Latest news with #SEDDS
Mail & Guardian
2 days ago
- Health
- Mail & Guardian
Exploring new paths in tackling the big three infectious diseases
Prof Joe Viljoen. Just a few drops of oil and water may be enough to change how the world treats tuberculosis, malaria and HIV/Aids – the 'big three infectious diseases', also known as BTIDs. This was the central message delivered by Prof Joe Viljoen during her inaugural lecture at the North-West University's (NWU's) Potchefstroom Campus on 13 June 2025. Prof Viljoen, from the Faculty of Health Sciences, presented her work under the title: 'Combating the BTIDs using innovative self-emulsification drug delivery systems.' Her lecture focused on how self-emulsifying drug delivery systems (SEDDSs) can improve treatment for TB, malaria and HIV/Aids. 'These diseases are mostly treated with drugs that are highly lipophilic (water insoluble),' explained Prof Viljoen. 'That makes them difficult to absorb, especially for patients who are malnourished and unable to take the high-fatty meals required for proper drug uptake.' Harnessing the body's natural movement SEDDSs are oil-based formulations combined with surfactants and co-surfactants. Once swallowed or applied to the skin, they mix with the body's fluids and form fine emulsions without the need for external mixing equipment. 'With just the body's natural movement, for example, peristalsis in the stomach, SEDDSs form into very small droplets that help drugs dissolve and be absorbed more effectively,' she said. These delivery systems further improve bioavailability by enabling drugs to bypass the liver's first-pass metabolism through lymphatic transport. For skin-based applications, Prof Viljoen explained the importance of choosing oils that help the drug pass through the skin where water is limited. 'We have to carefully balance the oily and water-loving components. Natural oils are key, as they help the drug penetrate the skin barrier and are better accepted by consumers due to being viewed as safer.' Challenges in developing SEDDSs include selecting the correct ingredients, ensuring stability and controlling droplet size to regulate drug release. Tools such as pseudoternary phase diagrams help design fixed-dose combinations, especially where drugs have different solubility characteristics. 'These systems are scalable, stable and can be produced at relatively low cost,' said Prof Viljoen. 'They could make a significant difference in the treatment of infectious diseases, particularly in low-resource settings.' The lecture concluded with a call for interdisciplinary efforts to advance the development of SEDDS-based therapies.
Globe and Mail
11-03-2025
- Business
- Globe and Mail
Lipid-Based Pharma Excipients Market Revenue to Reach $1.32 Billion by 2030
"Lipid-Based Pharma Excipients Market Research Report by Arizton" According to Arizton's latest research report, the lipid-based pharma excipients market is growing at a CAGR of 5.63% during 2024-2030. Report Scope: Market Size (2030): $1.32 Billion Market Size (2024): $953.01 Million CAGR (2024-2030): 5.63% Historic Year: 2021-2023 Base Year: 2024 Forecast Year: 2025-2030 Market Segmentation: Product Type, Functionality, Formulation, End-User, and Geography Geographical Analysis: North America, Europe, APAC, Latin America, and Middle East & Africa Competitive Landscape of the Global Lipid-Based Pharmaceutical Excipients Market The global lipid-based pharmaceutical excipients market has experienced significant growth, driven by the increasing demand for advanced drug delivery systems and the need for high-quality excipients to improve drug formulations. Key lipid-based excipients, such as solid lipid nanoparticles, liposomes, and lipid emulsions, enhance the bioavailability, stability, and targeted delivery of poorly soluble drugs. As competition intensifies, companies are focusing on strategies such as product innovation, strategic partnerships, geographic expansion, and offering customized solutions to maintain competitiveness. Major players, including BASF, Lonza, and Evonik Industries, are investing heavily in R&D, forming partnerships, and acquiring firms to expand their portfolios and market reach. North America remains the largest market, while APAC is the fastest-growing region due to rising pharmaceutical investments. Companies expanding into emerging markets like Latin America and the Middle East & Africa are also contributing to market growth. With continued demand for novel drug formulations, the lipid-based excipients market is expected to keep growing, driven by innovation and tailored solutions. Europe Lipid-Based Pharma Excipients Market Growth and Challenges The European lipid-based pharmaceutical excipients market is experiencing significant growth, driven by increasing demand for advanced drug delivery systems, especially for poorly soluble drugs. Lipid-based excipients like Solid Lipid Nanoparticles (SLNs) and Self-Emulsifying Drug Delivery Systems (SEDDS) enhance drug solubility and stability. The rise of biologics, mRNA-based therapies, and personalized medicine further boosts demand. The success of mRNA vaccines has increased interest in lipid nanoparticles (LNPs) for gene therapy and vaccines. However, challenges such as supply chain disruptions, high production costs, and competition from synthetic excipients complicate market growth. Regulatory complexity, geopolitical tensions, and the limited number of specialized suppliers also impact the market. To address these, companies are investing in sustainable, domestic lipid production, while innovations in algae-derived and fermentation-based lipids are gaining traction to meet environmental and ethical standards. Despite these challenges, the market is poised for continued growth driven by advancements in drug delivery technologies. Pharma & Biotech Companies are the Major End-Users Lipid-based excipients have become a cornerstone in the pharmaceutical and biotechnology industries, playing a vital role in enhancing the solubility and bioavailability of lipophilic active ingredients, particularly in oral formulations. These excipients are increasingly used to improve the solubility of poorly water-soluble drugs, making them essential for drug development and manufacturing. The growing demand for lipid-based excipients is driven by pharmaceutical companies seeking to improve product quality, achieve high production volumes, and remain competitive. With over 40,000 pharmaceutical companies globally, the demand for lipid-based excipients is significant, as they help optimize drug delivery systems and meet various requirements such as stability, efficacy, and route of administration. North America, Europe, and the APAC region account for about 75% of the global demand for lipid excipients, with the US leading in pharmaceutical production, contributing to nearly 45% of global drug manufacturing. China and Germany follow as major players in pharmaceutical production. APAC, particularly China, is emerging as a key hub for pharmaceutical manufacturing, creating substantial growth opportunities for lipid-based excipients in the region. Advancements in Lipid Nanoparticles and Drug Delivery Systems Lipid nanoparticles (LNPs) have emerged as a groundbreaking technology in the pharmaceutical industry, enhancing drug stability, bioavailability, and targeted delivery. LNPs, including solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), and liposomes, are versatile drug carriers used to deliver a range of therapeutic agents. They offer advantages like improved solubility, stability, and targeted delivery, which reduce off-target effects and toxicity. LNPs gained significant attention during the COVID-19 pandemic, playing a key role in mRNA vaccine development by protecting fragile mRNA and ensuring effective delivery into cells. The applications of LNPs are expanding in areas like cancer therapy, gene therapy, vaccines, and neurological disorders, notably allowing for targeted delivery and crossing the blood-brain barrier. The growing focus on personalized medicine, chronic diseases, and precision therapies is driving further demand for lipid-based drug delivery systems. With increased R&D investments, regulatory support, and strategic partnerships, the market for lipid-based excipients is poised for substantial growth. The integration of AI and ML in drug formulation will further enhance the design and functionality of lipid nanoparticles, making them a key component in future pharmaceutical advancements. Key Vendors ABF Ingredients – ABITEC BASF Croda International Gattefosé IOI Oleo GMbH Merck KGaA AAK Alsiano Biopharma PEG Scientific CD Formulation CLARIANT Colorcon CordenPharma CREMER OLEO Evonik Kao Corporation Lipoid NOF CORPORATION Pothe Hille & Co The East Africa Wax Company VAV Life Sciences (VAV) WAXOILS Market Segmentation Product Type Fats Phospholipids Oils Waxes Others Functionality Solubilizers & Wetting Agents Emulsifiers & Surfactants Structuring Agents & Lubricants Emollients, Penetration Enhancers, & Solvents Others Formulation Enteral Injectables Topical End-User Pharma & Biotech Companies Contract Manufacturing Organizations (CMOs) Contract Research Organizations (CROs) & Contract Development and Manufacturing Organizations (CDMOs) Academic & Research Institutes Geography North America The U.S. Canada Europe Germany Switzerland Ireland Belgium Italy France Netherlands The U.K. Spain APAC China Japan India South Korea Australia Latin America Brazil Mexico Argentina Colombia Middle East & Africa Turkey South Africa Saudi Arabia The UAE The Arizton Advisory & Intelligence market research report provides valuable market insights for industry stakeholders, investors, researchers, consultants, and business strategists aiming to gain a thorough understanding of the lipid-based pharma excipients market. Request for Free Sample to get a glance of the report now: What Key Findings Will Our Research Analysis Reveal? How big is the global lipid-based pharma excipients market? What is the growth rate of the global lipid-based pharma excipients market? Which region dominates the global lipid-based pharma excipients market share? Who are the key players in the global lipid-based pharma excipients market? What are the significant trends in the lipid-based pharma excipients industry? Global Biopharmaceutical Excipients Market - Focused Insights 2024-2029 Global Biopharmaceutical Contract Manufacturing Market - Focused Insights 2024-2029 Why Arizton? 100% Customer Satisfaction 24x7 availability – we are always there when you need us 200+ Fortune 500 Companies trust Arizton's report 80% of our reports are exclusive and first in the industry 100% more data and analysis 1500+ reports published till date Post-Purchase Benefit 1hr of free analyst discussion 10% off on customization About Us: Arizton Advisory and Intelligence is an innovative and quality-driven firm that offers cutting-edge research solutions to clients worldwide. We excel in providing comprehensive market intelligence reports and advisory and consulting services. We offer comprehensive market research reports on consumer goods & retail technology, automotive and mobility, smart tech, healthcare, life sciences, industrial machinery, chemicals, materials, I.T. and media, logistics, and packaging. These reports contain detailed industry analysis, market size, share, growth drivers, and trend forecasts. Arizton comprises a team of exuberant and well-experienced analysts who have mastered generating incisive reports. Our specialist analysts possess exemplary skills in market research. We train our team in advanced research practices, techniques, and ethics to outperform in fabricating impregnable research reports.
