Latest news with #LEAF
Yahoo
10-05-2025
- General
- Yahoo
Sussex primary schools host lambs as part of popular scheme
Thousands of primary school children in Sussex have had the rare chance to care for lambs at school. This is thanks to the Loan a Lamb scheme, an initiative run by the South of England Agricultural Society's Education Committee. The scheme, which has just completed its fourth successful year, saw more than 3,500 pupils from 10 primary schools experience hands-on farming by looking after a ewe and her lambs for a week. Pupils at St Mary's experience hands-on animal care through Loan a Lamb (Image: southern news and picture ltd) The schools that took part in the initiative were Goring CofE Primary School, Southway Junior School, Thakeham Primary School, West Wittering Parochial CofE Primary School, St Wilfrid's CofE Primary School, St Lawrence CofE Primary School, St Mary's CofE Primary School, Cradle Hill Community Primary School, Muschamp Primary School, and Holmesdale Community Infant School. With increasing concerns about children being disconnected from where their food comes from, the Loan a Lamb scheme was designed to tackle the issue head-on. Over 3,500 pupils gain insight into farming life through Loan a Lamb (Image: Cradle Hill) By bringing real farm animals into schools, children gain first-hand experience in animal care, food production, and the realities of farming life. The initiative, which is run in partnership with local farmers, LEAF (Linking Environment and Farming) Education, and financially supported by the East Sussex Proficiency Test Committee, saw each participating school host a ewe and her lambs in a specially provided hutch for a week. Schools received all necessary equipment, guidance, and support to ensure the highest standards of animal welfare and learning. Chairman Alan Smith praises pupils' care and curiosity during lamb visits (Image: southern news and picture ltd) Alan Smith, chairman of the South of England Agricultural Society and Education Committee member, said: "Many children are growing up without a true understanding of how food is produced, with little to no connection with farming, and often don't realise the hard work and dedication that goes into producing the food on their plates. "This disconnect has profound implications for the future of agriculture. "The Society has a primary focus of agricultural education and, thanks to some fantastic local farmers, Loan a Lamb is our way of bridging the gap by bringing farming into the classroom. "It gives students a hands-on experience of caring for animals, learning about their welfare and understanding the importance of sustainable food production." Alan concluded: "The enthusiasm and care students showed the animals has been incredible, and it is clear from previous feedback from schools that this initiative has a lasting impact. "Teachers have told us how it sparked curiosity, empathy and even aspirations for careers in farming and animal care. "Some students who had never seen a sheep up close have gone on to visit farms, explore agricultural studies and develop a respect for the industry. "That is why we are so passionate about Loan a Lamb - it's not just a one-week experience; it's a foundation for lifelong learning."
South Wales Argus
08-05-2025
- General
- South Wales Argus
Farmers urged to join in with Open Farm Sunday 2025
The event organiser LEAF (Linking Environment And Farming) called on farmers not to miss out on the annual flagship initiative this year. Open Farm Sunday manager Annabel Shackleton said: "Inviting people on farm, no matter how few or how many, is a surefire way to help put public perception of farming on the right track. "We know we can influence consumer attitudes – survey data from last year's Open Farm Sunday shows that 87 per cent of visitors left with greater trust in British farming, and 91 per cent felt motivated to buy more British produce as a result. "By hosting Open Farm Sunday, you can turn that key and cultivate stronger community connections that promote farming's commitment to a more sustainable approach while driving demand for produce grown and reared in the UK." Visit the Open Farm Sunday website for further information.
Yahoo
27-04-2025
- Automotive
- Yahoo
6 EVs That Depreciate the Fastest Over 5 Years
Recently, iSeeCars published a study that charts the top 25 cars that best hold their value after purchase, as well as the 25 worst — the cars the depreciate in value faster than other ride. The list breaks the prices down by vehicle type: trucks, sedans, SUVs, hatchbacks, sports cars and electric vehicles (EVs). Check Out: Learn More: Are you considering an EV purchase? Are you worried about how quickly an EV may depreciate in price? GOBankingRates has pulled the six fastest-depreciating EVs on the market, the ones you should pause and consider before purchasing. See which vehicles you should avoid if you want to maintain a high resale value. Average 5-year depreciation: 72.2% Loss of value vs. MSRP: $51,953 As noted by CarSupermarket, the I-Pace was one of the first EVs of its type. That was a marketplace advantage at first; but, as EV tech advanced rapidly, the I-Pace was almost immediately dated and left in the dust — especially with regard to charging range and speed. Discover More: Also See: Average 5-year depreciation: 65.2% Loss of value vs. MSRP: $52,165 Much like the Jaguar I-Pace, Find My Electric has noted the Tesla Model S depreciates rapidly due to being outpaced by an ever-advancing EV world; further, like many luxury vehicles, the Model S depreciates quickly on the secondary market because used-car buyers have been found to be less interested in luxury amenities. See More: Average 5-year depreciation: 64.1% Loss of value vs. MSRP: $18,043 According to SlashGear, the overall rapid depreciation of the LEAF has less to do with the EV itself, but rather the logo that marks the front of the vehicle — Nissans in general reportedly have a poorer reputation than competitors after five years of use, and the depreciation rate of the LEAF is commiserate with the overall depreciation rate of Nissans overall. Average 5-year depreciation: 63.4% Loss of value vs. MSRP: $53,846 As is typical with many high-end SUVs, the Tesla Model X suffers a rapid depreciation that is common to very expensive SUVs; additionally, per FindMyElectric, luxury rides depreciate quickly in general because, again, used-vehicle shoppers don't place a premium on luxury features. Moreover, as newer luxury EVs flood the market from Tesla's many competitors, the resale value of older X's continues to spiral downward. Average 5-year depreciation: 60.4% Loss of value vs. MSRP: $36,225 TopSpeed has charted the Tesla Model Y's rapid depreciation as being due to, again, secondhand shoppers not hunting for luxury vehicles, but also because the Y gets outpaced by technological advancements made at a rapidity that the Y cannot compete with. Average 5-year depreciation: 60.1% Loss of value vs. MSRP: $59,691 The Porsche Taycan, while a well-known brand, comes with high depreciation for what CoPilotSearch has described as ever-changing advances in battery technology and 'charging infrastructure,' as well as customer preferences moving away from the Taycan in general. More From GOBankingRates Mark Cuban: Trump's Tariffs Will Affect This Class of People the Most 7 Tax Loopholes the Rich Use To Pay Less and Build More Wealth How To Get the Most Value From Your Costco Membership in 2025 How Much Money Is Needed To Be Considered Middle Class in Every State? This article originally appeared on 6 EVs That Depreciate the Fastest Over 5 Years
Yahoo
27-04-2025
- Automotive
- Yahoo
6 EVs That Depreciate the Fastest Over 5 Years
Recently, iSeeCars published a study that charts the top 25 cars that best hold their value after purchase, as well as the 25 worst — the cars the depreciate in value faster than other ride. The list breaks the prices down by vehicle type: trucks, sedans, SUVs, hatchbacks, sports cars and electric vehicles (EVs). Check Out: Learn More: Are you considering an EV purchase? Are you worried about how quickly an EV may depreciate in price? GOBankingRates has pulled the six fastest-depreciating EVs on the market, the ones you should pause and consider before purchasing. See which vehicles you should avoid if you want to maintain a high resale value. Average 5-year depreciation: 72.2% Loss of value vs. MSRP: $51,953 As noted by CarSupermarket, the I-Pace was one of the first EVs of its type. That was a marketplace advantage at first; but, as EV tech advanced rapidly, the I-Pace was almost immediately dated and left in the dust — especially with regard to charging range and speed. Discover More: Also See: Average 5-year depreciation: 65.2% Loss of value vs. MSRP: $52,165 Much like the Jaguar I-Pace, Find My Electric has noted the Tesla Model S depreciates rapidly due to being outpaced by an ever-advancing EV world; further, like many luxury vehicles, the Model S depreciates quickly on the secondary market because used-car buyers have been found to be less interested in luxury amenities. See More: Average 5-year depreciation: 64.1% Loss of value vs. MSRP: $18,043 According to SlashGear, the overall rapid depreciation of the LEAF has less to do with the EV itself, but rather the logo that marks the front of the vehicle — Nissans in general reportedly have a poorer reputation than competitors after five years of use, and the depreciation rate of the LEAF is commiserate with the overall depreciation rate of Nissans overall. Average 5-year depreciation: 63.4% Loss of value vs. MSRP: $53,846 As is typical with many high-end SUVs, the Tesla Model X suffers a rapid depreciation that is common to very expensive SUVs; additionally, per FindMyElectric, luxury rides depreciate quickly in general because, again, used-vehicle shoppers don't place a premium on luxury features. Moreover, as newer luxury EVs flood the market from Tesla's many competitors, the resale value of older X's continues to spiral downward. Average 5-year depreciation: 60.4% Loss of value vs. MSRP: $36,225 TopSpeed has charted the Tesla Model Y's rapid depreciation as being due to, again, secondhand shoppers not hunting for luxury vehicles, but also because the Y gets outpaced by technological advancements made at a rapidity that the Y cannot compete with. Average 5-year depreciation: 60.1% Loss of value vs. MSRP: $59,691 The Porsche Taycan, while a well-known brand, comes with high depreciation for what CoPilotSearch has described as ever-changing advances in battery technology and 'charging infrastructure,' as well as customer preferences moving away from the Taycan in general. More From GOBankingRates Mark Cuban: Trump's Tariffs Will Affect This Class of People the Most 7 Tax Loopholes the Rich Use To Pay Less and Build More Wealth How To Get the Most Value From Your Costco Membership in 2025 How Much Money Is Needed To Be Considered Middle Class in Every State? This article originally appeared on 6 EVs That Depreciate the Fastest Over 5 Years
Cision Canada
24-04-2025
- Health
- Cision Canada
XYRA Announces the Issuance of a Fifth New US Patent in a Series of Patents Which Protect the Use of Budiodarone in the Management of Atrial Fibrillation till after 2040
Budiodarone shown in Phase 2 to reduce atrial fibrillation symptoms and long episodes of atrial fibrillation (LEAF) FDA gives guidance on steps necessary to gain approval and incorporate wearable AF monitoring devices into label for budiodarone Five granted US patents align with FDA's guidance and protect the drug and label till after 2040 LOS ALTOS, Calif., April 24, 2025 /CNW/ -- XYRA LLC, a private biopharmaceutical company, is committed to developing innovative therapies for cardiac rhythm disorders with high unmet need. With widespread use of FDA approved wearable Atrial Fibrillation (AF) monitoring devices in detecting as well as monitoring arrhythmias, it is now possible to identify subjects with long episodes of AF (LEAF) and symptoms who are at high risk of complications including stroke, heart failure and progression to permanent AF. Having recently received FDA guidance on the approval pathway and a proposed label for budiodarone in the management of AF which will require monitoring with an FDA approved wearable device, the company is now pleased to announce the issuance of a series of new US patents that align with this guidance. The company (XYRA) now has 5 new patents that align with our proposed US label indications (Patent No. 11,759,640) and directions for use (Patent No. 11,839,768) of budiodarone and allow a physician to identify and treat a patient with LEAF with the lowest most effective dose of the drug. Patent No. 12,115,373 instructs a physician treating a patient with non-permanent AF on how to switch a patient from an existing antiarrhythmic drug to an effective dose of budiodarone to eliminate LEAF. The newest patent, Patent No. 12,257,228, instructs a physician how to cardiovert a patient with persistent AF to normal sinus rhythm with oral budiodarone, before treating them chronically to prevent recurrence. The fifth patent, (Patent No. 11,975,202) covers the use of budiodarone and monitoring with wearables to prevent progression of non-permanent to permanent AF. Progression of non-permanent to permanent AF occurs frequently and is associated with high risk of thrombo-embolic strokes, heart attacks, congestive heart failure and poor outcomes. Preventing such progression would have immense public health benefits for the up to 7 million US subjects with non-permanent AF who are destined to progress to permanent AF if left untreated. These 5 patents complement the previously issued patent (Patent No. 9,549,912) that uses a form of budiodarone to eliminate LEAF to create a safe harbor for stroke risk reduction and they extend coverage well past 2040. "We know the odds of having a stroke with AF goes up 5-fold in the 5 days after a LEAF greater than 5.5 hours. So now that we can identify subjects with these events with widely available wearable AF monitoring devices, it makes sense to treat them with budiodarone and monitor the response to therapy to prevent it happening again" said Peter Milner M.D., FACC, managing member XYRA. He added. "These 5 new patents direct intervention with the right dose of budiodarone at the most opportune point in their disease process to improve symptoms, eliminate LEAF and modify progression of the disease. This will reduce stroke and heart failure risk and potentially long-term delay, or prevent, progression to harmful permanent AF". About Budiodarone: Budiodarone is a Phase 3 enabled potentially first-in-class mixed ion channel blocker with esterase metabolism and thus a significantly shorter half-life than amiodarone with no evidence of accumulation to date in human or animal studies. It has been shown to treat AF by controlling symptoms, eliminating LEAF, reducing AF burden, and maintaining normal sinus rhythm. About Atrial Fibrillation: Atrial Fibrillation (AF) is the most common sustained arrhythmia in adults, with approximately 44 million individuals estimated to have AF worldwide. It is associated with thromboembolic risk, impairment in cardiac performance, and other morbidities. In addition to the patients with symptomatic AF, the diagnosis is often first detected after a stroke, the development of left ventricular dysfunction, or incidentally. The management of AF has evolved over time. Due to accumulating evidence of improved outcomes, previous management strategies that focused on simple ventricular rate control have evolved to present therapies that seek to restore and maintain sinus rhythm. AF may be treated with anti-arrhythmic drugs (AAD), electrophysiological ablation, or some combination of the two. XYRA LLC, is a private biopharmaceutical company committed to developing innovative therapies for cardiac rhythm disorders with high unmet need. The company's goal is to make AF management comparable to that of other common cardiac conditions like hypertension and hypercholesterolemia in which, upward dose titration of effective drugs guided by simple widely available monitoring tools used to confirm compliance and response to therapy, have consistently improved outcomes.
