Latest news with #Ueno
Yahoo
03-06-2025
- Politics
- Yahoo
Translators' Voices: China shares technological achievements with the world for mutual benefit
BEIJING, June 2, 2025 /PRNewswire/ -- May 30, 2025 marks the ninth National Science and Technology Workers Day. In the early morning of the previous day, Tianwen-2, the country's first asteroid probe and sampling mission, soared into the sky, carrying with it humanity's aspirations for the stars and the universe. The nation will thrive when science and technology develops, and the country will be strong when science and technology becomes advanced. The book series of Xi Jinping: The Governance of China contains multiple important speeches on science and technology. In the article "Strive for Greater Strength and Self-Reliance in Science and Technology" included in the fourth volume of the book series, President Xi emphasized that science and technology respond to the call of the times and have a global impact; they belong to all of humanity. "We should participate to the full in global science and technology governance, contribute Chinese wisdom, and shape a philosophy of technology for good purposes, so that science and technology better serve human wellbeing, and enable China's science and technology industry to contribute more to building a global community of shared future!" In the fifth installment of the "Decoding the Book of Xi Jinping: The Governance of China" series, the Global Times focuses on the theme of "practicing the philosophy of technology for good purposes and polishing China's new name card in scientific and technological innovation." We continue to invite Chinese and international scholars, translators of the work, practitioners of its concepts, and overseas readers to share their insights, understandings and reflection on China's philosophy of science and technology development and international cooperation. In the fifth article of the "Translator's Voices" column, Global Times (GT) reporter Ma Ruiqian talked to Tomokazu Ueno (Ueno), a Japanese expert at the Center for Asia-Pacific of China International Communications Group. Ueno was involved in the translation and editorial work for the Japanese editions of Xi Jinping: The Governance of China. GT: China's scientific and technological development over the past decades - especially in recent years - has drawn global attention. Some say that technological innovation has become a "new calling card" of China. Do you agree with this view? You've mentioned that the application of technology in everyday life has brought greater convenience to ordinary people. What experiences from your work and life in China have led you to feel this way? Ueno: I fully agree with this view - technology has indeed become one of the symbols of China's modernization. What impresses me most is how quickly technological applications are integrated into society and made practical. For example, when I first arrived in Beijing and rented an apartment through a real estate agency, I was amazed to find that the entire rental process could be completed through a smartphone app. At places like train stations and hospitals, online systems are also widely used, so there's almost no need to wait in long lines like before. What also shocked me was that not only young people, but even most elderly people can use smartphones proficiently. Nearly all purchases can be made via mobile payment, which brings great convenience to daily life. To be honest, after getting used to this lifestyle, every time I go back to Japan to visit family, I find it a bit troublesome to carry cash, a wallet, transportation cards and various point cards again. GT: Yes, technological innovation not only facilitates the daily lives of ordinary people in China but also serves as a key driver for the high-quality development of related industries. In May, during an inspection tour in Central China's Henan Province, President Xi, emphasized the importance of "technological empowerment" and "independent innovation." You have witnessed firsthand how technology is empowering the logistics and agricultural sectors in Xinjiang. How do you view the significance of technological empowerment for the development of Chinese industries? Ueno: When I was interviewing in the Xinjiang Uygur Autonomous Region, I was deeply impressed by the high level of mechanization in local agriculture. Not only are large tractors used during the harvest, but new agricultural technologies are also widely applied in planting methods, field management, product transportation, environmental protection and water conservation. Agricultural technology is widely applied across the board. I realized that in China, even agriculture - one of the most traditional industries - is actively embracing high-tech tools. This not only significantly increases farmers' incomes but also strongly boosts local development. This example shows that China clearly understands that in order to improve people's livelihoods and help them lead better lives, it is essential to revitalize local industries and promote sustainable development in different regions. The key to achieving this is technological innovation. In China, progress in high technology is closely tied to improvements in living standards. GT: The fourth volume of Xi Jinping: The Governance of China includes an article titled "Strive for Greater Strength and Self-Reliance in Science and Technology." In the article, President Xi points out that "science and technology respond to the call of the times and have a global impact; they belong to all of humanity." How do you understand the "global impact" of science and technology as mentioned by President Xi? Ueno: The way I understand this is that science and technology know no borders - they can bring benefits to the entire world and help address global challenges. China has consistently emphasized contributing to the world through "Chinese wisdom" and "Chinese solutions," and it has put this philosophy into practice. Chinese technologies and their applications have already played a role in many areas around the world - including environmental protection, poverty alleviation, industrial development and improvements in people's livelihoods - achieving notable results. There is no doubt that the path China is taking - one that respects the idea that science and technology respond to the call of the times and have a global impact - is the right path for today's world. GT: At the meeting with China's sci-tech workers in 2024, President Xi said that Chinese modernization should be supported by sci-tech modernization. You will soon host the fifth season of Finding Answers in China, which also focuses on Chinese modernization. How do you understand the idea that science and technology "respond to the call of the times"? How do you think sci-tech modernization has contributed to the success of Chinese modernization? Ueno: I believe that "responding to the call of the times" means that science and technology reflect the defining features of a given era and serve as a driving force that propels modern society forward. One of my strongest impressions regarding this idea came during an interview I conducted for Finding Answers in China, when I spoke with a Japanese entrepreneur engaged in water treatment projects in China. He remarked that while some countries still only prioritize development at the expense of environmental protection - and some leaders even continue to question the reality of global warming - China, along with the global mainstream, has shifted toward emphasizing environmental. Environmental protection technology is one of the most representative fields that respond to the call of the times, and I've personally witnessed how China has significantly increased its attention and investment in this area over the past decade. This perfectly embodies the principle of "green development" emphasized in Chinese modernization - using technology to resolve the tension between development and the environment, and striving for harmonious coexistence between humanity and nature. GT: In his article "Strive for Greater Strength and Self-Reliance in Science and Technology," President Xi stated, "We should participate to the full in global science and technology governance, contribute Chinese wisdom, and shape a philosophy of technology for good purposes." In your view, what is the significance of China's philosophy and practice of "technology for good purposes" for the international community, especially for the vast number of Global South countries? Ueno: Science and technology have a dual nature - depending on how they are used, they can either advance human development or cause harm. The philosophy of "technology for good purposes" is essentially a profound proposition about how a country should make good use of its scientific and technological resources within the international community. From a global perspective, developing countries with relatively weak scientific foundations have an even greater need for science and technology to achieve development. China not only makes active calls, but also takes concrete actions to share its technological achievements with these countries, aiming to bring benefits to all of humanity. This approach emphasizes not monopoly over technology and wealth, but sharing and mutual benefit. Such a philosophy helps narrow the development gap between nations and thereby promotes global stability and prosperity. GT: What are your expectations for China's further participation in global science and technology governance and its growing role in the future of technological development? In Japan, there are sometimes mixed views regarding China's pursuit of self-reliance and its technological rise. What is your opinion on this? And what message would you like to share about bilateral cooperation in the field of science and technology? Ueno: In interviews with Japanese companies operating in China, I've noticed that many of them are now not only setting up manufacturing bases in China but also relocating their research and development centers here. I believe there is already a solid foundation and a wealth of achievements in China-Japan cooperation in science and technology, with considerable potential for further growth. Looking ahead, I hope both sides can continue to expand collaboration based on their respective strengths. However, especially since the beginning of this year, there seems to be a growing headwind against cooperation. Science, by its nature, is a pursuit of rationality. It is regrettable when irrational political interference obstructs scientific collaboration. China has not compromised under such pressure and continues to uphold the principle of win-win cooperation. I can sense that China is playing an increasingly important role in guiding the world toward the right path. 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Business Recorder
26-05-2025
- Business
- Business Recorder
Japanese bonds extend rally as higher yields help bring in buyers
TOKYO: Japanese government bonds (JGBs) extended their rally to a second day on Monday as elevated yields attracted buyers, while caution prevailed before the auction of super-long debt this week. Long-dated debt has been sold off around the world in recent weeks, and in Japan, concerns have been exacerbated by a decrease in bond buying by the central bank and political jockeying over stimulus. Very low demand at the auction of 20-year JGBs last week underscored the diminishing capacity to absorb debt issuance to finance the government's fiscal deficit. Japan's bond yields jump after poor outcome of 20-year debt auction All eyes will be on the sale of 40-year bonds, Japan's longest tenor, on Wednesday. With no big and dependable buyers, super-long yields have floated up 'like a kite without a string,' said Mizuho chief market economist Yasunari Ueno. 'The macroeconomic issue of fiscal discipline is something that needs to be addressed by the government and ruling coalition,' Ueno said, adding, the Ministry of Finance should address the supply and demand balance for super-long bonds 'by adjusting issuance'. The 40-year JGB yield fell 7 basis points to 3.48%, down from the record 3.675% touched last Thursday. The 30-year yield fell 6 basis points to 3.005%, retreating from the all-time high of 3.185% hit last week. The benchmark 10-year yield fell 2.5 basis points to 1.52%.
Forbes
02-05-2025
- Entertainment
- Forbes
It Took 51 Tries To Nail This Delicious Yuzu Matcha Martini
On The Rocks x House of Suntory Collaboration When it comes to crafting new cocktails from scratch, even the best mixologists may need to try dozens of times before finalizing a recipe. And it took a Japanese bartending legend over 50 tries to create one the better ready-to-serve cocktails on the market. Hidetsugu Ueno of Tokyo's famed Bar High Five was tasked with crafting two new, shelf-stable cocktails for a new collaboration between On The Rocks Premium Cocktails and The House of Suntory. The results—dubbed 'The Harmony Collection,' now on the U.S. market—were a Japanese Boulevardier and Yuzu Matcha Martini. Both use spirits from Suntory's collection; the Boulevardier with Suntory Whisky Toki, and the Martini with Haku Vodka. (On The Rocks and Suntory Global Spirits have had a partnership since 2016. Suntory acquired On The Rocks in 2020.) And while the Japanese Boulevardier is a tasty go-to over ice (with some latitude for at-home customization with garnishes), the Yuzu Matcha Martini stands out, both for its rich mouthfeel and surprising balance of key ingredients and flavors. According to brand press notes, 'the Yuzu Matcha Martini masterfully balances bright yuzu citrus with the earthy depth of green tea, delivering a harmonious fusion of tangy vibrancy and subtle bitterness.' That's certainly a tall order. And during a recent tasting of The Harmony Collection, the martini may have exceeded even those lofty tasting notes. The drink itself—best served in a pre-chilled martini glass, of course—walks a delicate balance between tart, sweet, and boozy. It's recognizably a vodka martini, with a punchy citrus kick from the yuzu on the midpalate. Perhaps more impressive is the restrained, integrated impact of matcha, which lends a subtle earthiness without overpowering the cocktail at any juncture. It's the sort of drink even the matcha-averse may quite enjoy; in fact, if I didn't know the drink's name ahead of time, I might have missed that ground green tea impact until the very end. That sort of balance in a ready-to-serve cocktail doesn't come automatically. Over the course of around a year, Ueno and the On The Rocks team went through 51 variations of the Yuzu Matcha Martini before finalizing the product. 'Many of the ingredients (such as fresh juice, matcha tea, and wines) used to create cocktails will quickly settle and separate once they sit,' says Ueno, speaking to Forbes. 'These ingredients contribute to the flavor, mouthfeel, color, etc. of the overall cocktail and recreating this unity over time is essential in delivering the optimal experience for our consumers. It takes a lot of testing, patience, and creativity.' The On The Rocks Yuzu Matcha Martini is proofed at 20% ABV and is now available in the U.S. as part of a 375ml bottle 2-pack for $29.99. That includes a bottle of the brand's Japanese Boulevardier, proofed to a boozier 32.5% ABV.
Los Angeles Times
11-03-2025
- Health
- Los Angeles Times
Inflammatory Breast Cancer (IBC): A Comprehensive Guide to Symptoms, Treatment, and Prevention
Inflammatory Breast Cancer (IBC) is a rare and fast-growing type of breast cancer. Inflammatory breast cancer occurs primarily in younger women and is influenced by factors such as ethnicity and body composition. Although it only accounts for about 1–5% of all breast cancer cases, it tends to spread quickly and involves the skin of the breast. Because of its unique features—like redness or swelling of the skin—IBC can be hard to diagnose. In the past, IBC had a poor outlook, but with better understanding of its biology and the use of treatments from many different medical specialties, patients now have improved chances of doing well. The symptoms of inflammatory breast cancer can appear suddenly and are often mistaken for less serious conditions. Key symptoms include: These symptoms are caused by the buildup of fluid (lymph) in the skin of the breast, a hallmark of IBC. If you notice any of these changes, it's essential to seek medical attention promptly, as early diagnosis and treatment are critical for managing IBC effectively. Doctors diagnose IBC using a mix of clinical signs, lab tests, and imaging studies. Clinical signs may include redness, swelling, and a rapid change in the appearance of the breast. Lab tests often involve analyzing breast cancer cells from biopsy samples to assess the presence and characteristics of cancer cells, such as hormone receptors or elevated HER2 levels. Researchers like Hance et al. [1] suggested a scoring system that uses clinical exams, lab findings, and imaging results together to help doctors be more certain about an IBC diagnosis. While this system still needs more study to confirm its accuracy, it offers a helpful starting point for a more unified way to diagnose IBC. Imaging is vital for checking how far the disease has spread. Assessing changes in breast tissue through imaging is crucial for accurate diagnosis and treatment planning. Some experts, including Ueno et al. [10], suggest using a complete imaging plan that includes looking at both breasts and the lymph nodes nearby. A Breast MRI can reveal detailed tissue changes, and a PET/CT scan can show if the cancer has spread to other parts of the body. By using these imaging tools, doctors can figure out the extent of the disease and plan the right treatment steps. IBC's aggressive behavior is partly due to the environment around the tumor. Scientists like Lim et al. [2] have found that IBC cells often behave like stem cells, allowing them to spread quickly. Other nearby cells, including immune and support cells, help the tumor grow. This rapid spread can lead to early metastasis to nearby lymph nodes, complicating treatment and prognosis. Understanding these connections shows why IBC is so difficult to treat and why new medicines might target both the cancer cells and the environment around them. IBC is also linked to specific inflammatory signals inside the body. Fouad et al. [5] found several pathways involved in helping these cancer cells grow, survive, and move throughout the body. By focusing on these pathways, researchers hope to create new treatments that stop the cancer from getting bigger or spreading. Genomic research has uncovered various genetic changes in IBC, such as in MYC, ATAD2, FAK1, CD44, ALK, and NOTCH3 [6]. These altered genes may offer doctors and scientists new ways to create special treatments just for IBC patients. By zeroing in on these genetic 'targets,' doctors might slow the disease or improve the effectiveness of current treatments. Inflammatory breast cancer is typically diagnosed at a more advanced stage compared to other breast cancers. Most cases are identified at a locally advanced stage (stage III) or metastatic stage (stage IV). The aggressive nature of IBC and its tendency to spread quickly contribute to a generally poorer prognosis compared to other types of breast cancer. However, with prompt and comprehensive treatment, some women with IBC can achieve long-term survival. Advances in treatment strategies and a better understanding of the disease are continually improving outcomes for IBC patients. Managing IBC usually requires a team of experts, including medical oncologists, surgeons, and radiation specialists. This approach often follows a sequence [3], [4], [8]: Inflammatory breast cancer patients face an aggressive disease that requires urgent treatment protocols, including chemotherapy and mastectomy, to improve survival rates and manage the rapid metastasis to lymph nodes and other organs. By studying IBC's unique genetic and molecular traits, researchers hope to find treatments that specifically target the changes seen in IBC cells. These therapies aim to stop the cancer from growing or coming back [6]. Clinical trials are looking at new drugs and combination treatments that might be particularly effective against IBC. Coping with inflammatory breast cancer can be challenging, both physically and emotionally. A strong support system, including family, friends, and a dedicated healthcare team, is essential. Women with IBC may experience anxiety, depression, and fear, but numerous resources are available to help manage these emotions. Effective coping strategies include: By utilizing these strategies, patients can better navigate the emotional and physical challenges of IBC, improving their overall well-being and quality of life. Because IBC often appears suddenly and can cause severe swelling, discomfort, or redness, patients may face greater stress and anxiety. An inflammatory breast cancer rash can present initially as an irritation or discoloration on the breast, often appearing suddenly and covering large areas. Tsai et al. [7] described how these noticeable changes can affect a patient's everyday life and emotional health. Early support from healthcare providers, counselors, friends, and family can help patients cope better. After treatment for inflammatory breast cancer, regular follow-up care is crucial to monitor for any signs of recurrence or metastasis. This follow-up care may include: Staying vigilant and proactive with follow-up care can help women with IBC reduce their risk of recurrence and improve their overall survival. Maintaining open communication with your healthcare team and adhering to recommended follow-up schedules are key components of effective post-treatment care. Inflammatory Breast Cancer remains one of the hardest breast cancers to diagnose and treat due to its speed of growth and unique features. Classified as an aggressive cancer, inflammatory breast cancers are notable for blocking lymph vessels, leading to distinctive symptoms such as skin rashes and inflammation. However, using a multidisciplinary approach that includes treatments before surgery, targeted surgery, and radiation, doctors have improved patient survival rates. Ongoing research into the genes and pathways that drive IBC offers hope for targeted treatments that may lead to even better results in the future. By continuously learning more about its biology and patient experiences, the medical community hopes to give IBC patients the best possible care and quality of life. [1] Jagsi, R., Mason, G., Overmoyer, B. A., Woodward, W. A., Badve, S., Schneider, R. J., Lang, J. E., Alpaugh, M., Williams, K. P., Vaught, D., Smith, A., Smith, K., Miller, K. D., & Susan G. Komen-IBCRF IBC Collaborative in partnership with the Milburn Foundation (2022). Inflammatory breast cancer defined: proposed common diagnostic criteria to guide treatment and research. Breast cancer research and treatment, 192(2), 235–243. [2] Di Bonito, M., Cantile, M., & Botti, G. (2019). Pathological and molecular characteristics of inflammatory breast cancer. Translational cancer research, 8(Suppl 5), S449–S456. [3] Robertson, F. M., & Cristofanilli, M. (2011). A global approach to inflammatory breast cancer. Future oncology (London, England), 7(1), 25–30. [4] van Uden, D. J. P., van Maaren, M. C., Strobbe, L. J. A., Bult, P., Stam, M. R., van der Hoeven, J. J., Siesling, S., de Wilt, J. H. W., & Blanken-Peeters, C. F. J. M. (2020). Better survival after surgery of the primary tumor in stage IV inflammatory breast cancer. Surgical oncology, 33, 43–50. [5] Fouad, T. M., Kogawa, T., Reuben, J. M., & Ueno, N. T. (2014). The role of inflammation in inflammatory breast cancer. Advances in experimental medicine and biology, 816, 53–73. [6] Fernandez, S. V., Robertson, F. M., Pei, J., Aburto-Chumpitaz, L., Mu, Z., Chu, K., Alpaugh, R. K., Huang, Y., Cao, Y., Ye, Z., Cai, K. Q., Boley, K. M., Klein-Szanto, A. J., Devarajan, K., Addya, S., & Cristofanilli, M. (2013). Inflammatory breast cancer (IBC): clues for targeted therapies. Breast cancer research and treatment, 140(1), 23–33. [7] Tsai, C. J., Li, J., Gonzalez-Angulo, A. M., Allen, P. K., Woodward, W. A., Ueno, N. T., Lucci, A., Krishnamurthy, S., Gong, Y., Yang, W., Cristofanilli, M., Valero, V., & Buchholz, T. A. (2015). Outcomes After Multidisciplinary Treatment of Inflammatory Breast Cancer in the Era of Neoadjuvant HER2-directed Therapy. American journal of clinical oncology, 38(3), 242–247. [8] Yamauchi, T., Imamura, C. K., Yamauchi, H., Jinno, H., Takahashi, M., Kitagawa, Y., ... & Ueno, N. T. (2016, February). CD44v as a potential predictive biomarker for pathologic complete response in primary HER2+ breast cancer: Utility of adaptive response biopsy in preoperative therapy. In CANCER RESEARCH (Vol. 76). 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA: AMER ASSOC CANCER RESEARCH. DOI: 10.1158/ [9] Rosso, K. J., Tadros, A. B., Weiss, A., Warneke, C. L., DeSnyder, S., Kuerer, H., Ueno, N. T., Stecklein, S. R., Woodward, W. A., & Lucci, A. (2017). Improved Locoregional Control in a Contemporary Cohort of Nonmetastatic Inflammatory Breast Cancer Patients Undergoing Surgery. Annals of surgical oncology, 24(10), 2981–2988. [10] Ueno, N. T., Espinosa Fernandez, J. R., Cristofanilli, M., Overmoyer, B., Rea, D., Berdichevski, F., El-Shinawi, M., Bellon, J., Le-Petross, H. T., Lucci, A., Babiera, G., DeSnyder, S. M., Teshome, M., Chang, E., Lim, B., Krishnamurthy, S., Stauder, M. C., Parmar, S., Mohamed, M. M., Alexander, A., … Woodward, W. A. (2018). International Consensus on the Clinical Management of Inflammatory Breast Cancer from the Morgan Welch Inflammatory Breast Cancer Research Program 10th Anniversary Conference. Journal of Cancer, 9(8), 1437–1447.
