Latest news with #RuiVieira
Yahoo
30-04-2025
- Business
- Yahoo
Nottingham Forest owner steps back from control of Premier League club
Nothingham Forest fans cheers during the English FA Cup semifinal soccer match between Nottingham Forest and Manchester City at Wembley stadium in London, Sunday, April 27, 2025. (AP Photo/Kirsty Wigglesworth) FILE - Olympiacos club owner Evangelos Marinakis walks on the pitch at the end of the Europa Conference League semifinal, first leg, soccer match between Aston Villa and Olympiacos at Villa Park in Birmingham, England, (AP Photo/Rui Vieira, file) FILE - Olympiacos club owner Evangelos Marinakis walks on the pitch at the end of the Europa Conference League semifinal, first leg, soccer match between Aston Villa and Olympiacos at Villa Park in Birmingham, England, (AP Photo/Rui Vieira, file) Nothingham Forest fans cheers during the English FA Cup semifinal soccer match between Nottingham Forest and Manchester City at Wembley stadium in London, Sunday, April 27, 2025. (AP Photo/Kirsty Wigglesworth) FILE - Olympiacos club owner Evangelos Marinakis walks on the pitch at the end of the Europa Conference League semifinal, first leg, soccer match between Aston Villa and Olympiacos at Villa Park in Birmingham, England, (AP Photo/Rui Vieira, file) NOTTINGHAM, England (AP) — Nottingham Forest owner Evangelos Marinakis has relinquished his position as a person with significant control of the Premier League club as it closes in on Champions League qualification. According to filings made to the U.K. government on Wednesday, Greek businessman Marinakis has ceased to have significant control of NF Football Investments Ltd, which owns Forest. Advertisement Marinakis is also president of Olympiacos, which is in position to qualify for the Champions League at the top of the Greek league. UEFA has rules to bar clubs from its competitions in any season if owners have 'decisive influence' over two clubs which qualify. Forest is a surprise contender to qualify for next season's Champions League after battling to avoid relegation last year. It is sixth in the standings, with the top five qualifying for European club soccer's top competition. It is level on points with fifth-placed Chelsea with a game in hand on all the teams above it. In separate filings Pittville One Limited was named as a person of significant control, while Sokratis Kominakis, who is part-owner of NF Football Investments, was appointed director. ___ AP soccer:
Yahoo
21-04-2025
- Sport
- Yahoo
Leeds on brink of Premier League promotion after smashing Stoke
Leeds are on the brink of a return to the Premier League (Rui Vieira) Leeds are on the cusp of promotion to the Premier League after Joel Piroe scored four goals in a 6-0 demolition of Stoke on Monday. Daniel Farke's men will return to the top division if Sheffield United fail to win at second-placed Burnley in the 1630 GMT kick-off. Advertisement Burnley will be promoted along with Leeds if they beat Chris Wilder's Sheffield United, who have won just one of their past four games. Leeds, who last played in the Premier League in the 2022/23 season, suffered the agony of defeat to Southampton in last season's Championship play-off final at Wembley. The Yorkshire club -- three-time English champions -- are now near certainties to gain promotion after humbling Stoke at Elland Road. Dutch forward Piroe, who had not scored since late February, returned to form with a vengeance, celebrating a hat-trick in the 20th minute. Junior Firpo made it four and Piroe, the club's leading scorer this season, netted his fourth goal shortly before half-time. Advertisement The game was already long over as a contest but Wilfried Gnonto nodded a sixth goal in the 59th minute. Farke and his players celebrated in front of their passionate fans at the final whistle but the champagne is still on ice. The German, who has previously managed in the Premier League with Norwich, praised the way his team had coped with the pressure. "To deliver such an emphatic performance is really amazing and all the credit goes to the boys for the way they have handled the situation and the spirit they have shown in recent weeks," he told the BBC. "It's the fate of a striker that sometimes you have a dry period or a dip in form. Joel had this but he has worked so hard and got himself out of it. Advertisement "In the last few weeks his performances were better but the ball didn't want to go in the net. It's a bit like shaking a bottle of ketchup -- all of a sudden everything comes out and that was a bit the case today." Leeds wobbled from the start of March, winning just one in six games, raising fears that they would again have to settle for a place in the play-offs. But they have now won their past four league games. At the other end of the table, Mustapha Bundu scored twice to keep alive bottom side Plymouth's survival hopes in a 3-1 win against sixth-placed Coventry. There were also 3-1 victories for relegation-threatened Derby and Luton while Portsmouth sealed their safety with a 1-0 win against 10-man Watford. Middlesbrough's play-off hopes were dented by a damaging 2-1 loss at Sheffield Wednesday. jw/bsp
Forbes
27-03-2025
- Health
- Forbes
Worrying Signals Emerge As Bird Flu Gains Resistance Mutation
Two new studies released in 2025 provide a mixed picture of how well our current antivirals are holding up against H5N1, the highly pathogenic bird flu virus that continues to spill over into mammals and humans. The good news: H5N1 viruses from recent human cases remain susceptible to frontline antiviral drugs. More concerning is a resistance mutation that emerged and spread rapidly during a poultry outbreak in Canada, raising flags about the virus's potential to evolve past our defenses. The antiviral oseltamivir (commonly known as Tamiflu) is currently recommended for treating and preventing H5N1 infections. It works by inhibiting neuraminidase, a surface protein the virus uses to release itself from infected cells and spread through the body. But this treatment only works if the virus remains sensitive to the drug. Tamiflu, the same antiviral used to treat ordinary seasonal influenza, is the front line medication ... More recommended for treating highly pathogenic bird flu (Photo by Rui Vieira/PA Images via Getty Images) In a study published in the CDC's journal Emerging Infectious Diseases, researchers tested H5N1 viruses from human infections reported in Cambodia, Chile, and the United States during 2023–2024. These viruses belonged to two clades (genetic lineages): 2.3.2.1c and 2.3.4.4b. All tested viruses were susceptible to oseltamivir and other neuraminidase inhibitors, including zanamivir and peramivir, as well as baloxavir, a newer drug that targets a different viral protein. Most also remained sensitive to older M2-blocking antivirals—except for two viruses isolated in Cambodia. These results support continued use of oseltamivir as the first-line treatment and for post-exposure prophylaxis in close contacts of infected individuals. Computer generated 3D model, showing a cross-section of the green RNP spirals, blue hemagglutinin, ... More red neuraminidase, and purple m2 ion channels that constitute the structure of the Influenza A Virus (Orthomyxovirus family) image courtesy CDC/Douglas Jordan, 2009. (Photo by Smith Collection/Gado/Getty Images) However, not all recent developments are reassuring. A separate study published in Emerging Microbes & Infections documented a large outbreak of H5N1 in poultry in British Columbia, Canada. Genetic sequencing of the virus revealed the presence of the H275Y mutation in the neuraminidase gene—well-known to confer resistance to oseltamivir. This mutation had previously rendered the majority of seasonal H1N1 viruses resistant to the drug during the 2008–2009 flu season. What makes the Canadian case notable is how quickly the resistant virus spread. Within 27 days of detection, it had jumped across 44 farms. While resistance mutations like H275Y are often associated with reduced viral fitness, the Canadian outbreak strain spread quickly between farms, suggesting that this particular virus was able to transmit efficiently despite carrying the mutation. The mutation appears to have arisen through reassortment, a genetic mixing process that occurs when influenza viruses exchange segments. In this case, the virus acquired its neuraminidase segment from a different influenza lineage circulating in North American birds. These findings illustrate how resistance can arise in animal populations, well before human outbreaks begin. They also highlight the importance of genomic surveillance—not only in people but also in poultry and wild birds, where the virus continues to evolve. Combination therapies may offer a way to slow resistance. Studies in animals have shown that using multiple drugs with different mechanisms simultaneously can reduce viral load more effectively and lower the chances of resistance emerging. But in the real world, access to such treatments remains limited. For now, Tamiflu still works—but the virus is changing. Our response must keep pace.
