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Salvia raises $60m to advance chronic migraine neuromodulation therapy
Salvia raises $60m to advance chronic migraine neuromodulation therapy

Yahoo

time27-05-2025

  • Business
  • Yahoo

Salvia raises $60m to advance chronic migraine neuromodulation therapy

Salvia BioElectronics has raised €53m ($60m) in a Series B funding round towards advancing its non-invasive approach to treating chronic migraine. The Dutch startup's MySalvia therapy for individuals with chronic migraine uses implants that target key nerves involved in migraine, aiming to reduce the frequency and intensity of migraine attacks. MySalvia users can activate the therapy, wherein electrical pulses intended to restore balance and relieve symptoms, are delivered by the neuromodulation implant via control of an external wearable device. More common in women than men, estimates suggest that chronic migraine affects 1-2% of the global population. Salvia's implantable neurostimulation system was granted breakthrough device designation by the US Food and Drug Administration (FDA) in 2020. In 2023, a 29-year-old Australian woman became the first patient to be treated as part of the clinical trial (NCT05868044) for the device. The patient reported improvement in the frequency and intensity of her headaches immediately following the treatment. Salvia founder and CEO, Hubert Martens commented: 'Chronic migraine is not 'just a headache'. 'It is a debilitating neurological condition that forces people out of their social life, their work, and the life they want to live. Our mission is to restore their freedom.' Martens added that the latest funding tranche, which brings Salvia's funding to date to around $97m, will support its advancement towards regulatory approval and commercialisation, with the ultimate goal being to reach the millions of people affected by chronic migraine. Other companies developing neuromodulation devices for migraine include Neurolief. In 2024, the company's Relivion neuromodulation device was approved by the Japanese Ministry of Health, Labor and Welfare (MHLW) for at-home use in the acute treatment of migraine. Neuromodulation is now accelerating towards real-world breakthroughs for other conditions including tinnitus, substance use disorder, Parkinson's disease, and epilepsy. According to a report by GlobalData, the overall global neurological devices market will reach a valuation of $20.9bn by 2033, up from $12.5bn in 2023. Recent moves by some of medtech's biggest players include Abbott's launch of a 'next-generation' delivery system in April 2025 for streamlining the electrode implantation process for its Proclaim DRG neurostimulation system, and the initiation of a pivotal trial investigating its deep brain stimulation system for treatment-resistant depression in March. "Salvia raises $60m to advance chronic migraine neuromodulation therapy" was originally created and published by Medical Device Network, a GlobalData owned brand. The information on this site has been included in good faith for general informational purposes only. It is not intended to amount to advice on which you should rely, and we give no representation, warranty or guarantee, whether express or implied as to its accuracy or completeness. You must obtain professional or specialist advice before taking, or refraining from, any action on the basis of the content on our site. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data

Dindigul lock, Ayakudi Guava, Kodaikanal Hill Garlic all made up of flowers captivate people at Kodaikanal flower show
Dindigul lock, Ayakudi Guava, Kodaikanal Hill Garlic all made up of flowers captivate people at Kodaikanal flower show

The Hindu

time24-05-2025

  • The Hindu

Dindigul lock, Ayakudi Guava, Kodaikanal Hill Garlic all made up of flowers captivate people at Kodaikanal flower show

Dindigul lock, Ayakudi Guava, and Kodaikanal Hill Garlic, all made up of flowers, were the highlight of the inaugural day of the 10-day annual summer festival and 62nd flower show at Bryant Park in Kodaikanal on Saturday. The flower show was inaugurated by Dindigul Member of Parliament. R. Sachithanantham and Dindigul Collector S. Saravanan in the presence of Additional Chief Secretary of Tourism, Culture and Religious Endowments Department K. Manivasan, Agricultural Production Commissioner and Secretary to the Agriculture and Farmers Welfare Department V. Dakshinamoorthy and Director (In-charge) of Horticulture and Plantation Crops B. Murugesh. The opening day of the event witnessed a decent crowd. The authorities said that they expected an increase in the number of visitors in the coming days. The government was organising the summer festival and flower show to showcase the art and culture of Tamil Nadu and the festival would be held till June 1. The people were captivated by over 70,000 flowers that were arranged in various shapes and sizes. Flowers from across the globe were displayed at the event. Flowers were arranged in the shape of peacocks and elephants were carved out of vegetables. There were also messages to create awareness among the tourists to avoid the use of plastic and protect the environment and wildlife Some of flowers on display included Salvia, Delphinium, Ornithogalum, Gazania, Penstemon, Verbena, Coreopsis, Dahlia, Lilium, Antirrhinum, pansy, Marigold, Dianthus, Zinnia, California Poppy, etc. Basic facilities including drinking water and toilet facilities, parking, transportation facilities and other arrangements were made to prevent traffic congestion. People were seen enthusiastically clicking photographs and selfies with the flowers on display. Cultural programmes, art performances and various competitions have been organised as part of the event. The authorities said that they expected around 1.5 lakh tourists to visit the 10-day event.

These deer-resistant flowers and plants are perfect for a Lower Hudson Valley garden
These deer-resistant flowers and plants are perfect for a Lower Hudson Valley garden

Yahoo

time24-04-2025

  • Lifestyle
  • Yahoo

These deer-resistant flowers and plants are perfect for a Lower Hudson Valley garden

Baffled by four-legged neighbors making a meal out of your garden? White-tailed deer, one of New York's most common species of herbivore, can "play a role in shaping the landscape," the state Department of Environment Conservation says, which at times competes with "human interests." While adorable to look at, the fairytale gets old fast when deer show up to the garden. Known to have an appetite for flowers and greens, they'll take to your yard like they're at a salad bar, and the produce is as fresh as it gets. Don't sweat the deer— get choosy about what you're planting. And at Down to Earth Living garden center in Pomona, there are plenty of options available. Plants like Salvia, also know as meadow sage, are deer-resistant, meaning the humble herbivores will avoid them. "They come in a variety of colors, from purple to blue, to pink to white, to raspberry," said Tina Anton of Down to Earth Living. "They're wonderful to do as groupings... a whole field of them is beautiful, and the deer don't really like them." Long-blooming and easy to care for, Anton recommends them for those looking to add more deer-resistant plants to their landscape. Other plants include springy florals and hardy evergreens. Choose from lovely foxgloves, with tall stalks and bell-like flowers in a range of bumblebee-attracting colors (they're toxic to animals, and people, so deer avoid them.) If you're looking for a flourish, perhaps forsythias are more your style— with their woody sprigs dotted with yellow blossoms (the deer hate those, too.) The moral of the story is: gardeners can be confident "that planting (deer-resistant plants) on a Thursday— they'll still be there on a Friday," according to Down to Earth Living's Stuart Leventhal. For those looking for to landscape with some trees, Leventhal recommended spruces of the Alberta and Norway varieties. Even fragrant and colorful peonies are deer-resistant, Anton said. All of the above flourish in New York's climate. While the Old Farmer's Almanac stresses that there are "no completely deer-proof plants (if food is scarce, they'll eat anything,)" there are lots of options to up your chances of keeping your garden glorious. Deer are less likely to eat poisonous plants, as well as fragrant plants with strong scents, such as herbs, the Old Farmer's Almanac explains. If you're gardening in the Lower Hudson Valley, look for plants that thrive in your hardiness zone (the region is home to zones 6a through 7b). You can find a hardiness map at See a few good options below. Yarrow Onion Horseradish Tarragon Asparagus Lavender Horehound Lemon Balm Mint Basil Sage, Russian and Garden varieties Anise Rosemary (zone 7) Thyme Eager to garden? Cold-weather annual plants are perfect for early spring in NY White-tailed deer are the most common species of deer you'll see in southeast New York, and that includes the Lower Hudson Valley. This species is multi-talented: according to the NYDEC, they can swim, run as fast as 40 mph, and yes— jump that 8-foot-high fence you think is protecting your garden. According to the species eats what is classified as "browse" (leaves and twigs of woody plants), "forbs" (weeds), grasses, nuts and fruits and mushrooms. The availability of their favorite snacks depend on time of year and climate. Deer love to eat narrow-leafed evergreens, such as arborvitae and fir, according to the Old Farmer's Almanac. You'll also want to avoid hostas, daylilies and English ivy, as deer are known to show preference for those plants. The answer is yes. Deer are known to carry blacklegged ticks (also known as deer ticks) from one place to the other. Deer ticks are the primary carrier of Lyme disease, so even more reason to keep the animal away from parts of the garden you'd like to enjoy (the deer themselves are not the source of Lyme, the CDC says.) Contributing: lohud's Peter Carr This article originally appeared on Rockland/Westchester Journal News: These flowers and plants are deer-resistant, and thrive in NY gardens

Mary Berry's favourite plants (and the ones she couldn't get to grips with)
Mary Berry's favourite plants (and the ones she couldn't get to grips with)

Telegraph

time13-04-2025

  • General
  • Telegraph

Mary Berry's favourite plants (and the ones she couldn't get to grips with)

We all have our favourite plants, as well as plants we long for but just can't grow – and, just as sadly, those we wish we had never planted. My cousin, Claire Austin, a serious perennial grower, surprised me by saying that she could not grow the newish, often adored Salvia 'Amistad': her garden in Wales is just too wet, so it is not winter-hardy with her. I approached a few other great gardeners, to find out what they just could not grow but wanted to, and the plants they love the most. Mary Berry Mary Berry 's favourite plant is Iris unguicularis 'Mary Barnard'. Its brilliant blue flowers show from January until March, giving her three months of picking, so she has tiny vases for them and mixes them with other spring favourites such as primroses. They last for a couple of days in water. Mary advises growing them in a sunny position; hers are in gravel and they spread well and have been welcome presents to her friends. She has, however, been disappointed with paperwhite narcissi. 'I have grown these, aiming to have them at Christmastime in abundance in a pot, but they were disappointing, and the sadness is that you can't plant them outside for flowers next year as they are tender,' she says. And she rues the day she planted bear's breech: 'I planted Acanthus mollis at my old house but after a few years it was so invasive and took over – and it was tricky to get rid of. It took up valuable space at the back of the border which I wanted for other precious plants.' This smart evergreen perennial can be perfect however if you have large areas to fill. Jim Carter and Imelda Staunton The actors Jim Carter and Imelda Staunton have a garden full of treasures, but they struggle with sweet peas. 'We wish we had better success with sweet peas,' says Jim. 'If we grow them in a pot they become a tangled lopsided mess, with short flower stems and masses of foliage. If we grow them in the garden they turn their backs on us and head towards the sun and away from our noses.' I too do find sweet peas quite hard work, and believe they are a labour of love. As to what Jim and Imelda are fond of: 'When we moved to this house 30 years ago we inherited a lot of wild garlic,' says Jim. 'Over the years we've edited it – it's pretty impossible to eradicate – and now its cheerful white flowers are a randomly scattered and welcome addition to the borders.' Adam Clayton Adam, bass guitarist for the rock band U2 and a keen gardener, says: 'One plant we have been attempting to grow, though we are on the borderline of its hardiness zone, is x Gordlinia grandiflora. We've tried planting it in a couple of spots, but unfortunately it has succumbed to frost. However, I believe that with the right placement, we may eventually succeed.' This is groundbreaking – this new cross between two species is pretty rare, and relatively untested in the UK. Adam's favourite is the tree-like Magnolia campbellii that grows up to 30 metres tall, with huge pink flowers. As for one he wishes he didn't have? 'A plant I wish had never been introduced to my garden – though it wasn't by me – is the Victorian-era planting of laurel,' he says. 'Removing this aggressive intruder has required significant effort, but clearing it has been well worth it.' I have cleared acres of this beast, Prunus laurocerasus, from many gardens. My method is quick and painless: chainsaw branches/stumps to the ground and screw in ecoplugs into the stumps – they never come back and the roots rot in the ground. David Haig Actor David Haig, a keen gardener, has a problem with clematis at his garden in south-east London. 'I wish I could grow clematis more successfully,' he says. 'Invariably ours get wilt and I have no idea why. The one clematis which has always thrived in our garden is Clematis 'Niobe', so we have three. It also happens to be my favourite 'horticultural colour', deep red, at times almost black.' It is not uncommon to have a problem establishing these. I bet it is not wilt that is the problem though, but slugs, and not enough water when establishing them, which can be a slow process. Sophie Conran Eremurus robustus – the foxtail lily or giant desert candle – is the bane of Sophie Conran. 'Its striking spires have been playing will-o'-the-wisp with me, by positively refusing to flourish, despite a few attempts and giving encouraging initial signs,' she says. 'They have all petered out and I have sulkily given up. I have however been assured that another try will reap rewards.' I was successful with these at the third attempt and now they are like weeds. A plant I tried to grow several times is Eupatorium maculatum, joe-pyeweed. I would love to have it, but Sophie, who obviously has far more moisture-retentive soil than mine, says: 'This giant of a plant has been banished from the borders as it spreads like wildfire, taking over the show and not giving much in the way of gentle beauty in return. I initially employed it as a filler when I started getting to grips with the big beds along the wall in the front garden, that had not much to speak of, and there it thrived in an alarming way. 'Eupatorium is just way too weed-like for me, and not nearly pretty enough to win my heart. I love nature and wild places, I even love naturalistic planting in other people's gardens, but when it comes to my borders I want lovely sunny English country garden flowers that have colour, form and abundance.' Matthew Rice Painter and designer Matthew Rice is a brilliant gardener but he finds blueberries just impossible in alkaline soil, despite endless peat and soil adjustments. 'I have abandoned ship as they yellow and wither – just not worth it,' he says. Many agree with this, but growing them in a large container with acid compost and adding sulphur chips does get around it. They love loads of moisture, but try to water from the rain butt, not the tap. He champions zinnia and has grown them for 20 years. 'They are obliging and floriferous, and flower continuously from June to the middle of October in dolly mixture colours you can't find anywhere else,' he says. 'I sow most direct into the soil in May.' Fergus Garrett Plantsman Fergus Garrett, head gardener of Great Dixter, bemoans he cannot succeed with Agave attenuata: 'The foxtail agave is sleek but muscular, with impressive rosettes of grey green, and fascinating. I've tried to overwinter it several times now but we are just too wet and too cold.' For those of us in dryer areas with free-draining soil in a warm, sheltered spot, it might just succeed. It's often said beware of gardeners bearing gifts, as they tend to be the incontinent spreaders. We all have some of these. Fergus Garrett's unruly number is Helianthus angustifolius which he planted in the stock beds. 'Although handsome in flower, with striking yellow flowers, it has simply taken over, running into everything and making a nuisance of itself,' he says. 'It needs to be free where its aggressive wandering habit is not an issue.' Debs Goodenough Debs Goodenough, former head gardener at Highgrove, struggles with Edgeworthia chrysantha: 'What a fabulous plant,' she enthuses, 'but on far too many attempts of growing this darling of a winter-flowering shrub at various gardens I've managed, it's looked at me, and said 'No'. This has been so frustrating when seeing so many good specimens and groupings at places like Hilliers and Wisley. I might try again, or maybe I'll just recommend it to others and enjoy their success.' Debs has made the same mistake that I have with Vinca. ' Vinca major 'Alba' is a sensible evergreen cover with lovely white flowers – how I mollycoddled those first plantings and diligently weeded out between plants for the first couple of years,' she says. 'Then it decided the bank wasn't enough and this not-so-lovely periwinkle was showing up everywhere in the garden from little bits which had transplanted themselves around. Two full years of meticulously digging out and now, five years on, it shows up in the most difficult places to weed.' I'm sure many of us have had a similar experience. Shane Connolly Florist Shane Connolly, who designed the flowers for the King's coronation, has issues with irises. 'One of the things I hugely admire in other people's gardens are irises, but I struggle to find a suitable spot in my Herefordshire garden,' he says. 'They do not seem to want to mix and mingle easily, so they have never really had time to settle in and shine. I especially love the Benton End ones. 'What do I wish I had never planted? Sadly Alchemilla mollis; it's just too enthusiastic,' he says. 'I once saw it controlled by regular strimming at Hodges Barn in Gloucestershire and it really is the only way.' As for his favourite, wintersweet, Chimonanthus praecox, is, he reckons, essential for fragrant winter arrangements. Derry Watkins Derry Watkins is a passionate plantswomen who runs Special Plant Nursery, and, like Debs Goodenough and I, has had a problem with Vinca. 'A Vinca I brought back seed of from Chile twenty years ago has been the bane of my rockery ever since,' she says. Also, ' Molinia arundinacea is beautiful, especially in autumn, but the seedlings are quickly deep-rooted. They like to seed into other plants and if you miss them when young, you need an axe to get them out.' Derry loves simple, easy-to-grow favourites that I also have and adore: Tulipa sprengeri, Smyrnium perfoliatum and Lunaria annua 'Corfu Blue'. 'They are all generous self-sowing plants with maximum impact for a fairly short period,' she says. 'They're beautiful and I never have to worry about them; they do their own thing when and where they want to. They're ephemeral, so the garden is ever changing.'

Hummingbird migration map 2025: See when, where hummingbirds can be spotted in Oklahoma
Hummingbird migration map 2025: See when, where hummingbirds can be spotted in Oklahoma

Yahoo

time25-03-2025

  • Yahoo

Hummingbird migration map 2025: See when, where hummingbirds can be spotted in Oklahoma

With spring well under way and the air progressively warming in Oklahoma, it's time for migratory species to make their way north once more. Among the migratory birds navigating their annual trek out of the south are several species of hummingbirds, some of which cross through Oklahoma. a website created by "backyard birding enthusiasts," has shared an interactive map of hummingbird sightings nationwide. The site says they usually track the birds migration from late-January to mid-May, but notes they don't post every single sighting due to the volume reported. Multiple hummingbird species chart a path through Oklahoma in the spring and either stay to nest or push on through to a further north location. The Ruby-throated and Black-chinned hummingbirds nest in Oklahoma and can be seen into the summer months, according to the Oklahoma City Audubon Society. The more commonly seen of the two is the Ruby-throated hummingbird, which typically arrives in Oklahoma in April and leaves in September. However, a Ruby-throated has already been spotted in Hochatown,, Oklahoma on March 22, according to the map. The Rufous hummingbird can be seen migrating through Oklahoma in the spring and fall as they head west and then north to the Pacific Northwest. Explore the map for yourself here: Submit your hummingbird sighting through Hummingbirds eat nectar from flowers and small insects, such as aphids and spiders. Each day, a hummingbird feeds in many small meals, and they can consume up to 12 times their own body weight in nectar each day. The easiest way to attract hummingbirds is by hanging a feeder. According to Hummingbird Central, there's no need to use red dye or pre-mixed commercial nectar, as it can be harmful to hummingbirds. Instead, the site recommends a homemade mixture consisting of four parts water to one part sugar, which emulates the amount of sugar naturally found in nectar. If you want to attract hummingbirds on a larger scale, you'll want to design your garden or flowerbeds around their needs: shelter, plenty of flowers and a bird bath. Hummingbird central recommends the following flowering plants: Lantana, Zinnias, Pentas, Salvia, Batface Cuphea, Hot Lips, Fire Bush, Nasturtiums, Coreopsis, among others. This article originally appeared on Oklahoman: Hummingbird migration map 2025: See when, where in Oklahoma

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