Latest news with #Melanoma
The Independent
25-05-2025
- Sport
- The Independent
Horse trainer Christophe Clement dies at 59 from rare eye cancer
Christophe Clement, who trained longshot Tonalist to victory in the 2014 Belmont Stakes and won a Breeders' Cup race in 2021, has died. He was 59. Clement announced his own death in a prepared statement that was posted to his stable's X account on Sunday. 'Unfortunately, if you are reading this, it means I was unable to beat my cancer,' it said. 'As many of you know, I have been fighting an incurable disease, metastatic uveal melanoma.' It's a type of cancer that affects the uvea, the middle layer of the eye. It accounts for just 5% of all melanoma cases in the U.S., however, it can be aggressive and spread to other parts of the body in up to 50% of cases, according to the Melanoma Research Alliance's website. The Paris-born Clement had been one of the top trainers in the U.S. over the last 34 years. He learned under his father, Miguel, who was a leading trainer in France. Clement later worked for the prominent French racing family of Alec Head. In the U.S., he first worked for Hall of Fame trainer Shug McGaughey. Clement went out on his own in 1991, winning with the first horse he saddled at Belmont Park in New York. 'Beyond his accomplishments as a trainer, which are many, Christophe Clement was a kind and generous man who made lasting contributions to the fabric of racing in New York," Dave O'Rouke, president and CEO of the New York Racing Association said in a statement. Clement had 2,576 career victories and purse earnings of over $184 million, according to Equibase. 'I am very proud that for over 30 years in this industry, we have operated every single day with the highest integrity, always putting the horses' wellbeing first,' he said in his farewell message. One of Clement's best-known horses was Gio Ponti, winner of Eclipse Awards as champion male turf horse in 2009 and 2010. He finished second to Zenyatta in the 2009 Breeders' Cup Classic at Santa Anita. In the 2014 Belmont, Tonalist spoiled the Triple Crown bid of California Chrome, who tied for fourth. Tonalist won by a head, after not having competed in the Kentucky Derby or Preakness that year. Steve Coburn, co-owner of California Chrome, caused controversy when he said afterward the horses that hadn't run in the other two races took 'the coward's way out.' He later apologized and congratulated the connections of Tonalist. Clement's lone Breeders' Cup victory was with Pizza Bianca, owned by celebrity chef Bobby Flay, in the Juvenile Fillies Turf. Clement had seven seconds and six thirds in other Cup races. 'It was Christophe's genuine love for the horse that truly set him apart," Eric Hamelback, CEO of the National Horseman's Benevolent and Protective Association, said in a statement. "He was a consummate professional and a welcoming gentleman whose demeanor was always positive, gracious and upbeat.' Clement's statement said he would leave his stable in the hands of his son and longtime assistant, Miguel. 'As I reflect on my journey, I realize I never worked a day in my life,' Clement's statement said. 'Every morning, I woke up and did what I loved most surrounded by so much love." Besides his son, he is survived by wife Valerie, daughter Charlotte Clement Collins, daughter-in-law Acacia Clement, son-in-law Shaun Collins and grandson Hugo Collins. ___
Metro
20-05-2025
- Health
- Metro
What your toes say about your health — 8 warning signs to look out for
Next time you're giving yourself a pedicure, consider looking beyond which shade of polish best compliments your favourite sandals. 'While often overlooked, your toenails and feet play a huge role in your overall health and it's important to pay attention to their condition,' says Sheena Bagga, pharmacist prescriber at LloydsPharmacy Online Doctor. Although many problems with toes and nails are easy to treat, changes to their appearance can be clues that something more sinister needsprofessional medical attention. Here, she tells Metro the main symptoms to look out for, and the different health issues each signal might point to. 'Yellow discolouration can indicate a toenail infection, which can occur on any part of the nail,' Sheena explains. 'This causes the nail to discolour, become crumbly, or thicken.' Alternatively, yellowing could be down to nail psoriasis, but this typically comes alongside pitting or patches, and it may also be lifted from the nail bed underneath. To prevent infections, the advice is to keep your nails short and clean, wear a clean pair of socks every day, and ensure your shoes fit correctly. A brown or black band running lengthwise along the nail – known as melanonychia – is normally nothing to worry about. When the cause is benign, it's likely either a variation in pigmentation or the result of an injury. But in some rare cases, Sheena says it's 'a tell-tale sign' of a type of skin cancer called Subungual Melanoma – so if you're concerned, it's worth getting it checked out. According to Sheena, toe swelling can be caused by a number of conditions, including lymphatic issues, poor blood flow, or even gout. 'Gout is a type of inflammatory arthritis characterised by sudden, severe joint pain, often in the big toe, caused by the buildup of uric acid crystals in the joints,' she explains. 'It is more likely to occur in people who are overweight, and consum There are less serious reasons for swelling though, including: Sitting or standing for long periods of time Wearing shoes that are too small Being overweight, dehydrated, or eating a diet that's heavy in salt Maintaining a healthy, balanced diet can help with some of these common issues, along with regular exercise and movement, but it's recommended to speak to your GP if you also experience symptoms like pain, aching, or difficulty moving. White lines or spots on the nail are called leukonychia, and are often caused by trauma such as stubbing your toe. However, these can sometimes can be a sign of deficiencies in protein, zinc, or iron, or of a fungal infections if the nail is also brittle and crumbly. 'Although rare, fully white nails are slightly more concerning and could be an indicator of a systematic illness in another part of the body,' adds Sheena. 'These include liver cirrhosis, hyperthyroidism, or diabetes.' If you're concerned and are experiencing additional side effects, contact your GP to help identify the cause. Always got cold feet? It could be a sign of poor circulation, which can also leave your toes with a bluish discolouration. More specifically, blue-tinged toes are a symptom of a condition called Raynaud's disease, which 'causes narrowing of the smaller arteries which supply blood to the extremities.' A doctor will be able to provide advice if you're having circulation problems, but Sheena notes that regular exercise can also be beneficial for managing the symptoms. Athlete's Foot is a common fungal infection that shows as itchy white patches between your toes. 'It can also affect the soles or sides of your feet, sometimes causing fluid-filled blisters,' Sheena adds. While it can be dealt with through over-the-counter remedies, prevention is better than cure. As such, you should make sure to completely dry your feet after washing them – especially between your toes – and wear clean socks every day, ideally cotton ones which allow the skin to breathe more easily. We've all ended up with a blister after a day on our feet, but ulcers are different – and much more worrying if you have diabetes. 'Unlike a blister that occurs under the skin, an ulcer is a break in the skin's surface, appearing as an open wound,' says Sheena. 'During the time the wound is exposed, it can leave you vulnerable to developing an infection, which in serious cases can lead to amputation.' Toenails that change shape and look curved, concave or 'spoon' shaped could indicate an iron deficiency or anaemia. More Trending Sheena says: 'Iron is essential for producing healthy red blood cells and maintaining proper nail health, so it's important to speak to a healthcare provider who may recommend taking a supplement.' Each person's toes look different, but healthy nails should have a smooth surface with light pink or translucent colouration and little variation in shade. View More » Keep this in mind, and hot foot it to your doctor if you think something could be wrong. Do you have a story to share? Get in touch by emailing MetroLifestyleTeam@
Miami Herald
09-05-2025
- Entertainment
- Miami Herald
Teddi Mellencamp shares how she's celebrating Mother's Day amid cancer battle
As Teddi Mellencamp continues to battle cancer, her focus is on this weekend and celebrating Mother's Day with her children. In April, in an exclusive interview with Us Weekly, Mellencamp said she wasn't just 'fighting for my life, but also for my family's life and all the people I love.' On Friday, May 9, Mellencamp took to Instagram to ask her followers how they were planning on celebrating Mother's Day. In the same post, Mellencamp shared her own Mother's Day plans, writing that she will be 'celebrating with kids on Saturday at Wango Tango and relaxing Sunday.' The former 'Real Housewives of Beverly Hills' star added that she was 'feeling good today and taking full advantage.' A day earlier, Mellencamp shared a photo of herself and her youngest daughter, Dove, and wondered in the caption if it's 'time to stop calling her baby Dove,' now that she's 5 years old. 'Nah, I didn't think so.' Her followers agreed. 'We even still call our middle 'baby Adeline.' When it fits, it fits,' one commenter shared. 'I still call my almost 24 year old my baby. Your youngest is always your baby,' said another. In addition to Dove, Mellencamp also shares a 12-year-old daughter, Slate, and a 10-year-old son, Cruz, with her estranged husband, Edwin Arroyave. Mellencamp is also a stepmom to Arroyave's 16-year-old daughter, Isabella, from a previous relationship. Mellencamp was first diagnosed with Melanoma in 2022. In February, she learned that the cancer had progressed to stage 4 melanoma, metastasizing to her lungs and brain. She underwent brain surgery to remove multiple tumors. While talking to Us Weekly in April, Mellencamp admitted that she no longer says her once popular catchphrase, 'Moms always come back.' 'I have not said that line to them since I've been back (from the hospital),' Mellencamp said. 'They all know that I'm fighting the hardest I possibly can, but I haven't said (it) because I don't want to lie to them. And I don't know.'
STV News
01-05-2025
- Health
- STV News
Almost half of Scots suffer sunburn at least once a year, research finds
A skin cancer patient is urging people to wear sun cream and cover up as new figures show almost half of people in the UK have sunburn at least once a year. Research from charity Melanoma Focus also found 36% of people in the United Kingdom, and 32% of those in Scotland, rarely or never apply sunscreen between May and September. It comes as melanoma skin cancer rates continue to rise in the UK, with around 17,500 new cases each year. The research found 49% of people in the UK, and 45% in Scotland, suffer from sunburn at least once every year. Stephen Maxwell, 58, from Clydebank in West Dunbartonshire, was diagnosed with melanoma in 2022 and he is now urging people to take care in the sun. Mr Maxwell, who has never holidayed abroad, was shocked to be diagnosed with skin cancer and thinks it may stem from the decade he spent working in greenhouses growing plants. He said: 'I went to the doctor after my mum noticed a strange lump on my back. It was a bit like a mole and initially the doctor thought there was nothing to worry about. 'I had the lump for two-and-a-half years and it started getting bigger and it turned purple. 'Eventually it was properly diagnosed and I had it removed – it was a melanoma cancer tumour the size of my fist. I had immunotherapy but it didn't work and the cancer spread to my bones.' The father-of-four, who has eight grandchildren, was told 18 months ago that he had six to nine months to live. Days before he was due to go into a hospice, he was given the opportunity to take part in a medical trial for a new treatment and started a course of Opdualag and steroids. He said he had a 'great' six months before coming off Opdualag at Christmas after experiencing some side-effects, and is now taking steroids and having scans. 'I'm still having scans and although the cancer is still there, it hasn't spread further and I'm living with it and I'm still here,' he said. 'Any form of sun you must wear protection, even if it's a hat, always a T-shirt and definitely the creams. 'I'm not ginger but I've got wee ginger bits in my beard so that means I've got the ginger gene so when you've got that you're at risk. 'If anybody has got the ginger gene they must cover up, and with climate change being the way it is now Scotland is getting more hot weather.' The survey of 2,000 UK adults, including 165 in Scotland, was carried out by Censuswide in April. Commenting on the figures, Melanoma Focus chief executive Susanna Daniels said: 'This data is extremely concerning as we know that more than five sunburns in your lifetime doubles your risk of melanoma, so burning every year has potentially long-term dangerous consequences. 'Nearly nine in 10 melanomas are preventable yet the UK has more deaths from melanoma per year than Australia. 'It is essential that everyone understands the risks associated with sunburn and prioritises sun protection by using factor 30+ sunscreen, wearing a hat, seeking shade and covering up in the heat of the day.' Melanoma Focus said melanoma skin cancer is the fifth most common cancer in the UK. The charity is calling on the UK Government to abolish VAT on factor 30+ sunscreen to make it more affordable to everyone. The UK Government has been asked for comment. Get all the latest news from around the country Follow STV News Scan the QR code on your mobile device for all the latest news from around the country
Zawya
22-04-2025
- Business
- Zawya
CK Life Sciences' Investigational Cancer Vaccines Deliver Promising Results - New Preclinical Study Data to be Presented at the 2025 American Association for Cancer Research (AACR) Annual Meeting
HONG KONG SAR - Media OutReach Newswire - 22 April 2025 - CK Life Sciences Int'l., (Holdings) Inc. ("the Company") announced that the Company will be presenting new data from its cancer vaccine research pipeline at the 2025 American Association for Cancer Research (AACR) Annual Meeting in Chicago, USA. The AACR Annual Meeting is a gathering central to the global cancer research community, bringing together scientists, clinicians, other healthcare professionals, survivors, patients and advocates every year to share the latest breakthroughs and developments in cancer science and medicine. Last year, the 2024 Annual Meeting attracted 23,000 in-person attendees and 6,700 online participants from 78 countries. In recent years, CK Life Sciences has regularly participated at the AACR Annual Meeting. The 2025 Annual Meeting will be held from 25-30 April. At the event, CK Life Sciences will exhibit posters highlighting data from preclinical studies of investigational cancer vaccines programs targeting (i) PRAME (Preferentially Expressed Antigen in Melanoma), (ii) PD-L1 (programmed cell death ligand 1), (iii) B7-H3 (B7 homolog 3) and (iv) Claudin 6 proteins, respectively. PRAME is a protein highly expressed in several cancers, including melanoma, liver cancer and leukemia. PD-L1 is one of the most important immune checkpoint proteins that is highly expressed in cancer cells to block T cell activation in the tumour microenvironment. B7-H3 is another immune checkpoint protein that modulates T cell responses and is often overexpressed in cancer. Claudin 6 is a tight junction protein that regulates epithelial barrier integrity and is overexpressed in cancers like breast cancer, lung cancer and endometrial cancer, where it is associated with tumour progression and metastasis. In addition, CK Life Sciences will be co-presenting with our research collaborator two posters showcasing our Artificial Intelligence (AI)-empowered platform for designing cancer vaccines. "CK Life Sciences is pleased with the preclinical efficacy results of its investigational cancer vaccines targeting PRAME, PD-L1, B7-H3 and Claudin 6 proteins, and we hope to further advance the research & development of these and other cancer vaccines. We are also excited about the progress achieved in our efforts to develop an AI platform aimed at designing cancer vaccines that are more likely to be immunogenic and clinically effective," said Melvin Toh, Vice President and Chief Scientific Officer at CK Life Sciences. Dr. Toh continued, "CK Life Sciences is determined to accelerate its R&D to benefit cancer patients. Currently, a number of therapeutic cancer vaccines are in clinical and discovery/preclinical research stages. Amongst them, seviprotimut-L, a cancer vaccine already in the final research stage, is being tested for the adjuvant treatment of stage IIB or IIC melanoma following definitive surgical resection. DETAILS ON POSTER PRESENTATIONS: Authors: Kin-Tak Chan, Hsin-Wei Chen, Pi-Hui Liang, You-Yu Lin, Tristan Zhang, Melvin Toh Session Category: Clinical Research Session Title: Vaccines and Cell Therapies Session Date and Time: 4/27/2025 2:00 PM - 5:00 PM Location: Poster Section 35 Poster Board Number: 9 Abstract 3533: Claudin 6 vaccines effectively inhibit tumor growth in a syngeneic mouse colon cancer model Authors: Na Wang, Melvin Toh, Hong Wang Session Category: Immunology Session Title: Vaccines, In Situ Vaccines, and Vaccine Combinations Session Date and Time: 4/28/2025 2:00 PM - 5:00 PM Location: Poster Section 39 Poster Board Number: 9 Abstract 3536: Synergistic effects of combined PD-L1 and B7-H3 fusion protein vaccination in a mouse model of pancreatic cancer Authors: Kenneth Nansheng Lin, Melvin Toh, Hong Wang Session Category: Immunology Session Title: Vaccines, In Situ Vaccines, and Vaccine Combinations Session Date and Time: 4/28/2025 2:00 PM - 5:00 PM Location: Poster Section 39 Poster Board Number: 12 Abstract 3538: The development of neoantigen-derived peptide vaccine driven by AI epitope design and computer assisted epitope enhancement Authors: Chi Han Samson Li, Hong Wang, Kin Tak Chan, Genwei Zhang, Jiewen Du, Lipeng Lai, Melvin Toh Session Category: Immunology Session Title: Vaccines, In Situ Vaccines, and Vaccine Combinations Session Date and Time: 4/28/2025 2:00 PM - 5:00 PM Location: Poster Section 39 Poster Board Number: 14 Abstract 3649: Artificial intelligence accelerates shared neoantigen peptide cancer vaccine development Authors: Genwei Zhang, Jiewen Du, Xiangrui Gao, Zhenghui Wang, Qingxia Zhang, Tongren Liu, Dong Chen, Chi Han Samson Li, Kin Tak Chan, Hong Wang, Melvin Toh, Lipeng Lai Session Category: Bioinformatics/ Computational Biology/ Systems Biology/ Convergent Science Session Title: Artificial Intelligence and Machine Learning for Therapeutic Election and Discovery Session Date and Time: 4/28/2025 2:00 PM - 5:00 PM Location: Poster Section 45 Poster Board Number: 11 The full abstracts are available in the AACR Online Itinerary Planner, which can be accessed at: DISCLAIMER This press release may contain forward-looking statements regarding the Group's research and development projects which may involve risks and uncertainties. Actual results may differ materially from expectations discussed in such forward-looking statements. All information in this press release is for general reference only and is not intended as investment advice or medical advice. CK Life Sciences Int'l., (Holdings) Inc. does not warrant or represent, express or implied, as to the accuracy, completeness or updated status of such information. No liability will be accepted for any loss or damage howsoever arising from or in reliance upon such information. Copyright ©2025 CK Life Sciences Int'l., (Holdings) Inc. All rights reserved. Hashtag: #CKLifeSciences #CancerVaccines #R&D #Pharmaceutical #AmericanAssociationforCancerResearch #AACR #PRAME #PD-L1 #B7-H3 #Claudin6Proteins #Melanoma #AI The issuer is solely responsible for the content of this announcement. CK Life Sciences Int'l., (Holdings) Inc.
