Latest news with #SeerInc
Associated Press
3 days ago
- Health
- Associated Press
Seer's Proteograph Platform Enables Unprecedented 20,000-Sample Proteomics Study with Korea University to Develop AI-Driven Diagnostics for Cancers in Young Adults
First-of-its-kind study will use Seer's next-generation workflow to identify early-onset cancer biomarkers and power deep, unbiased mass spectrometry-based proteomics Seer's new Proteograph ONE Assay to accelerate analysis and reduce costs, making large-scale studies feasible REDWOOD CITY, Calif., June 01, 2025 (GLOBE NEWSWIRE) -- Seer, Inc. (Nasdaq: SEER), the pioneer and trusted partner for deep, unbiased proteomic insights, and Korea University, a leading research institution committed to innovation and global impact, today announced the launch of a population-level study aimed at identifying novel blood-based biomarkers that could lead to cancer diagnostics for young adults in their 20s and 30s. Relying on Seer's newly launched Proteograph® ONE Assay and SP200 Automation Instrument along with the Thermo Scientific™ Orbitrap™ Astral™ mass spectrometer, this is the first large-scale plasma proteomics initiative of its kind to leverage mass spectrometry and AI-driven analytics to enhance early cancer detection and improve patient outcomes. Seer's latest platform advances will allow deep, unbiased proteomic analysis of 20,000 plasma samples in less time and cost than has ever before been possible. These will include samples from 15,000 cancer patients and 5,000 healthy patients that will serve as controls, sourced from Korea's leading cancer institutions: Seoul National University Hospital, the National Cancer Center, and Samsung Medical Center. The three-year study is funded by the K-Health MIRAE initiative under the Ministry of Health and Welfare, Republic of Korea, which supports ambitious, high-impact health research. 'We carefully evaluated multiple approaches to expand the dynamic range of the plasma proteome—including some attempting to replicate Seer's Proteograph platform—and Seer's assay stood out as the only solution capable of delivering the depth, scale, and, critically, reproducibility needed for this ambitious study,' said Professor Sang-Won Lee at the Center of Proteogenome Research (CPGR) of Korea University. 'The unique combination of Seer's latest platform and CPGR's proprietary dual online liquid chromatography technology gives us the ability to conduct population-scale research that would otherwise be prohibitively complex and slow. This collaboration represents a major step toward developing AI-powered diagnostics that could fundamentally improve how we detect and treat cancer in younger adults.' By leveraging the power of deep proteomic analysis, this study aims to catalyze a new wave of diagnostics that are more sensitive, scalable, and personalized—ultimately driving earlier interventions and improving survival outcomes in young adult cancer patients worldwide. Transformational Technology for Population-Scale Proteomics At the heart of the study is Seer's Proteograph ONE workflow, introduced this week at the 2025 American Society for Mass Spectrometry (ASMS) Conference in Baltimore, MD. The next-generation system dramatically increases scale and efficiency in proteomic analysis by: 'Korea University selected Seer's new Proteograph ONE workflow as the foundation for this critical and forward-looking initiative so that they can unlock the full potential of proteomics in population-scale research,' said Omid Farokhzad, Chair and CEO of Seer. 'We're excited to help define a new generation of diagnostics that can transform how diseases like cancer are detected and managed around the world.' The study also employs Thermo Scientific's Orbitrap Astral MS—the industry's leading mass spectrometer for proteomic research. The Proteograph offerings combined with the Orbitrap Astral MS provide a deep, full-range plasma proteome analysis at faster speeds to enable critical breakthrough discoveries in large-population studies. 'When it comes to plasma proteomics studies such as this, the Orbitrap Astral MS and Proteograph ONE workflow provide a powerful solution to drive groundbreaking research,' said Dan Shine, senior vice president and president of analytical instruments, Thermo Fisher Scientific. 'We're proud to be a part of initiatives like this to enable earlier detection and help progress precision medicine.' The next-generation offerings mark a significant evolution of the Proteograph Product Suite, delivering the scale, speed, and efficiency required to make population-level proteomics both practical and accessible. The collaboration with Korea University exemplifies the real-world impact of this technology—demonstrating how deep, unbiased proteomic insights powered by Seer's platform can now inform large-scale studies, accelerate biomarker discovery, and drive the development of AI-enabled diagnostics that redefine precision medicine. About Seer, Inc. Seer, Inc. (Nasdaq: SEER) sets the standard in deep, unbiased proteomics—delivering insights with a scale, speed, precision, and reproducibility previously unattainable. Seer's Proteograph Product Suite uniquely integrates proprietary engineered nanoparticles, streamlined automation instrumentation, optimized consumables, and advanced analytical software to solve challenges conventional methods have failed to overcome. Traditional proteomic technologies have struggled with inconsistent data, limited throughput, and prohibitive complexity, but Seer's robust and scalable workflow consistently reveals biological insights that others cannot. Seer's products are for research use only and are not intended for diagnostic procedures. For more information about Seer's differentiated approach and ongoing leadership in proteomics, visit Media Contact: Consort Partners [email protected] Investor Contact: Carrie Mendivil [email protected]
Yahoo
3 days ago
- Health
- Yahoo
Seer's Proteograph Platform Enables Unprecedented 20,000-Sample Proteomics Study with Korea University to Develop AI-Driven Diagnostics for Cancers in Young Adults
First-of-its-kind study will use Seer's next-generation workflow to identify early-onset cancer biomarkers and power deep, unbiased mass spectrometry-based proteomics Seer's new Proteograph ONE Assay to accelerate analysis and reduce costs, making large-scale studies feasible REDWOOD CITY, Calif., June 01, 2025 (GLOBE NEWSWIRE) -- Seer, Inc. (Nasdaq: SEER), the pioneer and trusted partner for deep, unbiased proteomic insights, and Korea University, a leading research institution committed to innovation and global impact, today announced the launch of a population-level study aimed at identifying novel blood-based biomarkers that could lead to cancer diagnostics for young adults in their 20s and 30s. Relying on Seer's newly launched Proteograph® ONE Assay and SP200 Automation Instrument along with the Thermo Scientific™ Orbitrap™ Astral™ mass spectrometer, this is the first large-scale plasma proteomics initiative of its kind to leverage mass spectrometry and AI-driven analytics to enhance early cancer detection and improve patient outcomes. Seer's latest platform advances will allow deep, unbiased proteomic analysis of 20,000 plasma samples in less time and cost than has ever before been possible. These will include samples from 15,000 cancer patients and 5,000 healthy patients that will serve as controls, sourced from Korea's leading cancer institutions: Seoul National University Hospital, the National Cancer Center, and Samsung Medical Center. The three-year study is funded by the K-Health MIRAE initiative under the Ministry of Health and Welfare, Republic of Korea, which supports ambitious, high-impact health research. 'We carefully evaluated multiple approaches to expand the dynamic range of the plasma proteome—including some attempting to replicate Seer's Proteograph platform—and Seer's assay stood out as the only solution capable of delivering the depth, scale, and, critically, reproducibility needed for this ambitious study,' said Professor Sang-Won Lee at the Center of Proteogenome Research (CPGR) of Korea University. 'The unique combination of Seer's latest platform and CPGR's proprietary dual online liquid chromatography technology gives us the ability to conduct population-scale research that would otherwise be prohibitively complex and slow. This collaboration represents a major step toward developing AI-powered diagnostics that could fundamentally improve how we detect and treat cancer in younger adults.' By leveraging the power of deep proteomic analysis, this study aims to catalyze a new wave of diagnostics that are more sensitive, scalable, and personalized—ultimately driving earlier interventions and improving survival outcomes in young adult cancer patients worldwide. Transformational Technology for Population-Scale Proteomics At the heart of the study is Seer's Proteograph ONE workflow, introduced this week at the 2025 American Society for Mass Spectrometry (ASMS) Conference in Baltimore, MD. The next-generation system dramatically increases scale and efficiency in proteomic analysis by: Processing 1,000+ samples per week per instrument Requiring only a single mass spectrometry injection per sample Completing 80-sample batches with <5 hours automated runtime Identifying up to 10 times more proteins than conventional mass spectrometry methods 'Korea University selected Seer's new Proteograph ONE workflow as the foundation for this critical and forward-looking initiative so that they can unlock the full potential of proteomics in population-scale research,' said Omid Farokhzad, Chair and CEO of Seer. 'We're excited to help define a new generation of diagnostics that can transform how diseases like cancer are detected and managed around the world.' The study also employs Thermo Scientific's Orbitrap Astral MS—the industry's leading mass spectrometer for proteomic research. The Proteograph offerings combined with the Orbitrap Astral MS provide a deep, full-range plasma proteome analysis at faster speeds to enable critical breakthrough discoveries in large-population studies. 'When it comes to plasma proteomics studies such as this, the Orbitrap Astral MS and Proteograph ONE workflow provide a powerful solution to drive groundbreaking research,' said Dan Shine, senior vice president and president of analytical instruments, Thermo Fisher Scientific. 'We're proud to be a part of initiatives like this to enable earlier detection and help progress precision medicine.' The next-generation offerings mark a significant evolution of the Proteograph Product Suite, delivering the scale, speed, and efficiency required to make population-level proteomics both practical and accessible. The collaboration with Korea University exemplifies the real-world impact of this technology—demonstrating how deep, unbiased proteomic insights powered by Seer's platform can now inform large-scale studies, accelerate biomarker discovery, and drive the development of AI-enabled diagnostics that redefine precision medicine. About Seer, Inc. Seer, Inc. (Nasdaq: SEER) sets the standard in deep, unbiased proteomics—delivering insights with a scale, speed, precision, and reproducibility previously unattainable. Seer's Proteograph Product Suite uniquely integrates proprietary engineered nanoparticles, streamlined automation instrumentation, optimized consumables, and advanced analytical software to solve challenges conventional methods have failed to overcome. Traditional proteomic technologies have struggled with inconsistent data, limited throughput, and prohibitive complexity, but Seer's robust and scalable workflow consistently reveals biological insights that others cannot. Seer's products are for research use only and are not intended for diagnostic procedures. For more information about Seer's differentiated approach and ongoing leadership in proteomics, visit Media Contact:Consort Partnerspr@ Investor Contact:Carrie Mendivilinvestor@ in to access your portfolio
Yahoo
14-05-2025
- Business
- Yahoo
Q1 2025 Seer Inc Earnings Call
Kelly Gura; Investor Relations; Seer Inc Omid Farokhzad; Chairman of the Board, Chief Executive Officer, Co-Founder; Seer Inc David Horn; President, Chief Financial Officer, Treasurer; Seer Inc Rachel Vatnsdal; Analyst; JPMorgan Operator Good day, and thank you for standing by. Welcome to Seer first quarter 2025 earnings conference call. At this time all participants are in a listen-only mode. After the speaker's presentation, there will be a question-and-answer session. (Operator Instructions)Please be advised that today's conference is being recorded. I would now like to hand the conference over to Kelly Gura, Investor Relations. Please go ahead. Kelly Gura Thank you. So earlier today, Seer released financial results for the quarter ended March 31, 2025. If you've not received this news release or if you'd like to be added to the company's distribution list, please send an email to investor@ In addition, during today's conference call, we will be referencing a slide presentation that can be accessed on the Events and Presentation section of Seer's Investor Relations website. Joining me today from Seer is Omid Farokhzad, Chief Executive Officer and Chair of the Board; and David Horn, Chief Financial Officer and President. Before we begin, I'd like to remind you that management will make statements during this call that are forward-looking statements within the meaning of federal securities laws. These statements involve material risks and uncertainties that could cause actual results or events to materially differ from those anticipated. Additional information regarding these risks and uncertainties appears in the section titled forward-looking statements in the press release Seer issued today. For a more complete list and description, please see the risk factors section of the company's quarterly report on Form 10-Q for the quarter ended March 31, 2025 and in its other filings with the Securities and Exchange Commission. Except as required by law, Seer disclaims any intention or obligation to update or revise any financial projections or forward-looking statements, whether because of new information, future events, or otherwise. This conference call contains time-sensitive information and is accurate only as of the live broadcast May 13, 2025. With that, I would like to turn the call over to Omid. Omid Farokhzad Thanks, Kelly, and thank you, everyone, for joining us this afternoon. I will begin our talk today by providing updates on our business, and I will then turn the call over to David to provide more detail on our financial results for the first quarter of 2025, as well as our outlook for the full year. Beginning with slide 3, we have always believed that our technology will redefine the trajectory of proteomics and make a meaningful impact within the scientific community. While near-term macroeconomics volatility, including the recently introduced tariffs and ongoing government funding challenges, are expected to persist and limit visibility for the balance of the year, our long-term vision and opportunity remain unchanged. In fact, I'm more confident in that belief than ever before. We delivered a strong start to the year with $4.2 million of revenue in the first quarter, driven by increasing demand for the Proteograph product suite. We shipped as many instruments in the first quarter as were shipped in all of 2024, and saw continued traction for Seer Technology Access Center, or STAC. Our impact is clearly reflected in the high-quality data our customers are generating and the acceleration of publication that further validate the power of our technology. Despite the heightened macroeconomic uncertainty and headwinds that our customers are facing, we're reiterating our full year 2025 revenue guidance of $17 to $18 million, representing 24% year-over-year growth at the midpoint. As the policy landscape continues to evolve, we will closely monitor the impact of US policy changes on our customers as we navigate through this dynamic environment. We continue to view our strong balance sheet of approximately $285 million in cash, cash equivalent and investments as a key differentiator in the current environment, and we remain disciplined in deploying it. In this context, we're making highly concentrated and impactful investments in R&D to execute on our product roadmap and continuing our share repurchase program to benefit shareholders, as we believe there is a significant dislocation between our core value proposition and what our stock price reflects today. While we've not seen direct effects on our supply chain to date from the recent tariff implementations, we are actively de-risking our business in two ways. For the near term, we have worked with our suppliers to ensure price stability at pre-tariff levels over the coming year. And for the longer term, we're evaluating our cost structure and taking steps to improve our margins. We're confident in our strategy, our operational discipline, and the growing demand for deep, unbiased products at scale. Now, I'd like to walk through our recent progress in our core initiatives of validating and enhancing access to the Proteograph product suite in more detail. Starting with the validation of our platform on slide 4, we proudly believe that the best-in-class quality and performance of the Proteograph product suite for deep, unbiased proteomics at scale makes us a trusted partner for our customers. We started Seer with the vision to change the arc of proteomics by providing unprecedented access at scale to the complexity of the proteome for widespread research. Seer is based on an extremely strong scientific foundation for nanoparticle engineering that formed the basis for the Proteograph product suite. As I take a moment to reflect, I believe the growing body of evidence demonstrates that we have already executed on this vision by making the previously impractical, unbiased proteomic studies readily possible today. Our customers have repeatedly demonstrated the power of our technology and the differentiated biological insight they get from the Proteograph product suite. This is recognized in hundreds of abstracts, webinars, seminars, and talks. We now have 42 customer publications, preprints, and reviews showcasing the capabilities of our platform, with many appearing in high-impact journals. Our customers are discovering novel biological that will solve challenges in human health, growing existing end markets that leverage proteomics and creating entirely new end markets that do not exist today. The combination of the Proteograph and mass spec is enabling the scientific community to conduct unbiased proteomic studies with a step change in scale and complexity. We see a future where millions of proteomes will be interrogated in an unbiased way, mirroring what we saw in genomics with increased throughput and accelerated adoption and a reduction in cost. But in proteomics, I believe the slope of adoption will be even steeper, the pace of discovery even more accelerated, and most importantly, the biological insights that will be unlocked will be truly unprecedented. In the past three years, we've started to see researchers move beyond pilot studies of tens of samples and opting to run studies of hundreds of samples, and in many cases, thousands. To that end, I'm pleased to share that Discovery Life Sciences, one of our centers of excellence and a leading omics service provider, in collaboration with us, has secured a significant contract from a new customer to run a 10,000-sample study on the Proteograph product suite and the Orbitrap Astral mass spectrometer. This customer conducted an extremely thorough and extensive evaluation process on the commercially available proteomic technologies and service providers. They concluded that the combination of the Proteograph product suite, the Orbitrap Astral, and the Discovery's expertise in mass spectrometer proteomic services will produce the deepest and most robust data set. We are excited to be engaging in more conversations for larger-scale projects, including multiple population-scale studies that would leverage the Proteograph product suite. As our platform gains broader awareness, there is a clear shift towards significantly larger studies, marking a key milestone for the proteomics market. While the size and timing of these projects may lead to some quarterly revenue variability, the momentum is encouraging. We believe Seer is uniquely positioned as the leading unbiased and scalable platform to enable the next generation of proteomics discovery. While we believe that we have already changed the arc of deep, unbiased proteomics, we're still at the very beginning of this journey. By leveraging the Proteograph product suite, our customers are starting to uncover novel biological insights, looking ahead, and really excited for our presence at the AFMS conference in a couple of weeks. The need for a scalable, deep, unbiased proteomics platform has never been greater. Now moving to slide 5 to take a closer look at our progress with accelerating access to the Proteograph product suite. We continue to see strong demand for STAC, which lowers the barrier of adoption of the Proteograph product suite. STAC allows the proteograph user to run samples in their own lab and have Seer run the mass spec, or alternatively, provides end-to-end services from sample to proteomics data and analysis. Encouragingly, in Q1, half of our instrument shipments were acquired by customers who had previously accessed our STAC, representing the highest number of STAC-to-instrument conversions in a single quarter. Furthermore, nearly half of STAC customers in Q1 were new. Taken together, STAC continues to be an excellent source of revenue and concurrently serves as a strategic and marketing asset by allowing users to experience the power of the Proteograph and for some of these users to bring an instrument in-house. Our customers are increasingly recognizing the value of our technology and the data that is being generated from it. Given the level of demand we're seeing, we have a line of sight into operational efficiencies that will expand the capacity of STAC. We look forward to seeing more data generated on the Proteograph as more customers get access to our technology. Our Strategic Instrument Placement Program, or SIPP, continues to be an important catalyst for adoption. As a reminder, SIPP removes barriers by utilizing available operating budgets for our customers who are capital constrained, particularly in the current macroeconomic environment. Under this program, we will loan an instrument to a customer with upfront purchase of consumable kits. A portion of our shipped instruments in Q1 was through this program. Now moving on to provide an update on our expanded partnership with Thermo Fisher Scientific to co-market and sell the Proteograph product suite alongside their Orbitrap Astral mass spectrometer. As a reminder, this powerful pairing makes it possible for the first time to achieve population-scale deep unbiased proteomics with exceptional robustness and reproducibility. In addition, this partnership further strengthens our commercial reach and makes it easier for our customers to access a seamless end-to-end solution for unbiased proteomics. We completed training of the Thermo Fisher US sales force in the first quarter, and the next phase of our partnership includes the training of the European sales force. Our respective sales teams are increasingly collaborating to identify and capture opportunities that are mutually beneficial, and we have already seen traction in several regions. In late April, Thermo Fisher Scientific hosted a compelling webinar featuring Dr. Brennan Keating that highlighted the impact of combining the Proteograph product suite with Orbitrap Astral mass spectrometer. This study demonstrated how deep unbiased proteomics profiling can reveal critical physiologic and immunologic changes in xenotransplant recipients. These insights provided valuable information on transplanted organ viability and host responses, which are key factors in advancing xenotransplantation as a viable solution to the organ shortage crisis. Looking ahead, we have a number of customer webinars coming up to provide further insight into what is possible using the Proteograph product suite. On our last earnings call, we highlighted the launch of our cell-lifestyle application on the Proteograph XT, which extended the power of Proteograph XT beyond plasma and tissue analysis. We've been very pleased with the feedback around the newly launched cell-lifestyle application. As a reminder, we now have over 10 Proteograph protocols available to conduct proteomic analysis on a diverse list of sample types, including non-human plasma or serum, conditioned media, cerebrospinal fluid, and dry blood samples. We plan to continue expanding the capabilities of the platform throughout the year. I am deeply proud of the team's hard work and execution this quarter. Looking ahead, I'm even more excited for the new data and catalysts that are coming over the next few months and will serve as a tailwind's foreseer. With that, I will now turn the call over to David. David Horn Thanks, Omid. Turning to slide 6. Total revenue for the first quarter of 2025 was $4.2 million, representing an increase of 37% compared to $3.1 million in the first quarter of 2024. It was primarily due to higher instrument consumable and service revenue. Revenue recognized primarily consisted of sales of Proteograph instruments, consumable kits, and service revenue, of which $52,000 was attributed to related parties. Product revenue for the first quarter of 2025 was $2.9 million, including $5,000 of related party revenue, and consisted of sales of Proteograph instruments and consumable kits. As Omid mentioned, while we continue to see pressure on CapEx budgets and elongated sales cycles for the outright purchase of new instruments, we were pleased by the traction we saw in terms of instrument shipments in the first quarter. Service revenue was $1.2 million for the first quarter of 2025, including $47,000 of related party revenue, and primarily consisted of revenue related to STAC service projects. We continue to be encouraged by customer interest in running projects through STAC and their ability to gain access to Proteograph data, including a significant number of new customers. Sample volumes increased on a year-over-year basis. As we have stated previously, we may continue to undertake projects for key strategic studies and other marketing efforts that will result in additional presentations and publications in the near term, but are conducted at a lower price point than our typical STAC service projects. Other revenue was $60,000 for the first quarter of 2025, and consisted of lease and shipping revenue. Total gross profit was $2.1 million for the first quarter of 2025, representing a gross margin of 49%, compared to $1.4 million in the first quarter of 2024, representing a gross margin of 44%. Gross margins were driven by a higher mix of service revenue in the first quarter of 2025 relative to the first quarter of 2024. We continue to expect variability in our gross margin on a quarter-by-quarter basis, since the proportion of instrument consumable and service revenue will fluctuate in any given quarter. We continue to expect overall volatility in our gross margins on a quarterly basis. At scale, we continue to believe our long-term gross margins will be in the range of 70% to 75%. Total operating expenses for the first quarter of 2025 were $22.8 million, including $4.5 million of stock-based compensation, a decrease of 14% compared to $26.6 million, including $7.2 million of stock-based compensation in the first quarter of 2024. Research and development expenses for the first quarter of 2025 were $11.4 million, a decrease of 7% compared to the $12.3 million in the first quarter of 2024. The decrease in R&D expenses was primarily due to decreases in stock-based compensation and laboratory expenses. Selling, general and administrative expenses for the first quarter of 2025 were $11.4 million, a decrease of 20% compared to $14.3 million in the first quarter of 2024. The decrease in SG&A expenses was primarily due to a decrease in stock-based compensation expenses. Net loss for the first quarter of 2025 was $19.9 million, compared to $20.7 million in the first quarter of 2024. Free cash flow loss was approximately $12.1 million for the quarter ended March 31, 2025. We continue to expect free cash flow loss to be in the range of $40 million to $45 million for the year. In addition, we continued our share repurchase activities in the first quarter of 2025, since we continue to believe that there is a significant dislocation in our share price. In the first quarter, we repurchased 352,000 Class A common shares at an average price of $1.91 per share. As of May 6, 2025, we had approximately 54.8 million Class A and 4 million Class B common shares outstanding We ended the quarter with approximately $285 million in cash, cash equivalents, and investments. Importantly, we believe that with our current cash, cash equivalents, and investments on hand, we have sufficient capital to reach cash flow breakeven. While a long-term target is to become a profitable company, we are balancing that goal with the investments needed to innovate and build the company to drive sustained growth in the future. We aim to continue managing our significant cash balance in an extremely prudent manner and believe that our strong balance sheet puts us at a significant advantage to capture the massive opportunity ahead. Turning now to our outlook for the year on slide 7, we continue to expect revenue to be in the range of $17 million to $18 million for 2025, representing growth of 24% at the midpoint over the full year 2024. Our guidance range assumes our customers will continue to face budget pressures, government funding uncertainty, and macroeconomic volatility as it relates to tariffs. The NIH and government funding environment remains extremely uncertain and dynamic. As a reminder, in 2024, revenue from academic and government entities represented approximately 30% of our overall revenue. Any fluctuations in NIH, government, and academic funding may impact these customers in 2025. In the last week, we have seen potential tariffs for pharmaceutical companies to be discussed, which will add additional uncertainty for our commercial customers, the impact of which remains to be seen. While we were encouraged by results in Q1, particularly around instrument shipments, we also saw some customers pause spending given this uncertainty. Therefore, we remain cautious due to this significant macroeconomic uncertainty, but are reaffirming our revenue guidance at this time. In terms of tariff impact on us, we have not seen any direct effects on our supply chain since our key suppliers manufacture the products we purchase from them in the United States. However, we are actively monitoring this rapidly evolving environment, and our supply situation could change. On the revenue side, we do see potential implications and impact from the tariffs imposed by other countries on products originating in the United States, especially as it relates to China. We do not expect revenue related to our STAC services to be impacted by tariffs. While the majority of our product sales are in the United States, approximately 25% of our total revenue is derived from product sales to customers who reside outside of the United States. While we do not anticipate a significant impact of sales to these customers, and our current exposure to China is limited, the environment remains extremely volatile and uncertain. We will continue to actively monitor the current environment for any changes that could impact us. At this point, I would like to turn the call back to Omid for closing comments. Omid Farokhzad Thank you, David. Moving on to slide 8. Our performance in the first quarter is a testament to the value our technology brings to our customers, especially given the challenging and dynamic macro environment. Looking ahead, I continue to believe we're well-positioned for a strong year ahead. We remain focused on four key growth drivers in 2025, which include expanding our user base and continuing to enhance access, driving larger cohort studies, continuing to drive product innovation, and enabling more customers to generate meaningful and actionable biological insights. I look forward to keeping you updated on our progress, and with that, we will now open it up for questions. Operator? Operator (Operator Instructions) Rachel Vatnsdal, JPMorgan. Rachel Vatnsdal Good afternoon. Thanks so much for taking my question today. So, one thing, you talked about this life sciences project. Can you just walk us through the magnitude of this on the Discovery Life Sciences project that you called out, and then how long do you expect that to last for? Omid Farokhzad Thank you so much. Let me have actually David comment on the DLS project. That's the relationship David has been managing for the last two years, and it's a very exciting project. It's a 10,000-sample study. David? David Horn Yeah, thanks for the question, Rachel. This is a really interesting project that's been evolving over a number of quarters in that this particular customer wanted to look at a large 10,000-sample cohort in deep proteomics and to really try and understand potential biomarker signatures and other things. I can't go into a ton of detail yet. They are going to have a press release likely coming out over the next month or so that will kind of go into detail. But really, it's the first-of-its-kind database that we know of that's going to be created. And I think, as Omid mentioned in his remarks, this is really something where they did an extensive analysis of all the available proteomics technologies and came to the conclusion that the Proteograph with the Astral performed, the service will be performed by Discovery Life Sciences, would give them the best, most robust data set for this cohort, such that they could then mine it for potential targets and biomarkers. So, we're really excited about this. It's the first real kind of population-scale study, and I think it's going to be really impactful in terms of the overall scientific impact of it. It will take some time. I'd say over the course of the next kind of 12 months to 18 months, I imagine. But it really just depends on how quickly they kind of bring together the cohort and things like that. So, we're excited about it. And more details to come here over the next month or so. Omid Farokhzad And, Rachel, let me just add to David's comment in that, about nine months ago in September, and this was at the Morgan Stanley Conference, I alluded to the fact that 2025 is the year where we're going to start seeing population-scale, deep, unbiased proteomics go live on the back of the Proteograph product suite that enables them. So, this 10,000-sample study is the first. I expect over the course of the coming months, you'll hear other announcements of even larger studies. So, we are in a new paradigm in terms of deep, unbiased, mass-spec-based proteomics really taking the scale. And I think the platform and the roadmap that we have, even 100,000 samples or hundreds of thousands of samples, are completely within the realm of reality in terms of cost-effectiveness, in terms of feasibility. And so, I'm super excited to keep you informed over the coming months. Rachel Vatnsdal Then maybe just in terms of the academic and government weakness, obviously, you talked a little bit about that in the prepared, but can you give us the updated expectation in terms of what are you expecting your US academic and government customers to decline for the full year? And then can you unpack for us a little bit in terms of the trends that you saw in March, or excuse me, in the first quarter and maybe just the month of March as well, but also what you saw in April. Have you seen orders and trends across that customer group continue to get worse, or have they kind of stabilized at this point? Thanks. Omid Farokhzad Yeah, and Rachel, maybe let me open up, and then I'll hand it to David for kind of a deeper color. So, as we had discussed with you at your conference, academic and government together is about 30% of our revenue and that 30% breaks down into roughly 18% academic and 12% government. So, and the guidance that we provided actually represents our expectation of weakening in terms of these two market segments in 2025. Now that said, if I look at the Q1 of 2025, there was actually a very nice balance both in terms of revenue and in terms of instrument placement between academic and government and biopharma. So, I think to answer directly, I would say we're now stabilized, but that said, I would only caveat it by saying it's such a moving target that maybe next week, I would have a completely different perspective. But if everything stays as is, then I think we are more or less stable and our guidance for the year holds. David, do you want to add additional color, please? David Horn Yeah, Rachel, thanks for the question. In terms of the trends we're seeing, obviously, we're very happy with the first quarter. I do feel like people are getting more cautious with things in terms of just the general trends out there, whether it's tariffs or NIH funding or even now with the commercial side with some of the drug pricing control proposals that have been floated in the last couple days. But again, I think given our customer base and given our installed base and the prospects and the funnel we have, we feel like it really will come down to kind of a case-by-case basis. I do think it's important to remember that any reduction in the NIH budget will likely impact future grants and non-existent grant funding. So, what we're arguing from some of our customers is they do have funding for the balance of the year, and it's a question of whether they, they seem to be able to have access to it but it's the going forward after that that, I think is the big question mark. So, kind of remains to be seen, but we are seeing a little a little more weakness here in the second quarter relative to the first quarter. Operator (Operator Instructions) I'm showing no further questions in queue at this time, so that will conclude today's question and answer session. This concludes today's conference call. Thank you for participating. You may now disconnect. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
28-02-2025
- Business
- Yahoo
Seer Inc (SEER) Q4 2024 Earnings Call Highlights: Navigating Revenue Decline with Strategic ...
Fourth Quarter Revenue: $4 million, a decrease of 10% from $4.4 million in Q4 2023. Full Year Revenue: $14.2 million, a decrease of 15% from $16.7 million in 2023. Gross Margin (Q4 2024): 51%, up from 45% in Q4 2023. Net Loss (Q4 2024): $21.7 million, compared to $17.8 million in Q4 2023. Net Loss (Full Year 2024): $86.6 million, compared to $86.3 million in 2023. Cash, Cash Equivalents, and Investments: Approximately $300 million as of December 31, 2024. Share Repurchase: Approximately 6.5 million shares repurchased, reducing shares outstanding by 10% to 59 million. Free Cash Flow Loss (Full Year 2024): $49.4 million, down from $66.4 million in 2023. 2025 Revenue Guidance: Expected to be in the range of $17 million to $18 million. Warning! GuruFocus has detected 3 Warning Sign with SEER. Release Date: February 27, 2025 For the complete transcript of the earnings call, please refer to the full earnings call transcript. Seer Inc (NASDAQ:SEER) reported a total revenue of $14.2 million for 2024, with a strong cash position of approximately $300 million. The company successfully repurchased approximately 6.5 million shares, reducing the total shares outstanding by about 10%. Seer Inc (NASDAQ:SEER) expanded its global reach, serving over 135 customers across 20 countries, and doubled its commercial team in North America. The Proteograph Product Suite has been validated through 33 customer publications, with 23 new peer-reviewed publications in 2024. Seer Inc (NASDAQ:SEER) has formed a strategic partnership with Thermo Fisher Scientific to co-market and sell the Proteograph Product Suite, enhancing commercial reach. Total revenue for 2024 decreased by 15% compared to 2023, primarily due to lower product sales and no grant revenue. The company reported a net loss of $86.6 million for the full year 2024, slightly higher than the $86.3 million loss in 2023. Seer Inc (NASDAQ:SEER) experienced a 10% decrease in fourth-quarter revenue compared to the same period in 2023, due to lower instrument sales. There is ongoing uncertainty regarding NIH and government funding, which could impact a portion of Seer Inc (NASDAQ:SEER)'s revenue in 2025. The company faces challenges with elongated sales cycles and pressure on CapEx budgets, affecting the outright purchase of new instruments. Q: How should we think about the split between instruments and consumables in 2025, and what is the expected pacing for the first and second half of the year? A: Omid Farokhzad, CEO, noted that 2024 was challenging for CapEx, with instrument placements skewed towards the latter half of the year. For 2025, they anticipate a different pace, with a stronger start due to a robust pipeline. David Horn, CFO, added that the product revenue breakdown will likely mirror 2024, with product revenue comprising about 72% and service revenue 27%. They expect more instrument placements and increased interest in larger projects. Q: Can you discuss the trajectory of the STAC program and its revenue outlook for 2025? A: Omid Farokhzad explained that the STAC program is not intended to expand into a service company, so capacity will remain consistent. Revenue growth is expected as early collaborations were priced lower, but now projects are priced closer to standard service rates. David Horn added that demand from large pharma and academic customers is strong, with repeat customers and increased ASPs contributing to positive trends. Q: What impact do NIH funding uncertainties have on your business, and what trends are you seeing with academic customers? A: Omid Farokhzad stated that about 30% of their revenue comes from government and academic entities. While indirect funding cuts could affect broader organizational investments, direct research funding remains intact. They have factored in a cautious outlook for these accounts in their guidance. David Horn noted that uncertainty is causing some delays, but some customers have confirmed their funding and are proceeding. Q: What does the publication pipeline look like for 2025, and are there any significant projects on the horizon? A: Omid Farokhzad highlighted that customer publications have been a bright spot, with over 30 publications to date. The STAC program facilitates quick data access, aiding in grant writing and presentations. He expects the pace of publications to continue in 2025, with recent conferences showcasing significant research enabled by their technology. Q: What is the expected impact of the Thermo Fisher collaboration on 2025 guidance, and are there plans for similar partnerships? A: David Horn mentioned that the Thermo Fisher collaboration is being operationalized in Q2 2025, with modest expectations built into the guidance. Omid Farokhzad added that while the Thermo partnership is non-exclusive, they are open to other collaborations to enhance access to their Proteograph technology, with ongoing discussions with other mass spec providers. For the complete transcript of the earnings call, please refer to the full earnings call transcript. This article first appeared on GuruFocus.
