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The Independent
2 minutes ago
- The Independent
Warning issued for common artificial sweetener that can interfere with cancer treatments
A popular sugar substitute may interfere with certain cancer treatments, according to new research. The University of Pittsburgh and UPMC Hillman Cancer Center have released new research suggesting that using sucralose — a popular sugar replacement used by those trying to lose weight or manage their blood sugar levels — may make it harder to the body to respond to certain cancer treatments. According to the research, patients with melanoma and non-small cell lung cancer who consumed high levels of sucralose responded worse to immunotherapy and had worse survival rates than individuals whose diets had low levels of the artificial sweetener. The research also revealed a potential pathway for counteracting the potential negative effects of sucralose. The researchers found supplements that boost the levels of amino acid arginine actually counteracted the negative effects of the sweetener on immunotherapy treatments in mice. That approach could be pursed in further clinical trials to see if it can be used in humans. Doctor Abby Overacre, assistant professor in the Department of Immunology at the University of Pittsbugh and UPMC Hillman said in a statement that finding ways around forcing dietary changes is a worthwhile course of action, especially for cancer patients who are already dealing with the burden of the disease. 'It's easy to say, 'Stop drinking diet soda,' but when patients are being treated for cancer, they are already dealing with enough, so asking them to drastically alter their diet may not be realistic,' she said. 'We need to meet patients where they are. That's why it's so exciting that arginine supplementation could be a simple approach to counteract the negative effects of sucralose on immunotherapy.' The study, which used testing on mice, found the negative effects were potentially caused by disruption to gut bacteria by the artificial sweetener. It found that sucralose caused a shift in the composition of the gut bacteria in mice which allowed for an increase in bacteria that degrade arginine. The increased arginine resulted in reduced levels of the amino acid in blood, tumor fluid, and stool. 'When arginine levels were depleted due to sucralose-driven shifts in the microbiome, T cells couldn't function properly,' Overacre said. 'As a result, immunotherapy wasn't as effective in mice that were fed sucralose.' Diwakar Davar, associate professor of medicine at the University of Pittsburgh and a medical oncologist and hematologist at UPMC Hillman, was a collaborator on the study and noted that the negative effects of sucralose was consistent across a range of treatments for a variety of cancer types and stages. He said that prebiotic supplements could theoretically be developed specifically for cancer patients with high levels of sucralose in their blood to help mitigate the negative effects. The researchers hope to pursue a clinical trial to determine whether or not boosting arginine through supplements will counteract the effects of the sucralose. They also plan to expand their research to look at the effects of other artificial sweeteners — such as aspartame, saccharin, xylitol, and stevia — on the immune system and on cancer treatments.


Reuters
3 minutes ago
- Reuters
Trump administration blocks funding for CDC health programs, WSJ reports
Aug 1 (Reuters) - U.S. President Donald Trump's administration is blocking funding for a swath of public-health programs run by the Centers for Disease Control and Prevention, the Wall Street Journal reported on Friday, citing unnamed sources. These include youth violence prevention programs, research on preventing gun injuries and deaths and efforts targeting diabetes, chronic kidney disease and tobacco use, according to the report. The money withheld could not be determined, but it could be as high as $200 million, the WSJ reported, citing a person familiar with the matter. The CDC did not immediately respond to a Reuters request for comment. The White House has previously stated its intention to reduce U.S. health spending by more than a quarter next year, with the National Institutes of Health and the Centers for Disease Control and Prevention facing the brunt of billions of dollars in cuts. Earlier this week, Susan Monarez was confirmed as CDC director to lead a downsized agency as the White House moves to slash its budget by nearly $3.6 billion, reducing it to about $4 billion. The cuts follow a layoff plan enacted by U.S. Health Secretary Robert F. Kennedy Jr. that eliminated 2,400 positions in CDC, though roughly 700 of those workers have since been rehired.


Daily Mail
34 minutes ago
- Daily Mail
Warning over common sweetener that could make cancer treatment less effective
A common artificial sweetener loved by millions weakens the effects of cancer treatments. University of Pittsburgh researchers discovered that sucralose, a zero-calorie sweetener, reduced immunotherapy effectiveness in melanoma and non-small cell lung cancer patients. Initially developed in the 1970s for people with obesity and diabetes to sweeten food while avoiding blood sugar spikes, sucralose, more commonly known as Splenda, has become ubiquitous. It's used in over 4,500 foods and drinks, including diet sodas and low-calorie foods. In the US, it accounts for 30 percent of the sweetener market. Cancer patients undergoing immunotherapy, which boosts the immune system to recognize and kill cancer cells, may reach for a diet soda or sugar-free baked good, believing they're making a healthy choice. However, sucralose kills some good bacteria that reside in the gut while allowing harmful strains to grow, impacting the body's ability to digest foods and break down fiber, train immune cells to fight pathogens, make vitamins like folate and B12, produce serotonin, and reduce inflammation. Senior author Dr Diwakar Davar, an oncologist and hematologist at UPMC, said in a statement: 'We found that sucralose impeded the effectiveness of immunotherapies across a range of cancer types, stages and treatment modalities. 'These observations raise the possibility of designing prebiotics, such as targeted nutrient supplementation for patients who consume high levels of sucralose.' The team used mouse models, some with lung cancer and some with melanoma, to test how sucralose altered their microbiomes, finding that the sweetener disrupted the delicate balance. This reduced key amino acids such as arginine, which are needed to fuel immune cells. It also led to dysfunctional CD8+ T cells, critical for fighting cancer, and blunted the effects of anti-PD-1 immunotherapy, a class of cancer treatments that includes popular medicines Keytruda and Opdivo. Lead author Dr Abby Overacre, an immunology professor at Pitt and UPMC Hillman, said: 'When arginine levels were depleted due to sucralose-driven shifts in the microbiome, T cells couldn't function properly. 'As a result, immunotherapy wasn't as effective in mice that were fed sucralose.' To assess the relevance of these findings for humans, they questioned 132 advanced cancer patients, including 91 people with melanoma and 41 with lung cancer, about their sucralose intake, as well as 25 people at high risk of their melanoma recurring. People reported drinking diet sodas, using the artificial sweetener in coffee and tea, and eating low-calorie snacks sweetened with it. A high amount of sucralose was considered anything above 0.16 mg per kilogram of body weight per day. For a 155-lb person, that's less than a single packet of Splenda. People with melanoma and lung cancer who consumed at least that much sucralose had a 3.2 times higher risk of their cancer progressing faster, as well as less tumor shrinkage in response to immunotherapy. People at risk of melanoma recurrence who drank or ate at least that much sucralose had a higher risk of their cancer returning after surgery and immunotherapy and fewer signs of a strong immune response to tumors. Experiments in mice revealed that disruption to the microbiome due to sucralose was the driving force behind alterations in their cancer-fighting T cells, which were starved of the crucial amino acid arginine. When scientists transplanted feces from sucralose-fed mice into untreated mice, the latter exhibited a similar poor immune response to immunotherapy. But when scientists supplemented their low levels of arginine using the amino acid citrulline, commonly found in melons, pumpkins, and legumes, T cells regained their cancer-killing ability, reversed their resistance to immunotherapy, and their tumors shrank. Their findings were published in the journal Cancer Discovery. Dr Overacre said: 'It's easy to say, 'Stop drinking diet soda,' but when patients are being treated for cancer, they are already dealing with enough, so asking them to drastically alter their diet may not be realistic. 'We need to meet patients where they are. That's why it's so exciting that arginine supplementation could be a simple approach to counteract the negative effects of sucralose on immunotherapy.' The researchers hope to launch a clinical trial investigating whether citrulline supplements, which boost arginine levels more than arginine itself, affect the gut microbiome and anti-tumor immune response in patients.