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Mid East Info
13-05-2025
- Health
- Mid East Info
Tirzepatide Outperforms Semaglutide by 47% in Weight Loss - Middle East Business News and Information
Participants achieved an average weight loss of 20.2% with tirzepatide vs. 13.7% with semaglutide In key secondary endpoints, tirzepatide was superior to semaglutide across all weight reduction targets and waist circumference reduction Dubai, United Arab Emirates, May, 2025 – A clinical study has presented detailed findings from SURMOUNT-5, a phase 3b open-label clinical trial, evaluating the safety and efficacy of tirzepatide, a dual GIP and GLP-1 receptor agonist, compared to semaglutide, a mono GLP-1 receptor agonist, in adults living with obesity, or overweight with at least one weight-related medical problem and without diabetes. At 72 weeks, tirzepatide met the primary endpoint and all five key secondary endpoints, demonstrating superiority compared to semaglutide across the trial. The detailed results were presented at the 32nd European Congress on Obesity (ECO) and simultaneously published in The New England Journal of Medicine. For the primary endpoint, participants treated with tirzepatide achieved an average weight reduction of 20.2% compared to 13.7% with semaglutide at 72 weeks using treatment-regimen estimand,1 a 47% greater relative weight loss. Participants using tirzepatide lost an average of 50.3 lbs (22.8 kg) and participants on semaglutide lost an average of 33.1 lbs (15.0 kg).2 In key secondary endpoints, tirzepatide was superior across all weight reduction targets with 64.6% of participants treated with tirzepatide achieving at least 15.0% weight loss compared to 40.1% on semaglutide. Additionally, participants treated with tirzepatide achieved a superior average waist circumference reduction of 7.2 in (18.4 cm), while those treated with semaglutide saw an average reduction of 5.1 in (13.0 cm). 'Thanks to the latest advancements in obesity management medications, more physicians and patients are witnessing significant weight reduction beyond what they have seen before' said Louis J. Aronne, MD, FACP, DABOM, director of the Comprehensive Weight Control Center and the Sanford I. Weill Professor of Metabolic Research at Weill Cornell Medicine, obesity expert at New York-Presbyterian/Weill Cornell Medical Center, and investigator of SURMOUNT-5. 'The SURMOUNT-5 head-to-head results demonstrated tirzepatide led to greater weight reduction compared to semaglutide, providing further evidence to support tirzepatide as an effective option for obesity management.' Primary and Key Secondary Endpoints: Tirzepatide Semaglutide Primary Endpoint Avg % weight loss -20.2% -13.7% Key Secondary Endpoints Achieved ≥10% weight loss 81.6% 60.5% Achieved ≥15% weight loss 64.6% 40.1% Achieved ≥20% weight loss 48.4% 27.3% Achieved ≥25% weight loss 31.6% 16.1% Waist circumference reduction -18.4 cm -13.0 cm 'In the SURMOUNT-5 trial, tirzepatide demonstrated a significantly higher magnitude of weight reduction compared to semaglutide across all comparisons,' said Leonard Glass, MD, FACE, senior vice president, global medical affairs, Lilly. 'These data confirm tirzepatide as a leading treatment option for people living with obesity and equip healthcare providers with critical insights to make well-informed treatment decisions as part of a comprehensive obesity care plan.' The safety profile of tirzepatide in SURMOUNT-5 was consistent with previous SURMOUNT trials. Adverse events reported during the trial were primarily gastrointestinal-related and were generally mild to moderate in severity. During the trial, 6.1% of participants taking tirzepatide discontinued treatment due to adverse events, compared to 8.0% of participants taking semaglutide. However, the study was not powered to compare the safety and tolerability of tirzepatide and the safety and tolerability of semaglutide. About SURMOUNT-5: SURMOUNT-5 (NCT05822830) was a 72-week, multi-center, randomized, open-label, phase 3b trial evaluating the efficacy and safety of tirzepatide compared with semaglutide in adults with obesity, or overweight with at least one of the following comorbidities: hypertension, dyslipidemia, obstructive sleep apnea (OSA) or cardiovascular disease, who did not have diabetes. Participants in both treatment groups received counseling on a reduced-calorie diet and increased physical activity. The trial randomized 751 participants across the U.S. and Puerto Rico in a 1:1 ratio to receive maximum tolerated dose of tirzepatide (10 mg or 15 mg) or semaglutide (1.7 mg or 2.4 mg). With tirzepatide, 89.3% received at least one dose of the 15 mg dose and with semaglutide 92.8% received at least one dose of the 2.4 mg dose. The primary objective of the study was to demonstrate tirzepatide's superiority in percent change from baseline in body weight at 72 weeks compared to semaglutide's. About tirzepatide: Tirzepatide is a once-weekly dual GIP (glucose-dependent insulinotropic polypeptide) receptor and GLP-1 (glucagon-like peptide-1) receptor agonist. Tirzepatide is a single molecule that activates the body's receptors for GIP and GLP-1, which are natural incretin hormones. Both GIP and GLP-1 receptors are found in areas of the human brain important for appetite regulation. Tirzepatide decreases calorie intake, and the effects are likely mediated by affecting appetite. Studies of tirzepatide in chronic kidney disease (CKD) and in morbidity/mortality in obesity (MMO) are ongoing. About Lilly: Lilly is a medicine company turning science into healing to make life better for people around the world. We've been pioneering life-changing discoveries for nearly 150 years, and today our medicines help more than 51 million people across the globe. Harnessing the power of biotechnology, chemistry and genetic medicine, our scientists are urgently advancing new discoveries to solve some of the world's most significant health challenges: redefining diabetes care; treating obesity and curtailing its most devastating long-term effects; advancing the fight against Alzheimer's disease; providing solutions to some of the most debilitating immune system disorders; and transforming the most difficult-to-treat cancers into manageable diseases. With each step toward a healthier world, we're motivated by one thing: making life better for millions more people. That includes delivering innovative clinical trials that reflect the diversity of our world and working to ensure our medicines are accessible and affordable.
WebMD
13-05-2025
- Health
- WebMD
Why Mounjaro Tops Ozempic for Weight Loss
May 12, 2025 – Turns out, two really is better than one – at least when it comes to weight loss drugs. In the first head-to-head trial of its kind, people with obesity who took tirzepatide (sold under the brand names Mounjaro and Zepbound) lost more weight and inches from their waist than those who took semaglutide (Ozempic, Wegovy). Semaglutide is a GLP-1 agonist that boosts the hunger-suppressing hormone GLP-1. Tirzepatide is a dual agonist, targeting both GLP-1 and GIP. That means it acts on two hormone pathways, while semaglutide works on one. "We've learnt over the past 20 years or so that you can overcome the plateau effect with obesity drugs if you can add in drugs with mechanisms that are completely different," said Louis J. Aronne, MD, who led the study and is also the director of the Comprehensive Weight Control Center at Weill Cornell Medicine in New York City. "This is exactly what we see here." In the study, people taking tirzepatide lost about 20% of their body weight, while those taking semaglutide lost around 14%. They also were more likely to hit big weight loss goals – among those who lost 25% or more body weight, twice as many (32%) were on tirzepatide compared with semaglutide (16%). The findings were presented Sunday at the European Congress on Obesity 2025 in Spain, and published in The New England Journal of Medicine on the same day. The trial was sponsored by Eli Lilly & Company, the maker of tirzepatide. "They're both very good medications," said David Horner, MD, of the University of Copenhagen in Denmark, who was not involved in the study. "One is not in doubt that tirzepatide has a greater weight loss benefit from the data. We're comparing a very good drug with a very good drug." First Head-to-Head Comparison Between Two Weight Loss Drugs Both tirzepatide and semaglutide have helped people lose weight in earlier studies, but this is the first time they've been compared side by side. Of the 751 people in the study, half took tirzepatide and half took semaglutide. Both groups received weekly shots for 72 weeks, using the highest dose they could handle without strong side effects. Most people in the study were women in their mid-40s. Most were White. Everyone had struggled with their weight for many years – 16 years, on average – and had tried and failed to lose weight through diet alone. Beyond the weight loss results, tirzepatide also helped people shrink their waistlines by an extra 2 inches – by 7 inches, versus 5 inches for semaglutide. That kind of difference is "clinically meaningful and has been shown to reduce blood pressure and other metabolic parameters," Aronne said. Sure enough, people on tirzepatide saw greater improvements in key health markers like blood pressure, blood sugar, insulin, and cholesterol. "In general, the more weight someone loses, then the better the metabolic parameters will be," Aronne said. Side effects were common and were mostly mild stomach problems like nausea or diarrhea, but few people stopped taking the medicine because of them, he said – only about 6% on tirzepatide and 8% on semaglutide. Of course, the right medicine for each patient depends on a lot of things – including insurance coverage and doctor recommendations – not just which one works best in studies, said Horner.
Web Release
12-05-2025
- Health
- Web Release
Tirzepatide Outperforms Semaglutide by 47% in Weight Loss
By Editor_wr On May 12, 2025 A clinical study has presented detailed findings from SURMOUNT-5, a phase 3b open-label clinical trial, evaluating the safety and efficacy of tirzepatide, a dual GIP and GLP-1 receptor agonist, compared to semaglutide, a mono GLP-1 receptor agonist, in adults living with obesity, or overweight with at least one weight-related medical problem and without diabetes. At 72 weeks, tirzepatide met the primary endpoint and all five key secondary endpoints, demonstrating superiority compared to semaglutide across the trial. The detailed results were presented at the 32nd European Congress on Obesity (ECO) and simultaneously published in The New England Journal of Medicine. For the primary endpoint, participants treated with tirzepatide achieved an average weight reduction of 20.2% compared to 13.7% with semaglutide at 72 weeks using treatment-regimen estimand,1 a 47% greater relative weight loss. Participants using tirzepatide lost an average of 50.3 lbs (22.8 kg) and participants on semaglutide lost an average of 33.1 lbs (15.0 kg).2 In key secondary endpoints, tirzepatide was superior across all weight reduction targets with 64.6% of participants treated with tirzepatide achieving at least 15.0% weight loss compared to 40.1% on semaglutide. Additionally, participants treated with tirzepatide achieved a superior average waist circumference reduction of 7.2 in (18.4 cm), while those treated with semaglutide saw an average reduction of 5.1 in (13.0 cm). 'Thanks to the latest advancements in obesity management medications, more physicians and patients are witnessing significant weight reduction beyond what they have seen before' said Louis J. Aronne, MD, FACP, DABOM, director of the Comprehensive Weight Control Center and the Sanford I. Weill Professor of Metabolic Research at Weill Cornell Medicine, obesity expert at New York-Presbyterian/Weill Cornell Medical Center, and investigator of SURMOUNT-5. 'The SURMOUNT-5 head-to-head results demonstrated tirzepatide led to greater weight reduction compared to semaglutide, providing further evidence to support tirzepatide as an effective option for obesity management.' Primary and Key Secondary Endpoints: Tirzepatide Semaglutide Primary Endpoint Avg % weight loss -20.2% -13.7% Key Secondary Endpoints Achieved ?10% weight loss 81.6% 60.5% Achieved ?15% weight loss 64.6% 40.1% Achieved ?20% weight loss 48.4% 27.3% Achieved ?25% weight loss 31.6% 16.1% Waist circumference reduction -18.4 cm -13.0 cm 'In the SURMOUNT-5 trial, tirzepatide demonstrated a significantly higher magnitude of weight reduction compared to semaglutide across all comparisons,' said Leonard Glass, MD, FACE, senior vice president, global medical affairs, Lilly. 'These data confirm tirzepatide as a leading treatment option for people living with obesity and equip healthcare providers with critical insights to make well-informed treatment decisions as part of a comprehensive obesity care plan.' The safety profile of tirzepatide in SURMOUNT-5 was consistent with previous SURMOUNT trials. Adverse events reported during the trial were primarily gastrointestinal-related and were generally mild to moderate in severity. During the trial, 6.1% of participants taking tirzepatide discontinued treatment due to adverse events, compared to 8.0% of participants taking semaglutide. However, the study was not powered to compare the safety and tolerability of tirzepatide and the safety and tolerability of semaglutide. Tirzepatide Outperforms Semaglutide by 47% in Weight Loss Comments are closed.
India Gazette
12-05-2025
- Health
- India Gazette
Weight loss drug Mounjaro shown more effective than Wegovy, claims Pharma company
New Delhi [India], May 12 (ANI): Eli Lilly and Company announced on Monday detailed results from SURMOUNT-5, a phase 3b open-label clinical trial, evaluating the safety and efficacy of tirzepatide, a dual GIP and GLP-1 receptor agonist, compared to semaglutide, a mono GLP-1 receptor agonist, in adults living with obesity, or overweight with at least one weight-related medical problem and without diabetes, according to a press statement. According to Eli Lilly, participants reduced 20.2 per cent weight with tirzepatide in comparison to 13.7 per cent with semaglutide across the trials. At 72 weeks, tirzepatide met the primary endpoint and all five key secondary endpoints, demonstrating superiority compared to semaglutide across the trial. The detailed results were presented at the 32nd European Congress on Obesity (ECO) and simultaneously published in The New England Journal of Medicine. The statement added, 'For the primary endpoint, participants treated with tirzepatide achieved an average weight reduction of 20.2 per cent compared to 13.7 per cent with semaglutide at 72 weeks using treatment-regimen estimand,1 47 per cent greater relative weight loss. Participants using tirzepatide lost an average of 22.8 kg and participants on semaglutide lost an average of 15.0 kg.2.' In key secondary endpoints, tirzepatide was superior across all weight reduction targets with 64.6 per cent of participants treated with tirzepatide achieving at least 15.0 per cent weight loss compared to 40.1 per cent on semaglutide. Additionally, participants treated with tirzepatide achieved a superior average waist circumference reduction of 7.2 in (18.4 cm), while those treated with semaglutide saw an average reduction of 5.1 in (13.0 cm). 'Thanks to the latest advancements in obesity management medications, more physicians and patients are witnessing significant weight reduction beyond what they have seen before,' said Louis J. Aronne, MD, FACP, DABOM, director of the Comprehensive Weight Control Center and the Sanford I. Weill Professor of Metabolic Research at Weill Cornell Medicine, obesity expert at New York-Presbyterian/Weill Cornell Medical Center, and investigator of SURMOUNT-5,' as per the statement. 'The SURMOUNT-5 head-to-head results demonstrated that tirzepatide led to greater weight reduction compared to semaglutide, providing further evidence to support tirzepatide as an effective option for obesity management.' 'Obesity is a chronic disease that requires comprehensive management, and Lilly is committed to supporting people with obesity and enhancing the standard of care in obesity management in India', said Winselow Tucker, President and General Manager, Eli Lilly and Company (India). 'The results from the SURMOUNT 5 trial provide robust evidence supporting Mounjaro (tirzepatide) as an effective option for obesity management in India.' The safety profile of tirzepatide in SURMOUNT-5 was consistent with previous SURMOUNT trials. Adverse events reported during the trial were primarily gastrointestinal-related and were generally mild to moderate in severity. During the trial, 6.1 per cent of participants taking tirzepatide discontinued treatment due to adverse events, compared to eight per cent of participants taking semaglutide. However, the study was not powered to compare the safety and tolerability of tirzepatide and the safety and tolerability of semaglutide. Tirzepatide is a weight loss drug for adults with obesity or with overweight who also have weight-related medical problems, as Zepbound in the US and Mounjaro in some countries outside of the US Tirzepatide is also commercialised as Mounjaro for adults with type 2 diabetes in the US and in some countries outside of the US. Semaglutide is a drug used as Wegovy for people living with obesity or for overweight adults who also have weight-related medical problems and Ozempic for people with type 2 diabetes. (ANI)
Miami Herald
08-05-2025
- Business
- Miami Herald
JTC Team Hosts Virtual Investor 'KOL Connect' Segment to Discuss Veru Inc.'s (NASDAQ:VERU) Enobosarm Taking GLP-1 Weight Loss to Next Level
Moderated discussion with preeminent obesity expert Louis J. Aronne, MD, FACP and Mitchell Steiner, M.D., F.A.C.S, President, CEO, and Founder of Veru Watch the "KOL Connect" segment here FRENCHTOWN, NJ / ACCESS Newswire / May 8, 2025 / JTC Team ("JTC"), a fully integrated corporate communications and investor relations firm, today released a Virtual Investor "KOL Connect" segment featuring Mitchell Steiner, M.D., F.A.C.S, President, CEO, and Key Opining Leader (KOL), Louis J. Aronne, MD, FACP. Veru Inc. (NASDAQ:VERU) is a late clinical stage biopharmaceutical company focused on developing innovative medicines for the treatment of cardiometabolic and inflammatory diseases. The Company's drug development program includes two late-stage novel small molecules, enobosarm and sabizabulin. Enobosarm, a selective androgen receptor modulator (SARM), is being developed as a next generation drug that makes weight reduction by GLP-1 RA drugs more tissue selective for loss of fat and preservation of lean mass thereby improving body composition and physical function. Sabizabulin, a microtubule disruptor, is being developed for the treatment of inflammation in atherosclerotic cardiovascular disease. As part of this "KOL Connect" segment, Dr. Steiner and Dr. Aronne discussed obesity and GLP-1s, the current treatment landscape and areas of unmet need, highlighting Veru's lead program, the enobosarm QUALITY Phase 2b study, and the clinical data released by Veru to date. The Virtual Investor "KOL Connect" segment featuring Veru Inc. is now available here. To access all Virtual Investor Events, visit About JTC TeamJTC is a fully integrated corporate communications firm that is dedicated to helping you tell your story to the right audiences in order to build awareness. JTC has developed a reputation of excellence for executing robust communication strategies that deliver results. The Company partners with both public and private companies across the Life Sciences and Technology industries to help raise awareness and build stakeholder value. For more information, please visit or connect with the company on X and LinkedIn. CONTACTJenene ThomasJTC Team, LLCT: +1 (908) 824-0775jtc@ SOURCE: JTC Team, LLC
