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Associated Press
11-03-2025
- Health
- Associated Press
AI-Driven Advancements in Neuroblastoma Diagnosis and Bone/Bone Marrow Metastasis Prediction
Groundbreaking Study Unveils Key Mechanisms in Neuroblastoma Bone and Bone Marrow Metastasis / -- Neuroblastoma (NB), the most prevalent extracranial solid tumor among children, is characterized by a high rate of metastasis. The pathogenesis of NB with bone or bone marrow metastasis (NB-BBM) and its complex immune microenvironment remain poorly understood, posing challenges for effective risk prediction for BBM and limiting therapeutic strategies. This research, published in the Genes & Diseases journal by a team from The Children's Hospital of Chongqing Medical University, highlights key genomic and single-cell transcriptomic alterations in NB-BBM, underscoring the significance of predictive pathology for NB-BBM and its role in understanding tumor onset, progression, and heterogeneity. The researchers used a Swin-Transformer deep learning model to analyze 142 paraffin-embedded hematoxylin-eosin-stained tumor section images to predict NB-BBM occurrence, achieving a classification accuracy exceeding 85%. In parallel, single-cell transcriptomics identified a tumor cell subpopulation (NB3) and two tumor-associated macrophage (TAM) subpopulations (SPP1+ TAMs and IGHM+ TAMs) closely associated with BBM progression. Interestingly, findings reveal that oxidative phosphorylation (OXPHOS) also plays a crucial role in BBM development. Additionally, this study highlighted transketolase (TKT) as a crucial metabolic molecule linked to BBM. The researchers showed that the TKT gene was strongly associated with the clinical features of NB patients, especially in the BBM group. Functional experiments validated TKT's involvement in malignant behavior, while pathway enrichment analysis showed correlations between high TKT expression and cell cycle activity. Moreover, expression analysis of immune checkpoint genes CD274, LAG3, and TIGIT revealed their significant upregulation in NB-BBM, suggesting potential targets for antibody-based immunotherapies. Furthermore, immunohistochemical validation demonstrated a pronounced expression of PD-L1 in NB-BBM, indicating its potential as a biomarker. Although this research provides a predictive model for NB-BBM risk assessment, it has certain limitations, including the need for multicenter validation of the predictive model and prospective studies to confirm clinical utility. Despite these challenges, this study offers a pathodiagnostic prediction for the risk of NB-BBM, enhances other imaging diagnoses, and elucidates the cellular heterogeneity of initial, progressive, and distant metastatic sites in NB. Reference Title of the original paper - Integrated multi-omics characterization of neuroblastoma with bone or bone marrow metastasis Journal: Genes & Diseases Genes & Diseases is a journal for molecular and translational medicine. The journal primarily focuses on publishing investigations on the molecular bases and experimental therapeutics of human diseases. Publication formats include full length research article, review article, short communication, correspondence, perspectives, commentary, views on news, and research watch. DOI: Funding Information: Key Project of the National Key R&D Plan 'Research on Prevention and Control of Major Chronic Non-Communicable Diseases' (China) Ministry of Science and Technology of the People's Republic of China National Key R&D Program of China (No. 2018YFC1313000, 2018YFC1313004) # # # # # # Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis is placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine. # # # # # # CN: 50-1221/R Genes & Diseases +86 23 6571 4691 X LinkedIn Instagram YouTube Other Legal Disclaimer:
Yahoo
27-02-2025
- Business
- Yahoo
Aircraft Wiring Harness Market is Forecasted to Reach US$ 1.8 Billion in 2028, Says Stratview Research
Detroit, Feb. 27, 2025 (GLOBE NEWSWIRE) -- The global aircraft wiring harness market is projected to witness a growth rate of 9.2% annually from 2023 to 2028, with an anticipated size of US$ 1.8 billion by 2028, according to an analysis by Stratview Research. Stratview Research, a global market research firm, has launched a report on the global aircraft wiring harness market, which provides a comprehensive outlook of the global and regional industry forecast, current & emerging trends, segment analysis, and competitive landscape. Click here to get a free sample of the report: Report Highlights Market Size in 2028 (billion US$) 1.8 Growth (CAGR) 9.2% during 2023-2028 Forecast Period 2023-2028 Trend Period 2017-2021 Base Year 2022 Number of Segments Covered 7 Number of Tables & Graphs 100+ Country-Level Market Assessment 20 Segment Insights on the Aircraft Wiring Harness Market The global aircraft wiring harness market is segmented based on platform type, application type, insulation material type, purpose type, product type, end-user type, and region. Based on platform type - The aircraft wiring harness market is segmented into commercial aircraft, regional aircraft, general aviation, military aircraft, and helicopters. Commercial aircraft is expected to remain the largest and fastest-growing platform type in the market during the forecast period, driven by a host of factors including snowballing commercial aircraft deliveries, the introduction of fuel-efficient commercial aircraft, and a growing aircraft fleet size. Based on the application type - The market is segmented into avionics, interiors, propulsion systems, airframes, and others. The interior application held the dominant share of the market in 2022 and is also expected to experience the highest growth during the forecast period. The increasing focus of airliners on improving the passenger travel experience and the modernization of existing fleets with new IFE systems are the major factors driving the growth of the interior segment. Based on the insulation material type - The market is segmented as XL ETFE (Cross-Linked Extruded Ethylene Tetrafluoroethylene), TKT (Teflon-Kapton-Teflon), PTFE (Polytetrafluoroethylene), PI (Polyimide), and others. PTFE is expected to remain the most preferred insulation material type in the market, driven by its exceptional properties, such as extreme temperature resistance (-200°C to 300°C), chemical inertness, low-dielectric constant, low coefficient of friction, and excellent FST properties. Based on end-user type - The aircraft wiring harness market is segmented into OE and aftermarket based on the end-user type. OE is estimated to remain the sole source of demand for wiring harnesses in the foreseeable future. The aftermarket holds a negligible share of the market. Wires & cables (or harnesses) do not need to be replaced because their life span is almost the same as the aircraft's life. To know the most attractive segments, click here for a free sample of the report: Which Region Shows the Most Promising Growth Forecast and Opportunity? The analysis suggests that North America is expected to remain the largest market for aircraft wiring harnesses during the forecast period. This growth outlook is primarily attributed to the following: The region is dominated by the USA, owing to the presence of major aircraft OEMs, wiring harness suppliers, airlines, and MRO companies. Likewise, Asia-Pacific is expected to witness the highest growth during the forecast period, driven by the assembly plants of Boeing and Airbus in China, increasing procurement of military aircraft, rising aircraft fleet size, and the upcoming indigenous aircraft program C919. China, Japan, and India are the growth engines of the region's market. Aircraft Wiring Harness Market Drivers Some of the key drivers listed in the report are given below. An expected increase in the production rate of key programs (A320neo, B737 Max, A220, B787, and A350XWB). The introduction of new aircraft programs (C919, MC-21, B777x, etc.). The increasing investments in electrical aircraft and the increasing use of wires & cables in modern aircraft. Top Companies in the Aircraft Wiring Harness Market? The market is highly concentrated, with the presence of some regional and global players. Most of the major players compete in some of the governing factors, including price, product offerings, regional presence, etc. Stratview Research has identified the following companies as the top market players. Safran S.A. Latécoère GKN Aerospace (Part of Melrose PLC) Ducommun Incorporated Carlisle Companies Inc. Amphenol Corporation Glenair. What Deliverables Will You Get in this Report? Key questions this report answers Relevant contents in the report How big is the sales opportunity? In-depth analysis of the Aircraft Wiring Harness Market How lucrative is the future? Market forecast and trend data and emerging trends Which regions offer the best sales opportunities? Global, regional, and country-level historical data and forecasts Which are the most attractive market segments? Market segment analysis and forecast Who are the top players and their market positioning? Competitive landscape analysis, Market share analysis How complex is the business environment? Porter's five forces analysis, PEST analysis, Life cycle analysis What are the factors affecting the market? Drivers & challenges Will I get the information on my specific requirements? 10% free customization For Customization or Any Other Queries, Get in Touch with Our Industry Experts at - sales@ Related Reports Which Might Be Useful: Aircraft Harsh Harness Market Aerospace Wires & Cables Market About us: Stratview Research is a global market research firm that highly specialises in aerospace & defense, chemicals, and a few other industries. It launches limited number of reports annually on the above-mentioned specialisations. Thorough analysis and accurate forecasts in this report enable the readers to take convincing business decisions. Stratview Research has been helping companies to meet their global and regional growth objectives by offering customised research services. These include market assessment, due diligence, opportunity screening, voice of customer analysis, market entry strategies, and more. Are you looking for any specific data customized to your objectives? We are just a mail away. CONTACT: Stratview Research Visit : Mail Us : sales@ Call Us : +1-313-307-4176Sign in to access your portfolio
