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Business Wire
a day ago
- Business
- Business Wire
LivaNova Initiates Process with U.S. Centers for Medicare and Medicaid Services for Reconsideration of National Coverage for VNS Therapy for Treatment-Resistant Depression
LONDON--(BUSINESS WIRE)--LivaNova PLC (Nasdaq: LIVN), a market-leading medical technology company, today announced it has initiated the process with the U.S. Centers for Medicare and Medicaid Services (CMS) to seek reconsideration of national Medicare coverage for VNS Therapy™ in unipolar patients with treatment-resistant depression (TRD). The first step in the process for making a National Coverage Determination (NCD) is the submission of a draft formal request for CMS reconsideration. "We have reached an important point in our pursuit to obtain national coverage for VNS Therapy for unipolar patients with depression that is difficult to treat,' said Ahmet Tezel, Ph.D., Chief Innovation Officer of LivaNova. Five critical articles featuring outcomes from in-depth data analyses on primary and select secondary endpoints in the RECOVER study have recently been published in or accepted by peer-reviewed journals, and the totality of data presented in these articles serves as the basis of the Company's request to CMS. The company believes these articles satisfy the Coverage with Evidence Development (CED) requirement of sharing peer-reviewed, publicly accessible results of pre-specified outcomes measured in the RECOVER study. In addition to the five articles, the request for coverage reconsideration includes strong 24-month clinical outcomes from the unipolar cohort of the RECOVER clinical study that demonstrate the substantial retention of benefits and the durability of VNS Therapy over time. 'We have reached an important point in our pursuit to obtain national coverage for VNS Therapy for unipolar patients with depression that is difficult to treat,' said Ahmet Tezel, Ph.D., Chief Innovation Officer of LivaNova. 'Our follow-on analyses of the RECOVER unipolar data demonstrate that symptoms alone may not be the sole source upon which to gauge the clinical impact of treatment. Instead, symptoms, function, and quality of life taken together present a more complete picture of treatment effectiveness. We are eager to review this powerful data with CMS during the reconsideration process.' Final Articles in Critical Series Analyze RECOVER Primary and Select Secondary Endpoint Data Two new in-depth analyses 1,2 on primary and select secondary endpoints in the RECOVER trial have recently been published and a third accepted by peer-reviewed journals. Prior to these articles, two initial articles were published in Brain Stimulation 3,4 in December 2024, completing the series of five critical articles in total. Collectively, the articles highlight the significant unmet need of this markedly ill population with TRD. The RECOVER data demonstrates that VNS Therapy improves symptoms, function, and quality of life in TRD patients over time. These are outcome measures identified as clinically relevant by CMS. Depressive symptoms, daily function, and quality of life taken together, as a novel composite metric, present a more complete picture of treatment effectiveness than symptoms alone. The fifth and final critical publication utilizes this composite metric and demonstrates favorable response to VNS Therapy in TRD patients who had previously failed multiple treatments, including interventional therapies. Researchers found that patients with previous ECT or TMS treatment had statistically significant and clinically meaningful benefits with active VNS Therapy. Notably, VNS Therapy is the only treatment that has demonstrated therapeutic effects in patients who previously failed ECT. 24-Month VNS Therapy Data Show Durability, Increasing Response Across All Outcome Measures New top-line 24-month data from the RECOVER study show that, across all outcome measures, VNS Therapy patients in the active arm of RECOVER experienced a substantial durability of benefit from month 12 to month 24. Of those patients who at 12 months had achieved clinically meaningful benefit, the median durability of benefit was 81.3% across all outcome measures at the 24-month assessment. This is considerable durability for these unipolar patients who, at baseline in the RECOVER study, had failed more than 13 antidepressant treatments on average. Observing all VNS Therapy patients in the active treatment arm of the RECOVER trial from month 12 to month 24, researchers also found improvement in all outcome measures, with the median rate of response, or clinically meaningful benefit, increasing from 40.2% at month 12 to 51.6% at month 24. 'There is no clinical evidence to demonstrate that there are any other therapies, including pharmacotherapies and interventional therapies such as electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS), that can claim this profound level of sustained durability and increasing benefit,' said A. John Rush, M.D., Professor Emeritus at Duke-National University of Singapore Medical School who has spent 25 years researching VNS Therapy for TRD and served as Chief Consultant on the RECOVER trial. 'These are critical findings that offer hope to treatment-resistant depression patients and their loved ones, who have struggled for years to find effective options. Patients not only stay better – they also continue to get better.' Improvement in suicidality shows statistically significant separation as early as month three LivaNova conducted additional in-depth analyses specifically evaluating suicidality for the active treatment arm of RECOVER through the first 12 months of therapy. Using a composite suicidality measure 5, results showed an estimated 43% higher odds of achieving meaningful improvement in suicidal ideation symptoms versus the control arm. Of specific interest, there was separation between the active and control arms on the composite suicidality metric as early as month three. Additionally, the observed separation was consistent throughout the initial 12 months. 'The composite suicidality outcome is especially encouraging because we can see a separation between the active and control arms so early in the study,' said Charles Conway, M.D., director of the Washington University Resistant Mood Disorders Center at Washington University School of Medicine in St. Louis. Conway is the RECOVER study's lead investigator. 'We're eager to further evaluate the suicidality data beyond 12 months and, in the context of the overall durability story of VNS Therapy, determine whether this benefit also continues to improve over time.' While not included in the initial submission to CMS, the suicidality data will be provided in detail to the agency upon publication in a peer-reviewed journal. RECOVER launched in 2019 as part of a CED framework per the CMS NCD process. For the unipolar cohort of RECOVER, enrollment was completed in March 2023, and the 12-month follow-up for those patients was completed in March 2024. No new safety issues were identified in the study. About RECOVER LivaNova's VNS Therapy™ System has been approved for the treatment of depression since earning CE Mark in 2001 and premarket approval (PMA) from the U.S. Food and Drug Administration in 2005. RECOVER stands for A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression. The largest randomized clinical study of its kind, RECOVER is examining up to 1,000 patients ages 18 or older who have unipolar or bipolar depression that is difficult to treat. A total of 493 adults with at least four documented unsuccessful attempts with antidepressant treatments participated in the unipolar cohort of the RECOVER study. The double-blind, randomized controlled study is assessing how VNS Therapy can offer patients relief from their depressive symptoms and improve quality of life. It is being carried out at up to 100 leading hospitals and medical centers across the United States. About VNS Therapy for Depression The VNS Therapy™ System, Symmetry™, is U.S. Food and Drug Administration-approved and indicated in the U.S. for the adjunctive long-term treatment of chronic or recurrent depression for patients 18 years of age or older who are experiencing a major depressive episode and have not had an adequate response to four or more adequate antidepressant treatments. The most commonly reported side effects are voice alteration or hoarseness, prickling or tingling in the skin, increased coughing, shortness of breath, and sore throat. Infection is the most common complication of the surgical procedure. Important safety information is available at References Conway CR, et al. An examination of symptoms, function, and quality of life as conjoint clinical outcome domains for treatment-resistant depression. Journal of Mood & Anxiety Disorders. April 14, 2025. DOI: 10.1016/ Sackeim HA, et al. Characterizing the effects of vagus nerve stimulation on symptom improvement in markedly treatment-resistant major depressive disorder: A RECOVER trial report. July 1, 2025. DOI: 10.1016/ Conway CR, et al. Vagus nerve stimulation in treatment-resistant depression: A one-year, randomized, sham-controlled trial. Brain Stimulation. Dec. 18, 2024. DOI: 10.1016/ Rush AJ, et al. Effects of vagus nerve stimulation on daily function and quality of life in markedly treatment-resistant major depression: Findings from a one-year, randomized, sham-controlled trial. Brain Stimulation. Dec. 18, 2024. DOI: 10.1016/ The composite suicidality metric was created by adding a suicidality-specific question from each of MADRS, Quick Inventory of Depressive Symptomology–Self Report, or QIDS-SR, and Quick Inventory of Depressive Symptomology–Clinical, or QIDS-C. About LivaNova LivaNova PLC is a global medical technology company built on nearly five decades of experience and a relentless commitment to provide hope for patients and their families through medical technologies, delivering life-changing solutions in select neurological and cardiac conditions. Headquartered in London, LivaNova employs approximately 2,900 employees and has a presence in more than 100 countries for the benefit of patients, healthcare professionals, and healthcare systems worldwide. For more information, please visit Safe Harbor Statement This news release contains 'forward-looking statements' concerning the Company's goals, beliefs, expectations, strategies, objectives, plans, underlying assumptions, and other statements that are not necessarily based on historical facts. These statements include, but are not limited to, statements regarding the RECOVER study, the VNS Therapy™ System, Symmetry™, and the likelihood that the Company is successful in obtaining national Medicare coverage for its VNS Therapy™ System. Actual events may differ materially from those indicated in our forward-looking statements as a result of various factors, including those factors set forth in Item 1A of the Company's most recent Annual Report on Form 10-K, as supplemented by any risk factors contained in Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. LivaNova undertakes no obligation to update the information contained in this press release to reflect subsequently occurring events or circumstances.
Time of India
29-05-2025
- Health
- Time of India
Infants prone to sleep, appetite issues in long Covid; preschoolers to dry cough: US study
New Delhi: Infants under two-years-old, suffering from long Covid are more likely to experience trouble sleeping, fussiness, poor appetite, stuffy nose, and cough, while children aged three to five are more likely to have a dry cough and tiredness, according to a new study in the US. "Children with these symptoms often had worse overall health, lower quality of life, and delays in development," co-first author Tanayott Thaweethai, associate director of biostatistics research and engagement at Massachusetts General Hospital, US, said. Long Covid refers to symptoms that persist well beyond having recovered from an acute COVID-19 infection. The findings, published in the Journal of the American Medical Association (JAMA) Pediatrics, are the latest from the US National Institutes of Health's 'RECOVER' initiative, aimed at understanding and preventing long Covid. An earlier analysis by the team in August 2024, found that children aged six to 11 displayed brain- and stomach-related symptoms such as headache, trouble focussing and sleeping, while teenagers experienced a loss of smell and taste, fatigue and physical pain. Notably, teens were found to display long Covid symptoms more similar to adults -- who often report brain fog and fatigue -- than to children. This study is "important because it shows that long COVID symptoms in young children are different from those in older children and adults," Thaweethai said. "Infants (or) toddlers (0-2 years) with infection history were more likely to experience trouble sleeping, fussiness, poor appetite, stuffy nose, and cough, and preschool-aged children (3-5 years) were more likely to experience dry cough and daytime tiredness (or) sleepiness or low energy," the authors wrote. The researchers examined 472 infants and 539 preschoolers, of which 278 infants and 399 pre-schoolers had previously suffered from COVID-19. The participants were enrolled between March 2022 and July 2024. Among those with a history of infection, 40 infants (14 per cent) and 61 pre-school children (15 per cent) were identified as having long Covid. Symptoms lasting at least 90 days after COVID infection for both age groups were analysed -- 41 symptoms in the infant group and 75 in preschoolers. Parts of India, including Delhi-NCR, West Bengal and Karnataka, are seeing an uptick in COVID-19 cases, which have been attributed to Omicron sub-variants. Severity of infections as of now is generally mild and there is no cause for worry, the Indian Council of Medical Research (ICMR) had said on May 26.>
Economic Times
29-05-2025
- Health
- Economic Times
Infants prone to sleep, appetite issues in long Covid; preschoolers to dry cough: US study
A recent US study, part of the NIH's RECOVER initiative, reveals distinct long Covid symptoms in young children. Infants under two are prone to sleep disturbances, fussiness, and appetite issues, while three-to-five-year-olds often experience dry coughs and fatigue. These persistent symptoms can negatively impact overall health, development, and quality of life in affected children. Tired of too many ads? Remove Ads Tired of too many ads? Remove Ads Infants under two-years-old, suffering from long Covid are more likely to experience trouble sleeping, fussiness, poor appetite, stuffy nose, and cough, while children aged three to five are more likely to have a dry cough and tiredness, according to a new study in the US. "Children with these symptoms often had worse overall health, lower quality of life, and delays in development," co-first author Tanayott Thaweethai, associate director of biostatistics research and engagement at Massachusetts General Hospital, US, Covid refers to symptoms that persist well beyond having recovered from an acute COVID-19 findings, published in the Journal of the American Medical Association (JAMA) Pediatrics, are the latest from the US National Institutes of Health's 'RECOVER' initiative, aimed at understanding and preventing long earlier analysis by the team in August 2024, found that children aged six to 11 displayed brain- and stomach-related symptoms such as headache, trouble focussing and sleeping, while teenagers experienced a loss of smell and taste, fatigue and physical teens were found to display long Covid symptoms more similar to adults -- who often report brain fog and fatigue -- than to study is "important because it shows that long COVID symptoms in young children are different from those in older children and adults," Thaweethai said."Infants (or) toddlers (0-2 years) with infection history were more likely to experience trouble sleeping, fussiness, poor appetite, stuffy nose, and cough, and preschool-aged children (3-5 years) were more likely to experience dry cough and daytime tiredness (or) sleepiness or low energy," the authors researchers examined 472 infants and 539 preschoolers, of which 278 infants and 399 pre-schoolers had previously suffered from COVID-19. The participants were enrolled between March 2022 and July those with a history of infection, 40 infants (14 per cent) and 61 pre-school children (15 per cent) were identified as having long Covid. Symptoms lasting at least 90 days after COVID infection for both age groups were analysed -- 41 symptoms in the infant group and 75 in of India, including Delhi-NCR, West Bengal and Karnataka, are seeing an uptick in COVID-19 cases, which have been attributed to Omicron of infections as of now is generally mild and there is no cause for worry, the Indian Council of Medical Research (ICMR) had said on May 26.
Time of India
28-05-2025
- Health
- Time of India
Infants prone to sleep, appetite issues in long Covid; preschoolers to dry cough: US study
Infants under two-years-old, suffering from long Covid are more likely to experience trouble sleeping, fussiness, poor appetite, stuffy nose, and cough, while children aged three to five are more likely to have a dry cough and tiredness, according to a new study in the US. "Children with these symptoms often had worse overall health, lower quality of life, and delays in development," co-first author Tanayott Thaweethai, associate director of biostatistics research and engagement at Massachusetts General Hospital, US, said. Long Covid refers to symptoms that persist well beyond having recovered from an acute COVID-19 infection. The findings, published in the Journal of the American Medical Association (JAMA) Pediatrics, are the latest from the US National Institutes of Health's 'RECOVER' initiative, aimed at understanding and preventing long Covid. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like CHAMPAGNE RUINART VALAP Iscriviti ora Undo An earlier analysis by the team in August 2024, found that children aged six to 11 displayed brain- and stomach-related symptoms such as headache, trouble focussing and sleeping, while teenagers experienced a loss of smell and taste, fatigue and physical pain. Notably, teens were found to display long Covid symptoms more similar to adults -- who often report brain fog and fatigue -- than to children. Live Events This study is "important because it shows that long COVID symptoms in young children are different from those in older children and adults," Thaweethai said. "Infants (or) toddlers (0-2 years) with infection history were more likely to experience trouble sleeping, fussiness, poor appetite, stuffy nose, and cough, and preschool-aged children (3-5 years) were more likely to experience dry cough and daytime tiredness (or) sleepiness or low energy," the authors wrote. The researchers examined 472 infants and 539 preschoolers, of which 278 infants and 399 pre-schoolers had previously suffered from COVID-19. The participants were enrolled between March 2022 and July 2024. Among those with a history of infection, 40 infants (14 per cent) and 61 pre-school children (15 per cent) were identified as having long Covid. Symptoms lasting at least 90 days after COVID infection for both age groups were analysed -- 41 symptoms in the infant group and 75 in preschoolers. Parts of India, including Delhi-NCR, West Bengal and Karnataka, are seeing an uptick in COVID-19 cases, which have been attributed to Omicron sub-variants. Severity of infections as of now is generally mild and there is no cause for worry, the Indian Council of Medical Research (ICMR) had said on May 26.
Fox News
25-03-2025
- Health
- Fox News
Trump administration to shutter HHS' long COVID office: report
A federal office dedicated to the research of long COVID is set to close following the Trump administration's decision to slash the Department of Health and Human Services (HHS) workforce. Ian Simon, head of the Office of Long COVID Research and Practice (OLC), made the announcement in an email on Monday, Politico reported. "The Office of Long COVID Research and Practice will be closing as part of the administration's reorganization coming this week," the email read, according to Politico. "We are proud of what we have accomplished together, advancing understanding, resources, and support for people living with Long COVID." Fox News Digital reached out to HHS and Simon for more information, but they did not immediately respond. It is unclear when the OLC will close nor whether its staff will remain employed by the federal government. The Biden-era office was established as a federal response to the widespread and long-term effects of COVID, which can result in chronic conditions that require comprehensive care. The decision to shutter the office comes after HHS Secretary Robert F. Kennedy Jr. said during his confirmation hearing in January that he was committed to continuing funding and prioritizing long COVID research. However, President Donald Trump directed HHS in a presidential action last month to "terminate the Secretary's Advisory Committee on Long COVID." The National Institutes of Health (NIH) said more than $1.5 billion was approved in the last several years for its Researching COVID to Enhance Recovery (RECOVER) Initiative, which studies the impact of long COVID. The NIH reported in 2023 that 23 million people were affected by the illness, while the Centers for Disease Control and Prevention estimated in 2023 that 6% of American adults suffered from long COVID, down from 7.5% in 2022. "While our office is closing, we hope that the work we have been dedicated to will continue in some form," the email read.
