Latest news with #ESOC
Yahoo
29-05-2025
- Business
- Yahoo
Brainomix Driving Treatment Decisions in Stroke: New Studies Presented at Leading European Stroke Conference
New evidence from the largest prospective evaluation of stroke AI imaging further validates Brainomix 360 Stroke impact on mechanical thrombectomy, expanding patient access across networks to the life-changing treatment The Oxford-based pioneer continues to drive cutting-edge research with its novel biomarkers, forging partnerships with world-leading stroke institutions across the US and Europe OXFORD, England and CHICAGO, May 29, 2025 /PRNewswire/ -- Brainomix, a global leader in AI-powered imaging solutions in stroke and lung fibrosis, presented a series of new studies at the European Stroke Organisation Conference (ESOC) in Helsinki, solidifying the position of its market-leading Brainomix 360 Stroke as the most clinically validated stroke AI imaging solution. Gary Ford (Professor of Stroke Medicine at Oxford University, and Chief Executive of Health Innovation Oxford & Thames Valley) presented new and expanded results from the largest prospective evaluation of stroke AI imaging software, showing that the use of Brainomix 360 Stroke was associated with an increase in mechanical thrombectomy rates across evaluation sites. The impact was particularly significant in primary stroke centers (104% increase), but was also observed in comprehensive stroke centers (73% increase), representing a network-wide benefit from Brainomix 360 Stroke to expand patient access to the life-changing procedure. Dr Albert Yoo (Texas Stroke Institute) presented results from a research collaboration between Brainomix and the TESLA Trial team, whose randomized study was originally published in JAMA in September 2024. In this new analysis of the trial data, Brainomix 360 Stroke was used to estimate the ischemic core volume and degree of hypoattenuation on the non-contrast CT (NCCT) scans taken upon admission for the 276 large vessel occlusion (LVO) patients included in the original study. The results showed that both ischemic core volume and the degree of hypoattenuation (as measured by net-water-uptake) modified the effect of mechanical thrombectomy and should therefore be considered when assessing suitability of endovascular treatment in patients with large core ischemic stroke. Building on its track record of cutting-edge stroke imaging research, Brainomix also presented a new study with leading academic clinicians from the Mayo Clinic and West Virginia University, exploring brain frailty as an independent predictor of functional outcome in patients undergoing mechanical thrombectomy. George Harston, Chief Medical & Innovation Officer at Brainomix, said: "This is an exciting study, where our next generation biomarkers were able to assess brain frailty, finding it to be a useful criterion when assessing a patient's suitability for mechanical thrombectomy and the likelihood of them achieving a good clinical outcome." This topic will be included with other breakthrough research projects in an upcoming webinar that Brainomix have organized with Dr Ansaar Rai and Dr Waleed Brinjikji on Thursday, June 12th. Brainomix supported a number of additional studies at ESOC, including: Dr Amelia Adcock (West Virginia University) presented the results of a comparative analysis of Brainomix 360 Stroke and with the findings demonstrating that both AI solutions accurately identified intracranial LVOs. Notably, Brainomix 360 Stroke did exhibit a higher sensitivity for more distal occlusions and was the only CT perfusion solution that showed a significant association between perfusion deficit and NIHSS. Dr Esra Zhubi (Semmelweis University, Budapest) presented results from a study where Brainomix 360 Stroke was used to assess collateral status on CT angiography. The team concluded that changes in collateral status during transfer for thrombectomy were strong predictors of outcome following thrombectomy in LVO patients. A research collaboration between Brainomix and Boston Medical Center assessed the accuracy of Brainomix 360 Stroke's automated hemorrhage detection tool to identify intracerebral hemorrhage (ICH). A total of 351 cases were successfully processed, with the Brainomix software exhibiting high overall sensitivity (93%) and specificity (94%), demonstrating high efficiency and efficacy for all subtypes of ICH detection to provide a reliable triage and notification service to aid clinicians in identifying cases. A study with leading stroke researchers in Czechia looked at the utility of CT Perfusion processed with Brainomix 360 Stroke to more effectively differentiate stroke mimics from strokes, as a way of optimizing care and reducing the risk of inappropriate treatment for stroke mimic patients. Notes to Editors About Brainomix Brainomix specializes in the creation of AI-powered software solutions to enable precision medicine for better treatment decisions in stroke and lung fibrosis. With origins as a spinout from the University of Oxford, Brainomix is an expanding commercial-stage company with offices in the UK, Ireland and the USA, and operations in more than 20 countries. A private company, backed by leading healthtech investors, Brainomix has innovated award-winning imaging biomarkers and software solutions that have been clinically adopted in hundreds of hospitals worldwide. Its first product, the Brainomix 360 stroke platform, provides clinicians with the most comprehensive stroke imaging solution, driving increased treatment rates and improving functional independence for patients. To learn more about Brainomix and its technology visit and follow us on Twitter, LinkedIn and Facebook. Contacts :Jeff Wyrtzen, Chief Marketing Officer jwyrtzen@ T +44 (0)1865 582730 Media Enquiries : Charles Consultants Sue Charles Sue@ M +44 (0)7968 726585 Logo: View original content to download multimedia: SOURCE Brainomix Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Hans India
22-05-2025
- Health
- Hans India
Birth control pill may triple risk of cryptogenic stroke in women: Study
New Delhi: Taking birth control pills or combined oral contraceptives containing both oestrogen and progestin may triple the risk of cryptogenic stroke in young women, according to a study. Strokes without a known cause are called cryptogenic. It accounts for up to 40 per cent of all ischaemic strokes in young adults. Despite its prevalence, the contribution of sex-specific risk factors, such as contraceptive use, has remained underexplored. The findings add to a growing body of evidence linking hormonal contraception to vascular risk in women of reproductive age. 'Our findings confirm earlier evidence linking oral contraceptives to stroke risk,' said lead author Dr. Mine Sezgin, Department of Neurology, Istanbul University. 'What's particularly notable is that the association remains strong even when accounting for other known risk factors, which suggests there may be additional mechanisms involved – possibly genetic or biological,' she added. The research included 268 women aged 18-49 years with cryptogenic ischaemic stroke (CIS) and 268 age-matched stroke-free controls across 14 centres in Europe. Of the participants, 66 patients and 38 controls were using combined combined oral contraceptives. While the researchers note that further prospective studies are needed, they advise clinicians to exercise caution when prescribing combined oral contraceptives to women with known vascular risk factors or a history of ischaemic stroke. 'Our findings should prompt more careful evaluation of stroke risk in young women, particularly those with additional risk factors,' Dr. Sezgin said. Next, the researchers plan to explore biological and genetic mechanisms underlying the observed association between combined oral contraceptive use and increased stroke risk to better understand how hormonal contraceptives may independently elevate stroke risk. The findings were presented at the ongoing European Stroke Organisation Conference (ESOC) 2025 in Helsinki, Finland.
Yahoo
21-05-2025
- Health
- Yahoo
ESOC 2025: Combined oral contraceptives triple risk of cryptogenic stroke in young women, new study shows
HELSINKI, May 20, 2025 /PRNewswire/ -- New research presented today at the European Stroke Organisation Conference (ESOC) 2025 revealed that the use of combined oral contraceptives (OCs) is associated with a threefold increase in the risk of cryptogenic ischaemic stroke (CIS) in young women.(1) The findings add to a growing body of evidence linking hormonal contraception to vascular risk in women of reproductive age. Cryptogenic ischaemic stroke, which is stroke with no identifiable cause, accounts for up to 40% of all ischaemic strokes in young adults.(2) Despite its prevalence, the contribution of sex-specific risk factors, such as contraceptive use, has remained underexplored. While prior studies have associated combined OCs with stroke risk, this is among the few studies to focus specifically on cryptogenic stroke in young women. The Searching for Explanations for Cryptogenic Stroke in the Young (SECRETO) study included 268 women aged 18–49 years with CIS and 268 age-matched stroke-free controls across 14 centres in Europe. Of the participants, 66 patients and 38 controls were using combined OCs. After adjusting for age and established comorbidities such as hypertension, smoking, migraine with aura, and abdominal obesity, OC use was associated with an adjusted odds ratio of 3.00 (95% CI: 1.61–5.57). No significant interactions were found between OC use and these risk factors, suggesting that the increased stroke risk may operate independently of other known contributors. "Our findings confirm earlier evidence linking oral contraceptives to stroke risk," said Dr. Mine Sezgin, Department of Neurology, Istanbul University, and lead author of the study. "What's particularly notable is that the association remains strong even when accounting for other known risk factors, which suggests there may be additional mechanisms involved – possibly genetic or biological." Most OC users in the study were taking ethinylestradiol-based formulations, with a median dose of 20 micrograms. Other types of estrogen, such as estradiol hemihydrate and estradiol valerate, were also recorded. "We calculated the equivalent estrogen dose for each patient to ensure consistency," Dr Sezgin explained. "While our data provides important initial insights, larger studies are needed to determine if certain formulations carry different levels of risk. This knowledge could help guide more personalised contraceptive choices for women." While the researchers note that further prospective studies are needed, they advise clinicians to exercise caution when prescribing combined OCs to women with known vascular risk factors or a history of ischaemic stroke. "Our findings should prompt more careful evaluation of stroke risk in young women, particularly those with additional risk factors," concluded Dr. Sezgin. Moving forward, the researchers plan to explore biological and genetic mechanisms underlying the observed association between combined OC use and increased stroke risk to better understand how hormonal contraceptives may independently elevate stroke risk. Note to editors: A reference to ESOC 2025 must be included in all coverage and/or articles associated with this study. About the study author: Dr. Mine Sezgin is a neurologist and stroke researcher based at the Istanbul University Faculty of Medicine. Her work focuses on sex-specific risk factors and stroke prevention in young adults. About the European Stroke Organisation (ESO): The ESO is a pan-European society of stroke researchers and physicians, national and regional stroke societies and lay organisations that was founded in December 2007. The aim of the ESO is to reduce the burden of stroke by changing the way that stroke is viewed and treated. This can only be achieved by professional and public education, and by making institutional changes. ESO serves as the voice of stroke in Europe, harmonising stroke management across the whole of Europe and taking action to reduce the burden of stroke regionally and globally. References: 1. Sezgin, M., et al. Hormonal contraception increases the risk of cryptogenic stroke in young women. Abstract O049, presented at the European Stroke Organisation Conference; 21 May 2025; Vienna, Austria. 2. Yaghi, S., & Elkind, M. S. (2014). Cryptogenic stroke: A diagnostic challenge. Neurology. Clinical practice, 4(5), 386–393. View original content: SOURCE European Stroke Organisation Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Korea Herald
21-05-2025
- Health
- Korea Herald
ESOC 2025: Combined oral contraceptives triple risk of cryptogenic stroke in young women, new study shows
, May 21, 2025 /PRNewswire/ -- New research presented today at the European Stroke Organisation Conference (ESOC) 2025 revealed that the use of combined oral contraceptives (OCs) is associated with a threefold increase in the risk of cryptogenic ischaemic stroke (CIS) in young women. (1) The findings add to a growing body of evidence linking hormonal contraception to vascular risk in women of reproductive age. Cryptogenic ischaemic stroke, which is stroke with no identifiable cause, accounts for up to 40% of all ischaemic strokes in young adults. (2) Despite its prevalence, the contribution of sex-specific risk factors, such as contraceptive use, has remained underexplored. While prior studies have associated combined OCs with stroke risk, this is among the few studies to focus specifically on cryptogenic stroke in young women. The Searching for Explanations for Cryptogenic Stroke in the Young (SECRETO) study included 268 women aged 18–49 years with CIS and 268 age-matched stroke-free controls across 14 centres in Europe. Of the participants, 66 patients and 38 controls were using combined OCs. After adjusting for age and established comorbidities such as hypertension, smoking, migraine with aura, and abdominal obesity, OC use was associated with an adjusted odds ratio of 3.00 (95% CI: 1.61–5.57). No significant interactions were found between OC use and these risk factors, suggesting that the increased stroke risk may operate independently of other known contributors. "Our findings confirm earlier evidence linking oral contraceptives to stroke risk," said Dr. Mine Sezgin, Department of Neurology, Istanbul University, and lead author of the study. "What's particularly notable is that the association remains strong even when accounting for other known risk factors, which suggests there may be additional mechanisms involved – possibly genetic or biological." Most OC users in the study were taking ethinylestradiol-based formulations, with a median dose of 20 micrograms. Other types of estrogen, such as estradiol hemihydrate and estradiol valerate, were also recorded. "We calculated the equivalent estrogen dose for each patient to ensure consistency," Dr Sezgin explained. "While our data provides important initial insights, larger studies are needed to determine if certain formulations carry different levels of risk. This knowledge could help guide more personalised contraceptive choices for women." While the researchers note that further prospective studies are needed, they advise clinicians to exercise caution when prescribing combined OCs to women with known vascular risk factors or a history of ischaemic stroke. "Our findings should prompt more careful evaluation of stroke risk in young women, particularly those with additional risk factors," concluded Dr. Sezgin. Moving forward, the researchers plan to explore biological and genetic mechanisms underlying the observed association between combined OC use and increased stroke risk to better understand how hormonal contraceptives may independently elevate stroke risk. Note to editors: A reference to ESOC 2025 must be included in all coverage and/or articles associated with this study. About the study author: Dr. Mine Sezgin is a neurologist and stroke researcher based at the Istanbul University Faculty of Medicine. Her work focuses on sex-specific risk factors and stroke prevention in young adults. About the European Stroke Organisation (ESO): The ESO is a pan-European society of stroke researchers and physicians, national and regional stroke societies and lay organisations that was founded in December 2007. The aim of the ESO is to reduce the burden of stroke by changing the way that stroke is viewed and treated. This can only be achieved by professional and public education, and by making institutional changes. ESO serves as the voice of stroke in Europe, harmonising stroke management across the whole of Europe and taking action to reduce the burden of stroke regionally and globally. 1. Sezgin, M., et al. Hormonal contraception increases the risk of cryptogenic stroke in young women. Abstract O049, presented at the European Stroke Organisation Conference; 21 May 2025; Vienna, Austria. 2. Yaghi, S., & Elkind, M. S. (2014). Cryptogenic stroke: A diagnostic challenge. Neurology. Clinical practice, 4 (5), 386–393.
Yahoo
20-05-2025
- Health
- Yahoo
ESOC 2025: Combined oral contraceptives triple risk of cryptogenic stroke in young women, new study shows
HELSINKI, May 20, 2025 /CNW/ -- New research presented today at the European Stroke Organisation Conference (ESOC) 2025 revealed that the use of combined oral contraceptives (OCs) is associated with a threefold increase in the risk of cryptogenic ischaemic stroke (CIS) in young women.(1) The findings add to a growing body of evidence linking hormonal contraception to vascular risk in women of reproductive age. Cryptogenic ischaemic stroke, which is stroke with no identifiable cause, accounts for up to 40% of all ischaemic strokes in young adults.(2) Despite its prevalence, the contribution of sex-specific risk factors, such as contraceptive use, has remained underexplored. While prior studies have associated combined OCs with stroke risk, this is among the few studies to focus specifically on cryptogenic stroke in young women. The Searching for Explanations for Cryptogenic Stroke in the Young (SECRETO) study included 268 women aged 18–49 years with CIS and 268 age-matched stroke-free controls across 14 centres in Europe. Of the participants, 66 patients and 38 controls were using combined OCs. After adjusting for age and established comorbidities such as hypertension, smoking, migraine with aura, and abdominal obesity, OC use was associated with an adjusted odds ratio of 3.00 (95% CI: 1.61–5.57). No significant interactions were found between OC use and these risk factors, suggesting that the increased stroke risk may operate independently of other known contributors. "Our findings confirm earlier evidence linking oral contraceptives to stroke risk," said Dr. Mine Sezgin, Department of Neurology, Istanbul University, and lead author of the study. "What's particularly notable is that the association remains strong even when accounting for other known risk factors, which suggests there may be additional mechanisms involved – possibly genetic or biological." Most OC users in the study were taking ethinylestradiol-based formulations, with a median dose of 20 micrograms. Other types of estrogen, such as estradiol hemihydrate and estradiol valerate, were also recorded. "We calculated the equivalent estrogen dose for each patient to ensure consistency," Dr Sezgin explained. "While our data provides important initial insights, larger studies are needed to determine if certain formulations carry different levels of risk. This knowledge could help guide more personalised contraceptive choices for women." While the researchers note that further prospective studies are needed, they advise clinicians to exercise caution when prescribing combined OCs to women with known vascular risk factors or a history of ischaemic stroke. "Our findings should prompt more careful evaluation of stroke risk in young women, particularly those with additional risk factors," concluded Dr. Sezgin. Moving forward, the researchers plan to explore biological and genetic mechanisms underlying the observed association between combined OC use and increased stroke risk to better understand how hormonal contraceptives may independently elevate stroke risk. Note to editors: A reference to ESOC 2025 must be included in all coverage and/or articles associated with this study. About the study author: Dr. Mine Sezgin is a neurologist and stroke researcher based at the Istanbul University Faculty of Medicine. Her work focuses on sex-specific risk factors and stroke prevention in young adults. About the European Stroke Organisation (ESO): The ESO is a pan-European society of stroke researchers and physicians, national and regional stroke societies and lay organisations that was founded in December 2007. The aim of the ESO is to reduce the burden of stroke by changing the way that stroke is viewed and treated. This can only be achieved by professional and public education, and by making institutional changes. ESO serves as the voice of stroke in Europe, harmonising stroke management across the whole of Europe and taking action to reduce the burden of stroke regionally and globally. References: 1. Sezgin, M., et al. Hormonal contraception increases the risk of cryptogenic stroke in young women. Abstract O049, presented at the European Stroke Organisation Conference; 21 May 2025; Vienna, Austria. 2. Yaghi, S., & Elkind, M. S. (2014). Cryptogenic stroke: A diagnostic challenge. Neurology. Clinical practice, 4(5), 386–393. View original content: SOURCE European Stroke Organisation View original content: Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
