28-05-2025
Can You Donate Part of Your Liver to Someone with Cirrhosis?
Liver donation can offer hope to people with later-stage liver disease. Cirrhosis (liver scarring) is typically not reversible, so treatment aims to manage symptoms and help prevent further complications.
If a person wishes to become a liver donor, they and the recipient will need to consider certain factors and undergo evaluation before deciding on this option.
What is living liver donation?
Living liver donation is a procedure in which a healthy adult donates a portion of their liver to someone with end stage liver disease.
Living liver donation is possible because the liver is the only solid organ in the human body that can regenerate itself completely. In healthy donors, the donated liver portion is typically about half the total liver, and this can fully regenerate within a few months.
Who can receive a living liver donation?
Living liver donation is an option for patients with end stage liver disease and various other conditions that lead to liver failure, such as cirrhosis.
If you have a family member or friend who would like to donate part of their liver to you, speak with your transplant team to open up the discussion around this option.
What do liver donors need to know before donating?
When considering liver donation, you'll want to take into account certain factors, such as:
Donor assessment: Any organ donor must have a thorough evaluation to make sure they're healthy enough to donate. This will also include blood tests such as ALT and albumin to measure liver function.
Understanding: It's strongly encouraged that a donor understand the recipient's liver disease, their outlook, and the risks involved with the procedure for both parties. This information can help you make an informed decision about donation.
Aftercare: After donation, both the donor's and the recipient's liver cells will start to regenerate. It's important that you are aware of what you can expect following the procedure, including timelines for recovery, strategies to aid healing, and when to expect follow-ups with your care team.
Are there any conditions that disqualify someone from being a liver donor?
Yes, you will not be able to donate if you have a diagnosis of certain conditions that could affect the health of your liver or increase your risks of complications, such as cirrhosis or metabolic dysfunction-associated steatohepatitis (previously known as nonalcoholic steatohepatitis).
Blood tests such as the ALT (alanine aminotransferase) test and albumin test are commonly used to assess liver function. The ALT test can detect liver damage or disease, often before symptoms appear, while the albumin test measures levels of a protein made by the liver, with low levels potentially indicating liver disease.
Can I donate anonymously to someone I don't know?
Yes, it's possible to donate part of your liver to someone you don't know. This is called non-directed or anonymous donation. Because the liver is able to regenerate, you can safely donate one part (or lobe) to someone in need.
You do not have to be a particular blood type to apply to donate, as liver donors do not necessarily have to be the same blood type.
How long does it take to recover after liver donation?
Donor surgery typically takes about 6 hours. Both the donor and recipient will typically stay in the hospital from 5 to 7 days, with close monitoring by their healthcare team while they recover.
After you donate, your liver cells will regenerate, and the organ will grow back to 90% of its original size within 6 to 12 weeks for healthy donors.
After you leave the hospital, it's important to work closely with your healthcare team to ensure your liver is healing properly.
