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Biogen strikes RNAi deal with City; Aurion withdraws IPO
Biogen strikes RNAi deal with City; Aurion withdraws IPO

Yahoo

time6 days ago

  • Business
  • Yahoo

Biogen strikes RNAi deal with City; Aurion withdraws IPO

This story was originally published on BioPharma Dive. To receive daily news and insights, subscribe to our free daily BioPharma Dive newsletter. Today, a brief rundown of news involving City Therapeutics and Grin Therapeutics, as well as updates from Savara Pharma, Aurion Biotech and Prothena that you may have missed. Biogen is partnering with RNA drug developer City Therapeutics to develop a better way of reaching a unspecified target that 'mediates key central nervous system diseases.' Biogen will pay City, a startup that launched publicly late last year, $16 million in upfront fees and invest another $30 million in convertible notes that could later become a minority stake. 'With this effort, we are further expanding the modalities in our R&D toolbox to potentially reach our targets of interest more precisely by adding an RNAi-based approach," Biogen research head Jane Grogan said in a statement. — Ned Pagliarulo Biotechnology startup Grin Therapeutics will get $50 million in a deal that hands Angelini Pharma rights outside of North America to an experimental drug Grin has developed for genetic epilepsies and other neurological conditions. On Tuesday, Grin also announced the closing of a $140 million Series D round that involved Angelini and Blackstone Life Sciences. Grin's drug, radiprodil, targets a receptor that is thought to contribute to epilepsy when overactivated. The company plans to start a Phase 3 trial in the third quarter that will test radiprodil in a neurodevelopmental condition that causes seizures. — Gwendolyn Wu The Food and Drug Administration declined to review a drug Savara is developing for a rare lung condition called pulmonary alveolar proteinosis. According to Savara, the agency deemed the company's application incomplete and asked for more information about how the treatment, Molbreevi, is made. The FDA didn't identify any safety issues or request more efficacy data, Savara said. The company will request a meeting with the FDA within the next month. Its share price fell by more than 20% Tuesday.— Ben Fidler Aurion Biotech has withdrawn plans to go public, according to a regulatory filing. The cell therapy developer filed for an initial public offering in January, but did so despite opposition from shareholder Alcon, leading to a legal spat between the firm and another equity holder, Deerfield Management, over Aurion's future. Alcon bought a majority stake in Aurion in late March, however, and replaced the biotech's CEO. Aurion said in a Friday filing that an IPO is no longer "in the best interests of the company." — Ben Fidler Shares in Prothena fell by more than 30% to open Tuesday trading following the company's disclosure Friday that a late-stage trial of a drug called birtamimab failed to reach its main goal. As a result, Prothena has decided to shelve further development of birtamimab, which it had been studying as a treatment for the disease AL amyloidosis. 'This is not the outcome that we expected, and we are surprised and disappointed by these results,' said Prothena CEO Gene Kinney, in a statement. The company is now considering ways to reduce expenses, among them an expected substantial workforce reduction.' — Ned Pagliarulo Recommended Reading Regeneron defeats Amgen in PCSK9 case; 2 cell therapy biotechs cut staff Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data

Influencer Marketing: How AI And Infrastructure Unlock Brand Growth
Influencer Marketing: How AI And Infrastructure Unlock Brand Growth

Forbes

time28-05-2025

  • Business
  • Forbes

Influencer Marketing: How AI And Infrastructure Unlock Brand Growth

AI is changing how creator marketing works, from identifying talent to measuring results. But most teams still aren't set up to take full advantage. The reason? Creator marketing lacks the infrastructure other parts of marketing rely on. There's no standard tech stack, no universal system, and much of the work still lives in spreadsheets, decks, or tools brands don't even own. That's a problem. Creator marketing is no longer experimental. According to Deloitte Digital's 2025 State of Social Research, creators now account for nearly a quarter of all social media budgets, more than any other line item. With investments at that scale, brands need a system that works. At the recent event, Digital Entertainment World, leaders from Traackr, Grin, Aspire, Later, and CreatorIQ joined Edelman's Steph Money to explore how AI is closing the infrastructure gap and what brands need to run creator marketing like any other core function of their business. Creator discovery is evolving from instinct to insight. AI is helping teams go beyond manual searches to uncover patterns in content, sentiment, and audience behavior. 'AI can scan performance, content style, sentiment, and audience match, then generate a short list aligned to your goals,' said Olivia McNaughten, Head of Marketing at Grin. 'You might find a creator who performs well, but if they're difficult to work with, that has a cost, too. AI can't see that. Only people can.' AI allows marketers to identify creators with real influence in relevant communities. It enables a more strategic approach to building creator portfolios similar to how media teams optimize media buys. Because AI handles the repetitive work, marketers have more time for what only humans can do: build trust and shape creative ideas. For many brands, creator data lives in too many places or isn't easily accessed. When programs are outsourced or fragmented, data ends up in spreadsheets, PowerPoints, or platforms the brand doesn't control. That makes it hard to track performance or build on what's working. 'You can't build anything sustainable if every campaign starts from zero,' said Taylor Rodriguez, Global VP of Customer Experience at Traackr. 'We talk to teams who have been running creator programs for years, but they can't tell you which partnerships are worth reinvesting in or what moved the needle. Without the right system, all that knowledge disappears.' Jacob Clark, VP of Customer Success at Aspire, added, 'We treat creator relationship data like we would customer data. Centralized, searchable, and actionable. When you build that kind of system, you're not just tracking performance. You're capturing the full history of how a partnership evolves. That helps you see who to reinvest in, what works across markets, and where future opportunities are hiding.' 'With AI layered on top, these insights become even more powerful. The more signals you collect, creator history, engagement, and performance, the more innovative and tailored the strategy becomes,' added Rodriguez. More content is being created than ever before. But more doesn't mean better. AI is helping marketers understand which content is driving real results and why. 'There's going to be a massive amount of content, and that's going to change what performance looks like,' said Bill Stanton, Head of Enterprise Sales at Later. 'Certain thresholds, certain metrics that were important a year ago, might now be watered down or no longer relevant.' He added, 'It's not about more data. It's about getting the right signals to make smarter calls about what's working and worth scaling.' 'You can't just track what went viral,' said Nate Harris, VP of Product Innovation at CreatorIQ. 'You have to understand why it worked and who it worked for. That's what informs your next move.' Harris continued, 'AI helps identify patterns. What kind of content drives action, and for which audiences? That insight is what turns performance data into a strategic advantage.' AI makes performance analysis more than a reporting function. It becomes a feedback loop that helps teams optimize creative, distribution, and targeting with each cycle. As creator budgets increase, so does the pressure to deliver results at scale. AI helps teams move faster, reduce friction, and make decisions with more clarity. 'The goal isn't just automation. It's elevation,' said Steph Money, SVP@Edelman AI 'AI gives marketers the power to scale strategy, not just execution. The real unlock is when creativity and data flow through the same infrastructure. You're not just producing content faster; you're making better decisions at every stage.' When creator discovery, relationship management, and performance are connected, Creator marketing becomes a continuous function like paid media or CRM. 'If we set up the systems the right way, creators get to spend more time making, and brands get to learn faster from what they make,' said Harris. That approach turns creator marketing into a long-term growth engine, not a side project. Creator marketing is evolving, but many brands are stuck in trial-and-error mode. Budgets are growing. Expectations are rising. And AI is accelerating what's possible. But none of that matters without infrastructure. As the speakers from Traackr, Grin, Aspire, Later, and CreatorIQ emphasized, creator marketing lacks what every other discipline has: a dedicated tech stack. That absence makes it harder to learn, measure, and scale. Without structure, even the best creative strategies won't go far. The brands that succeed won't be the ones with the most content. They'll be the ones with a clear system and the ability to make that system smarter with every campaign

Grin Unveils New AI-Enabled Management Tools and Seamless Practice Integration at AAO 2025
Grin Unveils New AI-Enabled Management Tools and Seamless Practice Integration at AAO 2025

Yahoo

time23-04-2025

  • Business
  • Yahoo

Grin Unveils New AI-Enabled Management Tools and Seamless Practice Integration at AAO 2025

With the new features, Grin will simplify workflows, strengthen patient outcomes, and drive growth for the next generation of orthodontic practices. NEW YORK, April 23, 2025--(BUSINESS WIRE)--Grin, the leading virtual care platform for digital oral healthcare solutions, is ushering in the next era of orthodontics with the debut of its new Grin Ecosystem: Grin Care, Growth, Thrive at the 2025 AAO Annual Session in Philadelphia. The launch will enable practices to deliver personalized care, grow their business, and operate more efficiently in the evolving landscape of oral healthcare. New features include Grin CoPilot, RapidReferral, AI Treatment Tracking, and other enhanced AI-enabled tools, and a new integration with Clarity™ by Solventum, which together create a scalable, patient-first platform. "At Grin, we believe the future of orthodontics is about more than digitization; it's about transformation," said Dr. Adam Schulhof, CEO and Co-Founder of Grin. "We're giving doctors smarter tools, faster insights, and clinical precision to care for patients, grow their practice, and thrive in a rapidly evolving industry without ever sacrificing a personalized, human-first experience that makes patient care so meaningful." On display, Grin will showcase its updated Care, Grow, Thrive Ecosystem, providing practices with automated, patient-focused AI care while elevating the personalized experience with the help of Grin Care Specialists. In their booth (#935), learn more about Grin's newest features: Grin CoPilot™ is a practice's always-on, AI-powered sidekick designed to assist, analyze, guide, and optimize care. The tool automates routine tasks and delivers real-time clinical insights for care with less complexity. Grin Care Specialists oversee the tool to ensure a human-driven, personalized experience for patients. CoPilot anticipates needs, allowing doctors to focus on delivering high-quality care. Integration with the Clarity™ Portal enables patient association between the two systems. Once connected, photo records generated from Grin scans can be directly uploaded into the Clarity™ Portal patient record. Grin Hygiene+, a new feature that tracks and visualizes oral hygiene scores over time. With a dedicated hygiene dashboard for practices and an interactive brushing companion in the patient app, Grin Hygiene+ helps elevate oral care by driving better habits and improving patient accountability. Newly enhanced patient app, which offers a reimagined mobile experience that empowers patients to take a more active role in their orthodontic journey. The upgraded interface provides enhanced visibility, personalized guidance, and seamless communication, empowering patients with greater control and confidence. Redesigned Grin Doctor Portal features improved navigation, a centralized notification center, internal patient chat, and upcoming practice-wide chat functionality. Dr. Schulhof will be speaking at the Solventum booth (#1911) on Friday, April 25th, and Saturday, April 26th. Discover how he and fellow thought leaders are transforming patient care through seamless technology integration and clinical innovation. 12:00–12:20 PM: Panel Discussion: Digital Efficiency at Your Fingertips 12:35–12:55 PM: Panel Discussion: The Power of Precision 12:55–1:15 PM: Bringing Clarity to Remote Care: How Integration and Innovation Improve Patient Care Grin will also be featured in the TechSelect Innovation Pavilion and will present live during TechSelect LIVE on Saturday, April 26th at 2:40 PM, showcasing the latest innovations in digital orthodontic care. Visit Grin at booth #935 at AAO 2025 in Philadelphia, April 25–27, to connect with real-world Grin Providers during in-booth office hours, hear from our Chief Technology Officer and Head of Product, and discover firsthand how Grin's ecosystem is transforming practices. Plus, meet our Grin Care Specialists and experience the future of virtual care. Can't attend? Catch the on-demand replay of the AAO showcase to explore the future of orthodontic innovation. Get a firsthand look at the Grin NextGen experience and see how Grin is leading the way in virtual care, practice growth, and patient engagement. About Grin Grin is a comprehensive digital platform that provides solutions for all oral health needs. The Grin App and Grin Scope® allow doctors to access a full patient management suite. Patients can access quality professional care from the convenience of their smart devices. Doctors can remotely monitor patients via virtual check-ins for complete visibility—reducing chair time, increasing patient volume, and ensuring safety and beautiful smile results. To learn more about Grin, you can visit us at View source version on Contacts Media Gillian CabanskiDirector of Marketing, Gringillian@ Sign in to access your portfolio

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