ACP and Annals of Internal Medicine present breaking scientific news at ACP's Internal Medicine Meeting 2025
Authors discuss research on AI in the exam room, switching GLP1-RAs for better glucose and weight control, and ACP's best practice advice for the use of cannabis and cannabinoids for noncancer pain
NEW ORLEANS, April 4, 2025 /PRNewswire/ -- Today at the American College of Physicians (ACP) annual meeting, Internal Medicine Meeting 2025, in New Orleans, Annals of Internal Medicine presented three breaking scientific research articles during a live plenary session featuring the authors of those articles. The articles were published in ACP's flagship journal concurrent with the live meeting presentation.
During the session, New in Annals of Internal Medicine: Hear it First from the Authors, Christine Laine, M.D., MPH, FACP Annals of Internal Medicine Editor-in-Chief and ACP Senior Vice President, interviewed each author to gain insight into their research. The articles presented were:
Comparison of Initial Artificial Intelligence (AI) and Final Physician Recommendations in AI-Assisted Virtual Urgent Care Visits. Zehavi Horowitz-Kugler M.D., Vice President, Medical Sciences at K Health, Inc., discussed findings from a study comparing artificial intelligence (AI)-driven clinical recommendations to physician decision-making for common acute complaints in a virtual primary care setting. In the study, AI recommendations were largely rated as superior to physicians by expert adjudicators. According to Dr. Horowitz-Kugler, this is because AI is trained on a massive amount of high-quality, real-world clinical data, which is far beyond what any physician would see in their lifetime. Combined with human physician discernment, this approach could improve patient care and outcomes.
Comparison of Dose Escalation Versus Switching to Tirzepatide Among People With Type 2 Diabetes Inadequately Controlled on Lower Doses of Dulaglutide. Liana K Billings, M.D., MMSc, Vice Chair of Research, Department of Medicine, Endeavor Health (NorthShore Hospitals), explained that for patients with inadequately controlled type 2 diabetes, switching to tirzepatide improves glucose control and increases weight loss more so than maximizing dulaglutide dose. This is important because delays in attaining at-goal glucose control can increase the risk and progression of diabetes-related complications, such as kidney disease and eye disease. Dr. Billings noted that adverse effects were similar in both groups.
Cannabis or Cannabinoids for the Management of Chronic Noncancer Pain: Best Practice Advice From the American College of Physicians. Adam J. Obley, M.D., FACP Associate Professor of Medicine at Oregon Health & Science University and a member of ACP's Clinical Guidelines Committee, explained that ACP's Best Practice Advice paper is intended to inform clinicians about the evidence regarding the benefits and harms of cannabis or cannabinoids and to provide advice for clinicians counseling patients seeking to use cannabis or cannabinoids for chronic noncancer pain. ACP suggests that physicians counsel their patients about the benefits and harms of cannabis or cannabinoids when patients are considering whether to start or continue their use to manage chronic noncancer pain. ACP advised caution, as the harms of cannabis use may outweigh the benefits for some patients, especially young adults and adolescents, those with substance use disorder, or patients with serious mental health issues. Patients who are pregnant, breastfeeding or actively trying to conceive should be counseled against cannabis use. For all patients, ACP recommends against the use of inhaled cannabis.
'Sharing this groundbreaking research at our plenary session and publishing it in Annals of Internal Medicine underscores its significance,' said Dr. Laine. 'These topics are relevant to internal medicine and primary care physicians and address issues commonly seen during the patient encounter. By giving physicians timely access to these scientific insights, we aim to improve care and enhance clinical practice.'
About the American College of Physicians
The American College of Physicians is the largest medical specialty organization in the United States with members in more than 172 countries worldwide. ACP membership includes 161,000 internal medicine physicians, related subspecialists, and medical students. Internal medicine physicians are specialists who apply scientific knowledge and clinical expertise to the diagnosis, treatment, and compassionate care of adults across the spectrum from health to complex illness. Follow ACP on X, Facebook, Instagram, Threads, and LinkedIn.
Annals of Internal Medicine is the flagship journal of the American College of Physicians (ACP). Annals is the most widely read and cited general internal medicine journal and one of the most influential peer-reviewed clinical journals in the world. Annals' mission is to promote excellence in medicine, enable physicians and other health care professionals to be well-informed members of the medical community and society, advance standards in the conduct and reporting of medical research, and contribute to improving the health of people worldwide. New content is published every Tuesday at Annals.org. Follow Annals on X, Facebook, Instagram, Threads, and LinkedIn.
Hashtags

Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
16 hours ago
- Yahoo
This Rare 'Silent' Cancer Has Quadrupled Among Millennials
A new study, published this week in the Annals of Internal Medicine, found that a rare form of cancer – appendix cancer, or appendiceal adenocarcinoma – is as much as three times as common among Gen X, born between 1965 and 1980, as it is among those born in the '40s. However, for older millennials who were born in the '80s (millennials were born between 1981-1996), the rates were more than four times higher. The Christie NHS Foundation Trust explains it accounts for 0.4% of all cancers of the bowel; it's a rare condition. But what is appendix cancer, how do you spot it, and why might it be on the rise? Appendiceal adenocarcinoma, the most common form of appendix cancer, can often develop 'without developing symptoms,' the Cleveland Clinic shares. Because it can be so hard to spot, it is sometimes described as a 'silent' cancer in its early stages. Often, people only notice signs when the tumours have spread; the NHS say that it is often only spotted during surgery. Some symptoms that may occur, however, include: Appendicitis Bloating A buildup of fluid in your abdomen An increased waist size Abdominal or pelvic pain. Changes in bowel habits (including diarrhoea) Nausea and vomiting Feeling full soon after you start eating. Speak to your GP immediately if you notice signs of appendix cancer. This study did not seek to find out why different generations have different rates of appendix cancer. But it is not the only cancer which has followed a similar generational pattern – bowel and breast cancer, for instance, are both affecting more and more young people while rates among older people stay roughly stable. Speaking to the New York Times, gastroenterologist and colon cancer expert Dr Andrew T. Chan, who was not involved in the study, suggested that some changes to our diet over time might be responsible for the uptick in bowel cancers. But it is hard to say more about appendix cancer, which is already a poorly understood condition. Cancer expert Professor Andreana Holowaty told the publication that the rise does not seem to be caused by an increase in diagnoses, however, not least because the disease is so hard to spot. 'Similar trends have been reported for other gastrointestinal cancers, suggestive of a potential shared cause contributing to this increasing cancer burden across generations,' the paper reads. Scientists' Bowel Cancer Breakthrough 'Pivotal' For Future Treatment These 3 Diet Changes May Reduce Your Bowel Cancer Risk By 47% The Nutrient Linked To Lower Cancer, Heart Disease, And Dementia Risk


New York Post
a day ago
- New York Post
Rare cancer diagnoses surge dramatically among millennials, Gen X
A rare type of cancer is growing among millennials and members of Generation X, new research shows. Diagnoses of appendix cancer have tripled in the US for people born between 1976 and 1984 — and it has quadrupled for those born between 1981 and 1989. Advertisement The study was published on Monday in the Annals of Internal Medicine. Researchers from the Vanderbilt University Medical Center analyzed data from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) Program to arrive at these findings. 'When you take these alarming rates that we are seeing for appendiceal cancer across generations, together with the fact that one in every three patients diagnosed with appendiceal cancer is diagnosed under the age of 50, these point to a timely need for everyone to be aware of the signs and symptoms of appendix cancer,' said lead author Andreana Holowatyj, PhD, assistant professor of Medicine at Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, in a press release from the university. Cancer of the appendix is rare, affecting only about one or two people per million each year in the US, according to the National Cancer Institute (NCI). Even so, doctors emphasize the importance of seeking medical attention if symptoms emerge. Advertisement 3 Appendix cancer has been rising among members of Generation X and millennials. Chinnapong – 'Ruling out the possibility of an appendix cancer diagnosis, or diagnosing it early, is important for this cancer as we continue to learn what factors may be contributing to this worrisome trend,' Holowatyj said. Appendiceal cancer forms in the appendix, which is a small organ located in the lower right abdomen. There are two main types: epithelial appendiceal cancer, which involves the cells of the lining of the appendix, and neuroendocrine appendiceal cancer, which results from the growth of neuroendocrine (carcinoid) tumors of the appendix, the NCI states. Advertisement In early stages of the disease, most people do not notice symptoms. 3 The rates have tripled in the US among people born between 1976 and 1984 — while quadrupling for those born between 1981 and 1989. Peakstock – As the cancer progresses, common symptoms include pain, a bloated feeling, a mass in the abdomen, nausea and vomiting, and sudden feelings of fullness while eating, according to the above source. Common treatments for this type of cancer include surgery to remove the appendix and any other affected organs, as well as chemotherapy to kill any metastasized cancer cells. Advertisement Based on the study findings, the researchers are calling for increased awareness among both the public and the medical community. 'As incidence rates in younger generations are often indicative of future disease burden, these results support the need for histology-specific investigations of appendiceal adenocarcinoma, as well as increased education and awareness of appendiceal adenocarcinomas among healthcare providers and the public,' the study stated. 3 Annals of Internal Medicine published the study on Monday, as researchers from Vanderbilt University Medical Center analyzed data from the National Cancer Institute's Surveillance Epidemiology and End Results (SEER) Program. charnsitr – There are no standard screening guidelines or risk factors for appendix cancer, which means up to half of diagnoses occur after the disease has already spread, according to the researchers. Five-year survival rates for appendix cancer range from 10% to 63%. The new study received funding from the Appendix Cancer Pseudomyxoma Peritonei (ACPMP) Research Foundation and the National Institutes of Health.
Yahoo
2 days ago
- Yahoo
Appendix cancers on the rise in younger generations, study finds
Although they are very rare, cancers of the appendix are on the rise, a new study finds. An analysis of a National Cancer Institute database found that compared with older generations, rates of appendix cancer have tripled among Gen X and quadrupled among millennials, according to the report, published Monday in the Annals of Internal Medicine. 'There is a disproportionate burden of appendix cancer among young individuals,' said the study's lead author, Andreana Holowatyj, an assistant professor of hematology and oncology at the Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center. Holowatyj's earlier research was 'the first to show that 1 in every 3 appendix cancers is diagnosed among adults younger than age 50,' she said in a phone interview. 'That's compared to 1 in every 8 colorectal cancers diagnosed among adults younger than age 50.' Still, appendix cancers are extremely rare: According to the National Cancer Institute, they occur at a rate of 1 to 2 per million people in the United States a year. To see whether rates of the cancer had changed over time, Holowatyj turned to the Surveillance, Epidemiology and End Results program, which includes data from nationally representative cancer registries that cover about 45.9% of the U.S. population. Overall, there were 4,858 cases of appendix cancer from 1975 through 2019. When the large proportion of patients diagnosed between ages 18 and 49 is combined with the new finding of a generational rise in Gen X and millennials, it's 'important that we find the causes underpinning these statistics in order to reverse this trend and reduce the disease burden,' Holowatyj said. The new study further confirms that there is a trend toward younger and younger patients from recent generations being hit with gastrointestinal cancers, said Dr. Andrea Cercek, a medical oncologist and a co-director of the Center for Early Onset Colorectal and GI Cancers at Memorial Sloan Kettering Cancer Center in New York City. In particular, rates of colorectal cancer in younger adults have been rising for several decades. The cause for the rise in such GI cancers needs more research. 'It's likely that there are environmental causes, which include exposures to food, water and micro plastics or lifestyle or dietary changes,' said Cercek, who wasn't involved with the new research. 'You can't really pin it down to one thing or another. It's likely multiple factors causing this rise after 1945.' The appendix is a small pouch that hangs off the large intestine on the lower right side of the abdomen. A blockage can lead to infection and inflammation, called appendicitis, which needs emergency treatment. Unlike other cancers of the GI tract, appendix cancers aren't easily found because they're not as easy to see on abdominal scans and won't be picked up by colonoscopies, said Dr. Deborah Doroshow, an associate professor of medicine at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai in New York City. 'So it's not easy to detect or screen for them.' In fact, Holowatyj said, about 95% of appendix cancers aren't spotted until after a person has appendicitis and the appendix is removed and examined by pathologists. As a result, the cancers tend to be at a late stage with poorer long-term prognoses, she added. Doroshow, who wasn't involved with the new study, said it's important for patients and their doctors to be more aware of subtle symptoms. Symptoms such as changes in energy level, a new persistent pain or unexplained weight loss in a young person shouldn't be ignored, she said. 'If a person is feeling that something is not right it's always best to get an opinion,' Doroshow said. 'We've diagnosed young people with cancer whom other health care providers had not taken seriously because they were young.' Women and people of color may find they need to advocate for themselves, she added. Doroshow said people shouldn't be worrying about every single abdominal pain. Rather, it's persistent pain that would be a concern. This article was originally published on