Latest news with #Telomir-Ag2
Miami Herald
21-05-2025
- Business
- Miami Herald
Telomir Pharmaceuticals Secures $3 Million at a Premium in Straight Equity Sale Involving No Warrants to Advance Rare Disease IND
Investment from largest shareholder strengthens balance sheet, signals insider conviction, and funds Telomir-1's upcoming IND submission for a rare disease indication MIAMI, FLORIDA / ACCESS Newswire / May 21, 2025 / Telomir Pharmaceuticals, Inc. (NASDAQ:TELO) ("Telomir" or the "Company"), an emerging leader in age-reversal science, today announced it has secured $3 million in equity financing, through a direct investment by The Bayshore Trust, the Company's largest shareholder. The transaction involved the purchase of 1 million restricted shares of the Company's common stock at $3.00 per share, representing an 18% premium to Telomir's closing share price of $2.54 on the date of execution. The transaction was structured as a straight restricted common stock transaction with no warrants, no discounts, and no convertible features. This transaction follows a prior $1 million equity investment at $7.00 per share made on December 9, 2024, through The Starwood Trust-an entity affiliated with the Company's largest shareholder - and complements an existing $5 million non-dilutive line of credit from the same affiliated group, which remains undrawn. "We've now raised $4 million in equity and secured a $5 million credit line - all through affiliated entities on shareholder-friendly terms," said Erez Aminov, Chairman and CEO of Telomir. "These investments included no warrants, no discounts, and no toxic structures. Every financing decision we make is grounded in a long-term view of shareholder value, and this raise reflects that discipline." From an operational standpoint, our first goal is to submit our IND by year-end and generate early human efficacy data in the most efficient and capital-responsible way. We believe pursuing a rare disease indication gives us a strategic entry point to demonstrate clinical impact and build broader value. Advancing a Growing Pipeline with Breakthrough Potential Telomir is advancing two highly innovative drug candidates: Telomir-1, a first-in-class age-reversal molecule targeting the root causes of cellular decline, and Telomir-Ag2, a stabilized Silver(II) compound designed to address the growing threat of drug-resistant infections. Telomir-1: Reversing Aging, Treating Disease, and Extending Longevity Telomir-1 is an oral small molecule that addresses five fundamental biological drivers of aging and chronic disease: mitochondrial dysfunction, oxidative stress, calcium imbalance, toxic metal accumulation (iron and copper), and telomere shortening. In preclinical models, Telomir-1 has demonstrated: Reversal of the biological clock, improving both lifespan and health spanImprovement of mitochondrial energy production in metabolically stressed cellsReduction of oxidative stress (ROS), a key contributor to age-related damageCorrection of calcium signaling pathways associated with neurodegeneration and cell deathProtection against metal-induced toxicity from iron and copperTelomere lengthening and stabilization to support cellular regeneration Therapeutic potential has been demonstrated across several critical indications: Progeria: Telomir confirms lifespan restoration and normalization of accelerated aging in a preclinical model of Progeria, a rare genetic disorder causing rapid agingType 2 diabetes: Telomir-1 reversed insulin resistance, lowered fasting glucose, and improved glucose homeostasis in zebrafish modelsWilson's disease: Telomir-1 protected cells from copper-induced toxicity, restoring mitochondrial function and reducing oxidative stressOncology: In a prostate cancer mice model, Telomir-1 reduced tumor volume by approximately 50%Chemotherapy support: Co-administration with Paclitaxel prevented mortality in animals otherwise experiencing toxicityRetinal and neural protection: In vitro studies showed strong protection of human retinal cells from oxidative and metal stress conditions These results support the advancement of Telomir-1 in multiple rare and high-value indications, including: Progeria and Werner SyndromeWilson's DiseaseType 2 DiabetesAutism Spectrum Disorder (ASD)Spasmodic Dysphonia (SD)Age-related Macular Degeneration (AMD) Telomir plans to engage with the FDA through the Rare Disease Endpoint Advancement (RDEA) Pilot Program, which supports the development of novel clinical endpoints for underserved conditions. In parallel, the Company is advancing a rare disease indication aligned with Telomir-1's mechanism of action to efficiently generate early human efficacy data and support broader clinical development. Telomir-Ag2: Stabilized Silver(II) for Drug-Resistant Infections Telomir-Ag2 is a novel Silver(II) complex stabilized using Telomir's proprietary chelation platform. Silver(II) has historically shown strong antimicrobial potential but has remained clinically impractical due to its instability-until now. Preclinical studies demonstrate that Telomir-Ag2 is active against: Escherichia coliPseudomonas aeruginosaEnterococcus faecalisStaphylococcus aureusMethicillin- and aminoglycoside-resistant Staphylococcus aureus (MARSA) Key features include: Superior antimicrobial performance over Silver(I) in minimum inhibitory concentration (MIC) assaysNo sulfa-based compounds, minimizing allergic and cytotoxic risksBroad potential as a topical product across burn treatment, wound care, and surgical infection prevention Telomir-Ag2 addresses a growing global market projected to exceed $30 billion across antimicrobial dressings, hospital-acquired infection prevention, and wound care. "Telomir-Ag2 may be the first stabilized Silver(II) compound viable for medical use," said Dr. Itzchak Angel, Chief Scientific Advisor of the Company. "It's broad-spectrum activity, especially against resistant strains, represents a major advancement in antimicrobial science." Cautionary Note Regarding Forward-Looking Statements This press release, statements of Telomir's management or advisors related thereto, and the statements contained in the news story linked in this release contain "forward-looking statements," which are statements other than historical facts made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These risks and uncertainties include, but are not limited to, the potential use of the data from our studies, our ability to develop and commercialize Telomir-1 for specific indications, and the safety of Telomir-1. Any forward-looking statements in this press release are based on Telomir's current expectations, estimates and projections only as of the date of this release. These risks and uncertainties include, but are not limited to, the potential use of the data from our studies, our ability to develop and commercialize Telomir-1 for specific indications and safety of Telomir-1. These and other risks concerning Telomir's programs and operations are described in additional detail in its Annual Report on Form 10-K for the fiscal year ended December 31, 2024, which is on file with the SEC. Telomir explicitly disclaims any obligation to update any forward-looking statements except to the extent required by law. Contact Information Helga Moya info@ 396-6723 SOURCE: Telomir Pharmaceuticals, Inc
Yahoo
21-05-2025
- Business
- Yahoo
EXCLUSIVE: Telomir Pharma To Raise $3 Million Via Equity Financing To Fund Its Rare Disease IND
On Wednesday, Telomir Pharmaceuticals, Inc. (NASDAQ:TELO) announced that it had secured $3 million in equity financing through a direct investment by The Bayshore Trust, the company's largest shareholder. The transaction involved the purchase of 1 million restricted shares of the company's common stock at $3.00 per share, representing an 18% premium to Telomir's closing share price of $2.54 on the execution date. The transaction was structured as a straight restricted common stock transaction follows a prior $1 million equity investment at $7.00 per share made on December 9, 2024, through The Starwood Trust, an entity affiliated with the company's largest shareholder, and complements an existing $5 million non-dilutive line of credit from the same affiliated group, which remains undrawn. Telomir Chair and CEO Erez Aminov said it had raised $4 million in equity and secured a $5 million credit line through affiliated entities. Telomir said its priority was to submit its IND by year-end and generate early human efficacy data in the most efficient and capital-responsible way. Telomir is advancing two highly innovative drug candidates, Telomir-1, a first-in-class age-reversal molecule targeting the root causes of cellular decline, and Telomir-Ag2, a stabilized Silver(II) compound to address the growing threat of drug-resistant infections. Telomir-1 is an oral small molecule that addresses five fundamental biological drivers of aging and chronic disease: mitochondrial dysfunction, oxidative stress, calcium imbalance, toxic metal accumulation (iron and copper), and telomere shortening. In preclinical models, Telomir-1 has demonstrated reversal of the biological clock, improving both lifespan and health span, improvement of mitochondrial energy production in metabolically stressed cells, reduction of oxidative stress (ROS), a key contributor to age-related damage, correction of calcium signaling pathways associated with neurodegeneration and cell death, protection against metal-induced toxicity from iron and copper and Telomere lengthening and stabilization to support cellular regeneration. Telomir-Ag2 is a novel Silver(II) complex stabilized using Telomir's proprietary chelation platform. Silver(II) has historically shown strong antimicrobial potential but has remained clinically impractical due to its instability—until now. Preclinical studies demonstrated that Telomir-Ag2 is active against Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus, and Methicillin- and aminoglycoside-resistant Staphylococcus aureus (MARSA). Price Action: TELO stock closed lower by 10.4% at $2.28 on Tuesday. Read Next:Up Next: Transform your trading with Benzinga Edge's one-of-a-kind market trade ideas and tools. Click now to access unique insights that can set you ahead in today's competitive market. Get the latest stock analysis from Benzinga? This article EXCLUSIVE: Telomir Pharma To Raise $3 Million Via Equity Financing To Fund Its Rare Disease IND originally appeared on © 2025 Benzinga does not provide investment advice. All rights reserved.
Miami Herald
15-05-2025
- Business
- Miami Herald
Telomir Pharmaceuticals Adds Telomir-Ag2 as a Novel Drug Candidate to Pipeline Following Breakthrough Efficacy Against MARSA and Drug-Resistant Infections, Targeting a $30B+ Antimicrobial Market Opportunity
Antimicrobial resistance is recognized as one of the top global public health threats, and Telomir-Ag2 strengthens Telomir's pipeline with a differentiated candidate designed to address this urgent and expanding crisis MIAMI, FL / ACCESS Newswire / May 15, 2025 / Telomir Pharmaceuticals, Inc. (NASDAQ:TELO), or Telomir, a leader in age-reversal science, today announced the identification of Telomir-Ag2 as a novel drug candidate for the treatment of bacterial infections, including those caused by drug-resistant pathogens. This follows Telomir's recent breakthrough in stabilizing Silver(II) in a biologically compatible form using its proprietary Telomir-1 platform. Telomir-Ag2 is a stabilized Silver(II) complex that demonstrated broad-spectrum antimicrobial activity in preclinical studies, including against methicillin- and aminoglycoside-resistant Staphylococcus aureus (MARSA), one of the most challenging pathogens in clinical settings. "In the lab, Silver(II) has always shown remarkable antimicrobial potential, but it was considered too unstable for real-world use," said Erez Aminov, CEO and Chairman of Telomir. "With Telomir-Ag2, we've taken that potential and made it practical. What we now have is a novel, biologically viable Silver(II) compound with broad-spectrum antibacterial activity - including against resistant strains. This creates the potential for a meaningful opportunity in areas where few effective solutions exist. We believe Telomir-Ag2 has the potential to not only address a critical unmet need in healthcare but also create meaningful long-term value for our shareholders." Study Results In Minimum Inhibitory Concentration (MIC) testing, Telomir-Ag2 demonstrated potent antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus, and MARSA. The compound also outperformed its Silver(I) counterpart, Telomir-Ag1, confirming the enhanced oxidative capacity and broader antimicrobial profile of Silver(II). "This is the first time we've seen a Silver(II) complex stabilized in a biologically friendly form while maintaining broad spectrum antimicrobial power," said Dr. Itzchak Angel, Chief Scientific Advisor at Telomir. "We're now looking at a completely new tool in the fight against antibiotic-resistant bacteria." The Urgency Behind MARSA and Burn Wound Infections MARSA is a drug-resistant variant of Staphylococcus aureus responsible for serious infections in hospitals and intensive care settings. In the United States, MRSA alone causes over 323,000 hospitalizations and more than 10,000 deaths annually, according to the CDC. Globally, resistant Staphylococcus aureus strains are estimated to contribute to over 100,000 deaths each year. Burn patients represent one of the highest-risk groups for these infections due to the loss of the skin's protective barrier. Infections in burn wounds are a major source of complications, delayed recovery, and mortality. While silver-based topical creams like silver sulfadiazine are commonly used, they present several limitations - including potential cytotoxicity to fibroblasts and keratinocytes and reduced efficacy over time due to rapid ion release. Telomir-Ag2 was designed to potentially overcome these challenges. By stabilizing Silver(II) through Telomir-1's proprietary chelation platform, the compound may enable more controlled silver release and sustained antimicrobial coverage. Telomir-Ag2 also contains no sulfa-based compounds, which are associated with allergic and cytotoxic reactions in some conventional silver formulations. Early findings suggest Silver(II) may support wound healing processes, making Telomir-Ag2 a compelling candidate for use in high-risk wounds, including burns and surgical sites. A New Class of Antimicrobials While most traditional antibiotics act on a single bacterial pathway, silver ions operate through multiple mechanisms simultaneously damaging membranes, binding to proteins and DNA, and generating reactive oxygen species (ROS). Silver(II), due to its high oxidative potential, is particularly effective, but has historically been too unstable for medical use. Telomir's potential ability to stabilize and deliver Silver(II) in a biologically compatible and effective form represents a significant step forward in antimicrobial innovation. "To our knowledge, Telomir-Ag2 is the first Silver(II) complex to move from theoretical promise to real therapeutic viability," said Dr. Alex Weisman, Scientific Chemical Advisor at Telomir. "This could pave the way for a new generation of broad-spectrum, resistance-resilient antimicrobials." Market Opportunity Telomir-Ag2 targets two rapidly growing segments within the healthcare market. The global silver wound dressings market is projected to grow from $1.03 billion in 2024 to $1.36 billion by 2030. Meanwhile, the antimicrobial coatings market is expected to increase from $11.65 billion in 2024 to $33.7 billion by 2031, reflecting a compound annual growth rate (CAGR) of 14.2% (Source: Verified Market Research, 2024). Strategic Value Potential The identification of Telomir-Ag2 adds a distinct and differentiated asset to Telomir's pipeline. The compound's broad-spectrum activity, including efficacy against drug-resistant strains such as MARSA, positions it as a potential therapeutic solution in high-need settings including hospitals, burn centers, and surgical care. Antimicrobial resistance has been formally recognized by the World Health Organization (WHO) as one of the top ten global public health threats facing humanity. According to WHO, drug-resistant infections could lead to 10 million deaths annually by 2050 without new solutions (WHO Fact Sheet, 2023). As Telomir-Ag2 progresses through development, Telomir believes it may provide strategic value through potential clinical utility, future partnerships, and the opportunity to address a high-priority medical challenge. Its advancement may contribute to long-term shareholder value and broaden Telomir's impact beyond age-related indications. Next Steps With preclinical efficacy confirmed, Telomir plans to move Telomir-Ag2 into formulation development, IND-enabling studies, and regulatory engagement. Telomir also plans to explore potential partnerships in the areas of wound care, infectious disease, and medical devices. "This is just the beginning," added Dr. Angel. "Silver(II) has always been the missing piece in advanced antimicrobial science. With Telomir-Ag2, we're closer than ever to making it part of modern medicine." Cautionary Note Regarding Forward-Looking Statements This press release, statements of Telomir's management or advisors related thereto, and the statements contained in the news story linked in this release contain "forward-looking statements," which are statements other than historical facts made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These risks and uncertainties include, but are not limited to, the potential use of the data from our studies, our ability to develop and commercialize Telomir-1 for specific indications, and the safety of Telomir-1. Any forward-looking statements in this press release are based on Telomir's current expectations, estimates and projections only as of the date of this release. These risks and uncertainties include, but are not limited to, the potential use of the data from our studies, our ability to develop and commercialize Telomir-1 for specific indications and safety of Telomir-1. These and other risks concerning Telomir's programs and operations are described in additional detail in its Annual Report on Form 10-K for the fiscal year ended December 31, 2024, which is on file with the SEC. Telomir explicitly disclaims any obligation to update any forward-looking statements except to the extent required by law. Contact Information Helga Moya info@ 396-6723 SOURCE: Telomir Pharmaceuticals, Inc
