Latest news with #Prograf
Irish Times
7 days ago
- Business
- Irish Times
Japanese pharmaceutical firm Astellas claims top honour at Manufacturing Excellence Awards 2025
A Japanese pharmaceutical manufacturer with operations in Co Kerry has been named the overall winner at the Manufacturing Excellence Awards 2025, held at the Crowne Plaza Hotel in Santry in Dublin. Astellas Ireland's Killorglin plant, which manufactures treatments including the immunosuppressant Prograf, was selected by a distinguished judging panel for exceptional performance across innovation, quality, sustainability and operational efficiency. The judging panel's citation stated that Astellas had 'set a benchmark in Irish manufacturing, demonstrating leadership, adaptability and a commitment to continuous improvement'. James O'Neill, lead pharma manufacturing operations at Astellas, commented: 'It's the first time entering from our operations and manufacturing side of things. The award win helps promote your site, what you're doing and what you're best in class at.' READ MORE The Kerry plant, established in 1990, employs 250 permanent staff and has made notable environmental advances, with its wind turbine and wood chip boiler reducing carbon dioxide emissions by more than 3,000 tonnes annually. The facility also won the award in the waste management category. Now in its second year, the Manufacturing Excellence Awards attracted 72 entries from 42 companies across Ireland. The ceremony was hosted by Colm O'Regan and attended by 134 industry professionals, with 17 trophies presented across various categories recognising excellence in Irish manufacturing. The Irish Manufacturing Council serves as the strategic partner for the awards programme, helping to promote collaboration between industries and the Council. Guangbo Hao, IMC secretary, highlighted the importance of the programme. 'The awards are a great opportunity to assess and recognise the excellence of the industries and a significant promotion for the collaboration between the industries and IMC,' he said. Among the award winners, Redmond McDonnell, chief executive of DesignPro Automation, expressed delight at winning in the manufacturer category, noting 'whenever you win amongst your peers, it's always a very good thing' and highlighting the value of recognition among customers and suppliers. John Byrne, chief executive of Hygeia, called it 'a fantastic achievement' for their 85-year-old company to win in the manufacturer category, noting that the recognition is 'an acknowledgment for both company and staff for what's been achieved through the year'. Judging coordinator Matt Cotterell noted that the Manufacturing Excellence Awards showcase the diversity of activities and capabilities within the Irish manufacturing sector. 'The awards feature companies that make a very valuable contribution to the Irish economy, providing a great range of employment opportunities whilst enriching the communities where they are based,' he said. Dr Cotterell explained that manufacturing is a team activity requiring multiple disciplinary activities with a focus on continuous improvement and customer satisfaction. 'It is technology-enabled but people are key, and the awards ceremony celebrates the valuable contribution of people in enabling companies to succeed and is a great networking event.' Winners of the Manufacturing Excellence Awards 2025 He added that sustainability and digital transformation are themes that featured strongly in all the award categories. 'Real-time monitoring of processes and systems performance is being implemented across the supply chain by manufacturers, allowing them to make data-informed decisions and improvements.' Heber McMahon, director of sales at Cygnum Timber Frame, said it was 'a pleasure' to be recognised alongside notable companies. Paul Murray, supply chain manager at Aryzta Ireland, noted that the company's award entry was well received. 'There are many other companies that we worked with who would have the standards that we have and we'll be speaking to them in due course,' he added. Boston Scientific Galway was the award winner in the manufacturing team category. 'We were delighted to take part in the awards night, and to be recognised amongst the high calibre companies was truly inspiring,' said Jonathan Carr, principal manufacturing engineer. 'The whole process and the evening event were extremely well run.' Cormac McAteer, senior engineering manager at Seagate Technology, commented that the awards 'demonstrate how capable you are as a company' when developing partnerships. Jade Power, ESG & contracts manager at Glenpatrick Spring Water, described being 'absolutely thrilled' that the firm was shortlisted, adding that the trophy win was 'the cream on top of the cake'. Adam Kane, community lead at events organiser Business River, stated: 'Events like this are made possible through the support of our partners. We are thankful to our strategic partner, Irish Manufacturing Council. I also want to recognise our communications partner, The Irish Times, as well as our supporter, Amárach Research. Their investment in the awards underlines their commitment and support of this key business area.' Dr Matt Cotterell (judging coordinator) – head of school of mechanical, electrical and process engineering, Munster Technological University Dr John Cosgrove – director of Smart Manufacturing, Technological University of the Shannon Barry Cox – standards development manager, National Standards Authority Of Ireland Jill Ellis – senior lecturer in food manufacturing, The National Centre for Food Manufacturing, University of Lincoln Guangbo Hao – professor in mechanical engineering, University College Cork (UCC) Rocco Lupoi – associate professor, School of Engineering, Trinity College Dublin Margaret Morgan – professor, Ulster University Joe O'Callaghan – programme director, UCC Morteza Tabatabaeipour – assistant professor, Ulster University Overall manufacturing excellence award Winner: Astellas Ireland (Kerry plant) Dr Matt Cotterell, awards judging coordinator and committee member at Irish Manufacturing Council, presents the overall manufacturing excellence award to the Astellas Ireland (Kerry Plant) team Manufacturing team of the year Winner: Boston Scientific Galway – PSPI Team Dr Matt Cotterell, awards judging coordinator and committee member at Irish Manufacturing Council, presents the manufacturing team of the year award to Jonathan Carr, Boston Scientific Galway Manufacturer of the year – large business Winner: Astellas Ireland (Kerry plant) Adam Kane, community lead at Business River, presents the manufacturer of the year - large business award to James O'Neill, Astellas Ireland (Kerry Plant) Manufacturer of the year – medium business Winner: DesignPro Automation Adam Kane, community lead at Business River, presents the manufacturer of the year - medium business award to Redmond McDonnell and Conor Doyle, DesignPro Automation Manufacturer of the year – small business Winner: Hygeia Adam Kane, community lead at Business River, presents the manufacturer of the year - small business award to John Byrne, Hygeia Manufacturer of the year – food & beverages Winner: Glenpatrick Spring Water Adam Kane, community lead at Business River, presents the manufacturer of the year - food & beverages award to Jade Power, Glenpatrick Spring Water Manufacturer of the year – life sciences Winner: Lawrence Engineering Adam Kane, community lead at Business River, presents the manufacturer of the year - life sciences award to Anthony McKeon, Lawrence Engineering Manufacturer of the year – wood products Winner: Cygnum Timber Frame Dr Emmett Kerr, committee member at Irish Manufacturing Council, presents the manufacturer of the year - wood products award to Heber McMahon, Cygnum Timber Frame Operational excellence award Winner: Viatris Little Island Dr Emmett Kerr, committee member at Irish Manufacturing Council, presents the operational excellence award to Donogh McCarthy, Viatris Little Island HR achievement award Winner: Irish Distillers Dr Emmett Kerr, committee member at Irish Manufacturing Council, presents the HR achievement award to Emily Moran, Irish Distillers Digital transformation award (sponsored by Irish Manufacturing Council) Winner: Boston Scientific Clonmel Dr Emmett Kerr, committee member at Irish Manufacturing Council, presents the digital transformation award to Sean Ward, Boston Scientific Clonmel Supply chain achievement award Winner: Aryzta Ireland Prof Ger Kelly, committee member at Irish Manufacturing Council, presents the supply chain achievement award to Paul Murray, ARYZTA Ireland Excellence in health & safety Winner: Aerogen Prof Ger Kelly, committee member at Irish Manufacturing Council, presents the excellence in health & safety award to Declan Lynch, Aerogen Waste management award Winner: Astellas Ireland (Kerry plant) Professor Ger Kelly, committee member at Irish Manufacturing Council, presents the waste management award to Eoghan Barry, Astellas Ireland (Kerry Plant) Energy achievement award Winner: C&D Foods Dr Guangbo Hao, committee member at Irish Manufacturing Council, presents the energy achievement award to Adam Kane, Business River on behalf of C&D Foods Innovation of the year Winner: Heron Joinery – Custom Roller/Turntable Dr Guangbo Hao, committee member at Irish Manufacturing Council, presents the innovation of the year award to Michael Bell, Heron Joinery Best use of technology Winner: Seagate Technology – AI-Enabled Generic Image Focus Quality System Dr Guangbo Hao, committee member at Irish Manufacturing Council, presents the best use of technology award to Cormac McAteer, Seagate Technology
Time Business News
24-05-2025
- Health
- Time Business News
Understanding Prograf: A Comprehensive Guide to Tacrolimus
Prograf, the brand name for tacrolimus, is a potent immunosuppressant medication primarily used to prevent organ rejection in patients who have undergone liver, kidney, or heart transplants. By inhibiting the body's immune response, Prograf helps ensure the transplanted organ is accepted and functions properly.(PharmaServe, Prograf operates by binding to an intracellular protein known as FKBP-12. This complex then inhibits calcineurin, a crucial enzyme in T-cell activation. As a result, the production of interleukin-2 (IL-2) is suppressed, leading to reduced T-cell proliferation and a weakened immune response .(CenterWatch, Wikipedia) Prograf is primarily prescribed for: Preventing organ rejection in liver, kidney, or heart transplant recipients. in liver, kidney, or heart transplant recipients. Managing ongoing rejection episodes in transplant patients. Treating certain autoimmune conditions, such as lupus nephritis and atopic dermatitis, when other treatments are ineffective.(Houston Chronicle, PharmaServe) The dosage of Prograf is individualized based on the type of transplant, the patient's weight, and blood tacrolimus levels. Typically, it is administered twice daily, either orally or intravenously. It's crucial to take Prograf on an empty stomach, either one hour before or two hours after meals, to ensure optimal absorption .(PharmaServe, Common side effects include: Tremors Headache Nausea and vomiting Diarrhea Hypertension(PharmaServe, Practo) Serious side effects may involve kidney dysfunction, increased risk of infections, and certain cancers. Regular monitoring through blood tests is essential to detect and manage these risks .(PharmaServe) Prograf can interact with various medications, potentially altering its effectiveness or increasing side effects. For instance, drugs that inhibit the enzyme CYP3A, such as ketoconazole, can increase tacrolimus levels, while CYP3A inducers like rifampin can decrease its levels .(PharmaServe) Before starting Prograf, inform your healthcare provider if you have:( Liver, kidney, or heart conditions unrelated to your transplant. A history of diabetes or high blood pressure. Any allergies to tacrolimus or other medications.( Pregnant or breastfeeding women should use Prograf only if absolutely necessary, as it can affect the unborn baby or pass into breast milk .(PharmaServe) Regular follow-up appointments are crucial for patients on Prograf. These visits typically include:( Blood tests to monitor tacrolimus levels and organ function. Assessments for signs of infection or other complications. Adjustments to the dosage based on test results and overall health status. Prograf is a vital medication for transplant recipients, aiding in the prevention of organ rejection. While it offers significant benefits, it's essential to be aware of potential side effects and interactions. Adhering to prescribed dosages, attending regular medical check-ups, and maintaining open communication with healthcare providers can help ensure the best outcomes for patients on Prograf therapy.(Houston Chronicle) TIME BUSINESS NEWS
Time Business News
24-05-2025
- Health
- Time Business News
Essential Prescription Medications: What You Should Know About Kreon, Prograf, Cialis, and More
Navigating the world of prescription medications can be overwhelming. From digestive aids to treatments for autoimmune diseases and sexual health, certain medications stand out for their effectiveness and wide use. Here's a quick guide to 12 key drugs—Kreon, Prograf, Cialis, Viagra, Humira, Xolair, Xgeva, Imuran, Dostinex, Femara, Prolia, and Ofev—their uses, and what makes them essential. — 1. Kreon Kreon is a digestive enzyme replacement used in conditions like cystic fibrosis and chronic pancreatitis. It helps the body absorb nutrients by replacing missing pancreatic enzymes. 2. Prograf Prograf (tacrolimus) is crucial for transplant patients. It suppresses the immune system to prevent organ rejection, especially after liver, kidney, or heart transplants. 3. Cialis Cialis (tadalafil) treats erectile dysfunction (ED) and benign prostatic hyperplasia (BPH). It's known for its long-lasting effects—up to 36 hours of improved performance and urinary relief. 4. Viagra Viagra (sildenafil) is a go-to solution for ED. It boosts blood flow to the penis, helping men achieve and maintain erections for up to four hours. 5. Humira Humira (adalimumab) is a biologic that fights inflammation in conditions like rheumatoid arthritis, Crohn's disease, and psoriasis. It targets TNF, a protein involved in immune responses. 6. Xolair Xolair (omalizumab) is used for asthma and chronic hives that don't respond to antihistamines. It blocks IgE, a key player in allergic reactions. 7. Xgeva Xgeva (denosumab) prevents bone complications in cancer patients with bone metastases. It helps strengthen bones and reduce fracture risk. 8. Imuran Imuran (azathioprine) treats autoimmune diseases like lupus and also prevents organ rejection. It slows down immune activity, reducing inflammation and tissue damage. 9. Dostinex Dostinex (cabergoline) lowers high prolactin levels, treating conditions like infertility and menstrual problems. It's also used for Parkinson's-related symptoms. 10. Femara Femara (letrozole) treats hormone-positive breast cancer in postmenopausal women by lowering estrogen levels, which slows tumor growth. 11. Prolia Prolia (denosumab) is used for osteoporosis. A twice-yearly injection strengthens bones and prevents fractures, especially in postmenopausal women. 12. Ofev Ofev (nintedanib) slows the progression of idiopathic pulmonary fibrosis (IPF) and other lung diseases by reducing lung scarring. — Why These Medications Matter From Cialis and Viagra enhancing men's health, to Humira and Imuran managing serious autoimmune conditions, these drugs improve lives every day. Prolia and Xgeva keep bones strong, while Kreon ensures proper digestion. For transplant and cancer patients, Prograf and Ofev can be life-saving. Always talk to your healthcare provider before starting any medication—each one comes with specific benefits and risks. TIME BUSINESS NEWS
