Latest news with #Perricone
News18
05-05-2025
- Health
- News18
Cream For Weight Loss May Replace Injections, Say Scientists
Last Updated: The research involves a thumbnail-sized patch with micro-needles, reportedly so fine they cause no pain or pierce blood vessels, allowing painless drug delivery through skin Weight loss medications are drawing global attention, with injections being introduced in several countries. A significant number of people are reportedly using treatments like Ozempic and Vigoli, with claims that around 12 million individuals have received such injections so far. However, new reports suggest that obesity could potentially be reduced through a topical cream instead of injections. According to scientists, this innovative cream, applied directly to the skin, may help reduce obesity within days. It is claimed that the product will soon be available on the market. In India alone, an estimated 230 million people are reported to be overweight. According to a report by the Daily Mail, various treatments, including different types of medications, have been developed to manage obesity. Now, scientists are reportedly working on a cream that may help reduce body weight through a transdermal drug delivery system. Dr. Nicholas Perricone, a dermatologist and anti-aging specialist, has reportedly highlighted that this method could benefit millions of people who are hesitant about injections but still wish to use weight loss medication. Researchers are said to be experimenting with a gel formulation based on the compound tirzepatide, which is used in the weight loss drug Mounjaro, now reportedly available in India. There are also claims of plans to collaborate with Eli Lilly, the manufacturer of the drug. advetisement The research reportedly involves developing a patch, no larger than a thumbnail, designed to deliver medication through the skin using micro-needles. These needles are claimed to be so fine that they cause no pain and do not penetrate blood vessels, potentially making the method suitable for those with a fear of injections. Dr. Perricone has reportedly stated that the patch is applied to the wrist and rubbed between both wrists. According to him, the medication is absorbed into the skin within a minute, without causing any noticeable sensation. According to reports, the gel is currently in the experimental phase and will need to undergo pre-clinical and human trials before becoming available on the market. 'Research is underway to develop a thumbnail-sized patch loaded with tiny needles that contains potent doses of weight-loss-inducing medicine. These barely there needles will penetrate the skin without reaching deeper pain receptors and blood vessels, making them ideal for people with even the worst fear of needles," Dr. Perricone was quoted by the Daily Mail as saying. 'You can certainly traverse the skin, getting to the dermalvascular [blood vessels deep in the skin], get it circulating, so that you get the benefits without a needle," she said, adding, 'You just put it on your wrist, and you rub your wrists together, and within about a minute, it's inside. It goes into the skin and then circulates [throughout the body]." According to a report by the Daily Mail, multiple companies are exploring innovative, needle-free alternatives to traditional weight-loss injections. In addition to Dr Perricone's lab, Las Vegas-based Skinvisible Pharmaceuticals is reportedly developing a cream formulation using the active peptide found in semaglutide—the key ingredient in Ozempic and Wegovy. The formulation is claimed to penetrate the skin around ten times more effectively than standard topical treatments, delivering a steady release of the drug into the body over six hours. In efficacy studies, researchers reportedly observed that nearly 70% of the drug successfully entered the skin layers when mixed into the cream. Meanwhile, Boston-based Anodyne Nanotech is said to be working on a patch-based weight-loss treatment called HeroPatch. The patch, which is smaller than a postage stamp, features one side covered in tiny dissolvable needles. The company reportedly plans to begin clinical trials soon. First Published:
Yahoo
24-04-2025
- Health
- Yahoo
This drink can fight aging, promote weight loss and boost energy, says doc: ‘It's the magic bullet I was looking for'
Proper hydration is crucial — but what if your glass of water could do more than quench your thirst? There's a turbocharged drink gaining popularity in the US that proponents say can boost your energy, fight signs of aging and even ward off signs of disease. 'This is going to change the world,' Dr. Nicholas Perricone, a renowned nutritionist and dermatologist, told The Post. In his new book, 'The Beauty Molecule: Introducing Neuroceuticals, the Breakthrough for Ageless Beauty,' Perricone breaks down the science behind the beverage and shares insider tips to maximize every sip. A decade ago, Perricone set out on a mission to find what he called the 'magic bullet' — an anti-inflammatory that's nontoxic, affordable, easy to use and widely accessible. In Asia, inhaling hydrogen gas for better health and vitality had long been a common practice. But when research out of Japan showed that drinking hydrogen-infused water can boost energy, Perricone's curiosity was piqued — though he remained skeptical. 'Hydrogen is a nonpolar molecule. It's not going to interact with the body,' Perricone remembers thinking at the time. To get to the bottom of it, Perricone traveled to Tokyo to meet with scientists studying hydrogen. They explained that, when applied to living cells, hydrogen has a potent antioxidant and anti-inflammatory effect. It also boosts cellular energy while targeting and neutralizing dangerous free radicals in the body. 'The toxic hydroxyl radical causes significant damage to cell structures and contributes to their functional decline; in other words, aging,' Perricone wrote in his new book. Back in the US, Perricone, with the help of colleague Dr. Peter Pugliese, began testing the effects of hydrogen water on energy. Their focus was on NAD+ and NADH, two forms of the same molecule that plays a key role in cellular energy as well as the aging process. It's the one of the only molecules in the skin that fluoresces, meaning it emits light or radiation when exposed to certain conditions, such as an LED light. To test whether hydrogen water could boost NADH, Perricone and his team conducted a study in which half the participants drank hydrogen water and the other half had a placebo. Afterward, they were placed under an LED light to track changes. Perricone expected it to take hours to see any results, but within just two minutes, the first participants' NADH levels spiked. 'I sure as hell knew it wasn't just water,' he said. By the end of the study, participants had a 12.5% average increase in NADH, with the elevated levels lasting for hours. 'This study proved to me that hydrogen can and does increase cellular energy,' Perricone wrote. Over the past eight years, Perricone has poured millions into developing his own hydrogen water — using the same technology and methods already popular in Japan. 'It's the magic bullet I was looking for,' he said. Not only is hydrogen water simple, inexpensive and nontoxic, but Perricone said it can help normalize metabolism. 'As we age, one of the biggest killers is the loss of metabolic control, which is seen in an increase in blood sugar, despite an increase in insulin,' Perricone wrote. This condition, called metabolic syndrome, causes high blood pressure, elevated blood sugar levels, belly fat and abnormal cholesterol or triglyceride levels. It's linked to a higher risk of heart disease, type 2 diabetes, stroke and even cognitive decline. Perricone believes that hydrogen water could be key in reversing the rise of metabolic syndrome across the country. He pointed to a study by Dr. Tyler LeBaron, founder of the Molecular Hydrogen Institute, which followed 60 people in India diagnosed with metabolic syndrome. Half drank hydrogen water, while the other half drank plain water — with no changes to diet or exercise. After 24 weeks, the results were staggering. 'One hundred percent of those drinking hydrogen water no longer had metabolic syndrome, and they also lost an average of seven pounds,' Perricone said, noting that the placebo group showed no improvements. 'If we can get this country drinking hydrogen water on a regular basis, we could lower our health care costs by a third,' he said. In his book, Perricone lists several other benefits associated with hydrogen water, including reducing skin aging, boosting gut health, enhancing nutrient absorption, removing toxins, speeding recovery from workouts and improving muscle tone and joint mobility. He even says it can combat the toxic effects of alcohol, alleviating hangovers, and fight jet lag. Several brans sell hydrogen water, while Perricone has launched his own line, priced at $69.00 for a 24-pack of 12 oz cans. It's proven a quick hit and has already sold out — though they promise to restock soon. But before you crack open a cold can, there are a few things you should know. 'You have to drink it out of the can; you can't pour it into a glass or sip it through a straw because you'll lose the hydrogen,' Perricone said. 'You also have to drink it within 10 minutes of opening.' Perricone recommends drinking hydrogen water twice a day, the same as the participants in the metabolic syndrome study. But he drinks more himself — typically three to four cans per day. 'It gets rid of brain fog in the morning very quickly,' he said. 'I like to have it midday before a workout and toward the end of the day because I often have a lot of work to do and want to have a nice clear brain.' Perricone also believes hydrogen water can be especially helpful for people who play sports, particularly children and teens. 'If there's a quick movement of the head, like in soccer, for example, micro-inflammation is created every time they work out,' he explained. 'I would love to see everybody who works out like this or plays sports to have a can of hydrogen water before or after to stop this low-grade inflammation, because it's cumulative and can damage the body over time. We want this to start in kindergarten.'
New York Post
23-04-2025
- Health
- New York Post
This drink can fight aging, promote weight loss, and boost energy, says doc: ‘It's the magic bullet I was looking for'
Proper hydration is crucial — but what if your glass of water could do more than quench your thirst? There's a tubocharged drink gaining popularity in the US that proponents say can boost your energy, fight signs of aging and even ward off signs of disease. 'This is going to change the world,' Dr. Nicholas Perricone, a renowned nutritionist and dermatologist, told The Post. 4 Perricone's second book 'The Beauty Molecule' was released April 15. Getty Images for the New You Awards Advertisement In his new book, 'The Beauty Molecule: Introducing Neuroceuticals, the Breakthrough for Ageless Beauty,' Perricone breaks down the science behind the beverage and shares insider tips to maximize every sip. Looking East for the 'magic bullet' A decade ago, Perricone set out on a mission to find what he called the 'magic bullet' — an anti-inflammatory that's non-toxic, affordable, easy to use and widely accessible. In Asia, inhaling hydrogen gas for better health and vitality had long been a common practice. But when research out of Japan showed that drinking hydrogen-infused water can boost energy, Perricone's curiosity was piqued — though he remained skeptical. Advertisement 'Hydrogen is a nonpolar molecule. It's not going to interact with the body,' Perricone remembers thinking at the time. To get to the bottom of it, Perricone traveled to Tokyo to meet with scientists studying hydrogen. They explained that, when applied to living cells, hydrogen has a potent antioxidant and anti-inflammatory effect. It also boosts cellular energy while targeting and neutralizing dangerous free radicals in the body. 4 Perricone recommends drinking two cans of hydrogen water per day. izzetugutmen – Advertisement 'The toxic hydroxyl radical causes significant damage to cell structures and contributes to their functional decline; in other words, aging,' Perricone wrote in his new book. Back in the US, Perricone, with the help of colleague Dr. Peter Pugliese, began testing the effects of hydrogen water on energy. Their focus was on NAD+ and NADH, two forms of the same molecule that plays a key role in cellular energy as well as the aging process. It's the one of the only molecules in the skin that fluoresces, meaning it emits light or radiation when exposed to certain conditions, such as an LED light. Advertisement To test whether hydrogen water could boost NADH, Perricone and his team conducted a study in which half the participants drank hydrogen water and the other half had a placebo. Afterward, they were placed under an LED light to track changes. Perricone expected it to take hours to see any results, but within just two minutes, the first participants' NADH levels spiked. 'I sure as hell knew it wasn't just water,' he said. By the end of the study, participants had a 12.5% average increase in NADH, with the elevated levels lasting for hours. 'This study proved to me that hydrogen can and does increase cellular energy,' Perricone wrote. 'If we can get this country drinking hydrogen water on a regular basis, we could lower our health care costs by a third.' Dr. Nicholas Perricone A multi-million dollar bet Over the past eight years, Perricone has poured millions into developing his own hydrogen water — using the same technology and methods already popular in Japan. Advertisement 'It's the magic bullet I was looking for,' he said. Not only is hydrogen water simple, inexpensive and non-toxic, but Perricone said it can help normalize metabolism. 'As we age, one of the biggest killers is the loss of metabolic control, which is seen in an increase in blood sugar, despite an increase in insulin,' Perricone wrote. 4 Hydrogen has been shown to help normalize metabolism. olga – Advertisement This condition, called metabolic syndrome, causes high blood pressure, elevated blood sugar levels, belly fat and abnormal cholesterol or triglyceride levels. It's linked to a higher risk of heart disease, type 2 diabetes, stroke and even cognitive decline. Perricone believes that hydrogen water could be key in reversing the rise of metabolic syndrome across the country. He pointed to a study by Dr. Tyler LeBaron, founder of the Molecular Hydrogen Institute, which followed 60 people in India diagnosed with metabolic syndrome. Half drank hydrogen water, while the other half drank plain water — with no changes to diet or exercise. Advertisement After 24 weeks, the results were staggering. 'One hundred percent of those drinking hydrogen water no longer had metabolic syndrome, and they also lost an average of seven pounds,' Perricone said, noting that the placebo group showed no improvements. 'If we can get this country drinking hydrogen water on a regular basis, we could lower our health care costs by a third,' he said. In his book, Perricone lists several other benefits associated with hydrogen water, including reducing skin aging, boosting gut health, enhancing nutrient absorption, removing toxins, speeding recovery from workouts and improving muscle tone and joint mobility. Advertisement He even says it can combat the toxic effects of alcohol, alleviating hangovers, and fight jet lag. Maximizing the benefits of hydrogen water Several brans sell hydrogen water, while Perricone has launched his own line, priced at $69.00 for a 24-pack of 12 oz cans. It's proven a quick hit and has already sold out — though they promise to restock soon. 4 Perricone has spent eight years developing his own brand of hydrogen water. Perricone Hydrogen Water Company But before you crack open a cold can, there are a few things you should know. 'You have to drink it out of the can; you can't pour it into a glass or sip it through a straw because you'll lose the hydrogen,' Perricone said. 'You also have to drink it within 10 minutes of opening.' Perricone recommends drinking hydrogen water twice a day, the same as the participants in the metabolic syndrome study. But he drinks more himself — typically three to four cans per day. 'It gets rid of brain fog in the morning very quickly,' he said. 'I like to have it midday before a workout and towards the end of the day because I often have a lot of work to do and want to have a nice clear brain.' Perricone also believes hydrogen water can be especially helpful for people who play sports, particularly children and teens. 'If there's a quick movement of the head, like in soccer, for example, micro-inflammation is created every time they work out,' he explained. 'I would love to see everybody who works out like this or plays sports to have a can of hydrogen water before or after to stop this low-grade inflammation, because it's cumulative and can damage the body over time. We want this to start in kindergarten.'
Mint
21-04-2025
- Health
- Mint
Obesity medicine: Scientists developing cream to reduce weight, says report
Obesity medicine: In a significant breakthrough, scientists are developing a cream to reduce body weight, reported. The latest discovery in obesity medicine will be available in less invasive creams and patches, known as transdermal drug delivery systems. The new technology could be leveraged to help millions of people uneasy about needles benefit from these drugs and reduce weight, the media report said, citing dermatologist and anti-ageing expert Dr Nicholas Perricone. Dr Perricone is presently working on research to develop a gel formulation of tirzepatide, the compound used to make the Mounjaro drug. He also hopes to work with Eli Lilly - the maker of Mounjaro 'because I think it would be unique, and I'm sure that it would definitely work', as per the report. 'Research is underway to develop a thumbnail-sized patch loaded with tiny needles that contains potent doses of weight-loss-inducing medicine. These barely there needles will penetrate the skin without reaching deeper pain receptors and blood vessels, making them ideal for people with even the worst fear of needles,' the report said. 'You can certainly traverse the skin, getting to the dermalvascular [blood vessels deep in the skin], get it circulating, so that you get the benefits without a needle,' Dr. Perricone told 'You just put it on your wrist, and you rub your wrists together, and within about a minute, it's inside. It goes into the skin and then circulates [throughout the body].' Currently, the gel is at an experimental stage. It still needs to undergo pre-clinical and human trials before it can be launched commercially. Besides Dr. Perricone's lab, Las Vegas-based Skinvisible Pharmaceuticals is also working on a cream formulation of the active peptide in the ingredient that is in Ozempic and Wegovy – semaglutide. It penetrates the skin approximately 10 times better than standard topical drugs and steadily releases the medicine into the body over six hours. In an efficacy study, scientists found that nearly 70 percent of the key drug penetrated the skin layers at a steady dose when it was mixed into a cream. Boston-based Anodyne Nanotech is also working on a patch-based weight-loss medicine. The company is planning to start clinical trials of its HeroPatch, a sticker smaller than a postage stamp that on one side is covered in tiny, dissolvable needles. Researchers have found that about 10 per cent of the drug mixed into the cream passed through the skin over six hours. First Published: 21 Apr 2025, 07:03 PM IST
