Latest news with #NuclearMagneticResonance
The Hindu
07-05-2025
- Science
- The Hindu
CCMB scientists discover proteins flexibility, could lead to new advances in medicine
Scientists at the CSIR-Centre for Cellular and Molecular Biology (CCMB) have shown that proteins do not always rely on their fixed three-dimensional shape for function, but their structures are flexible to carry out multiple tasks. These findings have the potential to pave the way for new advances in medicine, agriculture and biotechnology in helping scientists to design proteins that can multitask more efficiently, said an official release on Wednesday. In a latest study, scientists — Mandar V. Deshmukh, Debadutta Patra and Jaydeep Paul — using a powerful Nuclear Magnetic Resonance (NMR) spectroscopy and computational methods, have detected tiny populations of protein structures (just 1%) that switch into different shapes for short periods. These rare shifts are vital for recognising different RNA forms and help explain how plants manage complex gene control. 'What we have shown is that a protein's ability to change shape, even slightly, can be just as important as its structure,' said lead author Mr. Deshmukh. 'By capturing the fleeting, dynamic states of these proteins, we have shown that their ability to rearrange their structure transiently gives them a functional edge in complex cellular environments,' he said. 'This enables organisms to regulate genes efficiently under varying conditions and could change the way we think about designing new medicines or improving plant traits,' added the scientist. The study shows how subtle changes in a protein's sequence can lead to significant differences in function, emphasising the need for a combined study of both structure and dynamics, particularly for proteins that are drug targets. 'Our results reveal nature's originality in designing a unique approach to grant promiscuity to a few proteins,' remarked joint first authors of the study Mr. Patra and Mr. Paul. This study, published in the latest issue of 'Journal of the American Chemical Society', also offers a plausible explanation for how plants fine-tune RNA processing without expanding their protein repertoire, added the press release.
Yahoo
07-04-2025
- Business
- Yahoo
Bruker Introduces Innovative Fourier 80 Multinuclear Benchtop FT-NMR
Unique Fourier 80 'Multi-Talent' offers 1H NMR and choice of 15 X-nuclei with just one click ASILOMAR, Calif., April 07, 2025--(BUSINESS WIRE)--At the Joint ENC-ISMAR Conference 2025, Bruker Corporation, the leading provider of Nuclear Magnetic Resonance (NMR) spectroscopy solutions, announced the launch of an innovative Fourier 80 multinuclear benchtop FT-NMR spectrometer, known as the 'Multi-Talent' configuration. This novel Fourier 80 'Multi-Talent' system represents a major advancement in permanent magnet-based FT-NMR technology, as its unique, next-generation capabilities meet the evolving needs of academic researchers and industry scientists with dramatically enhanced versatility in benchtop FT-NMR multinuclear analysis. The Fourier 80 'Multi-Talent' system measures or decouples 1H, and in addition can select one of 15 different X-nuclei to be either observed in X{1H} experiments, or selected X-nuclei can be decoupled for proton observation in 1H{X} experiments. This enables many types of X-nucleus observations, various 2D experiments, and importantly also the exquisitely sensitive inverse 1H observation methods for 13C, 19F or 15N experiments. Similarly, the Fourier 80 'Multi-Talent' can observe 19F{1H} with proton decoupling for the simplification of 19F spectra, a capability of high interest to pharmaceutical customers studying fluorinated drug candidates. For battery research, the Fourier 80 'Multi-Talent' enables nuclei observations from Li-brine mining, like 7Li, 23Na, and 11B for the formulation of battery electrolytes. Novel electrochemical systems can be explored to advance next generation battery technologies. These unprecedented benchtop capabilities are selectable via software, eliminating the need for NMR probe tuning and matching. The 'Multi-Talent' uses standard 5 mm NMR samples, includes gradient spectroscopy, with options for adjustable sample temperature (AT), or sample changer automation. The user-friendly Fourier 80 interface ensures that novice and experienced users can navigate through measurements effortlessly, streamlining complex tasks and enhancing productivity. Dr. Agnes Haber, the Fourier 80 Product Manager at Bruker BioSpin, stated: "The Fourier 80 'Multi-Talent' represents a game-changing advancement in benchtop FT-NMR, with next-generation multinuclear capabilities addressing the demand for a versatile system for 1H-NMR, plus an unprecedented choice of fifteen X-nuclei, with ease, and even under automation. We have already successfully installed a dozen Fourier 80 multinuclear systems in customer labs, and we anticipate that this novel system may become the new de facto standard in benchtop multinuclear NMR spectroscopy." About Bruker Corporation – Leader of the Post-Genomic Era (Nasdaq: BRKR) Bruker is enabling scientists and engineers to make breakthrough post-genomic discoveries and develop new applications that improve the quality of human life. Bruker's high performance scientific instruments and high value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular, and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity, and customer success in post-genomic life science molecular and cell biology research, in applied and biopharma applications, in microscopy and nanoanalysis, as well as in industrial and cleantech research, and next-gen semiconductor metrology in support of AI. Bruker offers differentiated, high-value life science and diagnostics systems and solutions in preclinical imaging, clinical phenomics research, proteomics and multiomics, spatial and single-cell biology, functional structural and condensate biology, as well as in clinical microbiology and molecular diagnostics. For more information, please visit View source version on Contacts Investor Contact: Joe KostkaDirector - Investor RelationsBruker CorporationT: +1 (978) 313-5800E: Media Contact: Markus ZieglerSr. Director and Head of Group MarketingBruker BioSpinT: +49 172 373-3531E: pr@
Yahoo
06-03-2025
- Business
- Yahoo
Molecular Spectroscopy Market Size Booms with CAGR 4.9% and Projected to Reach $5.6 Million by 2030
NEW YORK, March 6, 2025 /PRNewswire/ -- According to a comprehensive report from The Insight Partners, "Molecular Spectroscopy Market share and Forecasts 2022 - 2030, Global and Regional Share, Trend, and Growth Opportunity Analysis By Product (Instrument and Accessories), Technology (UV-Visible Spectroscopy, Infrared Spectroscopy, Nuclear Magnetic Resonance Spectroscopy, Raman Spectroscopy, Near-Infrared Spectroscopy, and Others), Application (Academic and Research Applications, Biotechnology Applications, Pharmaceutical Applications, and Others), and Geography (North America, Europe, Asia Pacific, Middle East & Africa, and South & Central America)", The global molecular spectroscopy market is expected to reach US$ 5.6 Million by 2030 from US$ 3.8 Million in 2022; it is estimated to record a CAGR of 4.9% during the forecast period To explore the valuable insights in the Molecular Spectroscopy Market report, you can easily download a sample PDF of the report- The Molecular Spectroscopy Market Report provides valuable insights that help market players identify emerging trends, opportunities, and competitive dynamics. It offers data on market size, growth forecasts, and regional demand, allowing companies to plan effectively. The report also highlights technological advancements, regulatory landscapes, and consumer behavior, enabling players to stay ahead of the curve. By understanding these factors, businesses can make informed decisions on product development, investments, and market strategies, ultimately gaining a competitive edge and driving growth in the market. Competitive Strategy and Development Key Players: Major companies operating in the molecular spectroscopy market are Thermo Fisher Scientific, Inc, Merck KGaA, PerkinElmer Inc., Agilent Technologies, Inc, Bruker, Horiba, Ltd, Shimadzu Corporation, JEOL Ltd, and JASCO, among others. Trending Topics: Process Spectroscopy Market, Computational molecular spectroscopy, UV-visible spectroscopy, Infrared Spectroscopy, Nuclear Magnetic Resonance Spectroscopy, Raman Spectroscopy, Near-Infrared Spectroscopy, Mass spectrometry (MS), etc. Global Headlines on the Molecular Spectroscopy Market Metrohm Expands Raman Portfolio MJH Life Sciences Spectroscopy Announces the Acquisition of Spectroscopy Europe and Spectroscopy World For Detailed Molecular Spectroscopy Market Insights, Visit: Molecular Spectroscopy Market Overview of Report Findings Market Growth: The global molecular spectroscopy market is expected to reach US$ 5.6 Million by 2030 from US$ 3.8 Million in 2022; it is estimated to record a CAGR of 4.9% during the forecast period. Due to technological advancements, increased need for pharmaceutical research and development, stringent environmental monitoring regulations, and food safety standards, the market for molecular spectroscopy is growing significantly. UV-visible, infrared, and NMR spectroscopy are molecular spectroscopy methods commonly used in the biotech and pharmaceutical sectors for qualitative and quantitative analysis, ensuring quality control and compliance. The market is expected to expand gradually over the next several years due to innovation being driven by industry giants like Agilent Technologies and Thermo Fisher Scientific. Pharmaceutical and Biotech Industry Growth: Rigid medication safety laws implemented by agencies such as the FDA and EMA have also forced pharmaceutical companies to employ spectroscopic methods to ensure compliance requirements. Also, the higher incidence of chronic diseases has increased the need for new medicine forms, placing a greater focus on molecular spectroscopy. Since the biotech and pharma industries expand globally, most prominently in developing economies, molecular spectroscopy is expected to be used more and more. Due to this, it is imperative for quality assurance, innovation, and precision in medicine. Raman spectroscopy is used to identify compounds, study molecular structure, and the quality and safety of drugs. Due to these technologies, which are not to be parted with for investigating biomolecules, impurity detection, and reaction monitoring, improved and more effective treatments are formulated. Besides, the need for molecular spectroscopy for protein characterization, stability studies, and process monitoring has increased due to the growth in biologics and biosimilars. Technological Advancements: Miniature spectrometers, sophisticated data analysis software, and Al and machine learning integration are some of the most important developments that have simplified molecular spectroscopy technologies and made them usable in various industries. For instance, with portable and handheld spectrometers, on-site testing is realized in environmental monitoring and food safety. Large-scale molecular analysis is possible owing to the improvements in Raman and Fourier-transform infrared (FTIR) spectroscopy, with increased sensitivity and resolution. These advances are most valuable to pharmaceutical R&D, where accurate characterization of molecules is necessary for drug development. In addition, processes have been streamlined, and real-time monitoring has been enabled by interfacing spectroscopy systems with automation and cloud-based systems. With such advancements evolving, they are expanding the scope of applications of molecular spectroscopy, pushing its application in scientific review and industrial uses. Geographic Insights: In 2023, North America led the market with a substantial revenue share, followed by Europe and Asia Pacific. Further, Asia Pacific is expected to record the highest CAGR during the forecast period. Stay Updated on The Latest Molecular Spectroscopy Market Trends: Market Segmentation Based on product, the molecular spectroscopy market is segmented into instrument and accessories. The instrument segment held a larger share of the market in 2022. In terms of technology, the molecular spectroscopy market is segmented into UV-visible spectroscopy, infrared spectroscopy, nuclear magnetic resonance spectroscopy, Raman spectroscopy, near-infrared spectroscopy, and others. The infrared spectroscopy segment dominated the market in 2022. On the basis of application, the molecular spectroscopy market is segmented into academic and research applications, biotechnology applications, pharmaceutical applications, and others. The pharmaceutical applications segment dominated the market in 2022. The molecular spectroscopy market is segmented into five major regions: North America, Europe, Asia Pacific, the Middle East & Africa, and South & Central America. Purchase Premium Copy of Global Molecular Spectroscopy Market Size and Growth Report (2023-2031) at: Conclusion The molecular spectroscopy market is growing because it is pivotal in many industries, such as pharma, biotech, and research. Molecular spectroscopic methods such as UV-visible, IR, Raman, NMR, and Near-Infrared (NIR) spectroscopy are used widely for qualitative and quantitative analysis of molecules, enabling precise identification, characterization, and monitoring of compounds. Moreover, the technological innovations that have resulted in the miniaturization of devices and increased resolution, along with integration with Al and machine learning, are expanding the scope of spectroscopy applications. Emerging economies also drive market growth through industrialization and research facility investment. Key players such as Thermo Fisher Scientific, Agilent Technologies, and Bruker Corporation are at the forefront of innovation and product development to meet evolving industry demands. With accuracy, compliance with regulations, and as technology innovation becomes imperative for industries, the market for molecular spectroscopy is predicted to grow incrementally, holding tremendous scope for research and industrial innovations. The report from The Insight Partners provides several stakeholders—including manufacturers, sales manager, and end users—with valuable insights into how to successfully navigate this evolving market landscape and unlock new opportunities. Related Reports- Spectroscopy IR Detector Market Size and Forecasts (2021 - 2031), Global and Regional Share, Trends, and Growth Opportunity Analysis Near Infrared Spectroscopy Market Size and Forecasts (2021 - 2031), Global and Regional Share, Trends, and Growth Opportunity Analysis Raman Spectroscopy Market Dynamics, Analysis, Growth, and Trends by 2031 Other related Life Sciences Market Research Reports - About Us: The Insight Partners is a one stop industry research provider of actionable intelligence. We help our clients in getting solutions to their research requirements through our syndicated and consulting research services. We specialize in industries such as Semiconductor and Electronics, Aerospace and Defense, Automotive and Transportation, Biotechnology, Healthcare IT, Manufacturing and Construction, Medical Device, Technology, Media and Telecommunications, Chemicals and Materials. Contact Us: If you have any queries about this report or if you would like further information, please contact us: Contact Person: Ankit MathurE-mail: +1-646-491-9876Press Release- Logo: View original content: SOURCE The Insight Partners
Associated Press
05-03-2025
- Business
- Associated Press
Volt Announces Successful Lithium Extraction from Generation 5 Field Unit in the Permian Basin, Texas, Achieving 99% Recoveries
Generation 5 Field Unit operating since February 11, conducting over 90 system tests to refine operating parameters. Internal Nuclear Magnetic Resonance (NMR) testing confirms lithium recoveries up to 99%, aligning with Volt's previous third-party verifications. System tests provide baseline for near-future automation, with an eye toward optimizing cost, throughput, and overall efficiency. Lithium stockpiling initiated to build inventory for potential customers. CALGARY, Alberta, March 05, 2025 (GLOBE NEWSWIRE) -- Volt Lithium Corp. (TSXV: VLT | OTCQB: VLTLF) ('Volt' or the 'Company') is pleased to announce the continued success of its Generation 5 Field Unit in the Permian Basin, Texas, where the team has achieved up to 99% lithium extraction while evaluating and refining key operating parameters. 'The first 90 system tests have been critical in understanding the full capabilities of our Generation 5 Field Unit,' commented Alex Wylie, President & CEO of Volt. 'We're especially pleased that scaling up to a 10,000-barrel-per-day system continues to deliver 99% extraction results. These insights will guide our next steps toward automating the unit for greater throughput and cost optimization.' Permian Basin Field Operations: Generation 5 Update Largest DLE System Deployed: Generation 5 marks Volt's most extensive and powerful DLE unit to date, transitioning quickly from modular assembly to a 10,000+ bpd operational capacity. High-Efficiency Extraction: The Company has conducted over 90 system tests to date, confirming up to 99% lithium recovery via internal NMR-based testing, which aligns with prior third-party validations of Volt's extraction technology. Establishing Baseline for Automation: Current system tests focus on reagent usage, cycle time, and processing parameters that will inform near-future automation. Once fully implemented, automation is expected to further enhance throughput, reduce costs, and streamline continuous production. Lithium Stockpiling Initiated: Volt has begun stockpiling lithium concentrate in anticipation of commercial demand, creating an inventory that positions the Company for future customer engagement. Volt will continue to refine operating metrics in the coming weeks, laying a solid foundation for automated, larger-scale operations. About Volt Volt is a lithium development and technology company aiming to be one of North America's first commercial producers of lithium from oilfield brine. Our strategy is to generate value for shareholders by leveraging management's hydrocarbon experience and existing infrastructure to extract lithium deposits from existing wells, thereby reducing capital costs, lowering risks and supporting the world's clean energy transition. With four differentiating pillars, and a proprietary Direct Lithium Extraction ('DLE') technology and process, Volt's innovative approach to development is focused on allowing the highest lithium recoveries with lowest costs, positioning us well for future commercialization. We are committed to operating efficiently and with transparency across all areas of the business staying sharply focused on creating long-term, sustainable shareholder value. Investors and/or other interested parties may sign up for updates about the Company's continued progress on its website: Alex Wylie, President & CEO T: +1.403.830.5811 or Bill McClain, Investor Relations T: +1.604.773.9423 Forward-Looking Statements This news release includes certain 'forward-looking statements' and 'forward-looking information' within the meaning of applicable Canadian securities laws. When used in this news release, the words 'anticipate', 'believe', 'estimate', 'expect', 'target', 'plan', 'forecast', 'may', 'will', 'would', 'could', 'schedule' and similar words or expressions, identify forward-looking statements or information. Statements, other than statements of historical fact, may constitute forward-looking information and include, without limitation, information with respect to the terms of the operational milestone, Volume Scale-up. Extraction Time Improvements and Continuous Processing vs Batch Processing, the deployment of the Field Unit in the Permian Basin, the production of battery grade lithium by the Field Unit, and the commercial production of lithium from oilfield brine. With respect to the forward-looking information contained in this press release, the Company has made numerous assumptions. While the Company considers these assumptions to be reasonable, these assumptions are inherently subject to significant uncertainties and contingencies and may prove to be incorrect. Additionally, there are known and unknown risk factors which could cause the Company's actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking information contained herein including those known risk factors outlined in the Company's annual information form for the year ended June 30, 2024 and (final) short form base shelf prospectus dated July 20, 2023. All forward-looking information herein is qualified in its entirety by this cautionary statement, and the Company disclaims any obligation to revise or update any such forward-looking information or to publicly announce the result of any revisions to any of the forward-looking information contained herein to reflect future results, events or developments, except as required by law.
Yahoo
06-02-2025
- Health
- Yahoo
Scientists say boiled eggs should be cooked for 32 minutes for 'perfect' result
Scientists have unveiled the best method to cook the 'perfect' boiled egg - but it's not for those who lack patience. The Italian National Research Council has revealed their new method - which they call "periodic cooking" - takes around 32 minutes. They say the time needed is "optimal" for boiling both the yolk and white of a chicken egg. The pioneering approach provides an evenly-cooked egg with a higher nutritional content than shell-on eggs cooked by conventional boiling or sous vide methods, according to the study published in the journal Communications Engineering. READ MORE: 'They must be panicking' - Paul Merson slams Man City transfer deadline day move as warning sent READ MORE: Air fryer warning as owners told to avoid using popular ingredient to prevent 'damage' But it won't be ideal for anyone wanting a quick breakfast as it takes over half-an-hour. Study leader Dr Pellegrino Musto explained: "The yolk and white in chicken eggs cook at two different temperatures: the albumen cooks at 85 degrees Celsius, while the yolk cooks at 65 degrees Celsius. "Conventional methods for cooking eggs by hard-boiling at 100 degrees Celsius result in the yolk being fully set, while cooking them at temperatures between 60 and 70 degrees Celsius in a water bath for one hour - a method known as sous vide - leaves the white undercooked." Dr Musto of the Italian research team, along with his colleagues, developed the method for consistently cooking eggs by first simulating the process in computational fluid dynamics software. He said: "The simulations suggested a method that consists of alternating an egg between a pan of boiling water kept at 100 degrees Celsius and a bowl kept at 30 degrees Celsius, transferring the egg from one to the other every two minutes for a total duration of 32 minutes." The research team then trialled the process in real life to produce food samples to analyse. Hard-boiled, soft-boiled, and sous vide eggs were also included in the analysis — the final cooked eggs were tested for their texture and sensory qualities, with their chemical properties evaluated using Nuclear Magnetic Resonance and High-Resolution Mass Spectrometry. Dr Musto said: "Periodically-cooked eggs had a soft yolk similar to that of a sous vide egg, while the consistency of the white was somewhere between that of sous vide and soft-boiled. "Temperatures in the periodically-cooked egg white ranged between 35 and 100 degrees Celsius during cooking, while the yolk remained at a consistent temperature of 67 degrees Celsius." He added: "Chemical analysis suggested that the periodically-cooked egg yolks also contained more polyphenols — micronutrients which have been explored for their health benefits." The research team believe their "egg-cellent" approach could also have applications in the curing and crystallisation of other materials.
