Latest news with #Inflammatory
Yahoo
3 hours ago
- Health
- Yahoo
RESTEM to Present Phase 2/3 IIMPACT Trial Design in Idiopathic Inflammatory Myopathy at EULAR 2025 Congress
MIAMI, June 06, 2025 (GLOBE NEWSWIRE) -- RESTEM – a clinical-stage biotechnology company that develops off-the-shelf, next-generation cell therapies designed to modulate the immune system, today announced that it will present the rationale and study design of its Phase 2/3 IIMPACT (Idiopathic Inflammatory Myopathy Phase 2/3 Adaptive Clinical Trial) trial of Restem-L, the Company's umbilical-lining modified progenitor cells (UMPC) program for the treatment of Polymyositis and Dermatomyositis (PM/DM), a rare autoimmune disease, now defined by the FDA as Idiopathic Inflammatory Myopathy (IIM). The oral presentation will be delivered at the European Alliance of Associations for Rheumatology's (EULAR) 2025 Congress, to take place June 11-14 in Barcelona, Spain. Details of the oral presentation are as follows: Abstract Title: Rationale and Study Design for a Phase 2/3, Double-blinded, Randomized, Dose-repeating, Cross-over Study to Assess Safety and Efficacy of Allogeneic Umbilical Cord Lining Stem Cells on Disease Severity and Steroid Tapering in Participants with Idiopathic Inflammatory Myopathy Abstract Number: OP0318 Session Title: Clinical Abstract Sessions: Novelties and innovative therapeutic strategies in inflammatory myopathies Session Date and Time: Friday, June 13, 2025, 10:30 AM CEST About Idiopathic Inflammatory Myopathy (IIM) Idiopathic inflammatory myopathies (IIM) are a group of conditions characterized by inflammation of muscles (myositis) and other body systems. Polymyositis and dermatomyositis are subtypes of IIM. Polymyositis causes inflammation and weakness of the skeletal muscles responsible for movement. Dermatomyositis is a form of polymyositis that is associated with skin rash, in addition to muscle inflammation. Both disorders can significantly compromise the quality of life and are very challenging to treat. Currently, the only treatment for these disorders is immunosuppressive drugs, which can be associated with significant toxicity and other side effects. About RESTEM RESTEM is a leading clinical-stage biotechnology company focused on developing off-the-shelf, next-generation cell therapies designed to modulate the immune system. Leveraging our proprietary products, robust clinical development expertise, and cutting-edge-manufacturing capabilities, we are advancing two potentially groundbreaking programs, Restem-L, our umbilical-lining modified progenitor cells (UMPC) program for autoimmune diseases; and our activated natural killer cell (aNK) therapeutics targeting senescence and age-associated disorders. Our therapies are uniquely positioned to redefine the standard of care for patients with limited options, by suggesting an immune system remodeling—rather than mere symptom suppression—offering a potential path to true disease resolution. RESTEM is headquartered in Miami, Florida. For more information, please visit and follow us on X and LinkedIn. Investor Contact Daniel Ferry LifeSci Advisors +1.617.430.7576 daniel@ Media Contact Nelson CabautanRestem Group, Inc. +1.800.490.0924 ncabatuan@ in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Hindustan Times
19-05-2025
- Health
- Hindustan Times
What is ectopic pregnancy? Doctor shares symptoms, prevention tips for this life-threatening condition
Ectopic pregnancy is a medical emergency where the fertilised egg implants outside the uterus, leading to life-threatening conditions. In an interview with HT lifestyle, Dr. Lepakshi Dasari, consultant gynaecologist and laparoscopic surgeon, Yashoda Hospitals, Hyderabad said, 'Ectopic pregnancies are considered medical emergencies. If undetected or untreated, they can cause the fallopian tube to rupture, leading to internal bleeding, shock, and even death. Timely diagnosis and medical or surgical intervention are critical to safeguard the mother's life.' Also read | Research suggests woman's risk of pregnancy loss linked to certain job hazards 'In a normal pregnancy, a fertilised egg travels through the fallopian tube and implants in the uterus. In an ectopic pregnancy, however, the fertilised egg implants outside the uterus, most commonly in the fallopian tube, though it can also occur in the cervix, ovary, or abdominal cavity. Unfortunately, these sites cannot support fetal development, and continuing the ectopic pregnancy is not possible. Ectopic pregnancy, though rare, accounting for 1–2% of all pregnancies, can be life-threatening if left undiagnosed and untreated,' Dr. Lepakshi Dasari explained. Symptoms appear between 4 and 12 weeks of gestation and may initially resemble early pregnancy. Distinct signs include: Pelvic Inflammatory Disease (PID): Can cause inflammation and blockage in the fallopian tubes. Scar tissue: From prior surgeries or infections can hinder egg movement. Congenital abnormalities: Structural issues in reproductive organs may contribute. Also read | Smoking during pregnancy poses risks for the mother and foetus. Here are 5 dangers of smoking while pregnant While ectopic pregnancies cannot always be prevented, risk can be reduced by: Note to readers: This article is for informational purposes only and not a substitute for professional medical advice. Always seek the advice of your doctor with any questions about a medical condition.
The Independent
10-02-2025
- Health
- The Independent
How a visit to the hair salon could lead to a deadly health issue
Maria Ashioti is a senior lecturer in Neuroscience, Inflammatory Disorders and Therapeutics at the University of Westminster. A trip to the hairdresser is typically seen as a relaxing indulgence. But for a few, a routine shampoo can pose a serious health risk, thanks to a rare condition known as beauty parlour stroke syndrome (BPSS). This phenomenon, first identified in 1993 by American neurologist Michael Weintraub, links stroke-like symptoms to hair washing at salons. Dr. Weintraub observed that some patients developed these symptoms after having their hair shampooed. But how can a simple hair wash lead to such a severe health issue? The culprit appears to be the awkward posture adopted at the salon's washbasin. Clients typically lean back, extending their neck over the basin's rigid edge. Research suggests this overextension, combined with neck rotation or sudden movements during shampooing, can compress or damage blood vessels supplying the brain. A stroke occurs when blood flow to the brain is abruptly reduced, often due to a blood clot or a ruptured blood vessel. This deprives brain cells of vital oxygen and nutrients, leading to damage and potentially death. In the context of BPSS, the unusual neck position during shampooing can cause the vertebrae in the upper spine to press against crucial arteries supplying the back and lower portions of the brain. Bone spurs, small bony fragments on the spine, can also exacerbate the problem by compressing or tearing these arteries. Strokes are often associated with older people and those with medical issues such as high blood pressure, diabetes or high cholesterol – but young, healthy people can have strokes too. While research suggests BPSS is most likely to occur in women over 50 – and previous history of narrowing or thinning of blood vessels and arthritis of the spinal column in the neck are particular risk factors – it could happen to anyone regardless of age or medical history. A 2016 Swiss study found only ten instances of BPSS during 2002-2013 so, although BPSS is much rarer than conventional stroke, it's still important to be aware of the symptoms. So, what should you look out for? Signs of BPSS include headache, lightheadedness, dizziness, blurred or narrowed vision, nausea, vomiting, pain in the neck and some paralysis on one side of the body – some patients also report a near loss of consciousness. Studies suggest that these symptoms may be delayed, making it difficult for doctors to diagnose BPSS rather than a conventional stroke. Precautions If you're worried about BPSS or experience pain and discomfort when using a backwash sink, ask to lean forward over the sink rather than extending your head backwards over the rim of the basin. If it is not possible to avoid a backwash at the salon, ask for neck support during hair washing. The speed at which the hair is washed, how long it takes and any force or jerking movement to the head and neck while washing all contribute to the risk. Request a gentle wash, try not to stay in position at the backwash longer than you have to and inform your hairdresser if you experience any discomfort during washing. Hairdresser shampooing is a generally safe and enjoyable activity for most people. For the most part, going to the hairdresser is important for mental health, self-esteem and confidence. So let's not throw in the hair towel just yet – use it as a neck support while we're being pampered instead.
