Latest news with #PAXG
Medscape
a day ago
- Health
- Medscape
In Pancreatic Cancer, Does New PAXG Beat Out mFOLFIRINOX?
CHICAGO — For patients with pancreatic resectable stage I-Ill pancreatic ductal adenocarcinoma (PDAC), neoadjuvant chemotherapy can help improve overall survival compared with upfront surgery. But what chemotherapy regimen provides the best survival outcomes? Findings from the phase 3 CASSANDRA PACT-21 trial, presented at the American Society of Clinical Oncology (ASCO) 2025 Annual Meeting, revealed that a newer regimen — PAXG chemotherapy — significantly prolonged event-free survival compared with standard-of-care chemotherapy with mFOLFIRINOX. Although immature, the overall survival data suggest that PAXG — capecitabine, cisplatin, nab-paclitaxel, and gemcitabine — may beat out mFOLFIRINOX — oxaliplatin, irinotecan, leucovorin, and 5-fluorouracil. PAXG also led to a significant improvement in key secondary outcomes, including the disease control rate, pathological stage, and detection of intraoperative or early postoperative metastases. Should these findings change practice? PAXG appears to be the 'most suitable option' for neoadjuvant treatment of these patients, reported Michele Reni, MD, with the Department of Medical Oncology, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy, who presented the findings at ASCO. However, study discussant Brian Wolpin, MD, MPH, is not yet ready to call PAXG the new standard of care. While preoperative PAXG is a 'very promising approach with the potential to change standard of care, more follow-up is needed, particularly overall survival data, to decide whether it should change our standard of care,' said Wolpin, chair of pancreatic cancer at Dana-Farber Cancer Institute in Boston, Massachusetts. In other words, the data are 'not quite sufficient' at this point to change standard of care, Wolpin said. The CASSANDRA PACT-21 trial enrolled 261 patients aged 75 and younger with treatment-naive stage I-III resectable or borderline resectable PDAC and a Karnofsky performance status (KPS) greater than 60%. After CA19-9 stratification, 133 were randomly allocated to PAXG and 128 to mFOLFIRINOX administered every 14 days for 4 months. After this, a second randomization was performed, with patients assigned to receive either 2 additional months of the same chemotherapy regimen followed by surgery, or surgery followed by the same chemotherapy. The primary endpoint was event-free survival, defined as absence of progression, recurrence, two consecutive CA19-9 increases ≥ 20% separated by at least 4 weeks, unresectability, intraoperative metastasis, or death. Median follow-up was 24.5 months in the PAXG group and 26 months in the mFOLFIRINOX group. In the final analysis, with 179 events, median event-free survival was 16 months with PAXG vs 10 months with mFOLFIRINOX. The 3-year event-free survival rate was 31% with PAXG vs 13% with mFOLFIRINOX (hazard ratio [HR], 0.64; P = .003). Subgroup analyses showed a doubling of 3-year event-free survival with PAXG over mFOLFIRINOX in the resectable group (41% vs 22%) and borderline resectable group (19% vs 9%), Reni noted. Reni said the overall survival data are immature, but favor PAXG over mFOLFIRINOX, with median overall survival of 37 months vs 26 months and a 3-year overall survival rate of 51% vs 40% (HR, 0.70; P = .07). Regarding key secondary endpoints, PAXG significantly improved the disease control rate (98% vs 91%), CA19-9 response ≥ 50% rate (88% vs 64%), pathological complete response rate (3% vs 0%), N0 resection rate (36% vs 23%), and detection of intra- or postoperative metastases (5% vs 12%). The secondary endpoints 'add some additional evidence' suggesting that PAXG may be an effective regimen compared to mFOLFIRINOX, Wolpin told ASCO attendees. In terms of adverse events, no statistically significant difference was detected, except for a higher rate of grade 3-4 neutropenia in the PAXG group (42% vs 29%), Reni reported. There was a trend toward worse score in nausea/vomiting scale in the mFOLFIRINOX group at 4 months compared with baseline. At 4 months, both groups had clinically meaningful deterioration in fatigue, taste, weight loss concern, and hepatic symptoms. In his discussion, Wolpin noted that even though PAXG looks like it may be a more effective therapy in preventing recurrence, the event-free survival rate was still only 31% at 3 years. "This really shows that we may hit a plateau with what we can do with chemotherapy and surgery, and there has to be some additional thought and implementation of biologically driven therapies,' he explained. Looking to the future, 'I eagerly await further survival data from the CASSANDRA trial," alongside other relevant trial data from PREOPANC-3 and ALLIANCE A021806, to "help define the appropriate therapy for these patients," Wolpin said.
Yahoo
17-04-2025
- Business
- Yahoo
Bitget Wallet makes surprising push into tokenized gold trading
Bitget Wallet is capitalizing on worldwide financial anxiety with the launch of tokenized gold trading through PAXG—a token issued by Paxos. As gold prices surged over $3,200 in light of increasing geopolitical tensions, the non-custodial wallet enabled the buying and trading of digital gold on a blockchain. The move is part of a larger trend of merging real-world asset trading with Web3 infrastructure. Each PAXG token is offered 1:1 with a physical ounce of gold on deposit in a vault, providing users a theoretically blockchain-based method to hedge against inflation and market volatility. Bitget Wallet supports both spot and futures trading on PAXG, representing how digital wallets are expanding from passive storage of assets to trading platforms. To drive usage, Bitget tied the launch of PAXG to a trading campaign set to last until April 20, which has a total prize pool of $9,000 in prizes. While it is not uncommon to see trading incentives like this in the DeFi space, it comes at a time when crypto platforms are trying to incentivize returns amid dipping retail volume and a cautious market sentiment. While Bitget Wallet presents slick messaging around stability and accessibility, it should also be viewed in the context of the emerging race among wallets and exchanges to provide tokenized versions of traditional assets and monetize the narrative around safety and security in uncertain financial times. "As traditional finance and Web3 converge, we believe digital access to real-world assets like gold should be effortless," said Alvin Kan, COO of Bitget Wallet. He also noted that, "With this campaign, we're giving users an easy way to tap into the gold narrative while enjoying the full benefits of onchain trading." At the time of writing, PAXG is trading at $3,238.84, as per CoinMarketCap's price feed. The current price is up by 7.15% in the last seven days. Sign in to access your portfolio
Yahoo
11-04-2025
- Business
- Yahoo
Gold Rally Makes Tether's XAUT Top-Performing Digital Asset as Crypto Markets Remain Flat
Tokenized gold, such as Tether's XAUT and Paxos' PAXG continued to be a favorite of crypto investors in Asia as investors seek a safe haven despite a de-escalation in trade war tensions. On-chain data shows that Tether's XAUT was a top-10 market performer out of all digital assets. Tether's tokenized gold, the largest by market cap, is up 3.4% in the last 24 hours. CoinGecko data shows the sector is up 4.3% in the last 24 hours, compared to the CoinDesk 20, an index of the performance of the largest digital assets, which is down 2%. The price of gold initially moved down during the early hours of the Asia trading day, after breaching an all-time high during the end of U.S. hours. It's currently trading for $3218 in Hong Kong. Equity markets in Asia showed mixed performance in the morning session, with Hong Kong's Hang Seng down 0.2%, Shanghai's SSE up 0.12%, Taipei's TAIEX up 1.6%, and Tokyo's Nikkei 225 down 3.5%. Gold typically rallies during periods of heightened economic or geopolitical uncertainty, as investors seek safety in assets seen as stores of value amid volatility. While trade tensions have calmed, investors are concerned about the lack of predictability in policy from the White House. Gold also benefits from an inverse relationship with interest rates: lower rates reduce the opportunity cost of holding non-yielding gold, making it more attractive. Investors are also concerned about the surging U.S. budget deficit. China state media is also reporting that stimulus measures are in the works for the country, with interest rate cuts and government spending to the tune of $136 billion proposed. Other market leaders include Curve DAO's CRV, up 18% on-day after news that the U.S. plans to significantly relax rules and enforcement pertaining to Decentralized Finance (DeFi). Sign in to access your portfolio
Yahoo
06-04-2025
- Business
- Yahoo
Gold-backed tokens slide as 'Liberation Day' tariffs put markets in meltdown
Gold-pegged cryptocurrencies Paxos Gold (PAXG) and Tether Gold (XAUT) eased from all-time peaks on Friday after a global financial market rout erased $2.5 trillion from shares in the United States. On April 1, gold hit a historical milestone its all-time high of $3167. Following on the heel of gold's all-time high, both tokens spiked on safe-haven demand initially. PAXG surged to an all-time high of $3,191 while XAUT climbed to $3,190, both above spot gold's high. However, the momentum was weak. PAXG dropped to $3,074 and XAUT to $3,064, mirroring spot gold's decline to $3,038 per ounce. The drop came after President Donald Trump announced reciprocal tariffs that unnerved investors and set off one of the sharpest stock market declines in years. Goldcoin (GLC) — yet another gold-pegged cryptocurrency — also displayed abnormal price volatility. It rose more than 17% in the past 24 hours, trading at $0.01056 at the last check. Its 24-hour trading volume rocketed 2800% higher, but from a low base. Although it is on an upward streak, GLC has one of the highest storage fees in the industry, at 0.6%, which could make it less attractive for long-term holders. Meld Gold (MCAU) maintained a relatively steady price of $57.66, up only 1.39% on the day after months of sideways action. Analysts like Peter Schiff find that while gold acts as a hedge in such uncertain times, sizeable losses and sell-offs on-equity markets often lead to the liquidation of even safe-haven assets to meet margin calls or stem wider portfolio drawdowns. On April 1, Schiff said, 'Today, as economic uncertainty spooks investors, they're again dumping stocks, but gold is rising. Gold has replaced Treasuries as the global safe haven. The implications are ominous' on X. According to the latest data, the market capitalization of leading tokenized gold cryptocurrencies is about $1.59 billion, with a 24-hour trading volume of about $113.7 million. This is a 1.93% decrease in the overall market cap and a 43.25% decrease in 24-hour trading volume.
Yahoo
04-04-2025
- Business
- Yahoo
Gold-Backed Cryptocurrencies Retreat From All-Time Highs Amid Stock-Market Rout
Gold-backed cryptocurrencies like Paxos Gold (PAXG) and Tether Gold (XAUT) retreated from record highs on Friday amid a global financial-markets sell-off that erased $2.5 trillion from U.S. equities alone in a single day after U.S. President Donald Trump unveiled his reciprocal tariffs. The tokens, which are backed by physical gold and track its price, initially rallied as investors sought shelter from the uncertainty the tariffs introduced. Gold is usually seen as a haven investment, but large-scale losses in equity markets often force investors to liquidate safer assets to cover margin calls and cash out losses. PAXG climbed to an all-time high of $3,191 with XAUT following closely behind to reach $3,190, exceeding spot gold's peak of $3,167. The initial rise didn't last, with PAXG dropping to $3,074 and XAUT to $3,064, mirroring gold's pullback to $3,038 per ounce. The tariffs announced on Wednesday spooked markets with their breadth and unclear targets. Investors, already jittery from a volatile global outlook, responded swiftly. The S&P 500 posted one of its steepest drops since the COVID-era panic in 2020 on Thursday, while the Nasdaq 100 saw its worst single-day point loss in history according to the Kobeissi Letter. The rout extended into a second day, with the MSCI World Index dropping 4.3% on Friday after losing 3.7% on Thursday. Still, gold-backed tokens remain 17% higher since the start of the year. The rally has been driven by Federal Reserve interest-rate cuts, sustained demand from Asia and a wave of central bank buying earlier in the year. In February, central banks reported net gold purchases of 24 metric tons, according to the World Gold Council. Poland led the pack, adding 29 tons and bringing its total reserves to 480 tons, now 20% of its foreign exchange holdings. China, Turkey, Jordan, and Qatar also increased their holdings. Sign in to access your portfolio
