Latest news with #EmilyP
Yahoo
23-04-2025
- Health
- Yahoo
Arbutus to Present Imdusiran and AB-101 Data at EASL Congress 2025
Five abstracts accepted for poster presentations WARMINSTER, Pa., April 23, 2025 (GLOBE NEWSWIRE) -- Arbutus Biopharma Corporation (Nasdaq: ABUS) ('Arbutus' or the 'Company'), a clinical-stage biopharmaceutical company focused on infectious disease, today announced that five abstracts, including one late-breaker, have been accepted for presentation at the European Association for the Study of the Liver (EASL) Congress 2025 taking place May 7 - 10, 2025 in Amsterdam, Netherlands. The following abstracts will be presented as posters in the Viral Hepatitis B and D: New Therapies, Unapproved Therapies or Strategies session on May 8, 2025, from 8:30 am – 5:00 pm CET. Abstract Number: 1768Title: IM-PROVE I: characterization of chronic hepatitis B (CHB) subjects with functional cure or HBV DNA suppression after completion of imdusiran plus short courses of pegylated interferon alfa-2a (IFN) and discontinuation of nucleos(t)ide analogue (NA) therapyPresenter: Prof. Man-Fung YuenPresentation Date: May 8, 2025Key Findings: Within this small group of subjects who achieved functional cure or HBV DNA<LLOQ after NA discontinuation in the IM-PROVE I study, HBsAg at baseline and at the time of NA discontinuation appear to be the only factors associated with functional cure, with no apparent differences in other baseline characteristics or HBV biomarkers collected, including HBcrAg and HBV RNA. Additional analysis of this dataset is ongoing, and the potential association of baseline characteristics and HBV biomarkers with functional cure should continue to be evaluated in larger trials. This will also be featured in the Poster Tour: Viral Hepatitis, on Thursday, May 8, 2025, at 16:22 CEST. Abstract Number: 2043Title: IM-PROVE I: Rapid loss followed by transient increases in HBV RNA in chronic hepatitis Bsubjects during treatment with imdusiran and pegylated interferon alfa-2a is associated with HBsAg seroclearancePresenter: Dr. Emily P. ThiPresentation Date: May 8, 2025Key Findings: Subjects who achieved functional cure after combination treatment with imdusiran plus interferon showed rapid HBV RNA decline during imdusiran lead-in, with 5 of 6 subjects achieving HBV RNA undetectability during this period. Transient elevations in HBV RNA were observed to occur during the interferon treatment period which was associated with further HBsAg decline and loss in some functional cure subjects. Abstract Number: 1990Title: First-in-human pharmacokinetics and pharmacodynamics of oral small-moleculePD-L1 inhibitor AB-101 and correlation to preclinical modelsPresenter: Dr. Emily P. ThiPresentation Date: May 8, 2025Key Findings: AB-101 was safe and well-tolerated in both single- and multiple-dose administrations in healthy subjects. Dose-responsive increases in PD-L1 receptor occupancy were observed in peripheral blood cells, which correlated with dose-dependent increases in AB-101 plasma concentrations. The clinical plasma PK profile of AB-101 to date indicates rapid distribution into tissues, mirroring the plasma profiles seen in preclinical efficacy models, which exhibited high liver biodistribution and target engagement. Abstract Number: 1978Title: Preliminary safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple doses of AB-101, a small-molecule PD-L1 inhibitor, in healthy and chronic hepatitis B subjectsPresenter: Prof. Edward J. GanePresentation Date: May 8, 2025Key Findings: Single doses of AB-101 up to 40 mg and repeat doses up to 40 mg QD for 7 days were well tolerated in healthy subjects. Preliminary PD data shows AB-101 receptor occupancy at doses ≥ 10 mg, with dose-responsive increases in PD-L1 receptor occupancy observed. Dosing in Part 3 in CHB subjects is ongoing and available data, including receptor occupancy and HBV virologic biomarkers, will be presented. The following late-breaker poster will be presented on May 7, 2025: Abstract Number: LB25153Title: Off-treatment antiviral efficacy and safety of repeat dosing of imdusiran followed by VTP-300 with or without nivolumab in virally-suppressed, non-cirrhotic subjects with chronic hepatitis B (CHB)Presenter: Dr. Grace Lai-Hung Wong Abstracts are available on the EASL Congress 2025 website at The posters are expected to be made available to conference attendees at the start of the meeting on May 7, 2025, and will be available subsequently on Arbutus' website at About Imdusiran (AB-729) Imdusiran is an RNAi therapeutic specifically designed to reduce all HBV viral proteins and antigens including hepatitis B surface antigen, which is thought to be a key prerequisite to enable reawakening of a patient's immune system to respond to the virus. Imdusiran targets hepatocytes using Arbutus' novel covalently conjugated N-Acetylgalactosamine (GalNAc) delivery technology enabling subcutaneous delivery. In a Phase 2a clinical trial, imdusiran achieved meaningful functional cure rates in patients with cHBV when combined with pegylated interferon (IFN) alfa-2α and nucleos(t)ide analogue (NA) therapy. Clinical data generated thus far has shown imdusiran to be generally safe and well-tolerated, while also providing meaningful reductions in hepatitis B surface antigen and hepatitis B DNA. The Company is currently reviewing development plans for a Phase 2b clinical trial of imdusiran combined with IFN and NA therapy. About AB-101 AB-101 is an oral PD-L1 inhibitor candidate that is designed to allow for controlled immune checkpoint blockade while minimizing the systemic safety issues typically seen with immune checkpoint antibody therapies. Immune checkpoints such as PD-1/PD-L1 play an important role in the induction and maintenance of immune tolerance and in T-cell activation. Preclinical data generated thus far indicates that AB-101 mediates re-activation of exhausted HBV-specific T-cells from cHBV patients. AB-101 is currently being evaluated in a Phase 1a/1b clinical trial. About HBV Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). HBV can cause chronic infection which leads to a higher risk of death from cirrhosis and liver cancer. Chronic HBV infection represents a significant unmet medical need. The World Health Organization estimates that over 250 million people worldwide suffer from chronic HBV infection, while other estimates indicate that approximately 2 million people in the United States suffer from chronic HBV infection. Approximately 1.1 million people die every year from complications related to chronic HBV infection despite the availability of effective vaccines and current treatment options. Forward-Looking Statements and Information This press release contains forward-looking statements within the meaning of the Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, and forward-looking information within the meaning of Canadian securities laws (collectively, forward-looking statements). Forward-looking statements in this press release include statements about: the potential to lead to a functional cure for HBV; the result of Arbutus' review of its pipeline and development plans for its cHBV programs and the potential for Arbutus' product candidates to achieve success in clinical trials. With respect to the forward-looking statements contained in this press release, Arbutus has made numerous assumptions regarding, among other things: the effectiveness and timeliness of clinical trials, and the usefulness of the data; the timeliness of regulatory approvals; the continued demand for Arbutus' assets; and the stability of economic and market conditions. While Arbutus considers these assumptions to be reasonable, these assumptions are inherently subject to significant business, economic, competitive, market and social uncertainties and contingencies. Additionally, there are known and unknown risk factors which could cause Arbutus' actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements contained herein. Known risk factors include, among others: ongoing and anticipated clinical trials may be more costly or take longer to complete than anticipated, and may never be initiated or completed, or may not generate results that warrant future development of the tested product candidate; Arbutus may elect to change its strategy regarding its product candidates and clinical development activities; Arbutus may not receive the necessary regulatory approvals for the clinical development of Arbutus' products; economic and market conditions may worsen; and market shifts may require a change in strategic focus. A more complete discussion of the risks and uncertainties facing Arbutus appears in Arbutus' Annual Report on Form 10-K, Arbutus' Quarterly Reports on Form 10-Q and Arbutus' continuous and periodic disclosure filings, which are available at and at All forward-looking statements herein are qualified in their entirety by this cautionary statement, and Arbutus disclaims any obligation to revise or update any such forward-looking statements or to publicly announce the result of any revisions to any of the forward-looking statements contained herein to reflect future results, events or developments, except as required by law. CONTACT: Arbutus Biopharma Corporation / ir@ in to access your portfolio
Buzz Feed
22-04-2025
- Entertainment
- Buzz Feed
25 Target Products If You Recently Sat On The Toilet Wondering How Your Bathroom Got So Nasty
We hope you love our recommendations! Some may have been sent as samples, but all were independently selected by our editors. Just FYI, BuzzFeed and its publishing partners may collect a share of sales and/or other compensation from the links on this page. These products from the good folks over at Target will take your bathroom from grime to shine in no time flat. 1. A pack of Scrubbing Bubbles drop-in toilet cleaners for an analog way to automate everyone's favorite task... (I'm joking, obvi). For those who would rather maintain a hard-fought clean for as long as possible, these handy tablets keep your potty clean and germ free for up to four weeks. Target 2. A bottle of Bar Keepers Friend liquid cleaner because, seriously — have you used this stuff?? From brass to stainless steel and from silver to porcelain, a quick coat of this stuff will leave it shining like the day it was made! Also available in a powdered form, I find the easy application of the liquid version tough to say no to. Always read the directions — this stuff is POWERFUL — and please send us a picture with your thank you note when your kitchen sink starts acting like a mirror. Target 3. A cashmere vanilla linen spray for when your bathroom needs a dash of crème brûlée and enchanté. While this list abounds in tough grime removers and space sparklers, sometimes a quick misting is all we have time for on a busy day. This luxurious spray does triple duty, as it can also be used on linens, hair/body. Target Promising review:"This spray smells heavenly! I got it for the gym and three pumps literally lasted my entire workout (and I sweat a lot). Would definitely recommend." — God is Love 4. A six-pack of microfiber cleaning cloths since paper towels are so over. JK! We love you paper towels! 🤧 That being said, for general housekeeping, this multi-pack has got your back for all your cleaning needs. Dusting? Nothing dusts like an ultra-fine microfiber. Need something more heavy-duty? Waffled texture's got you covered. Best of all, they're a quick wash away from being ready for another clean-a-thon. Your wallet, and a few trees, will definitely thank you. Target Promising review:"All cloths clean really well for their specific purpose. Doesn't leave streaks behind and easy to wash. I bought 2 packs and keep one set in our bathrooms and the kitchen." — Emily P 5. A Scrub Daddy PowerPaste and Scrub Mommy sponge for those of us who love a power couple. Seriously, we've all fallen for the entire Scrub family by this point. But now we have an all-new reason to invite them over: a tough-on-grease paste that polishes, cleans, and protects surfaces. Pair that with Scrub Mommy's magnificent design (did you know it's top-rack dishwasher safe??) and you're living space will go from meh to muah in no time! Target Promising reviews:"If you have a glass shower door — immediately yes, buy now!! You don't have to use much paste. Was able to do entire job without taking breaks (like I do for stronger scented cleaners). Followed directions and at the end I used a slightly damp microfiber cloth to get the last bit of residue." — B "My favorite thing to clean the bathroom with. I live with three messy boys (my husband and two sons) who really know how to do a number on the bathroom. I don't know how our tub gets so much scum built up so quickly, but this cuts right through it with a bit of elbow grease. And the sink with the hairs EVERYWHERE? Quick work of that. Now the toilet… gross, but this stuff gets the job done without too much work or sweat!" — Sara 6. A toilet wand with disposable pads to leave your potty pristine while keeping a friendly distance from the bowl. This toilet wand comes with a handy caddy that keeps a stack of fresh, detergent-loaded scrubbing pads at the ready. Also, a handy button on the handle makes it easy to dispose of the scrubbers in the trash by ejecting them like an escape pod. Basically, it's about as 007 as a toilet wand can get! Target Promising review:"We all hate cleaning the toilets, right? Well this little Clorox toilet wand is easy to use and no need to attach the scrubber by hand. They click right in from the caddy." — Crystal B 7. A posh and neutral cleaning caddy to channel your inner beige-fluencer. With its wooden handle grip and brushed steel body, this rust-resistant caddy will keep all your cleaning agents organized and see you through many a scrub sesh! Target Promising review:"Exactly as described. Perfect size for under-cabinet storage. I bought one for each bathroom to have cleaning supplies." — Bibi 8. A bamboo storage cabinet for the ones who really need to add some storage to the bathroom. This cute little number mixes a heck of a lot of shelf space with a large open storage cabinet with a slatted door that's perfect for stacking TP or any other bathroom items you don't always want to stare at. Target Promising review:"This is so nice and sturdy!! And so simple to put together! And beautiful!!! I want to buy one for every room!" — Roach 9. Or try a reed oil diffuser if you're are all about passive solutions. This diffuser works great for spaces that could always use a little help in the smell department. Think your bathroom, so you can have a spa day every day or entryways so that your first step through the door sets the cozy train in motion. Great for those who already have a handful of essential oils or those who'd like to get in on the aromatherapy action! Target For essential oil diffusers: According to Johns Hopkins, you may want to avoid diffusing oils around larger groups and young children because of the side effects of different oils. You may also want to avoid using an oil diffuser around pets with breathing problems, according to the ASPCA. Promising review:"When it comes to home fragrances I always try to find the long lasting and concentrated one. This oil diffuser is amazing the smell is wonderful, lasts a REALLY long period and the essence does not go away, I highly recommended!!" — Marian 10. A Dyson cordless stick vacuum because some of us want the Batmobile of handheld vacuums and refuse to settle for anything less. This trendy-looking appliance isn't just another pretty face — the powerful Dyson vacuum technology inside traps dust and allergens as small as 0.3 microns. That's about a hundredth of the width of a human hair... divided in half! 🤯 Target Promising review:"Lightweight and easy to use. Amazing the hidden dirt it picks up. Vacuumed one day prior and the dirt cup was filled with dirt and debris. It's going to be a very useful daily vacuum." — CM 11. An extendable scrubber to keep you from having to switch from scrubber to scrubber and to help avoid the bathroom cleaning hunch so many of us assume is a necessary evil. No more! This scrubbing wand features a wide adjustment range that can go from medium to mop-sized or longer! Apply the cleaner of your choice and do your best Wayne Gretzky impression as you literally wipe the floor with your opponents (meaning dirt, of course). Target Promising review:"Game changer for shower walls and bathroom areas that need a lil' extra scrub but might be too high to reach. With its extendable handle — it's great!!! I used a clean rag with fresh water and wrapped the scrubber and then went over the entire shower when I was all done to ensure no soapy residue. Absolutely recommend this product to reduce the time it takes to clean the shower. 😉" — Happytocook4myfam 12. And a jar of the Pink Stuff cleaning paste because, while TikTok might have made it famous, we come back to it since this stuff works! This cruelty-free, all-purpose cleaning paste will astonish you with its nearly infinite applications and absolutely astonishing results. Just add a dab to your scrubber of choice, treat the area in question, and rinse with hot water. You'll swear this paste is more of a time machine than a cleaner. Target 13. A rust-resistant, matte-black shower caddy because... rust? Can't say we're big fans of it in the restroom. Keep it uninvited to the party and free the ledge of your tub from any more accumulating product bottles with this chic and secure caddy. Target Promising review:"LI have had this in my shower for a WHILE now and haven't had any problems with rusting. The fact that you can just set your bottles in upside down and dispense from the rack is genius." — Shananana 14. A powerful scrubbing steam mop for those of us who will accept nothing less than literal cartoon sparkles shining from the floor once we're done cleaning. Combining rotating buffing pads with powerful steaming, this steam mop can thoroughly sanitize whatever hard floor surface it comes into contact with — and can do it chemical free! Target Promising review:"I like the rotating pads with the steam. I used on my kitchen floor, and the floor was nice and clean. I didn't have to apply any pressure while cleaning the floor." — Essdee28 15. A few bathroom drawer organizers to take your over-stuffed drawers from bleh to bliss. 🧘✨ Cleaning STARTS with organizing, after all, and with all kinds of sizes, shapes, and capacities to choose from, you can origami any drawer into order with these convenient little trays. Target Promising review:"I love these bins. I have many sizes. They are modular, so they stack using other sizes, too. I also like that they are plain and simple, and the plastic is thick and not flimsy. Great in the bathroom, kitchen, closet, wherever." — MMD 16. A woven wastebasket because every bathroom needs a little trash bin, so why not make it this gorgeous little number instead of the standard can? Featuring a lovely textured pattern and an all-important lid (bathroom refuse is rarely beautiful), this basket will brighten up any WC it finds itself in. Target 17. A Bissell carpet cleaner to give your rugs and bath mats the royal treatment. These loyal household members don't usually get the same attention as their hard-surface peers, but with this thing, you can remove months, if not YEARS, of dust and dander in the space of a few minutes. Its compact size makes it highly transportable — which is good because ALL of your friends are going to want to take it for a test ride. Target Promising review:"Quickly cleaned carpets that had last had a professional cleaning 24 months ago. Yes, you have to refill / empty it often. But, cleaned better than our consumer-grade upright extractor." — Dan 18. An orange and rosemary cleaning concentrate to add some autumnal notes to your fall cleaning. Why does spring get to have all the fun?? Add a little of this plant-based cleaner to some water in a spray bottle or a mop bucket, and get ready to be dazzled as your bathroom transforms into an oasis of clean. The itsy-bitsy bottle and the concentrated formula ensure your cleaning's not only apartment-friendly but also planet-friendly since it spares our transport system a good bit of water weight. Target Promising review:"We usually buy scent-free "green" products and are very "smell sensitive" to synthetic fragrance in our household. We like this Grove. Co. concentrates a lot -- the smell is not offensive, and the cleaning power is terrific. It's easy to mix in a repurposed empty spray bottle (no need to buy one just for this). The plastic-free packaging is great. We've repeat-purchased this product several times at Target because it's a "keeper."" — Maggie Price: $7.99 19. A super cute utility cart which can upgrade even the drabbest bathroom into a lavatorial palace! This elegant storage solution boasts smooth casters, plenty of storage, and frankly it's BEE-AUTIFUL! As an added bonus, when it's time to clean your bathroom you can just slide this puppy into the hallway. Target Promising review:"Love these utility metal carts. They're multifunctional and hold quite a lot of things as well." — C Price: $40 (available in three colors) 20. A power spin scrubber to make cleaning those hard-to-reach spots actually fun (yes, fun!). This extendable power scrubber can handle it all – whether it's the grout between your tiles or the soap scum that's been playing hide-and-seek on your shower wall. With powerful scrubbing action and adjustable length, you'll feel like a cleaning machine! Or, well, like you're using one at least. 🦾 Target Promising review:"Im obsessed… This works 10000% better than scrubbing ever could. My shower is WHITE WHITE. It's amazing, I dont think it ever was this clean, and its a new house lol. Its so worth the money. Its such a good clean. I love it!!!" — Phoebe 21. A three-tier wire drawer organizer to stow away anything and everything that can fit into a larger bathroom cabinet. Think hair brushes, bath bombs, Epsom salts — you name it! The easy sliding drawers won't rust over time, and you'll keep your a.m. routine shorter and much sweeter when you're not digging around crowded drawers. Target Promising review:"The drawers pull out so smooth and the shelf stays put on my desk perfectly!" — Megan Price: $35 (available in five colors) 22. An eco-friendly scrubber to continue the theme of green-clean we've got going on. The folks at Scotch-Brite have been hard at work figuring out a way to blend ecology and quiet luxury, and we think they finally cracked it! 👨🔬 Maybe that's a bit much, but we do love how this scrubber blends chic and scouring in one streamlined package. Target Promising review:"Makes washing dishes simpler. Hard to find a sponge that will help with the scrubbing." — Erika Price: $4.19+ (available in two pack sizes) 23. A hinged bamboo organizer for those of us who need countertop storage in our storage. This handy bit of bathroom decor looks terrific and helps maximize storage for beauty products. Target Promising review:"Super cute and great for helping make the most out of small spaces." — Acardona Price: $25 24. A rustic bathroom etagere that can hold all those vibe-y hand towels, candles, and little planters your dream bathroom longs to be adorned with. With sturdy construction and adjustable feet (for all the Virgos already mentally leveling each shelf), this posh addition makes itself home in any bathroom – be it shiplap walls or subway tiles. Target Promising review:"Is just like the picture. Easy to put together by one person with little experience. Sturdy" — Snow angel Price: $79.99 (originally $209.99) 25. And Swiffer wet and dry sweeper because one is the loneliest number, and that's why we chose this heavy-duty Swiffer which not only boasts two functions but also a 50% gain in sweeper width. (1.5 is definitely less lonely than one, I mean, c'mon!) From wet to dry and from window to wall, this capable addition to your household cleaning tools will save you time and valuable cleaning closet space. Target Promising review:"Easy to put together. This swiffer easily cleans and removes dust bunnies I didn't even know I had! And leaves my wood floors shiny!" — KitKat Price: $20.99 Reviews have been edited for length and/or clarity.
