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India Today
22-05-2025
- Health
- India Today
Indian-origin urologist in US plays key role in first human bladder transplant
An Indian-origin urologist played a key role as a team of doctors at University of California Health performed the first successful human bladder transplant. Inderbir Gill, who studied medicine in Punjab, was part of the medical breakthrough that will be of help to individuals with bladder dysfunction caused by long-term surgery was successfully completed at Ronald Reagan UCLA Medical Center on May 4, in a joint effort by Inderbir Gill, MD, Founding Executive Director of USC Urology, and Nima Nassiri, MD, Urologic Transplant Surgeon and Director of the UCLA Vascularised Composite Bladder Allograft Transplant Program, the varsity said in a statement issued on May surgery is a historic moment in medicine and stands to impact how we manage carefully selected patients with highly symptomatic "terminal" bladders that are no longer functioning," said Dr WAS THE FIRST BLADDER TRANSPLANT IN HUMAN PERFORMED? The surgery was done on a 41-year-old patient who had previously lost most of his bladder during a tumour removal process. Both of his kidneys were also subsequently removed due to cancer and end-stage kidney disease, and he had been on dialysis for seven years. Additionally, both of his kidneys were removed due to renal cancer, which developed against the backdrop of pre-existing end-stage kidney disease. As a result, he had been undergoing dialysis for seven complex procedure involved transplanting both a new bladder and a new kidney, which were recovered from a donor. The surgeons first transplanted the kidney and then the bladder. Then they connected the kidney to the new bladder using the technique they had pioneered. The entire medical procedure lasted approximately eight kidney immediately made a large volume of urine, and the patient's kidney function improved immediately," Dr Nassiri said. "There was no need for any dialysis after surgery, and the urine drained properly into the new bladder," he added."Despite the complexity of the case, everything went according to plan and the surgery was successful," said Dr Gill. "The patient is doing well, and we are satisfied with his clinical progress to date," he IS DOCTOR INDERBIR SINGH GILL?Dr Gill began his medical education at Government Medical College in Tribune reported that Gill is an alumnus of Dayanand Medical College and Hospital, 1989, he moved to the United States to advance his medical training and pursue his Gill is the Chairman and Distinguished Professor of the Catherine and Joseph Aresty Department of Urology at the Keck School of Medicine, University of Southern California, Los Angeles. He also serves as the Executive Director of the USC Institute of Urology and holds the Shirley and Donald Skinner Chair in Urologic Cancer previously served as Chairman and Professor in the Department of Urology at the Cleveland Clinic in Cleveland, Ohio, where he was a faculty member for 12 years, from 1997 to July 2, a team of surgeons led by Inderbir Gill performed Mumbai's first robotic kidney transplant at Sir H N Reliance Foundation Hospital and Research Centre in AND AWARDS FOR GROUNDBREAKING WORKAmong his many accolades, Dr Gill was honoured with the prestigious Dr BC Roy National Award for Eminent Medical Person, presented by the President of India in 2005. He was the first Indian medical practitioner living outside the country to receive the following year, in 2006, he received the St Paul's Medal from the British Urological Association, further recognising his global contributions to the field of 2022, Dr Gill received the SIU Distinguished Career Award from the Socit Internationale d'Urologie, recognising his outstanding contributions to urology on an international scale. Most recently, in 2024, he was awarded the Spence Medal by the American Association of Genitourinary Surgeons (AAGUS), one of the highest honours in the primary academic focus is advanced robotic urologic oncologic surgery for cancers of the kidney, bladder and prostate.
Straits Times
20-05-2025
- Health
- Straits Times
US surgeons perform first human bladder transplant
Dr Inderbir Gill (left) who performed the surgery along with Dr Nima Nassiri, with the patient, Mr Oscar Larrainzar, who had a rare form of bladder cancer. PHOTO: UCLA HEALTH/FACEBOOK LOS ANGELES – Surgeons in Southern California have performed the first human bladder transplant, introducing a new, potentially life-changing procedure for people with debilitating bladder conditions. The operation was performed this month by a pair of surgeons from UCLA and the University of Southern California on a 41-year-old man who had lost much of his bladder capacity from treatments for a rare form of bladder cancer. 'I was a ticking time bomb,' the patient, Mr Oscar Larrainzar, said on May 18 during a follow-up appointment with his doctors. 'But now I have hope.' The doctors plan to perform bladder transplants in four more patients as part of a clinical trial before pursuing a larger trial. Dr Inderbir Gill, who performed the surgery along with Dr Nima Nassiri, called it 'the realisation of a dream' for treating thousands of patients with crippling pelvic pain, inflammation and recurrent infections. 'There is no question: A potential door has been opened for these people that did not exist earlier,' said Dr Gill, also chair of the urology department at USC. Until now, most patients who undergo a bladder removal have a portion of their intestine repurposed to help them pass urine. But bowel tissue, riddled with bacteria, is 'inherently contaminated,' Dr Gill said, and introducing it to the 'inherently sterile' urinary tract leads to complications in up to 80 per cent of patients. Mr Larrainzar, whose kidneys had both been removed almost four years earlier, also received a kidney transplant. Dr Nassiri said that kidney transplants can sometimes take up to a week to process urine, but that when the kidney and bladder were connected inside Mr Larrainzar, there was 'immediate output,' and his creatinine level, which measures kidney function, started to improve immediately. The biggest risks of organ transplantation are the body's potential rejection of the organ and the side effects caused by the immune-suppressing drugs given to prevent organ rejection. That is why, for Dr Rachel Forbes, a transplant surgeon at Vanderbilt University Medical Center who was not involved in the procedure, the excitement is more tempered. 'It's obviously a technical advance,' she said, but 'we already have existing options for people without bladders, and without the downside of requiring immunosuppression.' Unless a patient is – like Larrainzar – going to be on those medications anyway, 'I would be a little bit nervous that you would be exchanging some complications for others,' she said. NYTIMES Join ST's Telegram channel and get the latest breaking news delivered to you.
The Guardian
19-05-2025
- Health
- The Guardian
Surgeons in California perform first ever successful bladder transplant
Surgeons in California have performed the first ever successful bladder transplant, aiding a patient who previously had his bladder and both kidneys removed as a result of cancer treatment and end-stage kidney disease. The treatment allowed the patient, 41-year-old father of four Oscar Larrainzar, to go off dialysis – although the surgery comes with considerable short- and long-term risks and unknowns. The bladder transplant was done by two surgeons who worked for years to develop the technique, which was used to transplant one kidney and a bladder recovered from a human donor. 'This surgery is a historic moment in medicine and stands to impact how we manage carefully selected patients with highly symptomatic 'terminal' bladders that are no longer functioning,' said Dr Inderbir Gill, the executive director of the University of Southern California Institute of Urology, and one of two surgeons who worked on the case, according to a press release. 'Transplantation is a life-saving and life-enhancing treatment option for many conditions affecting major organs, and now the bladder can be added to the list.' Gill performed the surgery with Dr Nima Nassiri of the University of California Los Angeles (UCLA) Institute of Urgology. 'This first attempt at bladder transplantation has been over four years in the making,' Nassiri said, in a statement. 'For the appropriately selected patient, it is exciting to be able to offer a new potential option.' Patients who have their bladder removed most often have a portion of intestine repurposed to pass urine, often resulting in a host of new complications, including infections and digestive issues. Those complications have led doctors around the world to seek bladder transplant techniques for years. The transplant performed in early May has so far succeeded, and doctors said they are 'satisfied' with Larrainzar's recovery, though many unknowns remain. For instance, how Larrainzar's new bladder will function over time and how long he will need to be on immune suppression medication to prevent rejection of the organ. Sign up to Headlines US Get the most important US headlines and highlights emailed direct to you every morning after newsletter promotion The doctors plan to perform more bladder transplants as part of a clinical trial at UCLA Health, with the goal of better understanding potential complications and helping patients who suffer debilitating bladder conditions.
The Independent
19-05-2025
- Health
- The Independent
World-first bladder transplant a ‘historic' success four years in the making
Surgeons have performed the world's first-ever human bladder transplant – calling it a 'historic' operation that has the potential to change the lives of millions patients with bladder diseases. For the first bladder transplant patient Oscar Larrainzar, after seven years on dialysis with no kidneys and a barely functioning bladder, the procedure was a success - with no dialysis needed post-op. 'My hope is to have a better life,' Mr Larrainzar said. 'I'm still 42 and I have kids, I would like to see them grow so as much as I can have a better life, normal life, in the best possible way, that's what I'm hoping for.' In a joint effort between Keck Medicine of USC and UCLA Health, surgeons performed the groundbreaking surgery on May 4, and the patient is now recovering well, the experts said. Dr Inderbir Gill, the founding executive director of USC Urology, said: 'This surgery is a historic moment in medicine and stands to impact how we manage carefully selected patients with highly symptomatic 'terminal' bladders that are no longer functioning. 'Transplantation is a lifesaving and life-enhancing treatment option for many conditions affecting major organs, and now the bladder can be added to the list.' Dr Gill worked with UCLA urologic transplant surgeon Nima Nassiri for years to develop the new and complex surgical technique, which involved transplanting a kidney, followed by a bladder, into the patient. The whole procedure lasted eight hours, the experts said. 'This first attempt at bladder transplantation has been over four years in the making,' Nassiri said. 'For the appropriately selected patient, it is exciting to be able to offer a new potential option.' Mr Larrainzar had been on dialysis for seven years after losing most of his bladder when a tumour was removed. Both of his kidneys had also been removed due to renal cancer. Dr Nassiri said following the surgery, Mr Larrainzar's kidney immediately began producing urine. 'There was no need for any dialysis after surgery, and the urine drained properly into the new bladder,' he said. Dr Gill said, despite the complexity of the case, everything went according to plan. 'The patient is doing well, and we are satisfied with his clinical progress to date,' he said. Millions of people around the world live with a degree of bladder disease or dysfunction, the urologists said, and current treatment for severe so-called terminal cases in which their bladders can stop functioning can involve creating a new bladder with part of the patient's intestine. Dr Nassiri said while those surgeries can help, they also come with short and long-term risks that can have ongoing effects on the patients' health. 'A bladder transplant, on the other hand, results in a more normal urinary reservoir, and may circumvent some short- and long-term issues associated with using the intestine,' he said. The experts acknowledged that because it is a first-of-its-kind procedure, there are many unknowns, including how well the bladder will function over time. 'Despite the unknowns, our goal is to understand if bladder transplantation can help patients with severely compromised bladders lead healthier lives,' Dr Gill said. The surgery was performed as part of a UCLA clinical trial, and the urologists hope to perform more of the pioneering surgeries in the near future.
The Sun
19-05-2025
- Health
- The Sun
World's first bladder transplant marks ‘historic moment' as man, 41, able to pee again for first time in 7 years
SURGEONS have performed the first-ever human bladder transplant - a game-changing procedure with the potential to help thousands living with deadly organ failure. The first person to undergo the operation is 41-year-old Oscar Larrainzar, a father of four who had previously lost most of his bladder during a tumour removal process. 3 The remainder of his bladder was too small to work and both his kidneys were subsequently removed due to cancer and end-stage kidney disease. He'd been on dialysis for seven years. The complex procedure carried out by surgeons from UCLA Health and Keck Medicine of USC involved the transplantation of both a new bladder and a new kidney, recovered from a donor, and lasted approximately eight hours long. UCLA urologic transplant surgeon Dr Nima Nassiri and Dr Inderbir Gill, assisted by a surgical team, said the results were quickly evident. 'The kidney immediately made a large volume of urine, and the patient's kidney function improved immediately,' Nassiri said. 'There was no need for any dialysis after surgery, and the urine drained properly into the new bladder.' 'Despite the complexity of the case,' Gill said, 'everything went according to plan and the surgery was successful. "The patient is doing well, and we are satisfied with his clinical progress to date.' It's not known how well the transplanted bladder will function over time and how much immunosuppression will be needed to prevent rejection of the transplanted organs. But to date, Larrainzer has been stable. I haven't peed in SIX YEARS and never will again - I live in constant agony and it could kill me 'This surgery is a historic moment in medicine and stands to impact how we manage carefully selected patients with highly symptomatic 'terminal' bladders that are no longer functioning,' said Gill, who is also a distinguished professor and chair of urology at the Keck School of Medicine of USC. 'Transplantation is a lifesaving and life-enhancing treatment option for many conditions affecting major organs, and now the bladder can be added to the list.' Bladder transplants haven't been carried out previously because of the complicated vascular structure of the pelvic area and the technical complexity of the procedure. Current treatments include the replacement or augmentation of the urinary reservoir - a procedure that uses part of a patient's intestine to create a "new" bladder or a pathway for urine to exit the body. While these surgeries can be effective, they come with many short-and long-term risks that compromise a patient's health, such as internal bleeding, bacterial infection and digestive issues. 'A bladder transplant, on the other hand,' Nassiri said, 'results in a more normal urinary reservoir and may circumvent some short- and long-term issues associated with using the intestine.' Organ transplants currently available Organ transplants, which replace failing or damaged organs with healthy ones from donors, are now available for a variety of organs. They've become possible due to advancements in surgery, medicine (including immunosuppressant drugs), and a better understanding of the donor process. Available organs include: Kidneys: The most commonly transplanted organ, helping patients with end-stage kidney disease. Liver: Treats various liver diseases, including cirrhosis and liver cancer. Heart: Addresses heart failure and other heart conditions. Lungs: Treats conditions like cystic fibrosis, pulmonary fibrosis, and other lung diseases. Pancreas: Transplants are used to treat diabetes and some pancreatic cancers. Intestine: Transplants are performed for patients with severe gastrointestinal disorders. 3
