Latest news with #Miralles
Yahoo
17-03-2025
- Business
- Yahoo
Contineum Therapeutics Announces Appointment of Diego Miralles, M.D. to Its Board of Directors
SAN DIEGO, March 17, 2025--(BUSINESS WIRE)--Contineum Therapeutics, Inc. (NASDAQ: CTNM) (Contineum or the Company), a clinical-stage biopharmaceutical company pioneering differentiated therapies for the treatment of neuroscience, inflammation and immunology (NI&I) indications, today announced the appointment of Diego Miralles, M.D. as a member of its board of directors, effective March 14, 2025. "We are excited to welcome Diego to our board," commented Eef Schimmelpennink, Contineum's Chairperson. "He has successfully led the development of novel therapies throughout his distinguished career and has an extensive track record in both early stage research and all stages of clinical development. During his time at Janssen Research, Dr. Miralles was engaged in the development and approval of several important medicines. He is an accomplished life sciences executive and his perspective in guiding life sciences companies will provide our board with valuable insights as we look ahead to key clinical development and operating milestones." Dr. Miralles has served as Chief Executive Officer at AZURNA Therapeutics, Inc., a private pharmaceutical development company, since January 2024. From December 2020 to September 2022, Dr. Miralles was Chief Executive Officer at Laronde Inc., an early-stage biotechnology company. From August 2017 to September 2020, Dr. Miralles served as Chief Executive Officer at Vividion Therapeutics, Inc., a private biopharmaceutical company. From October 2007 to March 2016, Dr. Miralles held executive positions of increasing responsibility leading various research and clinical development programs at Johnson & Johnson. Dr. Miralles has served on the board of directors of Artiva Biotherapeutics, Inc., a publicly traded biotechnology company, since May 2024 and in January 2025, he was appointed as chair of the Clinical Strategy Committee. Dr. Miralles has also been a member of the board of directors at Rady Children's Institute for Genomic Medicine since 2008 and served as a member of the board of directors at NeuBase Therapeutics, Inc., a public biopharmaceutical company, from April 2019 to April 2021. Dr. Miralles received his M.D. degree from the University of Buenos Aires, his residency in Internal Medicine at the Mayo Clinic and fellowship in Infectious Diseases at The New York Hospital/Cornell University and was on the faculty at Duke University. "I am impressed with Contineum's progress as it works to meet the significant unmet needs in several NI&I indications," stated Dr. Miralles. "The Company's robust pipeline enables multiple opportunities with de-risked, clinically-validated targets. I am thrilled to join a passionate board of directors with a unified vision to help guide the Company as it initiates multiple proof-of-concept clinical trials." About Contineum Therapeutics Contineum Therapeutics (Nasdaq: CTNM) is a clinical-stage biopharmaceutical company pioneering novel, oral small molecule therapies for NI&I indications with significant unmet need. Contineum is advancing a pipeline of internally-developed programs with multiple drug candidates now in clinical trials. PIPE-791 is an LPA1 receptor antagonist in clinical development for idiopathic pulmonary fibrosis, progressive multiple sclerosis and chronic pain, and PIPE-307 is a selective inhibitor of the M1 receptor in clinical development for relapsing-remitting multiple sclerosis and major depressive disorder. For more information, please visit Forward-Looking Statements Certain statements contained in this press release, other than historical information, constitute forward-looking statements within the meaning of the federal securities laws. Forward-looking statements include, but are not limited to, statements regarding the Company's plans for, and the anticipated benefits of, and market opportunities for its drug candidates, including PIPE-791 and PIPE-307; its business strategies and plans; and the quotations of the Company's management and board members. These statements involve known and unknown risks, uncertainties and other important factors that are in some cases beyond the Company's control and may cause its actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. These risks and uncertainties, include, but are not limited to, the following: the Company is heavily dependent on the success of PIPE-791 and PIPE-307, both of which are in the early stages of clinical development, and neither of these drug candidates may progress through clinical development or receive regulatory approval; the results of earlier preclinical studies and clinical trials, including those conducted by third parties, may not be predictive of future results and unexpected adverse side effects or inadequate efficacy of the Company's drug candidates may limit their development, regulatory approval and/or commercialization; the timing and outcome of research, development and regulatory review is uncertain; clinical trials and preclinical studies may not proceed at the time or in the manner expected, or at all; the potential for our programs and prospects to be negatively impacted by developments relating to our competitors, including the results of studies or regulatory determinations relating to our competitors; risks associated with reliance on third parties to successfully conduct clinical trials and, in the case of PIPE-307, the Company's reliance, pursuant to a global license and development agreement, upon Janssen Pharmaceutica NV, a Johnson & Johnson company, to develop PIPE-307 for any other indication other than RRMS and, after completion of the Company's PIPE-307 Phase 2 VISTA trial, Janssen Pharmaceutica NV's decision, in its sole discretion, whether or not to further develop PIPE-307 for RRMS; the Company has incurred significant operating expenses since inception and it expects that its operating expenses will continue to significantly increase for the foreseeable future; the Company's license agreement with Janssen Pharmaceutica NV may not result in the successful development of PIPE-307; the Company may be unable to obtain, maintain and enforce intellectual property protection for its technology and drug candidates; and unstable market and economic conditions and military conflict may adversely affect our business and financial condition and the broader economy and biotechnology industry. Additional risks and uncertainties that could affect the Company's business, operations and results are included under the captions, "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operations" in its most recent filing on Form 10-K and in other filings that it makes with the SEC from time to time. These documents are available on the Company's website at under the Investor section and on the SEC's website at Accordingly, readers should not rely upon forward-looking statements as predictions of future events. Except as required by applicable law, the Company undertakes no obligation to update publicly or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise. View source version on Contacts Steve KunszaboContineum TherapeuticsSenior Director, Investor Relations & Corporate Communications858-649-1158skunszabo@
Yahoo
28-01-2025
- General
- Yahoo
Column: Did a famous grave in the Altadena hills survive the fires?
On a hill above Altadena named Little Round Top, a grave stood for 136 years as the community below it blossomed. Here lay the remains of Owen Brown, son of the legendary abolitionist John Brown. Owen moved to Pasadena in the 1880s and was greeted by locals as a hero for fighting alongside his father in the Bleeding Kansas wars and Harper's Ferry raid. His funeral in 1889 attracted thousands of mourners, and he was put to rest near a cabin where he and a brother spent his last years. The grave became a place of veneration, then a site of controversy in the early 2000s when Little Round Top's owner began to shoo away the curious. Lawsuits were filed to push for public access. Brown's tombstone disappeared for a decade before being found hundreds of feet down the hill. His final resting place is now open to the public. A new owner gave a local group $300,000 to restore it in 2018, the Los Angeles County Board of Supervisors designated it as a historical landmark in December, and the site is now under the care of the Santa Monica Mountains Conservancy. The saga was supposed to get its most prominent airing yet on Wednesday at Mountain View Cemetery, where two of Owen's siblings are buried and where a plaque is inscribed with his name and image. Altadena resident and filmmaker Pablo Miralles had been scheduled to debut a 20-minute documentary on Owen's life. Read more: John Brown's Son Escaped to Southland Facebook is where I learned about the screening. Facebook is also where I learned that Miralles and his family lost their home in the Eaton fire. He and his son fled with important documents, photos and a painting his grandmother took with her as she escaped the Nazi invasion of the Netherlands. Gone are Miralles' production notebook and the final paychecks for his crew. The documentary was already saved online, though Miralles has no idea when it will screen. 'People need to find places to live — we need to find a place to live,' said Miralles last week at Stumptown Coffee in Pasadena. 'I'm proud of my film, but it can wait.' Few were better qualified to make a documentary about Owen Brown than Miralles. His parents, immigrants from Argentina, moved from Eagle Rock to Altadena in the 1970s after finding a home large enough for them and their seven children. They ignored friends who said Altadena was 'dangerous' and financed the purchase through a Black-owned bank. Their regular bank had refused 'because they told my father that our house would be on a Black street,' Miralles said. He remembers a bucolic upbringing in a multiracial paradise that informed the rest of his life and eventually became his muse. The 60-year-old created a well-received documentary about how his alma mater, John Muir High in Pasadena, resegregated as white families enrolled their children in private and charter schools. Last year, Miralles wrote and directed a play that imagined a friendship between two of the City of Roses' most famous natives, Julia Child and Jackie Robinson. (I appeared in his 2012 documentary about the intense soccer rivalry between the U.S. and Mexico). 'I didn't know I would cover Pasadena like I have,' he said, 'but when you recognize that you came from a place with a history of struggle, you kind of have to.' Altadena's charm lured Miralles back as a resident in 2019. By then, he had made a four-minute short for the Owen Brown Gravesite Committee about their cause. 'You learn about [John Brown] in school, that he's a maniac and a madman intent on killing white slave owners,' said Miralles, who had hiked up to Owen's grave but otherwise didn't know much about him at the time. "But when you read his papers, he wasn't that at all.' Miralles' short film impressed committee chair Michele Zack. She asked Miralles to make a longer film that the Pasadena Unified School District could show in classrooms. Owen joined his father in the armed conflicts that made John Brown such a divisive figure in U.S. history. In Kansas, Owen killed a man in a skirmish between abolitionists and pro-slavery settlers. He stayed behind to guard weapons and horses while his father led the raid on Harper's Ferry in 1859, which resulted in the deaths of two of Owen's brothers and in John's capture and execution. 'The 1850s resonate so strongly with what's happening right now,' said Zack, who also lost her home in the Eaton fire. 'You think we're divided now? We were divided even more in the 1850s. Owen Brown is symbolic of all that, and here's this history right in our backyard.' She still wants to screen the Brown documentary to the public — but not any time soon. "There's so much suffering and loss and pain right now, and that's going to go on for years — but we're not going to postpone [the film] for years," Zack said. Miralles and his team were busy putting the final touches on the project. In fact, the sound engineer was working on it the day the Eaton fire forced him to evacuate (his house remains standing). "The idea that the original radical abolitionists have their literal roots here — the man is still there, his bones are there — is just so important," Miralles said. "We need to live up to the ideals of this nation like Owen, which means we locals will fight to maintain diversity here." He looked at his phone's home screen to check the time. It featured a photo of him, his wife, their son and their two dogs at their home in early January. Read more: History etched in stone We got into his SUV and drove into Altadena. The plan was to visit his incinerated home, then see if Brown's grave came out unscathed. Neither he nor Zack knew its fate. Miralles drove by his former school, Franklin Elementary — destroyed. A chimney was all that remained of the home where his brother lived. 'Here are a lot of my friends,' Miralles said with a sigh as his head darted from side to side. 'Just blocks and blocks and blocks.' He decided to not stop at his home 'because I don't want to put on a hazmat suit again.' Instead, we passed through checkpoint after checkpoint — 'Military vehicles in my hood. It's kind of crazy" — before getting on a winding street that ended near Brown's grave. Signs all around warned people to proceed at their own risk. Another proclaimed, 'Looters Will be Shot.' Others said the fire danger was "extreme." The paved street turned into a one-lane gravel road leading into the Angeles National Forest. Miralles parked near a long-abandoned car that occupied the spot 'where Owen's cabin used to be.' A worker from the California Conservation Corps soon approached us to ask what we were doing up there. Miralles explained the purpose of our visit. The worker nodded. 'I wondered why there was a trail going up there,' he said, waving over to Little Round Top before walking back to clear more brush. The first part of the trail is narrow, with a steep drop that forced me to look ahead instead of writing in my notebook. Vibrant yucca, scrub oak and sage stood alongside dried-out chaparral. Along the way were interpretive signs that told the stories of two pioneers of Black Los Angeles: Biddy Mason, a formerly enslaved woman who became a wealthy property owner downtown, and Robert Owens, a successful businessman and Mason's relative by marriage who used to collect wood in the hills we were trekking through. We eventually got to the base of Little Round Top, named after a famous Civil War battle, and looked down at a devastated Altadena of blackened trees and leveled properties. I asked Miralles what he saw. 'It's not what I see,' he replied. 'It's what I don't see.' From there, we hiked up a short but steep switchback that ended on a dirt plateau. Pine trees offered shade for two benches. Before us was Brown's grave. Stones outlined where his body lies. Someone had drawn a heart in the dirt. At the head of the grave was a tombstone that listed Brown's name, his years of life and the legend 'Son of John Brown the Liberator.' There were no signs of fire damage. Miralles looked relieved. 'There used to be way more vegetation here, but it's all cleared,' he said as we looked down at Altadena again. To our right in the distance was La Cañada Flintridge. A streak of pink fire retardant soiled the valley below. 'I hope people recognize the importance of this grave and what Owen and his family represented for this country,' he said as we looked at Brown's tombstone. Then he looked back to his Altadena. A plume of dust now rose from a neighborhood. "I used to hike these hills growing up. There would be fires every three to four years, he said. "But I never thought what happened to us would ever happen." Sign up for Essential California for news, features and recommendations from the L.A. Times and beyond in your inbox six days a week. This story originally appeared in Los Angeles Times.
Los Angeles Times
28-01-2025
- General
- Los Angeles Times
Column: Did a famous grave in the Altadena hills survive the fires?
On a hill above Altadena named Little Round Top, a grave stood for 136 years as the community below it blossomed. Here lay the remains of Owen Brown, son of the legendary abolitionist John Brown. Owen moved to Pasadena in the 1880s and was greeted by locals as a hero for fighting alongside his father in the Bleeding Kansas wars and Harper's Ferry raid. His funeral in 1889 attracted thousands of mourners, and he was put to rest near a cabin where he and a brother spent his last years. The grave became a place of veneration, then a site of controversy in the early 2000s when Little Round Top's owner began to shoo away the curious. Lawsuits were filed to push for public access. Brown's tombstone disappeared for a decade before being found hundreds of feet down the hill. His final resting place is now open to the public. A new owner gave a local group $300,000 to restore it in 2018, the Los Angeles County Board of Supervisors designated it as a historical landmark in December, and the site is now under the care of the Santa Monica Mountains Conservancy. The saga was supposed to get its most prominent airing yet on Wednesday at Mountain View Cemetery, where two of Owen's siblings are buried and where a plaque is inscribed with his name and image. Altadena resident and filmmaker Pablo Miralles had been scheduled to debut a 20-minute documentary on Owen's life. Facebook is where I learned about the screening. Facebook is also where I learned that Miralles and his family lost their home in the Eaton fire. He and his son fled with important documents, photos and a painting his grandmother took with her as she escaped the Nazi invasion of the Netherlands. Gone are Miralles' production notebook and the final paychecks for his crew. The documentary was already saved online, though Miralles has no idea when it will screen. 'People need to find places to live — we need to find a place to live,' said Miralles last week at Stumptown Coffee in Pasadena. 'I'm proud of my film, but it can wait.' Few were better qualified to make a documentary about Owen Brown than Miralles. His parents, immigrants from Argentina, moved from Eagle Rock to Altadena in the 1970s after finding a home large enough for them and their seven children. They ignored friends who said Altadena was 'dangerous' and financed the purchase through a Black-owned bank. Their regular bank had refused 'because they told my father that our house would be on a Black street,' Miralles said. He remembers a bucolic upbringing in a multiracial paradise that informed the rest of his life and eventually became his muse. The 60-year-old created a well-received documentary about how his alma mater, John Muir High in Pasadena, resegregated as white families enrolled their children in private and charter schools. Last year, Miralles wrote and directed a play that imagined a friendship between two of the City of Roses' most famous natives, Julia Child and Jackie Robinson. (I appeared in his 2012 documentary about the intense soccer rivalry between the U.S. and Mexico). 'I didn't know I would cover Pasadena like I have,' he said, 'but when you recognize that you came from a place with a history of struggle, you kind of have to.' Altadena's charm lured Miralles back as a resident in 2019. By then, he had made a four-minute short for the Owen Brown Gravesite Committee about their cause. 'You learn about [John Brown] in school, that he's a maniac and a madman intent on killing white slave owners,' said Miralles, who had hiked up to Owen's grave but otherwise didn't know much about him at the time. 'But when you read his papers, he wasn't that at all.' Miralles' short film impressed committee chair Michele Zack. She asked Miralles to make a longer film that the Pasadena Unified School District could show in classrooms. Owen joined his father in the armed conflicts that made John Brown such a divisive figure in U.S. history. In Kansas, Owen killed a man in a skirmish between abolitionists and pro-slavery settlers. He stayed behind to guard weapons and horses while his father led the raid on Harper's Ferry in 1859, which resulted in the deaths of two of Owen's brothers and in John's capture and execution. 'The 1850s resonate so strongly with what's happening right now,' said Zack, who also lost her home in the Eaton fire. 'You think we're divided now? We were divided even more in the 1850s. Owen Brown is symbolic of all that, and here's this history right in our backyard.' She still wants to screen the Brown documentary to the public — but not any time soon. 'There's so much suffering and loss and pain right now, and that's going to go on for years — but we're not going to postpone [the film] for years,' Zack said. Miralles and his team were busy putting the final touches on the project. In fact, the sound engineer was working on it the day the Eaton fire forced him to evacuate (his house remains standing). 'The idea that the original radical abolitionists have their literal roots here — the man is still there, his bones are there — is just so important,' Miralles said. 'We need to live up to the ideals of this nation like Owen, which means we locals will fight to maintain diversity here.' He looked at his phone's home screen to check the time. It featured a photo of him, his wife, their son and their two dogs at their home in early January. We got into his SUV and drove into Altadena. The plan was to visit his incinerated home, then see if Brown's grave came out unscathed. Neither he nor Zack knew its fate. Miralles drove by his former school, Franklin Elementary — destroyed. A chimney was all that remained of the home where his brother lived. 'Here are a lot of my friends,' Miralles said with a sigh as his head darted from side to side. 'Just blocks and blocks and blocks.' He decided to not stop at his home 'because I don't want to put on a hazmat suit again.' Instead, we passed through checkpoint after checkpoint — 'Military vehicles in my hood. It's kind of crazy' — before getting on a winding street that ended near Brown's grave. Signs all around warned people to proceed at their own risk. Another proclaimed, 'Looters Will be Shot.' Others said the fire danger was 'extreme.' The paved street turned into a one-lane gravel road leading into the Angeles National Forest. Miralles parked near a long-abandoned car that occupied the spot 'where Owen's cabin used to be.' A worker from the California Conservation Corps soon approached us to ask what we were doing up there. Miralles explained the purpose of our visit. The worker nodded. 'I wondered why there was a trail going up there,' he said, waving over to Little Round Top before walking back to clear more brush. The first part of the trail is narrow, with a steep drop that forced me to look ahead instead of writing in my notebook. Vibrant yucca, scrub oak and sage stood alongside dried-out chaparral. Along the way were interpretive signs that told the stories of two pioneers of Black Los Angeles: Biddy Mason, a formerly enslaved woman who became a wealthy property owner downtown, and Robert Owens, a successful businessman and Mason's relative by marriage who used to collect wood in the hills we were trekking through. We eventually got to the base of Little Round Top, named after a famous Civil War battle, and looked down at a devastated Altadena of blackened trees and leveled properties. I asked Miralles what he saw. 'It's not what I see,' he replied. 'It's what I don't see.' From there, we hiked up a short but steep switchback that ended on a dirt plateau. Pine trees offered shade for two benches. Before us was Brown's grave. Stones outlined where his body lies. Someone had drawn a heart in the dirt. At the head of the grave was a tombstone that listed Brown's name, his years of life and the legend 'Son of John Brown the Liberator.' There were no signs of fire damage. Miralles looked relieved. 'There used to be way more vegetation here, but it's all cleared,' he said as we looked down at Altadena again. To our right in the distance was La Cañada Flintridge. A streak of pink fire retardant soiled the valley below. 'I hope people recognize the importance of this grave and what Owen and his family represented for this country,' he said as we looked at Brown's tombstone. Then he looked back to his Altadena. A plume of dust now rose from a neighborhood. 'I used to hike these hills growing up. There would be fires every three to four years, he said. 'But I never thought what happened to us would ever happen.'
