Latest news with #Koppel
Yahoo
4 days ago
- Business
- Yahoo
Kailera Therapeutics Appoints Adam Koppel and Christopher Hite to Board of Directors
BOSTON and SAN DIEGO, June 05, 2025 (GLOBE NEWSWIRE) -- Kailera Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on advancing a broad pipeline of next-generation therapies for the treatment of obesity and related conditions, today announced the appointments of Adam Koppel and Christopher Hite to its Board of Directors. 'We are thrilled to welcome Adam and Chris to our Board of Directors. Their extensive track records as respected advisors to biopharma companies on corporate and financial strategy will be incredibly valuable as we continue to execute on our mission to advance next-generation therapies for the treatment of obesity,' said Ron Renaud, President and Chief Executive Officer, Kailera. 'It's an exciting time to join Kailera's Board as they progress their pipeline toward late-stage global trials, and I look forward to contributing to the company's continued success and long-term value creation,' said Dr. Koppel. Mr. Hite added, 'I am pleased to join the Board of Kailera at this important time of innovation in the obesity space that has positively impacted millions of patients worldwide. Kailera has a clear strategy to advance their diversified pipeline, and I look forward to supporting the leadership team as they work towards achieving their mission.' Dr. Koppel is a distinguished investor and strategic leader with more than 25 years of biopharmaceutical industry experience. He is a Partner on Bain Capital's Life Sciences team and initially joined Bain Capital in 2003. Previously, Dr. Koppel was EVP of Corporate Development and Chief Strategy Officer at Biogen. He currently sits on the Board of Directors of Areteia Therapeutics and Cardurion Pharmaceuticals and serves on the Board of Trustees at Newton Wellesley Hospital. Dr. Koppel also co-chairs the Harvard Medical School Discovery Council and serves on the Mass General Brigham Innovation Growth Board. He received an M.D. and Ph.D. in Neuroscience from the University of Pennsylvania School of Medicine. Dr. Koppel also received an M.B.A. from The Wharton School at the University of Pennsylvania, where he was a Palmer Scholar, and graduated magna cum laude from Harvard University with an A.B. and A.M. in History and Science. Mr. Hite, a seasoned financial executive with over 25 years of financial and strategic experience in the biopharmaceutical industry, will serve as an independent board member and audit committee chair. Mr. Hite currently serves as Executive Vice President and Vice Chairman at Royalty Pharma. Prior to joining Royalty Pharma in 2020, he was at Citibank for over a decade, serving most recently as Vice Chairman of Banking, Capital Markets and Advisory (BCMA) and a member of the BCMA Executive Committee, and previously as the Global Head of Healthcare Investment Banking. Prior to joining Citibank, Mr. Hite was the Global Head of Healthcare Investment Banking at Lehman Brothers. He serves on the Board of Trustees at Lehigh University, the Board of Advisors of Faster Cures, a center of the Milken Institute, and served on the Board of Directors of Acceleron Pharma Inc. until its acquisition by Merck in November 2021. Mr. Hite has a B.S. from Lehigh University, and a J.D. and M.B.A. from the University of Pittsburgh. About Kailera Therapeutics Kailera Therapeutics (Kailera) is developing a broad, advanced, and differentiated portfolio of clinical-stage injectable and oral therapies for the treatment of obesity and related conditions. Kailera's most advanced program, KAI-9531 (being developed in China as HRS9531), is an injectable GLP-1/GIP receptor dual agonist that has demonstrated positive results in Phase 2 trials in obesity and type 2 diabetes in China. The Company is also advancing a diversified pipeline leveraging several mechanisms and routes of delivery, including oral administration. Kailera's mission is to develop next-generation weight management therapies that give people the power to transform their lives and elevate their overall health. The Company is based in Waltham, MA and San Diego, CA. For more information, visit and follow us on LinkedIn and X. Contact Information Maura Gavaghan Vice President, Corporate Communications and Investor Relations while retrieving data Sign in to access your portfolio Error while retrieving data Error while retrieving data Error while retrieving data Error while retrieving data
Business Wire
29-04-2025
- Health
- Business Wire
Artificial Intelligence Identifies Brain Network Predictive of Psychosis in Alzheimer's Disease
MANHASSET, N.Y.--(BUSINESS WIRE)--Researchers at Northwell Health's Feinstein Institutes for Medical Research have developed an artificial intelligence (AI)-based tool that identifies a brain metabolic network capable of predicting psychosis in Alzheimer's disease (AD). This discovery, published this week in Brain Communications, offers a potential breakthrough for earlier diagnosis, treatment development and personalized medicine for individuals with AD. The study, led by Jeremy L. Koppel, MD, associate professor at the Feinstein Institutes' Institute of Molecular Medicine, and associate professor An Vo, PhD, used an AI-derived metabolic brain map that looks at FDG-PET scans of people with AD, including some who experienced psychosis (hallucinations and delusions) and some who did not. The AI identified a unique pattern of brain activity, like a fingerprint, in the brains of those with psychosis. They called this pattern the ADPN (Alzheimer's Disease Psychosis Network). 'This discovery of the ADPN provides a critical tool for advancing our understanding and management of psychosis in Alzheimer's disease,' said Dr. Koppel. 'This biomarker can potentially identify individuals at risk of developing psychosis, allowing for earlier and more targeted interventions.' Psychosis, characterized by delusions and hallucinations, affects a significant portion of individuals with AD and is associated with accelerated cognitive decline, increased caregiver burden and premature mortality. Current treatments are limited and often carry significant risks. The ADPN, however, was helpful in distinguishing the difference in brain patterns between people with AD and psychosis, especially between the areas responsible for movement and the areas responsible for language and social understanding. It was also able to predict who would develop psychosis in the future. The stronger the ADPN 'fingerprint,' the worse the person's cognitive decline. 'The discovery of the ADPN exemplifies the power of AI and interdisciplinary collaboration in advancing our understanding of complex neurological disorders like Alzheimer's disease,' said Kevin J. Tracey MD, president and CEO of the Feinstein Institutes and Karches Family Distinguished Chair in Medical Research. 'This innovative approach, integrating neuroimaging with cutting-edge computational tools, offers a new path towards earlier diagnosis, personalized treatment strategies, and ultimately, improved outcomes for individuals affected by this devastating disease.' Dr. Koppel is an internationally recognized clinical scientist who continues to identify AD's potential causes and treatments. He recently received a National Institutes of Health grant for nearly $500,000 to look at ptau181 and other biomarkers in psychosis before AD begins as well as a $1 million grant from the Alzheimer's Foundation of America to expand research into developing new treatments to address the hallucinations, delusions and aggression that come with dementia. Last year, he and his lab published in the Journal of the American Medical Association (JAMA) Psychiatry papers that showed an increase in specific tau proteins that indicated blood biomarkers could be used to detect psychotic symptoms in AD patients. About the Feinstein Institutes The Feinstein Institutes for Medical Research is the home of the research institutes of Northwell Health, the largest health care provider and private employer in New York State. Encompassing 50+ research labs, 3,000 clinical research studies and 5,000 researchers and staff, the Feinstein Institutes raises the standard of medical innovation through its six institutes of behavioral science, bioelectronic medicine, cancer, health system science, molecular medicine, and translational research. We are the global scientific leader in bioelectronic medicine – an innovative field of science that has the potential to revolutionize medicine. The Feinstein Institutes publishes two open-access, international peer-reviewed journals Molecular Medicine and Bioelectronic Medicine. Through the Elmezzi Graduate School of Molecular Medicine, we offer an accelerated PhD program. For more information about how we produce knowledge to cure disease, visit and follow us on LinkedIn.
Yahoo
24-03-2025
- Politics
- Yahoo
'Nightline' looks back on its 45 years in anniversary episode
It's been 45 years since ABC News' iconic late-night show "Nightline" debuted on March 24, 1980. To celebrate the occasion on Monday, past and present anchors dive into its history and enduring appeal in a special episode. The seeds for the show were sown in November 1979, when then-ABC News President Roone Arledge created "The Iran Crisis–America Held Hostage" to cover the aftermath of the infamous terrorist attack on the United States embassy in Tehran. Watch the 45th anniversary episode of "Nightline" late-night Monday, March 24, from 12:35 a.m. to 1:05 a.m. ET and streaming the next day on Hulu. By the time the hostage crisis ended, resulting in their release 444 days later, "Nightline" and anchor Tep Koppel had forged an important relationship with the American public. He served as the show's host until 2005. "Every night, Ted Koppel came on and did something that you'd never seen before," ABC News' Terry Moran, who anchored the show from 2005 to 2013, said of its early days. That became a hallmark of the program -- bringing people who are worlds apart together for town hall-style conversations. "The Iranian ambassador and the Iraqi ambassador; they wouldn't talk to each other, but they talked to me," Koppel said. MORE: About ABC News Live Since then, "Nightline" has never shied away from complicated conversations. That included going to South Africa during the era of apartheid -- the system of institutionalized racial segregation that existed there from the late '40s to the early '90s. "If I had to point to one group of broadcasts as being the most significant out of 6,000 that I did over 25 years, I think I'd have to pick that one," Koppel said of the 1985 reports. Those stories happened in the U.S. as well, with Cynthia McFadden (who co-anchored the show from 2005 to 2014) recalling her 2012 reporting on resurgent white supremacist group the Ku Klux Klan. "The experience of being at a cross burning was literally seared into me. I will never forget that day," she said. "If you thought that that kind of hate was over, we had the opportunity to show America that it was not." "Nightline" has also examined American life through the cultural lens, sometimes taking a lighter approach to heavy topics. That included bringing Kermit the Frog and his fellow Muppets on set to discuss complexities of the 1987 stock market crash. "When the Muppets came in, I mean, people came from every office, all over the New York headquarters to meet the Muppets," Koppel said. "They wanted to watch that interview. You know, 'How is Ted going to handle the frog?'" MORE: Aaron Brown, veteran ABC News anchor, dies at 76 Anchors like Juju Chang, who has shared anchoring duties with Byron Pitts since 2014, appreciate that the job lets them report from the field. "I'd rather be sweating out in the street somewhere and covering a story and looking somebody in the eye and hearing their story and trying to tell it," she said. Pitts noted that the show endures by staying true to its original mission: offering Americans a way to stay informed as their day draws to a close. "Nightline is a place where the country can show up together and hear the truth," he said. "We provide context and clarity and comfort for the nation. And who doesn't want that before they go to sleep?" ABC News' Kelsey Klimara and Mack Muldofsky also contributed to this report. 'Nightline' looks back on its 45 years in anniversary episode originally appeared on
Yahoo
29-01-2025
- Business
- Yahoo
Beaver County receives several state grants for parks, green spaces
HARRISBURG ― A wave of state grants will benefit various projects planned for community spaces around the Beaver Valley. On Jan. 28, officials announced the Commonwealth Financing Authority Greenways, Trails and Recreation Program was funding several projects in communities such as Aliquippa, Rochester, Hopewell Township and others with plans to renovate their public spaces. The focus of these grants will be expansions to recreational greenspaces in the region and funding renovations at community parks. 'I'm very pleased to announce state funding to help local communities pay for these worthy projects,' said Sen. Elder Vogel, R-47, New Sewickley Township. 'Creating useful open space and upgrading playgrounds for children expands opportunities for state fun, exercise and outdoor recreation.' 'Some of the funds will be used to transform abandoned lots in Aliquippa and Rochester Borough into recreational greenspaces,' said state Rep. Rob Matzie, D-16, Harmony Township. 'Other funds will support playground improvements in Hopewell. All the projects are going to give residents new outdoor spaces to enjoy.' According to the local representatives, the following projects were awarded funds: $100,000 to Primary Health Network to transform a 1-acre section of blighted land along Virginia Avenue in Rochester into a recreational greenspace with a pergola, community gardens, a central water feature, walking trails, sidewalks and ADA-accessible playground equipment. $90,872 to Hopewell Township for playground improvements at Woodlawn Park, including removing an abandoned building and installing new playground equipment and surfacing. $86,730 to Hopewell Township to remove aging playground equipment at the Sharon Grange Park in Aliquippa and install new equipment. $75,000 to Koppel for its community park project. $47,500 to hydroponic farming company GetBlok Farms LLC to transform two abandoned lots into a multi-purpose open greenspace in downtown Aliquippa for passive recreation, hosting vendors and produce pickup. $44,470 to Patterson Township for community park improvements. The Commonwealth Financing Authority is an independent agency of the Pennsylvania Department of Community and Economic Development, which administers the state's economic stimulus packages. The Greenways, Trails and Recreation Program was started in 2012 to plan, acquire, develop, rehabilitate and repair greenways, recreational trails, open spaces, parks and beautification projects. This article originally appeared on Beaver County Times: Beaver County receives several state grants for parks, green spaces
