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Medical News Today
13 hours ago
- Health
- Medical News Today
Velcade interactions: Alcohol, medications, and other factors
Velcade has possible interactions with some other drugs and certain supplements. Examples include certain anticonvulsant medications and St. John's wort. Talk with your doctor to avoid potentially harmful effects from Velcade is prescribed for treating multiple myeloma and mantle cell lymphoma in adults. An interaction occurs when a substance causes another to have a different effect than expected. By learning about possible Velcade interactions, you can work with your doctor to ensure this medication is safe and effective for you.»For additional information about Velcade, including details about its uses, see this Velcade overview interactions with other drugs Before you start treatment with Velcade, tell your doctor and pharmacist about any prescription, over-the-counter, and other medications you take. By sharing this information with them, you may help prevent possible interactions. To learn whether Velcade interacts with supplements, herbs, or vitamins, see the 'Velcade and other interactions' you have questions about drug interactions that may affect you, ask your doctor or a table of drugs that can interact with Velcade. However, it doesn't include all drugs that may interact with this medication. Some of these interactions are described in detail in 'Drug interactions in depth.'Drug class or drug nameDrug examplesInteraction result with Velcadeblood pressure medications• angiotensin converting enzyme (ACE) inhibitors, such as lisinopril (Zestril)• angiotensin II receptor blockers (ARBs), such as valsartan (Diovan)• beta-blockers, such as carvedilol (Coreg)can increase the risk for low blood pressure as a side effect of Velcadeoral diabetes medications• metformin (Fortamet, Glumetza)• empagliflozin (Jardiance)can increase the effects of antidiabetic medications or make them less effectivecertain antiandrogens• apalutamide (Erleada)• enzalutamide (Xtandi)can make Velcade less effectivecertain anticonvulsant medications• carbamazepine (Tegretol, others)• phenytoin (Dilantin)can make Velcade less effectivecertain antifungal medications• ketoconazole• itraconazole (Sporanox, Tolsura)can increase the risk for side effects of Velcadecertain antivirals• ritonavir (Norvir) and treatments that contain it• nelfinavir (Viracept)can increase the risk for side effects of Velcadecobicistat and treatments that contain it• Genvoya (cobicistat/elvitegravir/emtricitabine/tenofovir alafenamide fumarate)• Stribild (cobicistat/elvitegravir/emtricitabine/tenofovir disoproxil fumarate)can increase the risk for side effects of Velcadeclarithromycin—can increase the risk for side effects of Velcadenefazodone—can increase the risk for side effects of Velcaderifampin (Rimactane)—can make Velcade less effectiveWhen to avoid Velcade Certain factors or conditions could prevent your doctor from prescribing Velcade due to the risk of harm. These are known as contraindications. Below are the contraindications of Before you start treatment with Velcade, it's important to tell your doctor if these contraindications apply to you. They can determine whether doctors prescribe administrationDoctors won't inject Velcade as an intrathecal injection, which involves injecting the medication into the spine. There are reports of death when it has been given as an intrathecal is only approved for administration by intravenous or subcutaneous injection. Talk with your doctor if you have questions about how you'll receive this had an allergic reaction to Velcade or any of its ingredientsIf you've had an allergic reaction to Velcade or any of its ingredients, your doctor will likely not prescribe it. Taking the drug could cause another allergic reaction. You can ask them about other treatments that may be better choices for and alcohol There are no known interactions between Velcade and alcohol. However, if you drink alcohol, your doctor may advise on avoiding or limiting it during is because drinking alcohol while taking the drug may worsen some of Velcade's side effects. For example, you may experience:nauseavomitingheadachelow blood sugarIn addition, consuming large amounts of alcohol can cause liver damage. Velcade may also damage the liver as a side effect. This means that drinking alcohol during treatment may increase the risk of liver you consume alcohol during Velcade treatment, these side effects may be more likely to occur. If you have questions about drinking alcohol during treatment, talk with your interactions in depth Here's a closer look at certain drug interactions of anticonvulsant medicationsVelcade interacts with phenytoin and carbamazepine, which are anticonvulsant medications prescribed for managing body relies on an enzyme (a special type of protein) called cytochrome P450 3A4 (CYP3A4) to break down Velcade. This makes it easier to remove it from your system. Carbamazepine and phenytoin increase CYP3A4 activity in the body, which means Velcade may be broken down faster than usual. This can make the medication less effective for treating multiple myeloma or mantle cell you or your doctor may takeDue to the risk of affecting Velcade's effectiveness, doctors typically won't prescribe the medication with phenytoin or carbamazepine. Instead, they can prescribe different anticonvulsant drugs that don't have this and treatments that contain itVelcade interacts with cobicistat (Tybost) and treatments that contain it. These medications are prescribed for treating hepatitis C and break down Velcade and make it easier to remove from your system, your body relies on an enzyme called cytochrome P450 3A4 (CYP3A4). However, Cobicistat works by decreasing CYP3A4 activity in your body. This can help certain medications work better, which is why it is included in certain treatments. However, decreasing CYP3A4 activity while you're using Velcade can increase your risk for side effects of this are some treatments containing cobicistat that may interact with Velcade:Genvoya (cobicistat/elvitegravir/emtricitabine/tenofovir alafenamide fumarate)Stribild (cobicistat/elvitegravir/emtricitabine/tenofovir disoproxil fumarate)Symtuza (cobicistat/darunavir/emtricitabine/tenofovir alafenamide fumarate)Evotaz (cobicistat/atazanavir)Prezcobix (darunavir/cobicistat)Steps you or your doctor may takeDue to the increased risk for Velcade side effects, some doctors avoid prescribing cobicistat and treatments that contain it with it's not always possible to avoid this interaction. In cases where Velcade and a treatment containing cobicistat must be used, your doctor may prescribe a lower Velcade dosage. They'll also monitor you closely for any symptoms of Velcade side effects throughout diabetes medicationsVelcade can interact with oral diabetes medications, which are prescribed for treating type 2 diabetes. In studies, people who used Velcade and oral diabetes medications experienced both high blood sugar and low blood sugar as side effects. However, these side effects weren't reported in people who took Velcade but didn't use oral diabetes are some oral antidiabetic medications that may interact with Velcade:metformin (Fortamet, Glumetza)sulfonylureas, such as glipizide (Glucotrol XL)dipeptidyl peptidase (DPP-4) inhibitors, such as sitagliptin (Januvia)sodium-glucose cotransporter 2 (SGLT2) inhibitors, such as empagliflozin (Jardiance)incretin mimetics, such as oral semaglutide (Rybelsus)Steps you or your doctor may takeAlthough Velcade appears to interact with oral antidiabetic medications, this likely won't prevent doctors from prescribing them together. Instead, your doctor can adjust the dose of your diabetes medications based on your blood sugar levels. They may want you to frequently monitor your blood sugar at home, especially when you first start treatment with Velcade or any time your dosage is isn't clear whether this interaction also applies to injectable diabetes medications, such as insulin or injectable semaglutide (Ozempic). If you're prescribed Velcade, you and your doctor can discuss plans to manage your blood and other interactions Velcade may have other interactions, such as with supplements, foods, vaccines, or lab are some potential interactions with Velcade. Keep in mind that the following information does not include all possible interactions with supplementsBefore you start treatment with Velcade, tell your doctor and pharmacist about any supplements, herbs, and vitamins you take. This information may help prevent possible addition to the interactions below, Velcade may interact with green tea supplements. These supplements may affect this medication's effectiveness when it is used to treat multiple myeloma. This interaction is not expected with green tea drinks or when Velcade is used to treat mantle cell lymphoma. Therefore, your doctor will likely advise against consuming green tea supplements if you're using Velcade to treat multiple you have questions about drug interactions that may affect you, ask your doctor or interactions with herbsDoctors typically recommend avoiding taking St. John's wort with Velcade. St. John's wort is an herbal supplement that may be used to treat depression and other John's wort may speed up the activity of an enzyme in your body called cytochrome P450 3A4 (CYP3A4). This enzyme helps break down speeding up this enzyme, St. John's wort can cause Velcade to break down more quickly, which may lead to a low level of this medication in your system. If this level becomes too low, the drug may not work to treat your doctor may be able to suggest a treatment option other than St. John's interactions with vitamins There are no specific reports of vitamins interacting with Velcade. However, that doesn't mean vitamin interactions won't occur or be recognized in the future. Because of this, you need to talk with your doctor or pharmacist before taking any vitamin product with interactions with foodGrapefruit and grapefruit juice can interact with Velcade. Specifically, grapefruit products can stop your body from breaking down this medication. This raises the level of Velcade in your body, which increases your risk of side effects. Due to this risk, your doctor may recommend not consuming grapefruit and grapefruit juice while taking the interactions with vaccinesThere aren't any known interactions between Velcade and vaccines. Talk with your doctor or pharmacist to check whether you're due for any interactions with lab testsVelcade isn't known to interact with lab tests. If you have concerns about this medication interacting with lab tests, talk with your INTERACTION WITH CANNABIS OR CBDCannabis (often called marijuana) and cannabis products, such as cannabidiol (CBD), have not been specifically reported to interact with Velcade. However, as with any drug or supplement, talk with your doctor before using cannabis in combination with Velcade. The effects of cannabis may affect how well you stick to your Velcade treatment Cannabis is illegal at a federal level but is legal in many states to varying and health-related interactionsCertain medical conditions and other factors may increase the risk of interactions with Velcade. Before you take this drug, be sure to talk with your doctor about your health history. Velcade may not be suitable if you have certain medical conditions or other factors affecting your conditions or factors that might interact with Velcade include:Breathing or lung conditions: Velcade side effects can include acute respiratory distress syndrome (ARDS) and other lung-related side effects. If you have a breathing or lung condition such as asthma, you may be at higher risk for lung-related side effects due to Velcade. Treatment with this medication could also worsen your condition. Talk with your doctor to learn more about the risks and benefits of Velcade treatment based on your lung failure or other heart conditions: New and worsening heart failure are possible Velcade side effects. If you have heart disease or another heart condition, you may have a higher risk of heart-related side effects from taking Velcade. If your doctor prescribes this medication to you, they'll likely closely monitor your heart health throughout of syncope: Velcade can cause low blood pressure as a side effect. If you have a history of syncope (fainting), you may be at higher risk of this side effect. If your doctor prescribes Velcade to you, it's important to stay hydrated throughout treatment to lower your risk of low blood pressure and conditions: If you have a liver condition such as cirrhosis, your doctor may prescribe a lower Velcade dosage. Your body relies on your liver to metabolize (break down) this medication. Having a liver condition can affect this process and raise your risk for Velcade side effects. Velcade can also cause liver damage as a side effect, and having a liver condition means you may be at a higher risk. Your doctor can help determine whether treatment with Velcade is safe based on your liver reaction: If you've had an allergic reaction to Velcade or any of its ingredients, your doctor will likely not prescribe this medication. Taking the drug could cause another allergic reaction. You can ask them about other treatments that may be more It's unknown whether it's safe to use Velcade while breastfeeding. There isn't enough information to determine whether the drug passes into breast milk or what effects it may have on a breastfed child. However, due to the possible risk of serious side effects, health experts recommend against breastfeeding during Velcade treatment or for at least 2 months after your last dose. If you're breastfeeding or planning to, talk with your doctor before using Velcade. They can talk with you about treatment options and ways to feed a child other than There haven't been enough clinical trials to determine whether Velcade is safe to use while pregnant. Animal studies show that the drug may cause congenital anomalies (commonly known as birth abnormalities) or pregnancy loss. However, it's important to note that animal studies don't always indicate what may happen in humans. If you're pregnant or planning to become pregnant, tell your doctor before starting Velcade. They can advise you on the right treatment plan for interactions You can take certain steps to help prevent interactions with Velcade. Your doctor and pharmacist are key resources, so reaching out to them before starting treatment can help. For example, it's important that you plan to do the following:Let them know if you drink alcohol or use them about any other medications you take, as well as any supplements, herbs, and a medication list, which your doctor and pharmacist can help you fill also important to read the Velcade label and other paperwork that may come with the drug. The label may have colored stickers that mention an interaction. The paperwork, sometimes called the medication guide or patient package insert, may contain details about Velcade doesn't come with paperwork, you can ask your pharmacist to print a copy. If you need help reading or understanding this information, ask your doctor or can also help prevent interactions with Velcade by taking it exactly as your doctor Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
Yahoo
02-04-2025
- Business
- Yahoo
Amneal and Shilpa introduce Boruzu in US for cancer treatment
Amneal Pharmaceuticals and Shilpa Medicare have launched the new presentation of bortezomib, Boruzu, for subcutaneous or intravenous administration, offering a ready-to-use option for patients with multiple myeloma and mantle cell lymphoma in the US. Boruzu is the first ready-to-use bortezomib injection for multiple myeloma and mantle cell lymphoma, and lowers the compounding preparation process needed for administration. A proteasome inhibitor, Boruzu references branded Velcade, a lyophilised powder that needs reconstitution before usage. Shilpa has created the molecule, while Amneal will handle the manufacturing and commercialisation of the product. The most commonly reported adverse events for Boruzu in clinical studies have been anaemia, anorexia, asthenic conditions, diarrhoea, euralgia, gastrointestinal issues, leukopenia, neutropenia, peripheral neuropathy, psychiatric disorders, pyrexia, reduced appetite and thrombocytopenia. Amneal pharmaceutical biosimilars and branded oncology senior vice-president Sean McGowan stated: "As we advance our broader strategy to build a leading injectables portfolio with durable, high-impact complex products, we are excited to announce the US launch of Boruzu in our oncology portfolio. 'This ready-to-use injectable marks a significant innovation for our customers by streamlining pharmacy preparation steps for clinicians while now carrying a unique J-code to facilitate reimbursement.' Amneal is a biopharmaceutical company based in Bridgewater, US. Through its affordable medicines segment, the company focuses on widening complex product categories as well as therapeutic areas, which include biosimilars and injectables. In its speciality segment, Amneal has a branded pharmaceutical portfolio focusing mainly on endocrine and central nervous system disorders. The company distributes pharmaceuticals and other products to the federal government of the US, as well as to institutional and retail markets, via its AvKARE segment. An integrated pharmaceutical group, Shilpa has business interests in peptides, oncology and non-oncology active pharmaceutical ingredients, differentiated finished dosage formulations and polymers. It also offers contract development and manufacturing organisation services to pharmaceutical firms, supported by research and development and manufacturing capabilities. In August 2024, the US Food and Drug Administration (FDA) approved Amneal's Crexont extended-release capsules for treating Parkinson's disease. "Amneal and Shilpa introduce Boruzu in US for cancer treatment" was originally created and published by Pharmaceutical Technology, a GlobalData owned brand. The information on this site has been included in good faith for general informational purposes only. It is not intended to amount to advice on which you should rely, and we give no representation, warranty or guarantee, whether express or implied as to its accuracy or completeness. You must obtain professional or specialist advice before taking, or refraining from, any action on the basis of the content on our site. Sign in to access your portfolio
