Latest news with #MarekHonczarenko
New Indian Express
04-06-2025
- Business
- New Indian Express
Sun Pharma shares plunge as its much touted psoriasis drug trial fails
CHENNAI: Shares of India's largest drug maker Sun Pharmaceutical Industries fell almost 1% on main stock exchanges on Wednesday following the company's announcement of a disappointing trial results of its much expected novel drug for psoriasis. The company said in a statement on Tuesday that it is discontinuing further development of its investigational drug SCD-044, a novel orally bioavailable anti-psoriasis drug following disappointing Phase 2 trial results. This investigational drug was tested for both psoriasis and atopic dermatitis indications. The company said that the trials (double-blind, placebo-controlled Phase 2 trial evaluated the efficacy and safety) were conducted in 263 patients with moderate to severe plaque psoriasis. The primary endpoint was the proportion of patients achieving a 75% reduction in the psoriasis area. The trial failed to meet this endpoint, although no major safety or tolerability issues were reported. 'While we are disappointed with the top-line results of the clinical trials, we would like to thank all the psoriasis and atopic dermatitis patients, the healthcare professionals and administrators who participated in these pivotal clinical trials,' said Dr. Marek Honczarenko, Senior Vice President and Head of Global Specialty Development at Sun Pharma.
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Business Standard
03-06-2025
- Business
- Business Standard
Sun Pharma halts development of SCD-044 drug after trial disappointment
Sun Pharmaceutical Industries on Tuesday announced that it will discontinue development of its experimental oral drug, SCD-044, following disappointing results in Phase 2 clinical trials for the treatment of moderate to severe psoriasis and atopic dermatitis (eczema). The trial did not achieve the primary objective: a 75 per cent improvement in the EASI (Eczema Area and Severity Index) score by Week 16, the company said. The Phase 2 clinical trial enrolled 250 patients and compared three different dosages of SCD-044 with a placebo. The study followed a randomised, double-blind, placebo-controlled design—standard methodology intended to minimise bias in clinical research. 'While we are disappointed with the top-line results of the clinical trials, we would like to thank all the psoriasis and atopic dermatitis patients, the healthcare professionals and administrators who participated in these pivotal clinical trials,' said Dr Marek Honczarenko, Senior Vice-President and Head of Global Specialty Development at Sun Pharma. Shares of Sun Pharmaceutical closed at ₹1,667.65 on Tuesday, down ₹7.25 or 0.43 per cent. In the fourth quarter of FY25, the company reported a 19 per cent year-on-year decline in net profit to ₹2,153.9 crore, compared with ₹2,658.74 crore in the same quarter of the previous fiscal.
