Latest news with #WNT
Associated Press
a day ago
- Business
- Associated Press
Allarity Therapeutics Announces Research Collaboration with Indiana Biosciences Research Institute to Further Advance Understanding of Stenoparib's Unique, Dual Therapeutic Mechanism of Action
TARPON SPRINGS, Fla., June 4, 2025 -- Allarity Therapeutics, Inc. ('Allarity' or the 'Company') (NASDAQ: ALLR), a Phase 2 clinical-stage pharmaceutical company dedicated to developing stenoparib—a differentiated, dual PARP and WNT pathway inhibitor—as a personalized cancer treatment using its proprietary, drug-specific Drug Response Predictor (DRP®) patient selection technology—today announced a research collaboration with the Indiana Biosciences Research Institute (IBRI). The collaboration is aimed primarily at further deepening the Company's mechanistic understanding of the dual mechanism of action of stenoparib. Stenoparib is a novel, orally available small-molecule inhibitor of PARP1/2 and tankyrase1/2. As such, stenoparib not only impairs DNA repair to selectively kill cancer cells but also inhibits the WNT signaling pathway—a cellular pathway commonly associated with chemoresistance and advanced-stage disease in multiple cancer types. This unique dual activity distinguishes stenoparib as a highly differentiated therapeutic candidate with the potential to address cancers that are resistant to standard-of-care therapies. Under the agreement, IBRI will conduct advanced molecular and cellular studies to clarify the individual and combined contributions of PARP inhibition and WNT pathway modulation to stenoparib's observed anticancer effects. 'Understanding how stenoparib exerts its dual biological effects is central to our long-term clinical development strategy. It will enhance our ability to raise awareness of this molecule among leading oncologists and help us engage more effectively with sophisticated biotech investors,' said Thomas Jensen, CEO of Allarity Therapeutics. 'In addition to deepening our understanding of the foundational biology behind stenoparib's differentiated profile, this research may further strengthen our DRP®-based patient selection strategy and potentially open new opportunities for additional therapeutic combinations and indications, such as colorectal cancer, where WNT pathway activation is very common.' The collaboration is also expected to support Allarity in potential future efforts to pursue marketing approval for stenoparib, and to further clarify its mechanism of action in both the Company's ongoing Phase 2 trial in advanced ovarian cancer and its recently announced combination trial evaluating stenoparib with temozolomide in recurrent small cell lung cancer (SCLC). Furthermore, this collaboration underscores Allarity's commitment to scientific excellence, translational research, and data-driven development, which form the foundation of its personalized oncology strategy. About The Indiana Biosciences Research Institute The Indiana Biosciences Research Institute (IBRI) is a leading translational research institute that accelerates innovation by bridging academic and industry science through collaboration. Its team of scientists is focused on solving high-impact biomedical challenges in areas such as cancer, diabetes, Alzheimer's disease, and pediatric rare diseases, while also providing molecular innovation platforms and enabling technologies to drive the development of novel therapies. For more information, visit About Stenoparib Stenoparib is an orally available, small-molecule dual-targeted inhibitor of PARP1/2 and tankyrase 1/2. At present, tankyrases are attracting significant attention as emerging therapeutic targets for cancer, principally due to their role in regulating the WNT signaling pathway. Aberrant WNT/β-catenin signaling has been implicated in the development and progression of numerous cancers. By inhibiting PARP and blocking WNT pathway activation, stenoparib's unique therapeutic action shows potential as a promising therapeutic for many cancer types, including ovarian cancer. Allarity has secured exclusive global rights for the development and commercialization of stenoparib, which was originally developed by Eisai Co. Ltd. and was formerly known under the names E7449 and 2X-121. About the Drug Response Predictor – DRP® Companion Diagnostic Allarity uses its drug-specific DRP® to select those patients who, by the gene expression signature of their cancer, may have a high likelihood of benefiting from a specific drug. By screening patients before treatment, and only treating those patients with a sufficiently high, drug-specific DRP score, the therapeutic benefit rate may be enhanced. The DRP method builds on the comparison of sensitive vs. resistant human cancer cell lines, including transcriptomic information from cell lines, combined with clinical tumor biology filters and prior clinical trial outcomes. DRP is based on messenger RNA expression profiles from patient biopsies. The DRP® platform has shown an ability to provide a statistically significant prediction of the clinical outcome from drug treatment in cancer patients across dozens of clinical studies (both retrospective and prospective). The DRP platform, which may be useful in all cancer types and is patented for dozens of anti-cancer drugs, has been extensively published in the peer-reviewed literature. About Allarity Therapeutics Allarity Therapeutics, Inc. (NASDAQ: ALLR) is a clinical-stage biopharmaceutical company dedicated to developing personalized cancer treatments. The Company is focused on development of stenoparib, a novel PARP/tankyrase inhibitor for advanced ovarian cancer patients, using its DRP® technology to develop a companion diagnostic that can be used to select those patients expected to derive the greatest clinical benefit from stenoparib. Allarity is headquartered in the U.S., with a research facility in Denmark, and is committed to addressing significant unmet medical needs in cancer treatment. For more information, visit Follow Allarity on Social Media LinkedIn: Forward-Looking Statements This press release contains 'forward-looking statements' within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements provide the Company's current expectations or forecasts of future events. The words 'anticipates,' 'believe,' 'continue,' 'could,' 'estimate,' 'expect,' 'intends,' 'may,' 'might,' 'plan,' 'possible,' 'potential,' 'predicts,' 'project,' 'should,' 'would' and similar expressions may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. These forward-looking statements include, but are not limited to, statements related to the research collaboration with the Indiana Biosciences Research Institute (IBRI); the potential to further elucidate the dual mechanism of action of stenoparib; the role of PARP inhibition and WNT pathway modulation in clinical benefit; the ability to enhance or refine the Company's DRP® companion diagnostic; the potential identification of new therapeutic indications or combinations; and the impact of the collaboration on future clinical strategy, development timelines, or regulatory engagement. Any forward-looking statements in this press release are based on management's current expectations of future events and are subject to multiple risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include, but are not limited to the risk that the collaboration may not yield actionable insights; the risk that mechanistic findings may not translate into clinical outcomes; the possibility that the DRP® may not be enhanced, validated, or accepted by regulators; and the broader risks related to drug development, including clinical, regulatory, manufacturing, and commercial risks. For a discussion of other risks and uncertainties, and other important factors, any of which could cause our actual results to differ from those contained in the forward-looking statements, see the section entitled 'Risk Factors' in our Form 10-K annual report filed with the Securities and Exchange Commission (the 'SEC') on March 31, 2025, available at the SEC's website at and as well as discussions of potential risks, uncertainties and other important factors in the Company's subsequent filings with the SEC. All information in this press release is as of the date of the release, and the Company undertakes no duty to update this information unless required by law. ### Company Contact: [email protected] Media Contact: Thomas Pedersen Carrotize PR & Communications +45 6062 9390 [email protected] Attachment
The 42
a day ago
- General
- The 42
'She was low on confidence' - Ward hails Ireland's Player of the Match Murphy
REPUBLIC OF IRELAND WNT manager Carla Ward has hailed the performance of Emily Murphy who was named the Player of the Match after their Nations League victory over Slovenia. Ireland's quest for automatic qualification to League A fell short in Páirc Uí Chaoimh but Murphy's impressive display was one of the many positives for the hosts to take forward to the play-offs in October. Belgium, Denmark, Iceland, and Austria await Ireland in the draw on Friday. Murphy, who scored the late winner against Türkiye last week, was prominent throughout and broke through for chances at goal while winning plenty of possession and breaking through tackles. She also played a part in Saoirse Noonan's goal as she provided the pass for Jessie Stapleton to send in the delivery for Noonan's header. But speaking after Ireland's 1-0 win, Ward said that Murphy was not playing with much confidence when she took over as the new manager back in January. 'She was low on confidence, had not played many minutes. We had an honest conversation with her after the first camp, that she might not be in the second camp, as we needed more from her. She's got better and better.' Similarly, Ireland's goal-scorer Saoirse Noonan had a breakthrough performance this evening. Her goal on 19 minutes proved to be the difference while her all-round display was equally effective before her withdrawal on 62 minutes for Amber Barrett. This was Noonan's first competitive start for Ireland, starring in front of a home crowd along with fellow Cork natives Megan Connolly and Denise O'Sullivan. 'I know she's been around a while,' Ward replied when asked about Noonan's performance. 'Her first competitive start for her country, which I reminded her of just before the game and said, 'Look, here's your moment.' I thought she was excellent. She held the ball up really, really well. Advertisement 'When she came on against Türkiye, she was excellent. And tonight, she's done exactly what we needed her to do. So, to get the goal on her home soil is pleasing.' Reflecting on Ireland's overall performance, Ward said she was satisfied that her team corrected the mistakes that marred last Friday's comeback 2-1 win in Istanbul. Ireland struggled to deal with Türkiye's counter-attack and fell behind just after half-time. She said Ireland adapted to being a 'mid-press team' against Slovenia which she wants to develop ahead of two important friendlies against the four-time World Cup winners USA in the summer before the Nations League play-offs in October. 'Probably the way I'd put it would be a Carla Ward team on the ball and an Irish mentality off the ball. That's what we need to build on. If we want to play in an exciting way going forward, we have to be better off the ball. 'And that was the start of it tonight. Now we go to the US and play the best in the world and try to continue that work but there is still a lot of work to do. 'There was an attitude and a mentality from the word go. 15 shots on goal which is huge. We've not struggled to create in this group but certainly maybe struggled to be clinical. But as I said I'm nothing but proud of the group tonight.' The Ireland team honour Louise Quinn after her final game tonight. Ryan Byrne / INPHO Ryan Byrne / INPHO / INPHO Louise Quinn made her final appearance in an Ireland shirt this evening, coming on for Abbie Larkin with 10 minutes to go. Ward praised the veteran defender for imparting inspirational words to the group on full-time which focused on the next generation and the importance of never taking the Irish jersey for granted. She added that she would like to have Quinn with the travelling group for their trip to America, but says Quinn has declined to go. 'I've been literally trying to convince her. 'She's been brilliant. Even in team meetings, she sparks conversation where maybe some of the younger ones don't. Her message at the end was so important, so important in terms of, now it's over to you guys.'
Irish Independent
2 days ago
- General
- Irish Independent
Ireland v Slovenia, Nations League – Girls in Green take the lead at Páirc Uí Chaoimh
Live | Ireland conclude their Nations League B Group 2 campaign with a visit from Slovenia. Carla Ward's team suffered a surprise 4-0 reverse in the first fixture so will be out for revenge at Páirc Uí Chaoimh in Cork. You can follow all the action as it happens in our liveblog below. 31' 28' That's the latest poor tackle from the visitors as Kolbl challenges Abbie Larkin for the ball with the latter hitting the desk in the process. The Ringsend woman is receiving treatment but looks ok to continue. 25' Ireland almost score twice in three minutes as a Megan Connolly corner drops to Kyra Carusa on the edge of the six yard box, but with her back to goal the forward's effort is just wide. 20' Goal Republic of Ireland Scorer Saoirse Noonan What a moment for the Cork woman! The Celtic striker marks her big day with the opening goal. Jessie Stapleton sends in a superb ball from the right wing and Noonan's header is excellent as it loops over the goalkeeper. A special finish on a special night for the former inter-county footballer. 19' Some fine feet by Abbie Larkin sees her find a pocket of space on the edge of the box but the Dubliner watches her shot is straight into the arms of the Slovenia goalkeeper. 13' 11' Slovenia have settled into the contest with Jessie Stapleton needing to be alert to divert a dangerous cross to safety. Irish skipper Katie McCabe is down receiving treatment after landing badly from a challenge by Prasnikar. 6' Two Irish corners test the visiting back line but Slovenia survive after the flag goes up on Kyra Carusa. 3' Ireland kick off shooting towards the city end at the Páirc with some of the GAA markings still visible after Saturday's clash between Cork and Kerry. Local striker Saoirse Noonan has Ireland's first chance of the night but her strong header is stopped by a good save by Slovenia 'keeper Mersnik. 43 minutes ago Pre-match stats - There are currently 12 places between Ireland (26) and Slovenia (38) in the FIFA Women's World Rankings. - Ten players in the current squad featured in the first WNT game in Páirc Uí Chaoimh last July when Ireland beat France 3-1 in their best ever result (considering France were No 2 in the FIFA Women's World Rankings at the time). Previous meetings: 30/10/2013 | Slovenia 0-3 Ireland | FIFA World Cup Qualifier | Ob Jezeru City Stadium, Velenje 20/08/2014 | Ireland 2-0 Slovenia | FIFA World Cup Qualifier | Tallaght Stadium 25/02/2025 | Slovenia 4-0 Ireland | UEFA Nations League | Bonifika Stadium, Koper 55 minutes ago Journey from Balbriggan to Zurich featured many highs and a few lows for Diane Caldwell Diane Caldwell is one of Ireland's recent retirees and I caught up with the Dubliner last weekend ahead of today's clash in Cork about the highs and lows across her century of caps with Ireland. Journey from Balbriggan to Zurich featured many highs and a few lows for Diane Caldwell In another world, Diane Caldwell would be just a couple of weeks away from the last dance. Today 12:23 PM David Kelly: Ireland arrive at Páirc Uí Chaoimh cathedral searching for divine inspiration Our man on the ground also penned this piece from Leeside ahead of tonight's big game. David Kelly: Ireland arrive at Páirc Uí Chaoimh cathedral searching for divine inspiration Angelus bells will peal across the Marina to accompany kick-off in 'The Park' tomorrow. Today 12:17 PM 'Jim McGuinness sent me a message after beating Ireland and hopefully I will get another one tomorrow' – Slovenia manager Sasa Kolman David has also been speaking to the Slovenia boss ahead of tonight's game, who has an interesting link with a certain Donegal man. 'Jim McGuinness sent me a message after beating Ireland and hopefully I will get another one tomorrow' – Slovenia manager Sasa Kolman Jim McGuinness inspired Sasa Kolman so much when the pair met during the current Donegal manager's time at Celtic as a youth coach in 2013 that the Slovenian manager felt like he could achieve anything. 1' Big match preview No matter what transpires in Cork this evening, Katie McCabe will finish this campaign as a European champion, writes David Kelly in his big match preview here. 'It takes its toll on you' – Katie McCabe details 'noise' surrounding FAI and women's team as Slovenian challenge awaits No matter what transpires in Cork this evening, Katie McCabe will finish this campaign as a European champion. Live Blog Software
The 42
2 days ago
- Sport
- The 42
'It's the whole calendar. I don't know who's in charge but it definitely needs to be looked at'
ON WHAT IS an important day for the Republic of Ireland WNT, fixture scheduling and Nations League format confusion have become equally important discussion points. Both Ireland manager Carla Ward, and team captain Katie McCabe, agree that the system needs to be reviewed. In the last week, McCabe has played in a Champions League final for Arsenal and a Nations League fixture for Ireland in Istanbul. The Ireland squad are heading to the USA in June to play two international friendlies, but she will not be available. Everything is packed in too tightly. The Nations League is Ireland's main concern at the moment, and the format has long been a source of confusion. In truth, the Ireland women's team is no stranger to convoluted qualification routes. Their path to the 2023 World Cup — and a first-ever major tournament — was far from linear. At one point, Denise O'Sullivan admitted that she found the whole system 'really confusing' and that her teammates 'tried to explain it 100 times' before she simply decided to detach from the diagrams and focus on the games in front of her. The Nations League is running a similarly protracted line. Ireland's yo-yo form between League A and League B has probably added to the confusion, but for now, they are in the second tier in what has been labelled the group of death. Tonight, they face Group B2 leaders Slovenia in Cork's Páirc Uí Chaoimh and thankfully, the aim is simple: win the game by four goals or more to achieve automatic promotion to League A. If they fall short in that mission, they still have a play-off route awaiting them in October. There's clarity with this fixture but broadly speaking, Ireland captain Katie McCabe feels the whole Nations League structure is chaotic. Advertisement 'It's nuts — the set-up, the goals, points, relegation and promotion,' she begins ahead of tonight's 6pm kick-off at Cork GAA headquarters. Similar to the attitude that her teammate O'Sullivan adopted for the World Cup play-off, McCabe is intent on narrowing her focus to keep her mind clear. Republic of Ireland players attending training at Páirc Uí Chaoimh. Ryan Byrne / INPHO Ryan Byrne / INPHO / INPHO 'All we can concentrate on is winning games and progressing performances game by game. I'll let you all do the maths and we [will] focus on winning matches. 'It's the timing of the fixtures as well, like what we had to do last year all through the summer where you're finishing a season and you've to kind of rest but kind of keep fit for the next block of games and it's hard mentally and physically from a periodisation point of view to do that. So, the timing of the fixtures needs to be looked at as well in my opinion.' McCabe helped Arsenal end an 18-year wait for Champions League success last week but left the celebrations early for Ireland's crucial Nations League trip to Türkiye. She wanted to be available for international duty but feels the schedule is too congested. It's an issue which has become synonymous with McCabe's club in recent years. Arsenal players including Leah Williamson and Beth Mead have suffered ACL injuries which are believed to be linked with the increased playing demands on female players. 'It's the whole calendar,' says McCabe. 'I don't know who's in charge of it but it definitely needs to be looked at. 'What it will create over time and we've already seen it in recent years is burnout in players and major injuries. You've got world-class players that will be sitting out of tournaments through injuries and we don't want to see that. We want the best players in the world playing at tournaments on the biggest stage. I just hope it doesn't cause too much more harm to us as players going forward.' Both McCabe and Ireland head coach Carla Ward agree that returning to League A is their objective but there is an argument for staying in League B at the moment. The next promotion to the top tier would give them a better pathway to the 2027 World Cup. McCabe stresses that League B is a difficult competition but wants to keep company with the best nations in world football. Ultimately, everyone in the Ireland camp is united in their ambition to get to the top tier. Ireland manager Carla Ward looks on at her team's last training before Tuesday's kick-off. Ryan Byrne / INPHO Ryan Byrne / INPHO / INPHO 'We've discussed it as staff,' says Ward, 'but it's bonkers because if you stay in [League] B now, you are in a better position to win League A and get one less qualifying round to the World Cup. But how does that give motivation?' 'We don't want to think like that. We are naturally competitive and we want to win the group. 'It needs looking at. As soon as the Nations League came along, it's good because there's no more friendlies. Every country is getting more competitive, but the structure to say that if we get promoted to League A, but then we get relegated, for example, we would be in a far weaker position than somebody in League B.' Now, that the confusing and tiring talk of scheduling and format structures is done, let's reset to focus on this evening's action. Ireland face a huge challenge in defeating Slovenia by more than four goals, but it's the route they're determined to take. A huge game awaits in Páirc Uí Chaoimh.
The Irish Sun
3 days ago
- Entertainment
- The Irish Sun
‘Feels like she's been with us for years' – RTE football pundit & wife joyful after birth of second child
RICHIE Sadlier and wife Fiona have revealed the birth of their second child - a daughter they've named Molly. They're now a family of four having 4 The 46-year-old cradling his newborn daughter Credit: @richiesadlier 4 He also shared this photo of wife Fiona holding her Credit: @richiesadlier 4 They had had the name Molly in their minds since 2018 Credit: @richiesadlier 4 Big brother Sam saying hello for the first time Credit: @richiesadlier In an emotional Instagram post, Richie shared photos from the maternity hospital as the whole family got acquainted with one another. Speaking from the heart he recounted: "Say hi to our gorgeous little daughter, Sam's little sister … Molly. "We decided on the name Molly in August 2018 when we began our first round of IVF. "We didn't have a boy's name picked, so from then on, every follicle, egg and embryo we encountered along the way was referred to as Molly. Read More On Irish Football "The room that could become a child's bedroom in our new home in 2020 was called Molly's room. "On our good days, long before there was a pregnancy, we wondered what Molly will think of us as parents, and what kind of kid she would be. "On our tougher days, during four years of unsuccessful fertility treatment, we questioned whether we'd ever get to meet her. "We never said the name to anyone in all that time, agreeing never to say it unless she made it. Most read in Football "She was born on May 20, and came home with us three days later, but it honestly feels like she's been with us for years." The welcome update on Neymar SENT OFF for attempting to score Maradona-style Hand of God goal ours after old club PSG win Champions League Ireland legend and fellow In a similar vein, another ex-Ireland WNT star in Stephanie Zambra expressed her delight at seeing and hearing the happy news. The former Two greats from the men's national team in Lastly, Since Molly was actually born almost two weeks ago, Sadlier had been able to carry out his media work as per usual over the weekend. This of course revolved around the national broadcaster's coverage of the Champions League final on Saturday night. He was in studio alongside Stephen Kelly and Kevin Doyle as they acclaimed one of the all-time great European Cup final displays by
