Latest news with #PCD
Time of India
05-05-2025
- Health
- Time of India
AIIMS researchers pioneer breakthrough diagnostic tool for rare genetic disorders
New Delhi: Researchers at the AIIMS-Delhi have developed a powerful new method to diagnose Primary Ciliary Dyskinesia , or PCD, a rare and often misdiagnosed genetic disorder affecting the respiratory system. The innovative technique, built around transmission electron microscopy , or TEM, stands to revolutionise the way ciliary disorders are detected and understood. The breakthrough, led by Dr Subhash Chandra Yadav, Electron Microscope Facility, Department of Anatomy, and Professor Kana Ram Jat, Department of Paediatrics, was published recently in the journal Microscopy and Microanalysis (University of Oxford). Published under the title 'An Innovative TEM-Based Ultrastructural Imaging Methodology for the Diagnosis of Respiratory Ciliary Disorders,' the study detailed the method that improves diagnostic accuracy dramatically by identifying structural defects in motile cilia in nearly 70 per cent of suspected cases -- an achievement unmatched even by cutting-edge whole-genome sequencing. The method was used on 200 patients with suspected ciliary disorders, and confirmed diagnoses in 135 cases. The scope of the technique extends far beyond PCD, researchers claimed. It can accurately detect a range of rare ciliary disorders related conditions, including respiratory anomalies, renal cystic disease, blindness, neural tube defects, intellectual disability, skeletal abnormalities (such as polydactyly and abnormally short limbs), ectodermal defects, situs inversus (a condition where internal organs are mirrored), and infertility. What sets this methodology apart is its comprehensive and refined workflow, researchers said. From meticulous sample collection and fixation to ultra-thin sectioning and advanced TEM imaging, every step is optimised to enhance the visibility of tiny defects - boosting detection capability by nearly 640 times compared to conventional methods, they said. Medical experts hail this innovation as a game-changer in genetic diagnostics. It promises faster and more accurate diagnoses and lays the groundwork for tailored therapies, improved patient care, and deeper insights into the mechanisms of ciliary disorders, said one of the authors.
The Print
04-05-2025
- Health
- The Print
AIIMS researchers pioneer breakthrough diagnostic tool for rare genetic disorders
The breakthrough, led by Dr Subhash Chandra Yadav, Electron Microscope Facility, Department of Anatomy, and Professor Kana Ram Jat, Department of Paediatrics, was published recently in the journal Microscopy and Microanalysis (University of Oxford). The innovative technique, built around transmission electron microscopy, or TEM, stands to revolutionise the way ciliary disorders are detected and understood. New Delhi, May 4 (PTI) Researchers at the AIIMS-Delhi have developed a powerful new method to diagnose Primary Ciliary Dyskinesia, or PCD, a rare and often misdiagnosed genetic disorder affecting the respiratory system. Published under the title 'An Innovative TEM-Based Ultrastructural Imaging Methodology for the Diagnosis of Respiratory Ciliary Disorders,' the study detailed the method that improves diagnostic accuracy dramatically by identifying structural defects in motile cilia in nearly 70 per cent of suspected cases — an achievement unmatched even by cutting-edge whole-genome sequencing. The method was used on 200 patients with suspected ciliary disorders, and confirmed diagnoses in 135 cases. The scope of the technique extends far beyond PCD, researchers claimed. It can accurately detect a range of rare ciliary disorders related conditions, including respiratory anomalies, renal cystic disease, blindness, neural tube defects, intellectual disability, skeletal abnormalities (such as polydactyly and abnormally short limbs), ectodermal defects, situs inversus (a condition where internal organs are mirrored), and infertility. What sets this methodology apart is its comprehensive and refined workflow, researchers said. From meticulous sample collection and fixation to ultra-thin sectioning and advanced TEM imaging, every step is optimised to enhance the visibility of tiny defects — boosting detection capability by nearly 640 times compared to conventional methods, they said. Medical experts hail this innovation as a game-changer in genetic diagnostics. It promises faster and more accurate diagnoses and lays the groundwork for tailored therapies, improved patient care, and deeper insights into the mechanisms of ciliary disorders, said one of the authors. PTI PLB VN VN This report is auto-generated from PTI news service. ThePrint holds no responsibility for its content.
Time of India
02-05-2025
- Health
- Time of India
AIIMS scientists develop new method to diagnose Primary Ciliary Dyskinesia with 640x greater precision
New Delhi : In a major stride for rare disease diagnostics , researchers at the All India Institute of Medical Sciences ( AIIMS ), New Delhi, have developed a groundbreaking method for diagnosing Primary Ciliary Dyskinesia (PCD) -- a rare and often misdiagnosed genetic disorder affecting the respiratory system -- using transmission electron microscopy (TEM). According to Dr Subhash Chandra Yadav from the Electron Microscope Facility, Department of Anatomy, AIIMS Delhi, this method is the first of its kind in India. "This type of diagnosis is the first of its kind in India, and no other hospital or research lab in the country currently provides such a diagnosis based on electron microscopy," said Dr Subhash Chandra Yadav of the Electron Microscope Facility, Department of Anatomy, AIIMS Delhi. Dr Yadav said that the AIIMS Delhi method for PCD diagnosis has now been internationally accepted as an innovative methodology and other ciliary diseases. "Our developed method for PCD diagnosis has now been internationally accepted as an innovative methodology for PCD and other ciliary diseases, with the research paper published in the top-rated Microscopy and Microanalysis journal from the University of Oxford," he said. The breakthrough, led by Dr Yadav and Prof Kana Ram Jat from the Department of Paediatrics, was detailed in the prestigious journal under the title "An Innovative TEM-Based Ultrastructural Imaging Methodology for the Diagnosis of Respiratory Ciliary Disorders ." According to a statement from AIIMS Delhi, the advanced method dramatically improves diagnostic accuracy, identifying structural defects in motile cilia in nearly 70 per cent of suspected cases, an achievement unmatched even by cutting-edge whole-genome sequencing. Validated on 200 patients with suspected ciliary disorders, the technique confirmed diagnoses in 135 cases. The scope of this technique extends far beyond PCD. It can accurately detect a range of rare ciliary disorder-related conditions, including respiratory anomalies, renal cystic disease, blindness, neural tube defects, intellectual disability, skeletal abnormalities (such as polydactyly and abnormally short limbs), ectodermal defects, situs inversus (a condition where internal organs are mirrored), and infertility. "What sets this methodology apart is its comprehensive and refined workflow. From meticulous sample collection and fixation to ultra-thin sectioning and advanced TEM imaging, every step is optimised to enhance the visibility of tiny defects, boosting detection capability by nearly 640 times compared to conventional methods," as per the statement. Medical experts hail this innovation as a game-changer in genetic diagnostics. It promises faster and more accurate diagnoses while laying the groundwork for personalised therapies, enhanced patient care, and deeper understanding of the mechanisms underlying ciliary disorders. This pioneering effort by AIIMS researchers marks a transformative milestone in India's diagnostic capabilities, bringing hope to countless patients and their families as they navigate the challenges of rare genetic diseases.
Time Business News
25-04-2025
- Business
- Time Business News
A Trusted Top 10 PCD Pharma Franchise Company in India
In this competitive and fluid world of Indian pharmaceuticals, Symlek Healthcare stands for Trust, Innovation and Excellence. We as Top 10 PCD Pharma Franchise Company in India take pride in providing quality healthcare solutions as well as creating value-added opportunities to our franchise partners all across the country. Who We Are Symlek Healthcare is a dynamic pharma company with a diversified portfolio of high-quality medicines across different therapeutic segments. With emphasis on affordability, accessibility, and quality, we have established a strong reputation in the PCD pharma franchise business. Our products are made in WHO-GMP certified plants, maintaining the highest international standards. Supported by a group of experienced professionals and advanced infrastructure, Symlek Healthcare has been able to expand its presence in several states of India. We are committed to empowering our franchise partners with the appropriate tools, support, and resources to develop their businesses effectively and ethically. Our Vision Our dream is to become a top player in the Indian pharma market by enabling healthy lives with cost-effective and innovative medicines. We aim to bring quality healthcare even to the remotest parts of the country through a strong chain of franchise partners who are working towards the same goal. Our Mission To provide high-quality pharma products at competitive rates. To empower young entrepreneurs by providing PCD franchise business. To uphold ethical practices and transparent transactions in every business activity. To serve the common good of society through healthcare excellence. Why Symlek Healthcare? Selecting a good PCD pharma company is an important choice for anyone planning to begin or grow a pharma venture. Here's why Symlek Healthcare should be your first choice: 1. Vast Product Range We offer a wide range of over 500 products. These include tablets, capsules, injections, syrups soft gels, ointments, protein powders and others. Our treatments cover antibiotics, anti-allergics, pain relievers, gut health, heart care, diabetes management, skin care, women's health and nutrition. 2. Quality Assurance Our quality commitment is not negotiable. Every product is stringently tested for quality at each step – from raw material purchasing to packaging. Our partners in manufacture are WHO-GMP certified, assuring international standards of quality. 3. Monopoly Rights We provide unique Top 10 PCD Pharma Franchise Company in India with monopoly rights to provide least competition in your desired area. This enables you to expand your business without market saturation and facilitates long-term customer relationships. 4. Attractive Promotional Support We realize the value of marketing and branding in today's competitive scenario. Our franchise partners are given a complete promotional kit containing visual aids, product cards, MR bags, pens, prescription pads, and more to establish a strong brand image. 5. Timely Delivery & Logistics We guarantee rapid and effective delivery of orders for our partners by a well-established logistics network. Our timely service and dedication to deadlines ensure our partners remain competitive in terms of product availability and establish long-term customer relationships. 6. Transparent Business Practices Symlek Healthcare is committed to establishing business relationships built on trust, integrity, and co-growth. We have transparent pricing and fair dealings – we always endeavor to maintain long-term relationships with our partners. PCD Pharma Franchise – A Golden Business Opportunity Investing in pharmaceuticals industry is making rapid progress in India due to rising awareness about health, rising income level and Government schemes. Initiating PDC pharmaceutical franchise with Symlek Healthcare is low-risk business opportunity with high potential for individual, distributors and healthcare professional. No matter whether you're a medical rep, a distributor, or a new businessperson – our franchise system is established to give you full business backing while enabling you to work autonomously in your area. Join Forces With Symlek Healthcare At Symlek Healthcare, we are constantly seeking to partner with enthusiastic and committed professionals who want to be a part of the healthcare industry while establishing a successful business. Our commitment towards quality, innovation and partner satisfaction makes us the go-to option for any Top 10 PCD Pharma Franchise Company in India. Join our wagon, become an associate of one of India's fastest growing pharmaceutical networks and help make healthcare available, affordable & effective to every individual. TIME BUSINESS NEWS
The National
22-04-2025
- Politics
- The National
Israel kills at least 25 people across Gaza since dawn
The Palestinian Civil Defence (PCD) said nine people were killed and six others reported missing after an Israeli air strike hit a house in central Khan Younis. Meanwhile, further strikes killed five people in al-Shati refugee camp, west of Gaza City, and five others in a tent sheltering refugees near Jabalia camp in northern Gaza. READ MORE: 'Pretty bad look': Anas Sarwar household receive £300k via family firm dividends Another strike killed four people west of Jabalia camp, while two more were killed in Rafah. In Lebanon, according to the Lebanese Civil Defense, an Israeli drone also targeted a car near the coastal town of Damour, about 20km south of Beirut, killing at least one person. At least 51,240 people, including an estimated 1864 people since the Israeli military resumed its offensive, have been killed since October 7, 2023, according the health ministry in Hamas-run Gaza.
