Latest news with #Gubler
Yahoo
20-05-2025
- Health
- Yahoo
Yellow Fever Resurgence Could Make COVID Look 'Pale' by Comparison
Yellow fever is a dangerous mosquito-borne virus that, for hundreds of years, has caused sporadic, deadly outbreaks in the tropics of South America, Central America, and Africa. According to a new perspective from infectious disease specialists and the Yellow Fever Advisory Group, the chances of the virus going global have only increased with each passing decade. A recent resurgence in yellow fever cases in Africa and the Americas has experts seriously worried about future spread to the Asia Pacific region. "The world is clearly at high risk for epidemic/pandemic yellow fever," the international team concludes, led by infectious disease specialist Duane Gubler from the National University of Singapore. "A yellow fever pandemic in today's world would cause a devastating public health crisis that, because of the much higher lethality, would make the COVID-19 pandemic pale by comparison." Unfortunately, the yellow fever virus has a long history of travel. Prior to the 1600s, yellow fever and its mosquito carriers were endemic to Africa. Later, they spread to the Americas via the transatlantic slave trade, sometimes killing up to 10 percent of some local populations in the New World. When the virus began taking over Europe, roughly a century later, it became known as the "American plague". The development of a highly effective yellow fever vaccine in the 1930s changed everything. Yellow fever mosquitoes were also almost completely eradicated in the Western Hemisphere, and the two factors stopped urban spread in the Americas. In the decades since, yellow fever mosquitoes have re-infested much of the neotropics, and while Africa continues to experience intermittent epidemics in urban centers, the Americas have been free of a yellow fever epidemic for 80-plus years, only experiencing small and infrequent outbreaks. Scientists are concerned that reprieve won't last for much longer. In recent years, there's been a worrisome resurgence in yellow fever outbreaks in Africa and the Americas, possibly because of poor vaccine coverage, expansion of human populations, lack of travel restrictions, and/or lack of mosquito control. According to Gubler and colleagues, tropical cities that have not historically experienced yellow fever now face "the greatest risk in over 70 years" of an epidemic. "Of primary concern in this regard is the Asia-Pacific region," the team adds, "where over two billion susceptible people live in areas infested by yellow fever mosquitoes." These mosquito populations aren't carrying the yellow fever virus just yet, but they are species that are capable of doing so. If a human traveller with yellow fever returns to the Asia-Pacific region after travel in Africa or South America, it is possible that local mosquitoes bite them and contract the virus. This could allow for spread among new insect populations in new regions, threatening local humans with a spillover event. "Today's megacities all have modern airports through which billions of people pass every year, many of them visiting remote locations and carrying exotic pathogens back to crowded tropical cities, where the probability of secondary transmission is increased," warns the recent perspective. "If the virus is introduced to a permissive nonendemic country, especially one located in Asia, the disease might be first misdiagnosed as dengue, likely resulting in spread before being recognized as the yellow fever virus." So what are we to do? Researchers say that first, we need to expand the global supply of yellow fever vaccines and improve coverage. Otherwise, outbreaks will continue and we won't be ready if the virus spreads to new regions. Gubler and colleagues also argue for increased surveillance of yellow fever cases in poor countries where the disease is endemic, and in non-endemic countries where the virus could possibly spread in the future. "Immunization services, disease surveillance, and the outbreak response in nearly 50 countries are already being disrupted – with setbacks at a similar level to what we saw during COVID-19," warned UNICEF Executive Director Catherine Russell in April 2025. "We cannot afford to lose ground in the fight against preventable diseases." The perspective was published in NPJ Viruses. Huge Study Reveals Where Gout Comes From, And It's Not What We Thought Should You Shower in The Morning or Night? It Depends on One Crucial Factor. Your Voice Could Hide The Tell-Tale Signs of Parkinson's Disease
Yahoo
22-03-2025
- Health
- Yahoo
THREE International Expands Visage Collection with Launch of Visage Crème Caviar
HONG KONG, March 21, 2025 /PRNewswire/ -- THREE International launched its luxury facial moisturizer, Visage Creme Caviar, at the company's global Vision 2025 conference in Hong Kong Saturday. The moisturizer is the latest addition to the Visage skincare line and incorporates both neurocosmetic and quorum sensing ingredients, as well as the rare and resilient botanical extracts the company is known for, once more bringing together the best of science and nature in a truly innovative combination. "Moisturization is a fundamental part of any skincare routine, but not all moisturizers are created equal," said Dr. Dan Gubler, Chief Scientific Officer of THREE International. "Visage Crème Caviar is more than a moisturizer. It's the culmination of years of research and discovery, pursuing nature's wonders and unlocking the secrets of plants." The formulation integrates botanical extracts sourced from the fruit of the Kochia plant. Dr. Gubler discovered the plant's potential to support skin health during study and exploration of northern Japan. "Six years ago, I began studying the Kochia plant, whose fruit showed incredible potential for skin health," said Dr. Gubler. "Its fruit, commonly called 'Mountain Caviar,' is rich in alkaloids and saponins, which act like tiny sponges, pulling moisture from the air and holding it in your skin to keep it hydrated all day. It's also an excellent source of omega-3 fatty acids, which help your skin stay soft and resilient, and vitamins and minerals that support your skin's natural defenses." Its neurocosmetic ingredients are designed to enhance the skin's natural responses to environmental stressors, helping to promote a smoother-looking, more luminous complexion. Quorum sensing technology works to augment the skin's microbiome, creating an environment that encourages both balance and optimal absorption of nutrients. "The patent-pending neurocosmetic technology in Visage Crème Caviar supports the health of the skin-brain connection, which helps promote a positive mood state," Dr. Gubler explained. "The quorum sensing ingredients help your cells communicate and coordinate in way that that enables the rest of the ingredients to really do their job and deliver the results your skin deserves." Visage Crème Caviar follows the success of Visage Super Serum, which saw rapid adoption due to its neurocosmetic properties aimed at supporting the skin's natural renewal processes. With this new release, the Visage Collection now includes a full skincare regimen: Visage Pure Cleanse, Visage Radiant Toner, Visage Super Serum, and Visage Crème Caviar. Each product in the line works synergistically to cleanse, tone, nourish, and deeply hydrate the skin. Further information about the research behind the formulation is available through the Explore With Dr. Dan video series, where Dr. Gubler documents discoveries of plant-based ingredients with potential applications in human health. Viewers can access the series at Visage Crème Caviar is available for purchase, along with the rest of the collection, at Discover the Future of Skincare Experience the revolutionary Visage Collection and see how innovative science can pamper your skin and help you feel great. Visit to explore the collection and connect with a Brand Ambassador for personalized recommendations. If you're passionate about skincare and human health, consider joining the THREE team as customer or Brand Ambassador—we'd love to work with you. THREE™ has redefined the science of supplementation with cutting-edge cellular absorption technology, ensuring that our products are efficient, effective, and unbeatably bioavailable. Behind our world-leading, advanced delivery products is our scientific community, a team of leaders, led by Dr. Dan Gubler, from across the medical field. Our mission is twofold: improve quality of life through holistic health education and to inform the development of world-leading advanced delivery products. THREE™ is a movement led by Daniel Picou, Founder & CEO, that is changing lives around the world by delivering healthy options to PEOPLE, greater PURPOSE through our caring community, and a dynamic PLATFORM for entrepreneurship. Learn more at: Media ContactTHREE International Communications | marketing@ View original content to download multimedia: SOURCE Three International Sign in to access your portfolio
South China Morning Post
22-02-2025
- Entertainment
- South China Morning Post
Who has Criminal Minds star Matthew Gray Gubler dated on and off screen?
For 15 seasons of TV show Criminal Minds , from 2005 to 2020, Matthew Gray Gubler played Dr Spencer Reid, a behavioural analyst for the FBI. Known for his sharp wit and expertise in solving complex crimes, the character quickly became a fan favourite. Matthew Gray Gubler starred in Criminal Minds for 15 seasons. Despite spending a decade and a half on the show, Reid was one of the few characters who never had a long-term romantic relationship. His first love interest was Supervisory Special Agent Jennifer 'JJ' Jareau (A.J. Cook), but their dynamic shifted to more of a brother-sister connection. In season eight, he seems to have finally found 'the one' in the form of geneticist Maeve Donovan (Beth Riesgraf), but she is murdered by her stalker. A new relationship with art teacher Maxine Brenner (Rachael Leigh Cook) in the series finale ended ambiguously, leaving their relationship status unclear. But while Gubler's on-screen love life remained largely unsuccessful, his real-life relationships are a different story. Let's take a closer look at his rumoured dating history. Was there love on the runway? Matthew Gray Gubler worked as a model before finding fame on TV. Photo: @gublergram/Instagram While studying at New York University's Tisch School of the Arts in the early noughties, Las Vegas native Gubler, now 44, was discovered by a model scout and went on to appear in campaigns for fashion brands such as Marc Jacobs and Tommy Hilfiger. In 2004, says Nicki Swift, he was linked with singer and fellow model Charlotte Kemp Muhl. However, Muhl later took to Instagram to clarify that the two were just friends. Friends and pop stars In 2007, Gubler dated 2 Broke Girls sitcom star Kat Dennings for a few months, according to Nicki Swift. Their relationship ended owing to the demanding filming schedule of Criminal Minds , but the two have remained close friends. 'I'm still really good friends with her. I love Kat. She's the best,' said Gubler in a 2015 interview with Glamour magazine. They would even go on to co-star in the 2019 comedy series Dollface .
