‘One in three person with diabetes develops chronic kidney disease'
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Lucknow: One in three people with diabetes eventually develop chronic kidney disease, which may lead to renal failure and cardiovascular complications, suggests a study undertaken by doctors at SGPGI.
Sharing details, head of molecular medicine and biotechnology, Prof Swasti Tiwari said: "Conducted at the ICMR Centre of Advanced Research and Excellence (CARE) in our department, the study concluded that early detection of CKD could ensure timely therapy and management. The study also identified biomarkers with the potential for the early diagnosis of kidney disease in patients with diabetes."
Adding that the biomarkers are unique in that they have the potential to predict CKD before its onset, she further said: "These biomarkers are found inside nanosized vesicles (thousands of times smaller than a hair) in human urine, making their diagnosis non-invasive.
The studies were initiated in 2019, in which around 1,000 diabetic patients were recruited from the communities at Lucknow and Puducherry. Patients were followed up for about five years.
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She said a patent was filed for the same in March 2024. "The ICMR included this innovation in their annual report for 2023-24. It is noteworthy that the laboratory in the department of molecular medicine & biotechnology at SGPGI was the first in India to demonstrate the usefulness of urine exosomes in kidney disease," she said.
The department also took the initiative for capacity building within the country for early disease diagnosis. Accordingly, two national capacity-building workshops were organised to impart technological skills generated through the CARE project.
The team included Dr Dharmendra K Chaudhary, Dr Sukhanshi Khandpal, Dr Deendayal Mishra, and Dr Biswajeet Sahoo from SGPGI, in addition to project staff members from the Community Medicine Department, PMIS, Puducherry.
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