Latest news with #GreatOrmondStreetHospital
The Sun
19-05-2025
- Entertainment
- The Sun
Goals 4 GOSH: Date, kick-off time and how to watch star-studded charity match as Chelsea legend Eden Hazard makes debut
CHELSEA legend Eden Hazard will nostalgically lace up his boots to feature in the star-studded Goals 4 GOSH charity match. This is set to be the fifth edition of the match which is put on to support Great Ormond Street Hospital. 1 Regional Development Director at Funeral Partners, Jamie Groves, spearheads the event and all the proceeds go to GOSH. Celebrities from TV, entertainment and music will also grace the pitch including the likes of Bionic from BBC's Gladiator, YouTube superstar Danny Aarons and UK rapper Swarmz And not only will fans get to watch a thrilling game of football, but there will be a lot of fun family activities on the day. When is the Goals 4 GOSH charity match? Goals 4 GOSH will take place on Sunday, May 25 - which is also the final day of the Premier League season. The huge charity match is scheduled to get underway at 4pm BST. Organisers have announced that there will also be a content creators tournament that is expected to start at around 10:30am BST. Plough Lane - the home of AFC Wimbledon is the chosen venue for this great event. How can I watch the Goals 4 GOSH charity match? Details of how to watch the Goals 4 GOSH charity match are yet to be confirmed. However, tickets are available for purchase through the official Goals 4 GOSH Instagram page. All proceeds will be going to the Great Ormond Street Hospital. Who is playing in the Goals 4 GOSH charity match? Eden Hazard Eman SV2 Wayne Routledge Troy Deeney Grime Gran Ron Hall Manny Joel Baya Gemma Davison Beau the Beard Nathan Dawe Swarmz A Star Lianne Sanderson Shane Long Danny Aarons Adrian Mariappa Joe Cole Jason Euell Paul Gorton Leon Jackman Nathan Khider Marc White Jay & Poppy Matty Briggs Specs Gonzalez Fara Williams Bionic Jolie Sharpe Stuart Douglas Colin Kazim-Richards Lia Lewis Big G Fenners Junior Andre Katie Chapman What has been said? Jamie Froves and Charlotte Styles won the Care Award for consistently putting such an incredible Goals 4 GOSH event. Speaking after winning the award, Jamie said: 'To be honest, I didn't realise there were even awards going on. 'Getting chosen, as the winner was a bit mind-blowing. 'Every single penny makes such a difference when it comes to the hospital's equipment, beds and everything else. 'They rely so much on the funding that the charity provides. 'So, it is a massive thanks to every single player, volunteer, supporter and everybody involved.'
Yahoo
12-05-2025
- Business
- Yahoo
Leucid Bio Announces Treatment of First Patient in AERIAL Trial of NKG2D CAR-T Therapy LEU011 for Solid Tumours
Initiation of AERIAL trial accelerated by successful first close of Series A1 financing LEU011 is first CAR-T candidate for the treatment of solid tumours to be manufactured at Great Ormond Street Hospital (GOSH) Enrolment continues in AERIAL trial with initial data for LEU011 expected in the second half of 2025 LONDON, May 12, 2025 /PRNewswire/ -- Leucid Bio ("Leucid" or "The Company"), a privately-held biotechnology company pursuing the development of innovative Chimeric Antigen Receptor T-cell (CAR-T) therapies using the Company's proprietary lateral CAR platform, today announced that the first patient has been dosed in the Phase 1 AERIAL trial evaluating the safety and clinical activity of LEU011 in patients with refractory solid tumours. Initiation of the AERIAL trial follows the successful first close of the Series A1 financing of £7.2 million in February 2025, co-led by Epidarex Capital and 2invest AG, bringing the Series A to £18.7 million to date. AERIAL is a multi-centre, dose-escalation trial designed to investigate a single intravenous dose of LEU011 following preconditioning chemotherapy in patients with refractory solid tumours. Initial proof-of-concept data for LEU011 is expected in the second half of 2025. LEU011 is an autologous lateral CAR-T cell therapy targeting NKG2D stress ligands, which are overexpressed on more than 80% of human tumour cells and the surrounding tumour microenvironment. LEU011 has been engineered to co-express the chemokine receptor, CXCR2, to enhance cell trafficking and tumour infiltration, thereby adding an extra mechanism to overcome significant limitations of CAR-T therapies currently in development for the treatment of solid tumours. LEU011 also represents the first CAR-T candidate for the treatment of solid tumours to be manufactured at the Zayed Centre for Research at GOSH. Leucid gained access to the state-of-the-art Good Manufacturing Practice (GMP) production facilities at GOSH through an agreement announced in March 2023. Filippo Petti, Chief Executive Officer, Leucid Bio, stated, "The initiation of the AERIAL trial is a significant milestone for Leucid. LEU011 has demonstrated striking anti-tumour activity preclinically, while illustrating the potential to overcome challenges in treating refractory solid tumours. It's been fantastic to work with the team at GOSH to accelerate the development of LEU011 in the pursuit of bringing effective cell therapies to patients in need." Stephen Mathew, Head of Innovation at the Great Ormond Street Hospital Cell and Gene Therapy Service, added, "We're proud to have supported the manufacturing of LEU011 through our partnership with Leucid Bio, using our specialised facilities and quality assurance. This exciting milestone reflects our mission to accelerate innovation in cell and gene therapies and bring hope for better and potentially curative treatments for rare and complex conditions." Additional information on the Phase 1 AERIAL trial can be found on under the identifier NCT06193902. About Leucid Bio Leucid Bio is a privately-held biotechnology company dedicated to the development of cell therapies for the treatment of solid tumours using the Company's proprietary lateral CAR platform. The Company's lead asset, LEU011, is an autologous CAR-T cell therapy targeting NKG2D ligands, which are expressed on more than 80% of human tumours. In addition, LEU011 co-expresses the chemokine receptor CXCR2 which is engineered to enhance cell trafficking and tumour infiltration. For more information, please visit the Leucid Bio website at About Great Ormond Street Hospital for Children NHS Foundation Trust Great Ormond Street Hospital is one of the world's leading children's hospitals with the broadest range of dedicated, children's healthcare specialists under one roof in the UK. The hospital's pioneering research, innovation and treatment gives hope to children from across the UK and the world with the rarest, most complex and often life-threatening conditions. GOSH is home to the Zayed Centre for Research into Rare Disease in Children, which brings together pioneering research and world-leading clinical care to drive new tests, treatments and cures for rare and complex diseases from lab bench to bedside. The Cell and Gene Therapy Facility within the Zayed Centre for Research is comprised of seven bespoke laboratories and provides comprehensive facilities for all stages of manufacture. View original content: SOURCE Leucid Bio Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
BBC News
04-05-2025
- Health
- BBC News
Bishop's Stortford blind boy raises £12,500 in four charity quests
A 10-year-old boy who is severely visually impaired and has raised more than £12,500 for charity says it is really important to "give back to those that have helped and supported me". Ben Hardy, from Bishop's Stortford in Hertfordshire, has a rare genetic condition called Nance Horan syndrome, which means he is legally categorised as blind. Since he was three years old, he has completed four challenges to raise funds for Addenbrooke's Hospital in Cambridge, Great Ormond Street Hospital (GOSH) in London, and Bishop's Stortford Food Hardy, his mother, said he was "inspiring" and he "just get's on with it and doesn't let things stop him". Mrs Hardy said when Ben was born with cataracts, it was "completely unexpected"."He has this super rare genetic disease, and when he was under two weeks he had his first surgeries on his eyes, at Addenbrooke's." He has since had nine said although his eyesight would only get worse and it had been "a challenge", he was still a "joyous and creative" boy. Ben said he took part in the challenges after receiving "a lot of help". "It's really important to give back to those that have helped and supported me, so I'd like to return and repay the favour," he was inspired to undertake two swimathons after taking up the sport, aged five. "When I first tried it, it was quite hard, but once I got used to it and I got more relaxed, it became a love and a passion," he added."When I am in the pool, I feel free; I feel relaxed and calm."He said it was important to "find something that you love and keep at it". His mum added that her son's "achievements have only been possible due to his team of teachers, nurses and doctors" as well as the support of his father Chris Hardy, and sisters Jess and far he has raised £7,000 for Addenbrooke' March, he swam 8km (5 miles) at Bishop's Stortford College's pool, where he is a pupil, and collected £2,000 for GOSH. In 2020, he completed a climbing challenge and in 2024 undertook another sponsored swim, raising £6,500 for the food bank. Rachael Cox, his head teacher, said: "He's an inspiration to us all, and we are so delighted to have him as one of our very first neurodiversity ambassadors." Mrs Hardy said: "Ben is so brave; he's gone through so much; he's so inspiring; he just gets on with things; he doesn't let things stop him."There are so many barriers, but with the help of everyone else we are finding different ways through."Ben said: "Keep on going and trying hard, and it will pay off."He was already working on his next challenge, and as he also loves drama, poetry, drumming and kayaking, it could involve any of those activities, he confirmed. Follow Beds, Herts and Bucks news on BBC Sounds, Facebook, Instagram and X.
The Sun
01-05-2025
- Health
- The Sun
Mum's one call from her boy's nursery led to a ‘rare and aggressive' diagnosis
RAFFI Starkowitz was just three years old when he suddenly became "unsteady" on his feet. The tot had previously been behaving and playing normally until nursery staff called his mum Nicky with worries that he was struggling to walk. 5 5 5 The parents rushed Raffi, from from Bushey, Hertfordshire, to Northwick Park Hospital in Harrow, where his mum works, and then to Great Ormond Street Hospital. While he was there, doctors diagnosed him with large cell anaplastic medulloblastoma - a rare and aggressive form of brain cancer. It mainly affects children and is known for spreading quickly through the brain and spinal cord, making it potentially life-threatening if not caught early Raffi has since undergone major brain surgery to remove the large cancerous tumour, as well as a lumbar puncture to collect spinal fluid and check if the cancer has spread, He has also just begun six weeks of chemotherapy treatment, where his dad, Neil, and Nicky will be taking some time off work to support him. Meanwhile, close family friend Jamie Gross, who works with Nicky at Northwick Park, is taking on a 100k ultra-marathon from London to Brighton to help fundraise for the family. The money raised, which has surpassed £20,000, will go towards the financial burdens faced by Raffi's parents from time off work, travel to Great Ormond Street, and medical expenses. The 47-year-old added: "When you have had this horror moment where things have turned upside down, you need your care and attention to be on that. "Not worrying about how you are going to cope financially - it's going to be terrible. "That's when I came up with the idea." The families each have two children at Hertsmere Jewish Primary School in Radlett and are members of the Bushey Synagogue community. Jamie described how just a few weeks ago Raffi had been playing "like any other child, without a care in the world" when the families were together. He said that the heartfelt thanks and deep gratitude of himself and Raffi's family goes out to everyone who has donated so far. The Bushey resident added: "The number one thing we are hoping for is that he survives and he recovers." The challenge, called Run for Raffi, will take place in just under a month with donations still being taken through GoFundMe, which - at time of writing - had already raised £20k of the £22k target. 5 5 The most common symptoms of a brain tumour More than 12,000 Brits are diagnosed with a primary brain tumour every year — of which around half are cancerous — with 5,300 losing their lives. The disease is the most deadly cancer in children and adults aged under 40, according to the Brain Tumour Charity. Brain tumours reduce life expectancies by an average of 27 years, with just 12 per cent of adults surviving five years after diagnosis. There are two main types, with non-cancerous benign tumours growing more slowly and being less likely to return after treatment. Cancerous malignant brain tumours can either start in the brain or spread there from elsewhere in the body and are more likely to return. Brain tumours can cause headaches, seizures, nausea, vomiting and memory problems, according to the NHS. They can also lead to changes in personality weakness or paralysis on one side of the problem and problems with speech or vision. The nine most common symptoms are: Headaches Seizures Feeling sick Being sick Memory problems Change in personality Weakness or paralysis on one side of the body Vision problems Speech problems If you are suffering any of these symptoms, particularly a headache that feels different from the ones you normally get, you should visit your GP. Source: NHS
Yahoo
06-03-2025
- Entertainment
- Yahoo
Bryanston School raises £20,000 for various causes
Bryanston School's A2 Charities Weekend raised £20,000 for various causes. The event, organised by pupils and staff, supported Great Ormond Street Hospital, Child Action Lanka, Ayati and DBA Africa. The school community enjoyed a range of activities, including a dance show, a hockey match, a dog show and a fashion show. One of the highlights was the "My Voice, My Story" performance, a collaboration between Bryanston's sixth form pupils and peers from the Gill Sherlock Memorial School in Uganda. READ MORE: Parkstone Grammar School netball team wins national final The funds from this will help purchase performing arts equipment for the Ugandan school. More than £14,000 was raised from a silent auction. Hannah Fearnley, head of charities and outreach, said: "This was a very special weekend, once again highlighting the community spirit and compassion at the heart of a Bryanston education. "There was such a buzz across the campus with so many activities raising money for great causes. "We're enormously grateful for everyone's support." The weekend also featured hamper sales and T-shirt stands, with two upper sixth pupils showcasing their own designs. Ayati, Child Action Lanka and Great Ormond Street Hospital are charities aiding children in various capacities, while DBA Africa focuses on youth sport academies and development.
