Latest news with #BritishLiverTrust
The Sun
3 days ago
- Health
- The Sun
Urgent paracetamol warning as world's most common painkiller is linked to disease that kills 30 Brits every day
A PHARMACIST has issued a warning about the world's most used painkiller paracetamol, warning it could be "quietly harming" your liver. The pill is safe to take for headaches, muscle pain and fever, as long as you're sticking to recommended amounts. But "taking too much – even slightly exceeding the recommended dose – can be extremely dangerous for your liver", warned Dipa Kamdar, a senior lecturer in pharmacy practice at Kingston University. It's easy to assume that alcohol is the main culprit of liver damage. "In fact, many everyday habits, often overlooked, can slowly cause damage that may eventually lead to serious conditions such as cirrhosis - permanent scarring of the liver - or liver failure," the pharmacist wrote in The Conversation. This can include eating foods high in saturated fat or sugar, as well as smoking or not exercising enough - as well as taking too much paracetamol. "Despite its remarkable resilience – and even its ability to regenerate – the liver is not indestructible," Dipa said. "One of the challenges with liver disease is that it can be a silent threat. In its early stages, it may cause only vague symptoms like constant fatigue or nausea. "As damage progresses, more obvious signs may emerge. One of the most recognisable is jaundice, where the skin and the whites of the eyes turn yellow." Liver disease kills more than 11,000 people in the UK each year, according to The British Liver Trust. That amounts to more than 31 deaths a day, the charity said. It warned that liver disease deaths in the UK have quadrupled in the last 50 years, at the same time as deaths from other major diseases have fallen. Scientists discover that even really low doses of paracetamol could damage your heart Dipa explained paracetamol could be dangerous to the liver due to the way the organ processes the painkiller. As it breaks down the drug, it produces a toxic by-product called NAPQI. Normally, the body neutralises this by producing a protective substance known as glutathione. But in high doses, the liver can become overwhelmed, potentially leading to potentially life-threatening damage. "In an overdose, glutathione stores become depleted, allowing NAPQI to accumulate and attack liver cells," Dipa warned. "This can result in acute liver failure, which can be fatal. "Even small overdoses, or combining paracetamol with alcohol, can increase the risk of serious harm," the pharmacist went on. "Always stick to the recommended dose and speak to a doctor if you find yourself needing pain relief regularly." 2 Studies have looked into the potential dangers of taking paracetamol. Research published in 2013 showed a link between liver failure and low doses of paracetamol. As Andrew Moore, an honorary senior research fellow at the University of Oxford, wrote in The Conversation: "Paracetamol is known to cause liver failure in overdose, but it also causes liver failure in people taking standard doses for pain relief. "The risk is only about one in a million, but it is a risk." Other habits damaging your liver Dipa shared other habits that may be silently damaging your liver. Drinking too much alcohol is the obvious one. When you drink, your liver works to break down the alcohol and clear it from your system, but having too much of it at once overwhelms this process and causes toxic by products to build up and damage liver cells. This can cause fat to accumulate in the liver and continued drinking can progress it to alcoholic hepatitis and then cirrhosis. Experts recommend sticking to no more than 14 units of alcohol per week, and including alcohol-free days to give your liver time to recover. It's also worth taking a look at your diet to protect your liver, as foods high in saturated fat - like red meat, fried foods and processed snacks - can raise cholesterol levels and contribute to liver fat accumulation. Sugary foods and drinks are also a major risk factor, the pharmacist said. Not exercising enough can contribute to weight gain, which ups the risk of liver disease. But exercising can benefit your liver even in you don't lose weight, Dipa noted. Finally, the chemicals from cigarette smoke can make your liver work harder and contribute to cirrhosis. The British Liver Trust says 90 per cent of liver disease cases can be prevented by lifestyle changes. "You can protect [your liver] by drinking alcohol in moderation, quitting smoking, taking medications responsibly, eating a balanced diet, staying active and keeping hydrated," Dipa said.
Times
28-04-2025
- Health
- Times
Liver disease is on the rise. Here's what you need to know
New data from the British Liver Trust has highlighted a fourfold rise in mortality rates for liver disease over the past 50 years, making it one of the leading causes of death in adults under 65. And because the organ has such huge reserves, many of those affected remain blissfully unaware that they are heading for trouble. Might you be one of them? The liver is the organ equivalent of Monty Python's Black Knight, who battles on despite losing his arm (and eventually all his limbs) in a sword fight with King Arthur, declaring: 'Tis but a scratch.' Put simply, by the time many people develop symptoms of liver damage, the organ is often approaching irreversible end-stage failure. There are lots of reasons people develop liver disease, but the main drivers behind the increase over the past 50 years have been viral infection (particularly hepatitis C in the UK), our expanding waistlines, alcohol, and a combination of all three. • Gulp! I took a £300 liver test after drinking Christmas dry Hepatitis C warrants a whole article in itself, not least because advances in antiviral therapy have transformed the outlook for people with the infection. Thankfully it is now much less common than it used to be. As for alcohol, the latest Health Survey for England revealed that 32 per cent of men and 15 per cent of women questioned admitted drinking more than the recommended maximum of 14 units a week, with the heaviest drinkers being in the 45-65 age group. The weekly limit errs on the low side as it is hard to predict how alcohol affects individuals, but I often encounter problems (not all liver related — see below) in people drinking 20-30 units a week, and in those consuming 50 or more it's not so much if they will run into trouble as when. However, the link between diet and lifestyle and non-alcohol related fatty liver disease — or, to use its latest medical title, metabolic dysfunction-associated steatotic liver disease (MASLD) — isn't so well appreciated, despite it being very common. The British Liver Trust estimates that at least one in five adults in the UK now have some degree of MASLD, most of whom will probably never know and go on to fall ill and die from something different. However, a significant minority will develop worrying liver disease unless mitigating steps are taken. Most (but not all) people with MASLD are overweight or obese, with apple-shaped men and women who store fat around their midriff being at particular risk. It is also linked to poor diet, a sedentary lifestyle, high cholesterol levels, raised blood pressure, type 2 diabetes and, in women, polycystic ovarian syndrome. If you have ever eaten foie gras you will know what a fatty liver looks like: pale and yellow rather than a healthy pink. We may not be cruelly force-fed ducks or geese, but overindulgence has a similar effect in humans, and the resulting fatty infiltration can be the start of a scarring process that leads to stiffening of the liver and, eventually, cirrhosis and failure. Indeed, similar fatty changes are typically the first sign of trouble in heavy drinkers too, and the pathway to irreversible liver failure much the same from a pathological point of view. You can both drink and eat yourself to a liver disease-related death. Routine blood tests can pick up signs that the liver is struggling (higher than normal levels of liver enzymes in the blood) but, because of the liver's initial resilience, getting the all clear from these doesn't mean yours is healthy. Ultrasound scans are better at detecting early signs of trouble, particularly a FibroScan, which evaluates the stiffness of the organ (a measure of scarring). Both are available on the NHS but generally only where there is a clinical indication, such as deranged blood results. Private screening scans are available to anyone willing to pay — typically £160 to £500 a time depending on the test and the clinic — but in many cases are only likely to confirm what you already suspect: that you are drinking too much, or your diet, lifestyle and/or weight need addressing. • Read more from Dr Mark Porter on The Times Treatment for MASLD is all about modifying risk factors. What is good for your heart is good for your liver, so lose excess weight, eat healthily, don't drink excessively and exercise. And, if you have underlying health issues such as type 2 diabetes, high blood pressure or very high cholesterol levels, ensure these are well controlled. And if a liver function test does come back as slightly abnormal, don't dismiss it (something we doctors are just as guilty of doing as our patients). At the very least regard it as a warning shot, and a prompt to take a closer look at your diet, lifestyle and weight. It won't just be your liver that thanks you. Totting up weekly units of alcohol is only half the story if you are worried about your drinking — or someone else's. Just as important is how drinking affects your social life, work, relationships and health. You don't need to drink heavily every day to have alcohol use disorder (AUD). The Audit questionnaire is a screening tool developed by the World Health Organisation. It's not foolproof, but should identify nine out of ten people at risk from their drinking. You can screen yourself at
Yahoo
27-02-2025
- Health
- Yahoo
Signs of liver disease after Gossip Girl actress Michelle Trachtenberg dies
Gossip Girl and Buffy the Vampire Slayer actress Michelle Trachtenberg, 39, was found dead Wednesday, February 26, in her New York City apartment. Trachtenberg's cause of death has not been revealed, but police have said it is not being treated as suspicious. However, there has been speculation it may be related to liver transplant surgery that she recently underwent, according to sources. One in 100 Americans are diagnosed with liver disease, and the condition kills nearly 50,000 every year according to the CDC. According to the British Liver Trust, in the UK there are more than 11,000 deaths due to liver disease each year. READ MORE: Police on Gene Hackman's cause of death after 'health warning' READ MORE: 19-year-old dies months after being told headache was ear infection The British Liver Trust also said that 9 in 10 cases could be prevented, with alcohol, viral hepatitis, and obesity being the major causes. Additionally, many people are diagnosed at the late stages, meaning their condition cannot be cured. So catching the disease early is the best way to increase the chances of successful treatment. But what are the signs of liver disease? There are different types of liver disease, the most common being: Alcohol-related liver disease, Non-alcoholic fatty liver disease, Hepatitis, Haemochromatosis, and Primary biliary cholangitis. Most of these are caused either by drinking too much alcohol or being overweight or obese. But they can also be caused by a weak immune system, catching a viral infection, or in the case of Haemochromatosis, a result of genes. In the early stages of liver disease, there are rarely symptoms. The NHS explains: "Once you start to get symptoms of liver disease, your liver is already damaged and scarred. This is known as cirrhosis." Symptoms of cirrhosis include: feeling very tired and weak all the time loss of appetite loss of sex drive (libido) yellow skin and whites of the eyes (jaundice) itchy skin feeling or being sick If you experience any of these symptoms the NHS recommends seeing a GP right away. The best way to prevent liver disease is to maintain a healthy lifestyle and not drinking over the recommended alcohol intake. Vaccines are also available for hepatitis B and hepatitis A. Trachtenberg's family said in a statement: "It is with great sadness to confirm that Michelle Trachtenberg has passed away. The family requests privacy for their loss." Authorities said the actress' death was not being treated as suspicious. "Criminality is not suspected. The medical examiner will determine the cause of death. The investigation remains ongoing," the NYPD said in a statement.
