Latest news with #Inaba
United News of India
6 days ago
- Health
- United News of India
Bharat Biotech's oral cholera vaccine Hillchol demonstrates success in Phase III
Hyderabad, May 21 (UNI) Bharat Biotech's Oral Cholera Vaccine Hillchol has demonstrated against both Ogawa and Inaba serotypes, proving non-inferior in healthy Indian adults and children, supporting its potential as an effective OCV. The study findings have been published in the ScienceDirect, Vaccine journal 126998 to assess a double-blind, randomized phase III clinical trial to evaluate safety, immunogenicity, non-inferiority & lot-to-lot consistency of single component oral cholera vaccine Hillchol in comparison to a comparator vaccine in a diverse participant group of 1,800 individuals, from infants to adults, across 10 clinical sites in India, Hyderabad based Vaccine maker said in a release here on Wednesday. In this study, participants were divided into three age groups: adults over 18 years, children aged 5 to under 18 years, and infants aged 1 to under 5 years. They were randomized in a 3:1 ratio to receive either Hillchol or a comparator vaccine. The primary endpoint focused on the proportion of participants achieving >4-fold increase in vibriocidal antibody titres against Ogawa and Inaba serotypes 14 days after two doses. While secondary endpoints included Geometric Mean Titre (GMT) measurements and safety. Key highlights from the findings are that Hillchol demonstrated a greater than 4-fold rise in vibriocidal antibodies against both Ogawa (68.3%) and Inaba (69.5%) serotypes, proving non-inferiority to licensed vaccines. Adverse events were mild and comparable between the two vaccines. The vaccine was well-tolerated and immunogenic across all age groups—including infants (≥1 year), children, and adults. Dr. Krishna Ella, Executive Chairman of Bharat Biotech, said, " T his publication reaffirms our commitment to advancing vaccines built on rigorous research, thorough clinical trials, and reliable clinical data." 'Cholera is a vaccine-preventable disease that has faced a surge in outbreaks along with a huge shortage of vaccines. The new generation Oral Cholera Vaccine Hillchol, featuring a simplified single stable O1 Hikojima strain, inducing robust antibodies against both Ogawa and Inaba serotypes, aims to enhance production efficiency and affordability, particularly in lower- and middle-income countries where waterborne diseases continue to pose serious health threats," Dr Ella added. Cholera is an acute diarrhoeal infection caused by ingesting food or water contaminated with Vibrio cholerae bacteria. Studies have estimated that 2.86 million cases and 95,000 deaths occur annually. With Hillchol, Bharat Biotech strengthens its commitment to combating global infectious diseases through innovation and clinical excellence. As cholera continues to threaten communities lacking clean water and sanitation, Hillchol provides a streamlined, scalable solution designed to support global health programs and ensure equitable access to life-saving vaccines. Global demand for OCVs is close to 100 million doses a year, and given that only one manufacturer supplies them, there is a global shortage. Bharat Biotech's facilities in Hyderabad and Bhubaneswar have a capacity to produce up to 200 million doses of Hillchol. UNI KNR BM
The Mainichi
25-05-2025
- Health
- The Mainichi
Japan's childless elderly turning wealth into goodwill
YOKOHAMA (Kyodo) -- As Japan ages, a growing number of seniors are turning their attention to charitable giving after death. Bequest donations as they are known, mainly by elderly people to hospitals, nonprofit organizations and other entities, are on the rise due largely to the increase in childless couples with no heirs. And while large sums of money left by such couples have been nestling in the national treasury, awareness about bequest donations has seen a sea change in recent years, with more organizations acting as a bridge between donors and recipients through wills or trusts. "I feel relieved because now I know how the money I've saved will be used," said 71-year-old Yoko Inaba (not her real name) who lives in a condominium for seniors in Yokohama, Kanagawa Prefecture. Inaba had a notarized will draw up in December, stating that her money will be donated to a medical facility for newborns after she dies. When Inaba was a teenager, her mother told her that because of birth complications, she had been at risk of dying or suffering brain paralysis, leaving her feeling a desire to contribute to the medical treatment of such infants in the future. The woman, who divorced when she was young, has no children and is estranged from her siblings. Through a financial institution, Inaba sought advice on her will from Readyfor Inc., a Tokyo-based crowdfunding service provider that has been mediating bequest donations since 2021. Since she had a medical facility in mind that she wished to donate money to, concrete preparations to probate her will went off without a hitch. Experts say more and more people like Inaba are considering bequest donations partly because of a growing number of both childless couples and unmarried individuals. According to the Supreme Court, the amount of money that goes into the national treasury in the absence of inheritors has been on the rise, totaling more than 100 billion yen ($700 million) in fiscal 2023 -- an approximate threefold increase from a decade earlier. But now awareness among those without heirs of bequest donations is seeing more take steps to plan what to do with their assets. Launched in response to a growing demand, Readyfor has some 250 organizations registered as potential donor recipients, including universities and medical institutions. Donors can choose beneficiaries with the advice of the company's expert staff who have experience of specializing in inheritance-related matters at major financial institutions. "Lots of people look back and wish to support things that have to do with their birthplace and their life in general," said Yusuke Sotome, a 34-year-old staff member at Readyfor. Donor gifts made to child care, health care and educational institutions are most popular, he said. "Despite people wishing to make end-of-life arrangements or to formulate a will, many of them are unable to do so because they don't have the necessary knowledge," Sotome said, expecting a future expansion of the service of supporting bequest donations.
Time of India
24-05-2025
- Health
- Time of India
Bharat Bio completes Phase III trials of new oral cholera vaccine Hillchol
Hyderabad: Vaccine maker Bharat Biotech on Wednesday said its oral cholera vaccine, Hillchol, successfully completed Phase III clinical trials demonstrating efficacy against both Ogawa and Inaba serotypes. Tired of too many ads? go ad free now The Hyderabad-based vaccine maker said Hillchol showed an over four-fold rise in vibriocidal antibodies—68.3% for Ogawa and 69.5% for Inaba serotypes. The vaccine proved non-inferior to licensed vaccines and maintained a strong safety profile across all age groups, with only mild adverse events reported, it added. The findings of the study have been published in the ScienceDirect vaccine journal. The double-blind, randomised Phase III clinical trial was conducted to evaluate the safety, immunogenicity, non-inferiority, and lot-to-lot consistency of the single-component Hillchol in comparison to a comparator vaccine, Shanchol, in a diverse group of 1,800 individuals, ranging from infants to adults, across 10 clinical sites in India. The study participants were divided into three age groups—adults over 18 years, children aged 5 to under 18 years, and infants aged 1 to under 5 years. The participants were randomised in a ratio of 3:1 to receive either Hillchol or a comparator vaccine. Pointing to the significant role Hillchol can play in addressing the global cholera crisis and vaccine shortages, Bharat Biotech executive chairman Dr Krishna Ella said the new generation oral cholera vaccine features a simplified single stable O1 Hikojima strain, which enhances production efficiency and affordability and is particularly beneficial for lower- and middle-income countries. He said the company's facilities in Hyderabad and Bhubaneswar are equipped to produce 200 million doses of Hillchol and can ease the global shortage of oral cholera vaccines. While currently the global demand for oral cholera vaccines is around 100 million doses per annum, there is only one manufacturer. Cholera, which is an acute diarrhoeal infection caused by ingesting food or water contaminated with Vibrio cholerae bacteria, is estimated to cause over 2.86 million cases and around 95,000 deaths globally every year.
Kyodo News
24-05-2025
- Health
- Kyodo News
FEATURE: Japan's childless elderly turning wealth into goodwill
By Takuma Obinata, KYODO NEWS - May 23, 2025 - 12:15 | Feature, All, Japan As Japan ages, a growing number of seniors are turning their attention to charitable giving after death. Bequest donations as they are known, mainly by elderly people to hospitals, nonprofit organizations and other entities, are on the rise due largely to the increase in childless couples with no heirs. And while large sums of money left by such couples have been nestling in the national treasury, awareness about bequest donations has seen a sea change in recent years, with more organizations acting as a bridge between donors and recipients through wills or trusts. "I feel relieved because now I know how the money I've saved will be used," said 71-year-old Yoko Inaba (not her real name) who lives in a condominium for seniors in Yokohama, Kanagawa Prefecture. Inaba had a notarized will draw up in December, stating that her money will be donated to a medical facility for newborns after she dies. When Inaba was a teenager, her mother told her that because of birth complications, she had been at risk of dying or suffering brain paralysis, leaving her feeling a desire to contribute to the medical treatment of such infants in the future. The woman, who divorced when she was young, has no children and is estranged from her siblings. Through a financial institution, Inaba sought advice on her will from Readyfor Inc., a Tokyo-based crowdfunding service provider that has been mediating bequest donations since 2021. Since she had a medical facility in mind that she wished to donate money to, concrete preparations to probate her will went off without a hitch. Experts say more and more people like Inaba are considering bequest donations partly because of a growing number of both childless couples and unmarried individuals. According to the Supreme Court, the amount of money that goes into the national treasury in the absence of inheritors has been on the rise, totaling more than 100 billion yen ($700 million) in fiscal 2023 -- an approximate threefold increase from a decade earlier. But now awareness among those without heirs of bequest donations is seeing more take steps to plan what to do with their assets. Launched in response to a growing demand, Readyfor has some 250 organizations registered as potential donor recipients, including universities and medical institutions. Donors can choose beneficiaries with the advice of the company's expert staff who have experience of specializing in inheritance-related matters at major financial institutions. "Lots of people look back and wish to support things that have to do with their birthplace and their life in general," said Yusuke Sotome, a 34-year-old staff member at Readyfor. Donor gifts made to child care, health care and educational institutions are most popular, he said. "Despite people wishing to make end-of-life arrangements or to formulate a will, many of them are unable to do so because they don't have the necessary knowledge," Sotome said, expecting a future expansion of the service of supporting bequest donations.
Kyodo News
23-05-2025
- Health
- Kyodo News
FEATURE: Japan's childless elderly turning wealth into goodwill
By Takuma Obinata, KYODO NEWS - 1 minute ago - 12:15 | Feature, All, Japan As Japan ages, a growing number of seniors are turning their attention to charitable giving after death. Bequest donations as they are known, mainly by elderly people to hospitals, nonprofit organizations and other entities, are on the rise due largely to the increase in childless couples with no heirs. And while large sums of money left by such couples have been nestling in the national treasury, awareness about bequest donations has seen a sea change in recent years, with more organizations acting as a bridge between donors and recipients through wills or trusts. "I feel relieved because now I know how the money I've saved will be used," said 71-year-old Yoko Inaba (not her real name) who lives in a condominium for seniors in Yokohama, Kanagawa Prefecture. Inaba had a notarized will draw up in December, stating that her money will be donated to a medical facility for newborns after she dies. When Inaba was a teenager, her mother told her that because of birth complications, she had been at risk of dying or suffering brain paralysis, leaving her feeling a desire to contribute to the medical treatment of such infants in the future. The woman, who divorced when she was young, has no children and is estranged from her siblings. Through a financial institution, Inaba sought advice on her will from Readyfor Inc., a Tokyo-based crowdfunding service provider that has been mediating bequest donations since 2021. Since she had a medical facility in mind that she wished to donate money to, concrete preparations to probate her will went off without a hitch. Experts say more and more people like Inaba are considering bequest donations partly because of a growing number of both childless couples and unmarried individuals. According to the Supreme Court, the amount of money that goes into the national treasury in the absence of inheritors has been on the rise, totaling more than 100 billion yen ($700 million) in fiscal 2023 -- an approximate threefold increase from a decade earlier. But now awareness among those without heirs of bequest donations is seeing more take steps to plan what to do with their assets. Launched in response to a growing demand, Readyfor has some 250 organizations registered as potential donor recipients, including universities and medical institutions. Donors can choose beneficiaries with the advice of the company's expert staff who have experience of specializing in inheritance-related matters at major financial institutions. "Lots of people look back and wish to support things that have to do with their birthplace and their life in general," said Yusuke Sotome, a 34-year-old staff member at Readyfor. Donor gifts made to child care, health care and educational institutions are most popular, he said. "Despite people wishing to make end-of-life arrangements or to formulate a will, many of them are unable to do so because they don't have the necessary knowledge," Sotome said, expecting a future expansion of the service of supporting bequest donations.
