07-05-2025
Alzheimer's Warning: Struggles with Navigation May Surface Before Memory Loss
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Alzheimer's disease, a progressive neurodegenerative disorder, is often associated with memory loss.
Alzheimer's disease is the most common form of dementia—a progressive neurological disorder that affects memory, thinking, and behaviour. It primarily impacts older adults and leads to a continuous decline in cognitive abilities, interfering with daily life and independence.
The condition is caused by the gradual degeneration and death of brain cells, which disrupts communication between neurons. This breakdown in brain function leads to symptoms such as memory loss, confusion, difficulty with language, problem-solving issues, and changes in mood or personality. Over time, these impairments worsen, making even basic tasks challenging.
Although there is no cure, early detection and supportive care can help manage symptoms and improve quality of life.
Early signs of Alzheimer's: What does the study say?
A recent study published in Current Biology has revealed that early signs of Alzheimer's disease may manifest through difficulties in navigation rather than memory loss. The research, led by Professor Neil Burgess and his team from the Space and Memory group at the UCL Institute of Cognitive Neuroscience, examined how individuals navigate through space under different environmental conditions.
Participants were divided into three groups—young adults, older adults, and individuals diagnosed with mild cognitive impairment (MCI), a condition often seen as an early stage of Alzheimer's. Using virtual reality headsets, they were asked to walk along a guided route marked by numbered cones and then return to their starting point without any assistance.
To assess their navigational abilities, researchers introduced three environmental variations: one unchanged, one with ground textures removed, and one where all visual landmarks were temporarily eliminated.
The findings showed that participants with MCI experienced the greatest difficulty, particularly when familiar visual cues were missing. These results suggest that impairments in spatial awareness may serve as an early indicator of Alzheimer's disease, potentially appearing well before memory-related symptoms become evident.
Experts' suggestion
Experts suggest that early detection of Alzheimer's is critical for effective intervention and improved long-term outcomes. Identifying navigational difficulties as a potential early symptom provides an opportunity to assess cognitive decline before more pronounced signs, such as memory loss, appear. They advise clinicians, caregivers, and family members to monitor changes in spatial orientation, such as disorientation in familiar environments, as these may serve as important early indicators warranting further medical evaluation.
Dr. Leah Mursaleen from Alzheimer's Research UK emphasises the need for advanced diagnostic methods. She acknowledged the importance of exploring new methods, such as applying virtual reality environments, to assess navigational behaviour. Referring to the study, she said, 'These results suggest this method can differentiate between participants with early-stage Alzheimer's disease."
According to Alzheimer's Society, spotting dementia early can be tricky, as the first symptoms are often subtle and easy to miss. However, they do acknowledge that trouble with navigation is one of the earliest changes seen in Alzheimer's, which makes this research especially important and relevant.
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