Latest news with #PAPD5
South China Morning Post
28-04-2025
- Health
- South China Morning Post
Scientists in Hong Kong offer new hope into treatment of Huntington's Disease
A research team at the Chinese University of Hong Kong (CUHK) has discovered a new underlying mechanism and possible therapeutic target for Huntington's Disease, a rare, incurable disease that can cause twitching movements and cognitive decline. Advertisement The team of the School of Life Sciences at CUHK revealed on Monday that they had found a 4.5-fold increase in the level of a protein called PAPD5 in the brains of patients with Huntington's Disease compared to healthy individuals, which contributed to neuronal apoptosis, or nerve cell death. Their research showed that blocking the activity of PAPD5 could reduce these harmful effects, opening up new possibilities for developing medication. The research paper was published in the international journal Nature Communications on April 9. 'We provide a new angle to understand the underlying mechanism. This PAPD5-mediated pathway was first uncovered in our study. It has not been reported before,' said Stephen Chen Zhefan, the assistant professor at the School of Life Sciences at CUHK and the lead author of the paper. Advertisement 'In addition to strengthening our understanding of the disease mechanisms, we also propose a new target for the future, a therapeutic development against Huntington's Disease.'
RTHK
28-04-2025
- Health
- RTHK
'New drug possibilities for Huntington's patients'
'New drug possibilities for Huntington's patients' The Chinese University research team is applying for a United States patent to use PAPD5 and BCH001 in treating Huntington's disease. Photo: RTHK A Chinese University research team on Monday announced that they have taken a vital step forwards finding a treatment for Huntington's disease patients, after they discovered an enzyme linked to the disease and its corresponding inhibitor. Patients of the rare inheritable disease mainly exhibit symptoms of uncontrolled muscle movements and cognitive decline, with some developing psychiatric disturbances. Currently, there is no cure for the disease. The team found that the level of an enzyme, known as PAPD5, is almost five times higher in patients with the disease compared with healthy individuals, with researchers saying the enzyme can be suppressed by the BCH001 inhibitor. 'So if there's a high PAPD5 level exhibited in the patient's brain cells, after treating the BCH001, the activity of PAPD5 will be lowered back to the normal level, and that would be the treatment strategy we have in mind,' said Professor Edwin Chan, who heads the team. The team is applying for a United States patent to use PAPD5 and BCH001 in treating the disease. It is also still finding other methods to inhibit the PAPD5 enzyme, and evaluating their effectiveness on cellular and rodent models. In Europe, seven out of 100,000 people have Huntington's disease. In Hong Kong, 20 patients were identified from 1984 to 1991. Chan said doctors currently treat the disease by suppressing its symptoms.
