Latest news with #Hemopurifier
Associated Press
14-05-2025
- Health
- Associated Press
Aethlon Medical Announces Publication of Preclinical Data Showing Ability of the Hemopurifier® to Remove Platelet-Derived Extracellular Vesicles from Plasma
Results Reinforce the Current Australian Oncology Clinical Trial and Support Investigation of the Hemopurifier Across Multiple Indications SAN DIEGO, May 14, 2025 /PRNewswire/ -- Aethlon Medical, Inc. (Nasdaq: AEMD), a medical therapeutic company focused on developing products to treat cancer and life-threatening infectious diseases, today announced the publication ( ) of a pre-clinical ex vivo study in pre-print vehicle bioRxiv, entitled, 'Ex Vivo Removal of CD41 positive platelet microparticles from Plasma by a Medical Device containing a Galanthus nivalis agglutinin (GNA) affinity resin.' Aethlon Medical's Hemopurifier® is a therapeutic blood filtration system designed to bind and remove harmful extracellular vesicles (EVs or exosomes) and life-threatening viruses from blood and other biological fluids, properties that support its evaluation not only in oncology and infectious diseases, but also in the organ transplantation and other areas of significant unmet medical need. Platelet-derived extracellular vesicles (PD-EVs) are the most numerous EV population in the body and are released by platelets in response to a variety of stimuli. The cargo contained within these EVs have been noted to participate in damage to blood vessels, activation of immune cells, and spread of tumor cells. Excessive levels of PD-EVs have been implicated in a myriad of diseases, including cancer, lupus, systemic sclerosis, multiple sclerosis, Alzheimer's disease, sepsis, acute and Long COVID. An independent research team had demonstrated that PD-EVs in Alzheimer's patients bound to the plant lectin Galanthus nivalis agglutinin (GNA). We hypothesized that the Aethlon Hemopurifier, which contains a proprietary GNA affinity resin would remove platelet derived EVs from plasma. In this experiment two hundred milliliters of donated healthy human plasma were circulated over the Aethlon Hemoupurifier (HP) to simulate a clinical HP session. The study results indicated a 98.5% removal of platelet -derived EVs at a timepoint equivalent to a 4-hour HP treatment. 'The data from this ex vivo study is exciting because it demonstrated for the first time that our device removes Platelet-derived EV's. This data is also supportive of our ongoing Oncology clinical trial in Australia as PD-EVs participate in the spread of cancers. We will be specifically looking at PD-EV removal in our subjects enrolled in the clinical trial,' said Steven P. LaRosa, MD, Chief Medical Officer at Aethlon Medical and senior author on the paper. 'Beyond Oncology we could envision many indications where removal of PD-EVs by the Hemopurifier could be a therapeutic strategy. The findings from this study raise the possibility of a 'pipeline within a device,' said James Frakes, Chief Executive Officer at Aethlon. Next steps will be to submit the findings of this study to a peer-review medical journal and specifically study PD-EV removal and their cargo from plasma samples from diseases of interest. About Aethlon and the Hemopurifier® Aethlon Medical is a medical therapeutic company focused on developing the Hemopurifier, a clinical stage immunotherapeutic device which is designed to combat cancer and life-threatening viral infections and for use in organ transplantation. In human studies, the Hemopurifier has demonstrated the removal of life-threatening viruses and in pre-clinical studies, the Hemopurifier has demonstrated the removal of harmful EVs from biological fluids, utilizing its proprietary lectin-based technology. This action has potential applications in cancer, where EVs may promote immune suppression and metastasis, and in life-threatening infectious diseases. The Hemopurifier is a U.S. Food and Drug Administration (FDA) designated Breakthrough Device indicated for the treatment of individuals with advanced or metastatic cancer who are either unresponsive to or intolerant of standard of care therapy, and with cancer types in which EVs have been shown to participate in the development or severity of the disease. The Hemopurifier also holds an FDA Breakthrough Device designation and an open Investigational Device Exemption (IDE) application related to the treatment of life-threatening viruses that are not addressed with approved therapies. Additional information can be found at Forward-Looking Statements This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 that involve risks and uncertainties. Statements containing words such as 'may,' 'believe,' 'anticipate,' 'expect,' 'intend,' 'plan,' 'project,' 'will,' 'projections,' 'estimate,' 'potentially' or similar expressions constitute forward-looking statements. Such forward-looking statements are subject to significant risks and uncertainties and actual results may differ materially from the results anticipated in the forward-looking statements. These forward-looking statements are based upon Aethlon's current expectations and involve assumptions that may never materialize or may prove to be incorrect. Factors that may contribute to such differences include, without limitation, the Company's ability to raise additional capital and to successfully complete development of the Hemopurifier; the Company's ability to successfully demonstrate the utility of the Hemopurifier in cancer and infectious diseases and in the transplant setting; the ability of the Hemopurifier to continue to show removal of platelet -derived EVs at a timepoint equivalent to a 4-hour HP treatment; the Company's ability to achieve and realize the anticipated benefits from potential milestones; the Company's ability to submit applications to and obtain approval from the additional Ethics Committees in Australia and India, including on the timing expected by the Company; the Company's ability to initiate and continue its planned oncology clinical trials in Australia and India, including on the timing expected by the Company; the Company's ability to manage and successfully complete its clinical trials, if initiated; the potential impact of Hemopurifier on the H5N1 Avian Influenza (H5N1 HPAI) virus in dairy cattle; the Company's ability to successfully manufacture the Hemopurifier in sufficient quantities for its clinical trials, and other potential risks. The foregoing list of risks and uncertainties is illustrative, but is not exhaustive. Additional factors that could cause results to differ materially from those anticipated in forward-looking statements can be found under the caption 'Risk Factors' in the Company's Annual Report on Form 10-K for the year ended March 31, 2024, and in the Company's other filings with the Securities and Exchange Commission, including its quarterly Reports on Form 10-Q. All forward-looking statements contained in this press release speak only as of the date on which they were made. Except as may be required by law, the Company does not intend, nor does it undertake any duty, to update this information to reflect future events or circumstances. Company Contact: Jim Frakes Interim Chief Executive Officer and Chief Financial Officer Aethlon Medical, Inc. [email protected] Investor Contact: Susan Noonan S.A. Noonan Communications, LLC [email protected] 917-513-5303 View original content: SOURCE Aethlon Medical, Inc.
Yahoo
14-05-2025
- Health
- Yahoo
Aethlon Medical Announces Publication of Preclinical Data Showing Ability of the Hemopurifier® to Remove Platelet-Derived Extracellular Vesicles from Plasma
Results Reinforce the Current Australian Oncology Clinical Trial and Support Investigation of the Hemopurifier Across Multiple Indications SAN DIEGO, May 14, 2025 /PRNewswire/ -- Aethlon Medical, Inc. (Nasdaq: AEMD), a medical therapeutic company focused on developing products to treat cancer and life-threatening infectious diseases, today announced the publication ( of a pre-clinical ex vivo study in pre-print vehicle bioRxiv, entitled, "Ex Vivo Removal of CD41 positive platelet microparticles from Plasma by a Medical Device containing a Galanthus nivalis agglutinin (GNA) affinity resin." Aethlon Medical's Hemopurifier® is a therapeutic blood filtration system designed to bind and remove harmful extracellular vesicles (EVs or exosomes) and life-threatening viruses from blood and other biological fluids, properties that support its evaluation not only in oncology and infectious diseases, but also in the organ transplantation and other areas of significant unmet medical need. Platelet-derived extracellular vesicles (PD-EVs) are the most numerous EV population in the body and are released by platelets in response to a variety of stimuli. The cargo contained within these EVs have been noted to participate in damage to blood vessels, activation of immune cells, and spread of tumor cells. Excessive levels of PD-EVs have been implicated in a myriad of diseases, including cancer, lupus, systemic sclerosis, multiple sclerosis, Alzheimer's disease, sepsis, acute and Long COVID. An independent research team had demonstrated that PD-EVs in Alzheimer's patients bound to the plant lectin Galanthus nivalis agglutinin (GNA). We hypothesized that the Aethlon Hemopurifier, which contains a proprietary GNA affinity resin would remove platelet derived EVs from plasma. In this experiment two hundred milliliters of donated healthy human plasma were circulated over the Aethlon Hemoupurifier (HP) to simulate a clinical HP session. The study results indicated a 98.5% removal of platelet -derived EVs at a timepoint equivalent to a 4-hour HP treatment. "The data from this ex vivo study is exciting because it demonstrated for the first time that our device removes Platelet-derived EV's. This data is also supportive of our ongoing Oncology clinical trial in Australia as PD-EVs participate in the spread of cancers. We will be specifically looking at PD-EV removal in our subjects enrolled in the clinical trial," said Steven P. LaRosa, MD, Chief Medical Officer at Aethlon Medical and senior author on the paper. "Beyond Oncology we could envision many indications where removal of PD-EVs by the Hemopurifier could be a therapeutic strategy. The findings from this study raise the possibility of a "pipeline within a device," said James Frakes, Chief Executive Officer at Aethlon. Next steps will be to submit the findings of this study to a peer-review medical journal and specifically study PD-EV removal and their cargo from plasma samples from diseases of interest. About Aethlon and the Hemopurifier®Aethlon Medical is a medical therapeutic company focused on developing the Hemopurifier, a clinical stage immunotherapeutic device which is designed to combat cancer and life-threatening viral infections and for use in organ transplantation. In human studies, the Hemopurifier has demonstrated the removal of life-threatening viruses and in pre-clinical studies, the Hemopurifier has demonstrated the removal of harmful EVs from biological fluids, utilizing its proprietary lectin-based technology. This action has potential applications in cancer, where EVs may promote immune suppression and metastasis, and in life-threatening infectious diseases. The Hemopurifier is a U.S. Food and Drug Administration (FDA) designated Breakthrough Device indicated for the treatment of individuals with advanced or metastatic cancer who are either unresponsive to or intolerant of standard of care therapy, and with cancer types in which EVs have been shown to participate in the development or severity of the disease. The Hemopurifier also holds an FDA Breakthrough Device designation and an open Investigational Device Exemption (IDE) application related to the treatment of life-threatening viruses that are not addressed with approved therapies. Additional information can be found at Forward-Looking StatementsThis press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 that involve risks and uncertainties. Statements containing words such as "may," "believe," "anticipate," "expect," "intend," "plan," "project," "will," "projections," "estimate," "potentially" or similar expressions constitute forward-looking statements. Such forward-looking statements are subject to significant risks and uncertainties and actual results may differ materially from the results anticipated in the forward-looking statements. These forward-looking statements are based upon Aethlon's current expectations and involve assumptions that may never materialize or may prove to be incorrect. Factors that may contribute to such differences include, without limitation, the Company's ability to raise additional capital and to successfully complete development of the Hemopurifier; the Company's ability to successfully demonstrate the utility of the Hemopurifier in cancer and infectious diseases and in the transplant setting; the ability of the Hemopurifier to continue to show removal of platelet -derived EVs at a timepoint equivalent to a 4-hour HP treatment; the Company's ability to achieve and realize the anticipated benefits from potential milestones; the Company's ability to submit applications to and obtain approval from the additional Ethics Committees in Australia and India, including on the timing expected by the Company; the Company's ability to initiate and continue its planned oncology clinical trials in Australia and India, including on the timing expected by the Company; the Company's ability to manage and successfully complete its clinical trials, if initiated; the potential impact of Hemopurifier on the H5N1 Avian Influenza (H5N1 HPAI) virus in dairy cattle; the Company's ability to successfully manufacture the Hemopurifier in sufficient quantities for its clinical trials, and other potential risks. The foregoing list of risks and uncertainties is illustrative, but is not exhaustive. Additional factors that could cause results to differ materially from those anticipated in forward-looking statements can be found under the caption "Risk Factors" in the Company's Annual Report on Form 10-K for the year ended March 31, 2024, and in the Company's other filings with the Securities and Exchange Commission, including its quarterly Reports on Form 10-Q. All forward-looking statements contained in this press release speak only as of the date on which they were made. Except as may be required by law, the Company does not intend, nor does it undertake any duty, to update this information to reflect future events or circumstances. Company Contact:Jim FrakesInterim Chief Executive Officer and Chief Financial OfficerAethlon Medical, Inc. Jfrakes@ Investor Contact:Susan NoonanS.A. Noonan Communications, LLCsusan@ 917-513-5303 View original content: SOURCE Aethlon Medical, Inc. 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Associated Press
12-03-2025
- Health
- Associated Press
Sigyn CEO Note: An Emerging New Industry, 15 Years in the Making
NEWMEDIAWIRE) - Sigyn Therapeutics, Inc. ('Sigyn' or the 'Company') (OTCQB: SIGY) today released the following note authored by its CEO, Jim Joyce. Dear Reader, Blood purification technologies have emerged to become leading post-exposure countermeasures to treat emerging pandemic viruses. When properly designed, these devices can also serve a dual-use purpose in everyday medicine. In this regard, Sigyn TherapyTM is a candidate first-line countermeasure to address viral threats, yet it also offers a mechanism to potentially enhance and prolong the lives of the 550,00 end-stage renal disease (ESRD) patients who rely on dialysis for survival in the United States. Additionally, Sigyn Therapy(TM) is able to target circulating factors underlying sepsis, a currently untreatable condition that is a leading cause of U.S. hospital deaths. The U.S. Government has supported the development of blood purification therapies through the Defense Advanced Research Projects Agency (DARPA). If you're unfamiliar, the Economist Magazine describes DARPA as 'the agency that shaped the modern world,' having contributed to groundbreaking innovations such as GPS, drones, stealth technology, the personal computer, and even the internet. DARPA Dialysis-Like Therapeutics Program DARPA also has a long history of supporting breakthrough advances in medicine. In 2010, the agency launched a five-year program entitled Dialysis-Like Therapeutics (DLT) to advance blood purification technologies to treat bloodstream infections and sepsis. Among the recipients of a DLT program contract was Aethlon Medical. As the founder of Aethlon, I oversaw development of the Hemopurifier(TM), a broad-spectrum virus clearance device that became the first blood purification technology to receive FDA Emergency-Use Authorization (EUA) to treat an emerging pandemic virus. In this case, Ebola virus, which occurred during the DLT program and under my leadership. Subsequently, blood purification therapies developed by two other members of the DARPA DLT team would be among the first therapies to receive EUA approval from FDA to treat COVID-19. Note: As compared to the Hemopurifier(TM), we designed Sigyn Therapy(TM) with the intent to process the bloodstream more efficiently; to have a greater capacity to capture therapeutic targets; to addresses viral pathogens plus a wide range of inflammatory targets; and to improve scalability with lower production costs. mRNA Vaccine Research Initiatives Not long after the launch of its DLT program, DARPA initiated a rapid mRNA vaccine development program that would play pivotal role in the development of the Moderna COVID-19 vaccine. When COVID-19 spread across the globe five years ago, the world faced an urgent need for a vaccine. At the time, the record for the fastest development of a vaccine to address a new virus was four years. In a groundbreaking achievement, mRNA-based vaccines from Moderna and Pfizer/BioNTech were available within a year of COVID-19 being declared a global health emergency by the World Health Organization. A study published in the journal The Lancet Infectious Diseases; estimated that these vaccines prevented between 14.4 to 19.8 million deaths worldwide in just their first year of distribution. This unprecedented speed in vaccine development may have shifted the historic focus of post-exposure treatment countermeasures from single-target antiviral drugs to broad-spectrum blood purification technologies. Especially as preventative vaccines can be developed and distributed in a mere fraction of the time it takes to bring a post-exposure antiviral drug to market. Whereas blood purification therapies can be available at the outset of a viral outbreak. Potential Advantages of Sigyn Therapy As compared to a post-exposure antiviral drug, Sigyn Therapy(TM) offers several key advantages. Unlike antiviral drugs, our technology provides an expansive mechanism of action to reduce the circulating presence of viruses, toxins, inflammatory cytokines, and other deleterious factors from the bloodstream of infected individuals. While antiviral drugs can target a specific type of virus, Sigyn Therapy(TM) offers a broad-spectrum strategy to potentially address different strains, species, and families of viruses. In closing, Sigyn Therapy(TM) is a candidate first-line countermeasures to address emerging viral threats. The continued convergence of global warming, urban crowding, and international travel will fuel new outbreaks. The question is not if, but how often these outbreaks will occur, how many lives will be lost, and what will be the global economic impact as emerging viral threats will not be constrained by borders. In the meantime, the expansive mechanism of Sigyn Therapy(TM) allows for its potential dual use in everyday medicine. Our lead clinical opportunity incorporates Sigyn Therapy(TM) in series with regularly scheduled dialysis treatments to reduce endotoxemia and concurrent inflammation that contributes to shorten the lives of end-stage renal disease (ESRD) patients. Extending the lives of those suffering from ESRD could establish a strategic competitive advantage within the dialysis industry. Thank you for taking the time to read my note. Sincerely, Jim About Sigyn Therapeutics(TM) Sigyn Therapeutics is developing next-generation blood purification therapies to address life-threatening infectious disease disorders. Sigyn Therapy(TM) has been demonstrated to reduce the presence of viral pathogens, bacterial toxins, inflammatory cytokines, and other relevant therapeutic targets from human blood plasma. Based on these capabilities, Sigyn Therapy(TM) is a candidate to treat life-threatening viruses, endotoxemia, and sepsis, the leading cause of death in U.S. hospitals. The clinical protocol of first-in-human studies incorporates Sigyn Therapy into regularly scheduled dialysis treatments to address endotoxemia and concurrent inflammation, which are highly prevalent disorders that shorten the lives of end-stage renal disease (ESRD) patients. The value of extending ESRD patient lives is quantifiable based its potential impact on dialysis industry revenues. The Company also has an oncology pipeline comprised of ImmunePrep(TM), a platform to enhance the delivery of immunotherapeutic antibodies; ChemoPrep(TM) to improve the delivery of chemotherapeutic agents; and ChemoPure(TM) to reduce chemotherapy toxicity. If successfully advanced, the Company's therapies offer to provide strategic value to the dialysis and biopharmaceutical industries. Sigyn Therapeutics, Inc. Johan Louw Senior Vice President of Strategic Programs 281.660.1815 [email protected] CEO, Inventor Cautionary Note Regarding Forward-Looking Statements This information in this press release contains forward-looking statements of Sigyn Therapeutics, Inc. ('Sigyn') that involve substantial risks and uncertainties. All statements contained in this summary are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 that involve risks and uncertainties. Statements containing words such as 'may,' 'believe,' 'anticipate,' 'expect,' 'intend,' 'plan,' 'project,' 'will,' 'projections,' 'estimate,' 'potentially' or similar expressions constitute forward-looking statements. Such forward-looking statements are subject to significant risks and uncertainties and actual results may differ materially from the results anticipated in the forward-looking statements. These forward-looking statements are based upon Sigyn's current expectations and involve assumptions that may never materialize or may prove to be incorrect. Factors that may contribute to such differences may include, without limitation, the Company's ability to clinically advance Sigyn Therapy in human studies required for market clearance, the Company's ability to manufacture Sigyn Therapy, the Company's ability to raise capital resources, and other potential risks. The foregoing list of risks and uncertainties is illustrative but is not exhaustive. Additional factors that could cause results to differ materially from those anticipated in forward-looking statements can be found under the caption 'Risk Factors' in the Company's Annual Report on Form 10-K, and in the Company's other filings with the Securities and Exchange Commission, including its quarterly Reports on Form 10-Q. All forward-looking statements contained in this report speak only as of the date on which they were made. Except as may be required by law, the Company does not intend, nor does it undertake any duty, to update this information to reflect future events or circumstances.
Associated Press
10-03-2025
- Health
- Associated Press
Aethlon Medical Publishes Preclinical Data on the Hemopurifier® in Transplant Immunology Journal
Preclinical Data Suggests Expanded Therapeutic Potential of the Hemopurifier® Beyond Virology and Oncology Results Support Further Evaluation of the Hemopurifier® as Part of a Machine Perfusion Circuit to Further Assess its Impact on the Function of Retrieved Kidneys SAN DIEGO, March 10, 2025 /PRNewswire/ -- Aethlon Medical, Inc. (Nasdaq: AEMD), a medical therapeutic company focused on developing products to treat cancer and life-threatening infectious diseases and for use in organ transplantation, today announced the publication of a pre-clinical study in the peer-reviewed journal Transplant Immunology ( on February 28, 2025, entitled, " A lectin affinity plasmapheresis device removes extracellular vesicles and microRNAs from renal perfusates following controlled oxygenated rewarming of discarded donor kidneys.' Aethlon Medical's Hemopurifier® is a therapeutic blood filtration system designed to bind and remove harmful extracellular vesicles and life-threatening viruses from blood and other biological fluids. Its capabilities have potential applications in oncology and infectious diseases, and organ transplantation. 'Kidney transplantation provides the highest quality of life for those afflicted with end stage renal disease, yet there is a shortage of organs available, and for those who do receive organs, complications may include delayed function and organ rejection,' stated Steven LaRosa, MD, Senior Author of the publication and Chief Medical Officer of Aethlon Medical. 'The use of machine perfusion of recovered organs as opposed to cold storage has helped but there is still room for improvement. The release of extracellular vesicles (EVs) and microRNAs from the donor kidney are hypothesized to play a role in these complications. With that in mind, we specifically examined the ability of the Hemopurifier to remove EVs and noxious microRNAs from the perfusion fluid from discarded kidneys that had undergone Controlled Oxygenated Rewarming. We demonstrated significant reductions in EVs as well as microRNAs implicated in renal dysfunction.' 'While the company's funding and focus are dedicated to the Australian and India Oncology trials, the data generated from this pre-clinical study demonstrates that extracellular vesicle removal as a therapeutic target for the Hemopurifier extends beyond virology and oncology. We believe there exists a 'pipeline within a device',' added James Frakes, Chief Executive Officer and Chief Financial Officer of Aethlon Medical. However, we acknowledge that further evaluation is needed, including incorporating the Hemopurifier into a machine perfusion circuit with discarded kidneys followed by a clinical trial. Our technology could be potentially 'bolted on' to existing organ preservation technology. About Aethlon and the Hemopurifier® Aethlon Medical is a medical therapeutic company focused on developing the Hemopurifier, a clinical stage immunotherapeutic device which is designed to combat cancer and life-threatening viral infections and for use in organ transplantation. In human studies, the Hemopurifier has demonstrated the removal of life-threatening viruses and in pre-clinical studies, the Hemopurifier has demonstrated the removal of harmful exosomes from biological fluids, utilizing its proprietary lectin-based technology. This action has potential applications in cancer, where exosomes may promote immune suppression and metastasis, and in life-threatening infectious diseases. The Hemopurifier is a U.S. Food and Drug Administration (FDA) designated Breakthrough Device indicated for the treatment of individuals with advanced or metastatic cancer who are either unresponsive to or intolerant of standard of care therapy, and with cancer types in which exosomes have been shown to participate in the development or severity of the disease. The Hemopurifier also holds an FDA Breakthrough Device designation and an open Investigational Device Exemption (IDE) application related to the treatment of life-threatening viruses that are not addressed with approved therapies. Additional information can be found at Forward-Looking Statements This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 that involve risks and uncertainties. Statements containing words such as 'may,' 'believe,' 'anticipate,' 'expect,' 'intend,' 'plan,' 'project,' 'will,' 'projections,' 'estimate,' 'potentially' or similar expressions constitute forward-looking statements. Such forward-looking statements are subject to significant risks and uncertainties and actual results may differ materially from the results anticipated in the forward-looking statements. These forward-looking statements are based upon Aethlon's current expectations and involve assumptions that may never materialize or may prove to be incorrect. Factors that may contribute to such differences include, without limitation, the Company's ability to raise additional capital and to successfully complete development of the Hemopurifier; the Company's ability to successfully demonstrate the utility of the Hemopurifier in removing EVs and microRNAs from renal perfusates; the Company's ability to conduct its planned oncology clinical trials in Australia and India; the Company's ability to manage and successfully complete its current and future clinical trials, if initiated; the Company's ability to conduct clinical trial(s) designed to demonstrate benefits of the incorporation of the Hemopurifier® into renal perfusion; the Company's ability to successfully manufacture the Hemopurifier in sufficient quantities for its clinical trials, and other potential risks. The foregoing list of risks and uncertainties is illustrative, but is not exhaustive. Additional factors that could cause results to differ materially from those anticipated in forward-looking statements can be found under the caption 'Risk Factors' in the Company's Annual Report on Form 10-K for the year ended March 31, 2024, and in the Company's other filings with the Securities and Exchange Commission, including its quarterly Reports on Form 10-Q. All forward-looking statements contained in this press release speak only as of the date on which they were made. Except as may be required by law, the Company does not intend, nor does it undertake any duty, to update this information to reflect future events or circumstances. Company Contact: Aethlon Medical, Inc. Susan Noonan
