Latest news with #MarcusBuggert
Time of India
02-05-2025
- Health
- Time of India
New study pinpoints blood biomarkers behind long COVID's lung damage
A recent study conducted by researchers at Karolinska Institutet in Sweden has identified specific blood biomarkers associated with long COVID , particularly in patients experiencing severe respiratory symptoms . Published in Nature Immunology, the study offers insights into the biological mechanisms underlying persistent symptoms following SARS-CoV-2 infection. The research team discovered a distinct plasma biomarker signature linked to breathlessness and other respiratory issues in long COVID patients. This signature involves apoptotic inflammatory networks centered on proteins such as CCL3, CD40, IKBKG, IL-18, and IRAK1. These proteins are associated with pathways related to cell cycle progression, lung injury, and platelet activation, suggesting a complex interplay between immune response and respiratory function in long COVID. The identification of these biomarkers holds potential for improving the diagnosis and treatment of long COVID. By understanding the specific biological markers associated with persistent respiratory symptoms, healthcare providers may develop targeted therapies to alleviate these conditions. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Buenos Aires: AI guru Andrew Ng recommends: Read These 5 Books And Turn Your Life Aroun... Blinkist: Andrew Ng's Reading List Undo All 265 participants in the study had been infected with COVID-19 during the initial phase of the pandemic—before vaccines were available. Researchers used cutting-edge tools to analyze thousands of proteins in their blood plasma and linked these findings to each patient's reported symptoms. In addition, they performed immunological tests using flow cytometry to gain deeper insights into the immune system's behavior. This study contributes to the growing body of evidence that long COVID involves distinct immunological changes detectable in the blood. Previous research has highlighted ongoing inflammation and immune dysregulation in long COVID patients, reinforcing the need for continued investigation into the condition's underlying mechanisms. The proteins were mainly found in patients with Long COVID and severe respiratory problems. This is a biomarker pattern that we know to be linked to inflammatory signal pathways involved in cell death and lung damage and that has also been observed in other patient groups with severe pulmonary disorders," Dr. Marcus Buggert, docent at the Department of Medicine, Karolinska Institutet (Huddinge). Masterclass for Students. Upskill Young Ones Today!– Join Now
Hans India
01-05-2025
- Health
- Hans India
Study finds long Covid biomarkers in blood linked to respiratory problems
A team of Swedish researchers has identified biomarkers in the blood associated with symptoms of long Covid, particularly severe respiratory disorders. Long Covid is a condition characterised by persistent symptoms including acute breathlessness and fatigue, after an infection caused by the SARS-CoV-2 virus. The team from Karolinska Institutet discovered a set of proteins in the blood of people with long Covid. The findings may pave the way for future diagnosis and treatment. "The proteins were mainly found in patients with long Covid and severe respiratory problems," said Marcus Buggert, docent at the Department of Medicine, Karolinska Institutet. "This is a biomarker pattern that we know to be linked to inflammatory signal pathways involved in cell death and lung damage and that has also been observed in other patient groups with severe pulmonary disorders," he added. For the study, the team analysed blood samples from 265 patients in Sweden and the UK, who contracted Covid when no vaccine was yet available. Using advanced techniques, the researchers measured thousands of proteins in the blood plasma, which they related to the patient's symptoms. The results, published in the journal Nature Immunology, exposed the underlying biological processes that can cause certain patients to experience severe symptoms long after previous Covid-19. "By identifying the proteins that are elevated in affected patients, we're creating a platform from which to develop diagnostic tools and new targeted therapies," Dr. Buggert said. "This is especially important since there are no specific biomarkers and treatments for long Covid." The team next aims to study lung and gastrointestinal tissue to understand what underpins this pattern. This will likely enable them to locate the source of the identified proteins and find if there is any remaining inflammation or tissue damage in specific organs of patients with long Covid, they said.
