, following the close of market. Codexis management will host a conference call and webcast at 4:30 pm Eastern Time to discuss the Company's financial results and provide a business update. Participants may access the live webcast on the Codexis Investor Relations website, where it will be archived for 90 days. The live call can be accessed by dialing 877-705-2976 (domestic) or 201-689-8798 (international). A telephone replay of the call will be available for 48 hours by dialing 877-660-6853 (domestic) or 201-612-7415 (international), access ID #13726635. About CodexisCodexis is a leading provider of enzymatic solutions for efficient and scalable therapeutics manufacturing that leverages its proprietary CodeEvolver® technology platform to discover, develop and enhance novel, high-performance enzymes. Codexis enzymes solve for real-world challenges associated with small molecule pharmaceuticals manufacturing and nucleic acid synthesis. The Company is currently developing its proprietary ECO Synthesis™ manufacturing platform to enable the scaled manufacture of RNAi therapeutics through an enzymatic route. Codexis' unique enzymes can drive improvements such as higher yields, reduced energy usage and waste generation, improved efficiency in manufacturing and greater sensitivity in genomic and diagnostic applications. For more information, visit For More Information Investor ContactCarrie McKim(336) 608-9706ir@ Media ContactLauren Musto(650) 421-8205media@
Yahoo
06-02-2025
- Business
- Yahoo
Codexis Appoints Arthur Levin, PhD, to Strategic Advisory Board
REDWOOD CITY, Calif., Feb. 06, 2025 (GLOBE NEWSWIRE) -- Codexis, Inc. (NASDAQ: CDXS), a leading provider of enzymatic solutions for efficient and scalable therapeutics manufacturing, today announced the appointment of Arthur Levin, PhD, to the Company's Strategic Advisory Board (SAB). Dr. Levin is a founding member of Avidity Biosciences, a biopharmaceutical company committed to delivering a new class of RNA therapeutics called antibody oligonucleotide conjugates, and currently serves on its Board of Directors. He brings three decades of experience developing oligonucleotides to Codexis as it continues to onboard customers for its Enzyme Catalyzed Oligonucleotide (ECO) Synthesis™ manufacturing platform. 'We are thrilled to have such a distinguished oligonucleotide leader as Art Levin join our SAB,' said Stefan Lutz, PhD, Senior Vice President of Research at Codexis. 'With extensive experience in the development of numerous oligonucleotides, including the first approved antisense drugs and the first microRNA-targeted therapeutic in clinical trials, Art will provide invaluable guidance as we continue on our growth trajectory with the ECO Synthesis platform.' Dr. Levin added, 'I am excited to partner with Codexis as it expands the possibility of RNAi therapeutics through its groundbreaking enzymatic technologies. As someone who has been in the oligonucleotide business for decades, it is exciting to see momentum for the space increasing so drastically. I look forward to working with the management team and SAB to help usher Codexis through this next phase of growth.' In addition to his role on the Board of Directors, Dr. Levin previously held the positions of Distinguished Scientist, Strategic Leader and Chief Scientific Officer at Avidity. Dr. Levin is a highly regarded key opinion leader in the RNA therapeutics field who has led teams responsible for the development of many oligonucleotides. Prior to joining Avidity, Dr. Levin was the Executive Vice President of Research and Development at miRagen Therapeutics and held senior drug development roles at Ionis (formerly Isis) Pharmaceuticals and Santaris Pharmaceuticals. He has published more than 100 scientific articles and has authored several of the most cited reviews in the field. In addition to Codexis, he serves on the scientific advisory boards of multiple institutions. Dr. Levin received a doctorate in toxicology from the University of Rochester and holds a bachelor's degree in biology from Muhlenberg College. About the Codexis Strategic Advisory Board Codexis' Strategic Advisory Board (SAB) was established in 2023 and is comprised of experts across oligonucleotide synthesis, manufacturing and commercialization. The SAB plays a pivotal role in guiding the Company's strategic direction and offers valuable insights to inform the continued development of the ECO Synthesis™ manufacturing platform. Current members include John Maraganore, PhD, founder and former Chief Executive Officer of Alnylam Pharmaceuticals; Masad Damha, PhD, Distinguished James McGill Professor at McGill University; Jim Lalonde, PhD, biotechnology consultant for start-up companies in enzyme engineering and former Senior Vice President of Research and Development at Codexis; and Carole Cobb, MBA, biotechnology consultant and former Chief Operating Officer at GreenLight Biosciences. More information about Codexis' SAB can be found on the About Us section of the Company's corporate website, located here. About Codexis Codexis is a leading provider of enzymatic solutions for efficient and scalable therapeutics manufacturing that leverages its proprietary CodeEvolver® technology platform to discover, develop and enhance novel, high-performance enzymes. Codexis enzymes solve for real-world challenges associated with small molecule pharmaceuticals manufacturing and nucleic acid synthesis. The Company is currently developing its proprietary ECO Synthesis™ manufacturing platform to enable the scaled manufacture of RNAi therapeutics through an enzymatic route. Codexis' unique enzymes can drive improvements such as higher yields, reduced energy usage and waste generation, improved efficiency in manufacturing and greater sensitivity in genomic and diagnostic applications. For more information, visit Forward-Looking Statements This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. In some cases, you can identify forward-looking statements by terminology such as 'aim,' 'anticipate,' 'assume,' 'believe,' 'contemplate,' 'continue,' 'could,' 'design,' 'due,' 'estimate,' 'expect,' 'goal,' 'intend,' 'may,' 'objective,' 'plan,' 'positioned,' 'potential,' 'predict,' 'seek,' 'should,' 'suggest,' 'target,' 'on track,' 'will,' 'would' and other similar expressions that are predictions of or indicate future events and future trends, or the negative of these terms or other comparable terminology. To the extent that statements contained in this press release are not descriptions of historical facts, they are forward-looking statements reflecting the current beliefs and expectations of management, including but not limited to statements regarding the potential of the ECO Synthesis™ platform, and it providing an opportunity for Codexis to efficiently capture meaningful market share. You should not place undue reliance on these forward-looking statements because they involve known and unknown risks, uncertainties and other factors that are, in some cases, beyond Codexis' control and that could materially affect actual results. Factors that could materially affect actual results include, among others: Codexis' dependence on its licensees and collaborators; if any of its collaborators terminate their development programs under their respective license agreements with Codexis; Codexis may need additional capital in the future in order to expand its business; if Codexis is unable to successfully develop and commercialize new technology such as its ECO Synthesis™ platform and its dsRNA ligase; Codexis dependence on a limited number of products and customers, and potential adverse effects to Codexis' business if its customers' products are not received well in the markets; if competitors and potential competitors who have greater resources and experience than Codexis develop products and technologies that make Codexis' products and technologies obsolete; if Codexis is unable to accurately forecast financial and operational performance; and market and economic conditions may negatively impact Codexis business, financial condition and share price. Additional information about factors that could materially affect actual results can be found in Codexis' Annual Report on Form 10-K filed with the Securities and Exchange Commission ('SEC') on February 28, 2024 and in Codexis' Quarterly Report on Form 10-Q filed with the SEC on October 31, 2024, including under the caption 'Risk Factors,' and in Codexis' other periodic reports filed with the SEC. Codexis expressly disclaims any intent or obligation to update these forward-looking statements, except as required by law. For More Information Investor ContactCarrie McKim(336) 608-9706ir@ Media ContactLauren Musto(650) 421-8205media@ A photo accompanying this announcement is available at: in to access your portfolio
