Latest news with #SPARE
Medscape
22-05-2025
- Health
- Medscape
Novel Autoantibodies Linked to Thrombosis Risk in Lupus
Anti–transcription factor A, mitochondrial (anti-TFAM) antibodies in patients with systemic lupus erythematosus (SLE) were associated with a threefold increased risk for thrombotic events. METHODOLOGY: Researchers discovered the autoantibody in an exploratory sample of 22 patients with SLE and nine healthy controls. The findings were validated using a sample of 158 patients with SLE and 98 healthy control individuals from the 'Study of biological Pathways, Disease Activity and Response markers in patients with Systemic Lupus Erythematosus' (SPARE) cohort. Researchers used comprehensive clinical, serological, and gene expression data collected from the SPARE cohort to identify clinical features associated with anti-TFAM antibodies. TAKEAWAY: Anti-TFAM antibodies were detected in 30.3% of patients with SLE (48 of 158) and 4% of healthy controls (four of 98). Patients with SLE who were positive for anti-TFAM antibodies showed significantly higher risk for thrombosis (odds ratio [OR], 2.9) and antiphospholipid syndrome (APS; OR, 5.4), independent of traditional APS-associated antibodies. The presence of both anti-TFAM antibodies and lupus anticoagulant demonstrated an additive effect, increasing thrombosis risk substantially (OR, 8.71). IN PRACTICE: 'Anti-TFAM antibodies are potential biomarkers for identifying SLE patients at risk of thrombosis, independent of traditional APS-associated antibodies. These novel autoantibodies may aid in disease evaluation and treatment strategies for SLE, as well as provide novel insights into disease mechanisms, particularly those related to thrombotic events and APS,' study authors wrote. SOURCE: The study was led by Eduardo Gómez-Bañuelos, MD, PhD, Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore. It was published online in Annals of the Rheumatic Diseases on May 10, 2025. LIMITATIONS: Due to the cross-sectional nature of the sample collection, the researchers could not determine whether anti-TFAM seroconversion occurs simultaneously or sequentially with vascular events in SLE. The significance of anti-TFAM antibodies with thrombotic events in other patient groups without SLE or primary APS requires further investigation. DISCLOSURES: The study was funded by the Jerome L. Greene Foundation, the National Institute of Allergy and Infectious Diseases, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases. One author disclosed receiving consulting fees and/or royalties from Celgene, Inova, Advise Connect Inspire, and Hillstar Bio Inc.
Yahoo
11-04-2025
- Entertainment
- Yahoo
Wordle hints today for #1,392: Clues and answer for Friday, April 11
Hey, there! The weekend is right around the corner. Let's make sure your Wordle streak stays intact before we get there. In case you need a helping hand, here's our daily Wordle guide with some hints and the answer for Friday's puzzle (#1,392). It may be that you're a Wordle newcomer and you're not completely sure how to play the game. We're here to help with that too. Wordle is a deceptively simple daily word game that first emerged in 2021. The gist is that there is one five-letter word to deduce every day by process of elimination. The daily word is the same for everyone. Wordle blew up in popularity in late 2021 after creator Josh Wardle made it easy for players to share an emoji-based grid with their friends and followers that detailed how they fared each day. The game's success spurred dozens of clones across a swathe of categories and formats. The New York Times purchased Wordle in early 2022 for an undisclosed sum. The publication said that players collectively played Wordle 5.3 billion times in 2024. So, it's little surprise that Wordle is one of the best online games and puzzles you can play daily. To start playing Wordle, you simply need to enter one five-letter word. The game will tell you how close you are to that day's secret word by highlighting letters that are in the correct position in green. Letters that appear in the word but aren't in the right spot will be highlighted in yellow. If you guess any letters that are not in the secret word, the game will gray those out on the virtual keyboard. You'll only have six guesses to find each day's word, though you still can use grayed-out letters to help narrow things down. It's also worth remembering that letters can appear in the secret word more than once. Wordle is free to play on the NYT's website and apps, as well as on Meta Quest headsets. The game refreshes at midnight local time. If you log into a New York Times account, you can track your stats, including the all-important win streak. If you have a NYT subscription that includes full access to the publication's games, you don't have to stop after a single round of Wordle. You'll have access to an archive of more than 1,300 previous Wordle games. So if you're a relative newcomer, you'll be able to go back and catch up on previous editions. In addition, paid NYT Games members have access to a tool called the Wordle Bot. This can tell you how well you performed at each day's game. Before today's Wordle hints, here are the answers to recent puzzles that you may have missed: Yesterday's Wordle answer for Thursday, April 10 — TURBO Wednesday, April 9 — WHEAT Tuesday, April 8 — SPARE Monday, April 7 — HAZEL Sunday, April 6 — VILLA Every day, we'll try to make Wordle a little easier for you. First, we'll offer a hint that describes the meaning of the word or how it might be used in a phrase or sentence. We'll also tell you if there are any double (or even triple) letters in the word. In case you still haven't quite figured it out by that point, we'll then provide the first letter of the word. Those who are still stumped after that can continue on to find out the answer for today's Wordle. This should go without saying, but make sure to scroll slowly. Spoilers are ahead. Here is a hint for today's Wordle answer: Robin Hood's preferred projectile. There is a pair of letters in today's Wordle answer. The first letter of today's Wordle answer is A. This is your final warning before we reveal today's Wordle answer. No take-backs. Don't blame us if you happen to scroll too far and accidentally spoil the game for yourself. What is today's Wordle? Today's Wordle answer is... ARROW Not to worry if you didn't figure out today's Wordle word. If you made it this far down the page, hopefully you at least kept your streak going. And, hey: there's always another game tomorrow.
Yahoo
10-04-2025
- Entertainment
- Yahoo
Wordle hints today for #1,391: Clues and answer for Thursday, April 10
Hey, there! We hope you're having a great week. Let's keep the good times — and your Wordle streak — rolling. To help with that, here's our daily Wordle guide with some hints and the answer for Thursday's puzzle (#1,391). It may be that you're a Wordle newcomer and you're not completely sure how to play the game. We're here to help with that too. Wordle is a deceptively simple daily word game that first emerged in 2021. The gist is that there is one five-letter word to deduce every day by process of elimination. The daily word is the same for everyone. Wordle blew up in popularity in late 2021 after creator Josh Wardle made it easy for players to share an emoji-based grid with their friends and followers that detailed how they fared each day. The game's success spurred dozens of clones across a swathe of categories and formats. The New York Times purchased Wordle in early 2022 for an undisclosed sum. The publication said that players collectively played Wordle 5.3 billion times in 2024. So, it's little surprise that Wordle is one of the best online games and puzzles you can play daily. To start playing Wordle, you simply need to enter one five-letter word. The game will tell you how close you are to that day's secret word by highlighting letters that are in the correct position in green. Letters that appear in the word but aren't in the right spot will be highlighted in yellow. If you guess any letters that are not in the secret word, the game will gray those out on the virtual keyboard. You'll only have six guesses to find each day's word, though you still can use grayed-out letters to help narrow things down. It's also worth remembering that letters can appear in the secret word more than once. Wordle is free to play on the NYT's website and apps, as well as on Meta Quest headsets. The game refreshes at midnight local time. If you log into a New York Times account, you can track your stats, including the all-important win streak. If you have a NYT subscription that includes full access to the publication's games, you don't have to stop after a single round of Wordle. You'll have access to an archive of more than 1,300 previous Wordle games. So if you're a relative newcomer, you'll be able to go back and catch up on previous editions. In addition, paid NYT Games members have access to a tool called the Wordle Bot. This can tell you how well you performed at each day's game. Before today's Wordle hints, here are the answers to recent puzzles that you may have missed: Yesterday's Wordle answer for Wednesday, April 9 — WHEAT Tuesday, April 8 — SPARE Monday, April 7 — HAZEL Sunday, April 6 — VILLA Saturday, April 5 — FOAMY Every day, we'll try to make Wordle a little easier for you. First, we'll offer a hint that describes the meaning of the word or how it might be used in a phrase or sentence. We'll also tell you if there are any double (or even triple) letters in the word. In case you still haven't quite figured it out by that point, we'll then provide the first letter of the word. Those who are still stumped after that can continue on to find out the answer for today's Wordle. This should go without saying, but make sure to scroll slowly. Spoilers are ahead. Here is a hint for today's Wordle answer: A 2013 animated movie about a racing snail. There are no repeated letters in today's Wordle answer. The first letter of today's Wordle answer is T. This is your final warning before we reveal today's Wordle answer. No take-backs. Don't blame us if you happen to scroll too far and accidentally spoil the game for yourself. What is today's Wordle? Today's Wordle answer is... TURBO Not to worry if you didn't figure out today's Wordle word. If you made it this far down the page, hopefully you at least kept your streak going. And, hey: there's always another game tomorrow.
Yahoo
10-04-2025
- Entertainment
- Yahoo
Wordle hints today for #1,390: Clues and answer for Wednesday, April 9
Hey, there! We've reached the midway point of the week and we hope your Wordle streak remains intact. To help keep your streak going — or kick off a fresh one — here's our daily Wordle guide with some hints and the answer for Wednesday's puzzle (#1,390). It may be that you're a Wordle newcomer and you're not completely sure how to play the game. We're here to help with that too. Wordle is a deceptively simple daily word game that first emerged in 2021. The gist is that there is one five-letter word to deduce every day by process of elimination. The daily word is the same for everyone. Wordle blew up in popularity in late 2021 after creator Josh Wardle made it easy for players to share an emoji-based grid with their friends and followers that detailed how they fared each day. The game's success spurred dozens of clones across a swathe of categories and formats. The New York Times purchased Wordle in early 2022 for an undisclosed sum. The publication said that players collectively played Wordle 5.3 billion times in 2024. So, it's little surprise that Wordle is one of the best online games and puzzles you can play daily. To start playing Wordle, you simply need to enter one five-letter word. The game will tell you how close you are to that day's secret word by highlighting letters that are in the correct position in green. Letters that appear in the word but aren't in the right spot will be highlighted in yellow. If you guess any letters that are not in the secret word, the game will gray those out on the virtual keyboard. You'll only have six guesses to find each day's word, though you still can use grayed-out letters to help narrow things down. It's also worth remembering that letters can appear in the secret word more than once. Wordle is free to play on the NYT's website and apps, as well as on Meta Quest headsets. The game refreshes at midnight local time. If you log into a New York Times account, you can track your stats, including the all-important win streak. If you have a NYT subscription that includes full access to the publication's games, you don't have to stop after a single round of Wordle. You'll have access to an archive of more than 1,300 previous Wordle games. So if you're a relative newcomer, you'll be able to go back and catch up on previous editions. In addition, paid NYT Games members have access to a tool called the Wordle Bot. This can tell you how well you performed at each day's game. Before today's Wordle hints, here are the answers to recent puzzles that you may have missed: Yesterday's Wordle answer for Tuesday, April 8 — SPARE Monday, April 7 — HAZEL Sunday, April 6 — VILLA Saturday, April 5 — FOAMY Friday, April 4 — KRILL Every day, we'll try to make Wordle a little easier for you. First, we'll offer a hint that describes the meaning of the word or how it might be used in a phrase or sentence. We'll also tell you if there are any double (or even triple) letters in the word. In case you still haven't quite figured it out by that point, we'll then provide the first letter of the word. Those who are still stumped after that can continue on to find out the answer for today's Wordle. This should go without saying, but make sure to scroll slowly. Spoilers are ahead. Here is a hint for today's Wordle answer: Separate the ____ from the chaff. There are no repeated letters in today's Wordle answer. The first letter of today's Wordle answer is W. This is your final warning before we reveal today's Wordle answer. No take-backs. Don't blame us if you happen to scroll too far and accidentally spoil the game for yourself. What is today's Wordle? Today's Wordle answer is... WHEAT Not to worry if you didn't figure out today's Wordle word. If you made it this far down the page, hopefully you at least kept your streak going. And, hey: there's always another game tomorrow.
