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Weight loss of 15pc recorded in new obesity drug trials, involving UCD professor
The findings that a new drug called CarigSema far outperforms Ozempic and other weight loss drugs - was announced in Chicago at the 85th Scientific Sessions of the American Diabetes Association.
'The REDEFINE 2 study showed that CagriSema, a new treatment in development for the disease of obesity, can allow patients with type 2 diabetes lose 15pc body weight, while putting their blood sugar levels back in the normal range,' said Professor Carel LeRoux, a leading weight-loss researcher at the UCD Conway Institute, and a principal investigator on the study.
'What patients often tell us is that they again can do all the things they want because they feel so much more functional,' said Prof Le Roux.
'We also see that the side effects are manageable and clinicians are getting much better at reducing common side effects.
'Taken together, this will allow clinicians to control the disease of obesity, which will allow us to disrupt the disease of type 2 diabetes.'
CarigSema is a combination of Cagrilintide and Semaglutide. The latter is marketed under the brands of Ozempic, Wegovy and Rybelsus.
CarigSema is seen as a potential follow-on treatment for people already being treated for obesity, and type 2 diabetes, or both, with Ozempic and Wegovy or Mounjaro – a drug that slows down the rate at which food leaves the stomach.
CarigSema is a combination of Semaglutide, a so-called GLP-1 analogue that is better known as Ozempic, and Cagrilintide is an analogue of Amylin.
An analogue in chemistry is the name for something that is similar, but not identical to something else, and often mimics its action inside the body.
The GLP-1 analogues, which include Ozempic and Wegovy, act by imitating incretin, a natural hormone that decreases blood sugars and reduces appetite.
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Meanwhile, Cagrilintide, is an analogue of Amylin, another natural hormone in the body and one which promotes satiety - the feeling of being full after eating.
'In a phase three clinical trial, participants with type 2 diabetes and obesity experienced unprecedented weight loss,' said Prof Le Roux, who said that the CarigSema trial 'marks a turning point' in weight and diabetes management.
'Many participants expressed joy in regaining abilities that their condition had previously hindered – playing with grandchildren, tying shoelaces and performing daily activities became accessible once more.'
The treatment, said Prof Le Roux, involves a weekly injection, which enables patients to manage their disease, and also accommodate healthier lifestyles.
The REDEFINE trial results offer a 'beacon of hope' for people living with type 2 diabetes and obesity, he said, with results that promise to promote not just weight loss, but to enhance people's quality of life and well-being.
'Patients can look forward to a future where managing diabetes can lead to healthier lifestyles and renewed vitality,' said Prof Le Roux.
