Latest news with #SHEP
Yahoo
06-05-2025
- Health
- Yahoo
FDA Approves New, Low-Dose Chlorthalidone for the Treatment of Hypertension in Adults: HemiClor™ (12.5 mg chlorthalidone)
WEST CONSHOHOCKEN, Pa., May 6, 2025 /PRNewswire/ -- PRM Pharma, LLC today announced the U.S. Food and Drug Administration (FDA) approval of HemiClor (12.5 mg chlorthalidone) tablets for the treatment of hypertension in adults, to lower blood pressure. HemiClor Logo Chlorthalidone, a thiazide-like diuretic, has been studied extensively over several decades in the treatment of hypertension. It is recognized in the 2017 ACC/AHA Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults as the preferred diuretic based on its prolonged half-life and evidence of cardiovascular outcome benefits.1 Landmark studies such as the ALLHAT and SHEP trials, sponsored by the National Heart, Lung, and Blood Institute, demonstrated that stepped-care treatment strategies—which often began with 12.5 mg of chlorthalidone—were effective in reducing the risk of cardiovascular events.2,3 These findings support the use of 12.5 mg as the recommended starting dose in current hypertension treatment guidelines, either to initiate antihypertensive therapy or to serve as add-on therapy when additional blood pressure reduction is needed.1,4 HemiClor now provides U.S. patients and healthcare professionals access to a 12.5 mg chlorthalidone tablet formulation that aligns with guideline recommendations. Until now, only higher-dose chlorthalidone tablets (25 mg and 50 mg) have been available in the U.S. This new low-dose option may help clinicians better individualize therapy and potentially reduce the risk of dose-related side effects. As noted in the approved prescribing information, metabolic adverse effects such as hypokalemia and hyperuricemia are dose-related; thus, a lower starting dose may help mitigate these risks when initiating treatment.5 "Chlorthalidone has played a key role in hypertension treatment strategies for decades," said William B. White, M.D., Professor Emeritus at the University of Connecticut School of Medicine and past president of the American Society of Hypertension. "Having access to a 12.5 mg dose in the U.S. may offer clinicians additional flexibility when initiating therapy and aligns with current treatment recommendations for many adult patients with stage 1 or stage 2 hypertension." Joseph T. McDevitt, President and CEO of PRM Pharma, LLC, added, "We are proud to introduce HemiClor as a new treatment option for adults with hypertension. Our mission is to address unmet clinical needs by developing low-dose pharmaceutical products that support evidence-based care. Lower effective doses may offer a more individualized approach to initiating therapies, particularly for elderly patients who are more susceptible to dose-related adverse effects."
Associated Press
30-01-2025
- Automotive
- Associated Press
HNO International Secures $10 Million Hydrogen Offtake Agreement with Texas-Based Mobility Company
HNO International (OTC: HNOI) is excited to announce a hydrogen offtake agreement with a Texas-based company supporting zero-emission mobility. Under the agreement, HNO will supply hydrogen from its 1.25 MW Scalable Hydrogen Energy Platform (SHEP™), which produces up to 500 kilograms of clean hydrogen daily. This hydrogen will power the customer's fleet of Class 8 hydrogen fuel cell vehicles (FCEVs), ensuring efficient and sustainable long-haul transportation. The agreement also integrates HNOI's Compact Hydrogen Refueling System (CHRS™) for refueling support. With room for expansion, HNOI is projecting to reach nearly $10 million in multi-year contracts as HNOI rapidly scales hydrogen production within the first year of operation. 'This agreement highlights the growing demand for clean hydrogen fuel in heavy-duty transportation,' said Don Owens, founder and CEO of HNO International. 'Our SHEP system and CHRS refueling stations provide reliable, scalable solutions for long-haul operations, helping reduce the environmental impact of freight mobility. We're excited to support this effort and look forward to expanding our production capacity to meet rising demand.' The Texas-based company, a leader in zero-emission mobility, is at the forefront of using hydrogen to decarbonize transportation. Their adoption of hydrogen fuel cell technology supports both environmental sustainability and business growth by offering a viable alternative to diesel without compromising operational efficiency. About HNO International HNO International (HNOI) is a company specializing in the design, integration, and development of hydrogen-based energy technologies. With over 15 years of experience in hydrogen production, HNOI is on a mission to help lead the renewable energy transition by making energy accessible to businesses and communities. Their solutions, the Scalable Hydrogen Energy Platform (SHEP™) and the Compact Hydrogen Refueling Station (CHRS™), are setting new standards for hydrogen production. Forward-Looking Statements This news release contains 'forward-looking statements' which are not purely historical and may include any statements regarding beliefs, plans, expectations or intentions regarding the future. Such forward-looking statements include, among other things, the development, costs and results of new business opportunities and words such as 'anticipate', 'seek', intend', 'believe', 'estimate', 'plan', or similar phrases may be deemed 'forward-looking statements' within the meaning of the Private Securities Litigation Reform Act of 1995. Investors should consult all of the information set forth herein and should also refer to the risk factors disclosure outlined in our annual report on Form 10-K, our quarterly reports on Form 10-Q and other periodic reports filed from time to time with the Securities and Exchange Commission. For more information, please visit
Globe and Mail
29-01-2025
- Business
- Globe and Mail
Nasdaq Uplisting and $20 Million Capital Raise: HNO International, Inc. (Stock Symbol: HNOI) Poised for Expansion
Investing in the Future of Clean Hydrogen Energy HNO International, Inc. (Stock Symbol: HNOI) is at the forefront of green hydrogen innovation, developing and commercializing advanced hydrogen-based energy technologies. With a strong foundation built over 13 years, HNOI is committed to accelerating the global transition toward sustainable energy solutions. The company is making significant strides with its flagship technologies: the Scalable Hydrogen Energy Platform (SHEP™) and the Compact Hydrogen Refueling Station (CHRS™), positioning itself as a leader in the burgeoning hydrogen economy. NASDAQ Uplist and Capital Raise with a Leading Investment Banking Firm HNOI recently announced a major milestone—its plans to uplist to the NASDAQ and secure up to $20 million in capital through a partnership with a respected Wall Street investment banking firm. This initiative is designed to fuel the company's expansion strategy, fund capital expenditures, and drive future acquisitions via a Regulation A offering. The investment banking firm, which has a long-standing track record in IPOs, private placements, and SPAC transactions, sees HNOI as a key player in the global energy transition. Their Managing Director commented: "The global demand for energy continues to climb at extraordinary rates, prompting the need for additional sources, of which HNO International is set to play a key role." This strategic move is expected to propel HNOI from the OTC market to a global stage, enhancing its visibility and access to institutional investors. Major Share Reduction: Strengthening Shareholder Value HNOI has also executed a significant share structure reduction, enhancing shareholder value and reinforcing confidence in its long-term vision. The company reduced its outstanding common stock by 82%, bringing the total outstanding shares down to only 74 million. This reduction was facilitated through a return exchange of 360 million shares by Chairman & CEO Donald Owens, reflecting strong leadership commitment to sustainable shareholder growth. Strategic Industry Alliances: Partnerships with Global Leaders HNOI is leveraging key partnerships to accelerate its impact across multiple industries. The company has aligned with Blue Origin, NASA, Amazon, Meta, and Microsoft, positioning itself among global innovators in clean energy technology. Additionally, HNOI has forged agreements with industry leaders to advance scalable hydrogen energy solutions: Teaming Agreement with Pneumatic and Hydraulic Company (PHC): This collaboration will support the deployment of 1-10 MW electrolyzer production plants, refueling systems, and microgrid solutions. With clients like SpaceX, Blue Origin, and NASA, PHC brings decades of expertise in fluid power solutions and high-pressure hydrogen systems to support HNOI's mission. Partnership with Dumore Enterprises: HNOI is testing its Hydrogen Carbon Cleaner (HCC) technology and hydrogen-diesel blending solutions in real-world applications. This initiative is expected to demonstrate fuel efficiency improvements, emissions reductions, and maintenance cost savings, paving the way for commercial adoption across industrial and transportation sectors. Vision for the Hydrogen Economy: CEO Shares Insights from NASDAQ Marketsite HNOI Chairman & CEO Donald Owens recently shared his ambitious vision for the hydrogen economy in an exclusive video interview from the NASDAQ Marketsite in Times Square. Key topics discussed include: Local Production & Consumption with SHEP™: Enabling decentralized hydrogen production to enhance energy security and reduce transportation costs. Hydrogen Refueling & Dispensing with CHRS™: Streamlining hydrogen infrastructure for rapid adoption. Powering Data Centers & Cryptocurrency Mining: Leveraging hydrogen to power critical infrastructure with zero-emission solutions. Why Investors Should Pay Attention HNOI represents a compelling investment opportunity at the intersection of renewable energy, hydrogen technology, and industrial innovation. With its upcoming NASDAQ uplist, reduced outstanding shares, and strategic partnerships with industry leaders, the company is poised for significant growth. Investors looking to capitalize on the future of hydrogen energy should keep HNOI on their radar. The combination of cutting-edge technology, market demand for clean energy solutions, and strategic financial positioning makes this an attractive proposition in the rapidly evolving energy sector. For more information, visit: Disclosure listed on the CorporateAds website Media Contact Company Name: HNO International, Inc. (OTC: HNOI) Contact Person: Donald Owens, Chairman Email: Send Email Phone: (951) 305-8872 Address: 4115 Eastman Drive Suite B City: Murrieta State: California Country: United States Website:
Associated Press
29-01-2025
- Business
- Associated Press
Nasdaq Uplisting and $20 Million Capital Raise: HNO International, Inc. (Stock Symbol: HNOI) Poised for Expansion
Investing in the Future of Clean Hydrogen Energy HNO International, Inc. (Stock Symbol: HNOI) is at the forefront of green hydrogen innovation, developing and commercializing advanced hydrogen-based energy technologies. With a strong foundation built over 13 years, HNOI is committed to accelerating the global transition toward sustainable energy solutions. The company is making significant strides with its flagship technologies: the Scalable Hydrogen Energy Platform (SHEP™) and the Compact Hydrogen Refueling Station (CHRS™), positioning itself as a leader in the burgeoning hydrogen economy. NASDAQ Uplist and Capital Raise with a Leading Investment Banking Firm HNOI recently announced a major milestone—its plans to uplist to the NASDAQ and secure up to $20 million in capital through a partnership with a respected Wall Street investment banking firm. This initiative is designed to fuel the company's expansion strategy, fund capital expenditures, and drive future acquisitions via a Regulation A offering. The investment banking firm, which has a long-standing track record in IPOs, private placements, and SPAC transactions, sees HNOI as a key player in the global energy transition. Their Managing Director commented: 'The global demand for energy continues to climb at extraordinary rates, prompting the need for additional sources, of which HNO International is set to play a key role.' This strategic move is expected to propel HNOI from the OTC market to a global stage, enhancing its visibility and access to institutional investors. Major Share Reduction: Strengthening Shareholder Value HNOI has also executed a significant share structure reduction, enhancing shareholder value and reinforcing confidence in its long-term vision. The company reduced its outstanding common stock by 82%, bringing the total outstanding shares down to only 74 million. This reduction was facilitated through a return exchange of 360 million shares by Chairman & CEO Donald Owens, reflecting strong leadership commitment to sustainable shareholder growth. Strategic Industry Alliances: Partnerships with Global Leaders HNOI is leveraging key partnerships to accelerate its impact across multiple industries. The company has aligned with Blue Origin, NASA, Amazon, Meta, and Microsoft, positioning itself among global innovators in clean energy technology. Additionally, HNOI has forged agreements with industry leaders to advance scalable hydrogen energy solutions: Teaming Agreement with Pneumatic and Hydraulic Company (PHC): This collaboration will support the deployment of 1-10 MW electrolyzer production plants, refueling systems, and microgrid solutions. With clients like SpaceX, Blue Origin, and NASA, PHC brings decades of expertise in fluid power solutions and high-pressure hydrogen systems to support HNOI's mission. Partnership with Dumore Enterprises: HNOI is testing its Hydrogen Carbon Cleaner (HCC) technology and hydrogen-diesel blending solutions in real-world applications. This initiative is expected to demonstrate fuel efficiency improvements, emissions reductions, and maintenance cost savings, paving the way for commercial adoption across industrial and transportation sectors. Vision for the Hydrogen Economy: CEO Shares Insights from NASDAQ Marketsite HNOI Chairman & CEO Donald Owens recently shared his ambitious vision for the hydrogen economy in an exclusive video interview from the NASDAQ Marketsite in Times Square. Key topics discussed include: Local Production & Consumption with SHEP™: Enabling decentralized hydrogen production to enhance energy security and reduce transportation costs. Hydrogen Refueling & Dispensing with CHRS™: Streamlining hydrogen infrastructure for rapid adoption. Powering Data Centers & Cryptocurrency Mining: Leveraging hydrogen to power critical infrastructure with zero-emission solutions. Why Investors Should Pay Attention HNOI represents a compelling investment opportunity at the intersection of renewable energy, hydrogen technology, and industrial innovation. With its upcoming NASDAQ uplist, reduced outstanding shares, and strategic partnerships with industry leaders, the company is poised for significant growth. Investors looking to capitalize on the future of hydrogen energy should keep HNOI on their radar. The combination of cutting-edge technology, market demand for clean energy solutions, and strategic financial positioning makes this an attractive proposition in the rapidly evolving energy sector. Media Contact Phone: (951) 305-8872 Address:4115 Eastman Drive Suite B City: Murrieta State: California Country: United States
