logo
NEL Animal Cardiovascular Center Achieves World's First Surgical Correction of Complex VSD in Canine Patient

NEL Animal Cardiovascular Center Achieves World's First Surgical Correction of Complex VSD in Canine Patient

Yahoo23-06-2025
ANYANG, South Korea, June 23, 2025--(BUSINESS WIRE)--NEL Animal Cardiovascular Center, a private 24-hour animal hospital in South Korea, said that its cardiac surgery team has successfully performed the world's first surgical correction of a complex ventricular septal defect (VSD) in a canine patient.
This veterinary milestone is highly significant, as it marks the first such case not only in Korea but also globally, with no previous reports of successful surgical treatment for complex VSDs.
The patient was diagnosed with a unique form of VSD—a single, continuous defect extending from the perimembranous to the subarterial region (Perimembranous VSD extending into subarterial region). Given that there had been no prior successful surgical cases even for typical VSDs in veterinary medicine, this breakthrough greatly expands the possibilities for surgical treatment of congenital heart disease in Korea's veterinary cardiac surgery field.
Over the past year, NEL's cardiac surgery team has gained experience through more than 50 open-heart surgeries using cardiopulmonary bypass. Based on this expertise, the team developed a thorough surgical plan. During the procedure, the complex VSD involving both membranous and subarterial regions was confirmed. The team performed incisions in the right atrium and pulmonary artery, successfully closing the defect with a bovine pericardial patch.
Immediately after surgery, the left-to-right shunt was completely resolved, and the risk of progressive regurgitation due to aortic valve prolapse was eliminated. The patient's cardiac function recovered to near-normal levels, and the long-term prognosis is considered highly favorable.
Subarterial VSDs are particularly dangerous due to the risk of aortic valve prolapse and severe regurgitation, making early surgical intervention crucial. The success of this surgery offers new hope for animals with congenital heart defects, demonstrating the potential for a surgical cure.
Dr. Tae-Heum Um, Director of NEL Animal Cardiovascular Center, stated,
"Although this was a complex defect, thorough discussion and preparation among our medical team led to a successful outcome. We will continue our efforts so that more animals with congenital heart disease can lead healthy and normal lives."
NEL Animal Cardiovascular Center is preparing an academic analysis and official report on this case, and sincerely hopes that this achievement contributes to the advancement of veterinary cardiac surgery not only in Korea, but also across Asia.
View source version on businesswire.com: https://www.businesswire.com/news/home/20250618427466/en/
Contacts
NEL Animal Cardiovascular CenterYoon il-yong+82-31-421-7579heart@thenel.org
Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

Psychologists now know exactly what makes someone cool. Turns out, the definitions are universal
Psychologists now know exactly what makes someone cool. Turns out, the definitions are universal

Fast Company

time2 hours ago

  • Fast Company

Psychologists now know exactly what makes someone cool. Turns out, the definitions are universal

The definition of ' cool ' would seem to be an ephemeral thing. (We're not talking temperature here. We're talking James Dean, Serena Williams, and Arthur Fonzarelli cool.) What inspires one to admire another would ostensibly vary from person to person. That didn't stop a global group of scientists from looking into what it means to be cool, though. And what they found was ' cool ' is a lot more universal than you might expect. 'Everyone wants to be cool, or at least avoid the stigma of being uncool, and society needs cool people because they challenge norms, inspire change, and advance culture,' said co-lead researcher Todd Pezzuti, PhD, an associate professor of marketing at the Universidad Adolfo Ibáñez in Chile, in a statement. The peer-reviewed study, which was published in the American Psychological Association's Journal of Experimental Psychology, included experiments with roughly 6,000 participants from around the world between 2018 and 2022. Participants were asked to think of someone who they thought was cool, not cool, good, or not good, then rate the personality and values of those people. Cool is universal in more ways than you might expect. For example, the study found that even in countries with languages based on non-Latin alphabets, such as South Korea and Turkey, 'people use the word cool, often pronouncing it similarly to how it is pronounced in English.' Cool people are likable but not always good Not surprisingly, there was some crossover between who participants thought of as a good person and a cool person. But despite the overlap in some traits, the two aren't the same, researchers found. 'To be seen as cool, someone usually needs to be somewhat likable or admirable, which makes them similar to good people,' said co-lead researcher Caleb Warren, PhD, an associate professor of marketing at the University of Arizona. 'However, cool people often have other traits that aren't necessarily considered 'good' in a moral sense.' That could explain why antiheroes, especially in films and TV shows, are so often seen as cool. There is a risk of homogenization of coolness, though, as music, films, and fashion become global products. When Taylor Swift and the Avengers become properties that dominate conversations and pop culture—not only in the United States, but in virtually every other country—pre-existing definitions of what it means to be cool can also become more fixed. Indeed, the perception of coolness, researchers wrote, 'is [now] stable across countries, which suggests that the meaning of cool has crystallized on a similar set of values and traits around the globe.' That said, being cool hasn't lost its coolness. It has simply progressed. 'Coolness has definitely evolved over time, but I don't think it has lost its edge. It's just become more functional,' Pezzuti said. 'The concept of coolness started in small, rebellious sub-cultures, including among Black jazz musicians in the 1940s and the beatniks in the 1950s. As society moves faster and puts more value on creativity and change, cool people are more essential than ever.' What makes someone cool? The study found that being cool largely comes down to six traits. Perhaps most obviously, cool people are more extraverted than uncool people. They're also powerful, hedonistic, adventurous, open, and autonomous. There are limits, of course. Take musicians, a group that produces plenty of cool people, as an example. 'A rock band seemed more cool when it displayed moderate levels of autonomy (e.g., not trying to write songs that everyone likes) than extreme autonomy (e.g., not caring at all what others think about their music),' the study reads. 'The same likely applies to the other cool attributes. For example, a hedonistic person who parties all night, abuses drugs, and has reckless sex will likely strike most people as being irresponsible rather than cool.' Good people, the study found, have many of those same qualities, but other personality traits were ranked more highly by the subjects. 'Being calm, conscientious, universalistic, agreeable, warm, secure, traditional, and conforming are more associated with good than with cool people,' the study reads. 'Being capable is both cool and good, but not distinctly either.'

Lab-grown liver grows veins, stops bleeding in mice with engineered clotting proteins
Lab-grown liver grows veins, stops bleeding in mice with engineered clotting proteins

Yahoo

time3 hours ago

  • Yahoo

Lab-grown liver grows veins, stops bleeding in mice with engineered clotting proteins

In a breakthrough that brings bioengineered organs one step closer to reality, scientists have created lab-grown liver tissue capable of forming its own blood vessels. A team from Cincinnati Children's Hospital, in collaboration with Japanese researchers, successfully engineered liver organoids that developed spontaneous vascular systems, overcoming a long-standing challenge in tissue engineering. This self-vascularizing liver tissue could pave the way for future transplantable grafts and offer new treatment possibilities for people with hemophilia and other coagulation disorders. Until now, most lab-grown organoids have lacked internal blood vessels, limiting their size, function, and medical potential. By enabling more effective circulation and tissue maturation, the new technique opens the door to growing complex, functional human organs entirely outside the body. "Our research represents a significant step forward in understanding and replicating the complex cellular interactions that occur in liver development,' said Takanori Takebe, director for commercial innovation at the Cincinnati Children's Center for Stem Cell and Organoid Research and Medicine (CuSTOM) and lead author of the study. 'The ability to generate functional sinusoidal vessels opens up new possibilities for modeling a wide range of human biology and disease, and treating coagulation disorders and beyond." At the heart of the process is the use of induced pluripotent stem cells (iPSCs), which are placed in specially formulated gels that guide their development into specific tissue types. These cells can be sourced from healthy donors or patients with particular medical conditions and may be gene-edited to model or correct diseases. To overcome the vascularization barrier, a key obstacle in scaling up organoids, the team spent nearly ten years refining their approach. They began by coaxing iPSCs to differentiate into CD32b+ liver sinusoidal endothelial progenitors (iLSEPs), a type of precursor cell specific to liver blood vessels. These were then introduced into an inverted multilayered air-liquid interface (IMALI) culture system, a setup that encouraged them to self-organize alongside other liver-supportive cells into more complex, layered tissue. The result was a quadruple progenitor mix, including hepatic endoderm, septum mesenchyme, arterial, and sinusoidal cells, that naturally developed into functioning sinusoid-like vessels. Unlike earlier efforts that used fully formed arterial cells, the team's use of liver-specific progenitors allowed for more integrated, lifelike vessel development. Crucially, spatial arrangement and developmental timing also played a role; the proximity of different cell types in the culture system allowed them to interact and mature just as they would in a developing human liver. "The success occurred in part because the different cell types were grown as neighbors that naturally communicated with each other to take their next development steps," says the study's first author, Norikazu Saiki, PhD, of the Institute of Science Tokyo. The vascularized organoids didn't just look more like real liver tissue—they also began to behave like it. The engineered structures produced perfused, sinusoid-like blood vessels that allowed fluid to move through, mimicking the natural rhythm of liver circulation. More remarkably, the organoids also developed the ability to secrete blood-clotting proteins critical for patients with coagulation disorders. Among the factors produced was Factor VIII, a protein missing in people with hemophilia A. When tested in mice engineered to mimic the disease, the organoid-derived Factor VIII was able to correct severe bleeding, offering a proof-of-concept for therapeutic use. The organoids also generated other coagulation-related proteins, suggesting the potential for broader applications in treating patients with rare clotting disorders or acute liver failure. In the U.S. alone, an estimated 33,000 males live with hemophilia, the majority of whom have hemophilia A, caused by a deficiency in Factor VIII. The condition can lead to frequent internal bleeding, especially in joints, resulting in chronic pain, restricted mobility, and long-term damage. More severe cases can pose life-threatening risks, with bleeding episodes in the brain potentially causing seizures or paralysis. If scaled successfully, these self-vascularizing liver organoids could serve as biological factories, producing essential proteins for people who don't respond to standard treatments or who lack access to gene therapy. For those with liver damage, they could someday offer a regenerative option, replacing lost function without requiring a full organ transplant. The full study has been published in Nature Biomedical Engineering.

Spice-Med Interactions: What Every Clinician Needs to Know
Spice-Med Interactions: What Every Clinician Needs to Know

Medscape

time4 hours ago

  • Medscape

Spice-Med Interactions: What Every Clinician Needs to Know

Spices have been valued for centuries in Ayurvedic and Chinese medicine because of their healing properties. In small amounts used for cooking, cinnamon, turmeric, and ginger are generally safe and may provide health benefits, depending on their quality and preparation methods. However, at higher therapeutic doses, they can interact with medications or cause side effects; therefore, long-term use should be monitored by a healthcare professional. Cinnamon Cinnamon spice is extracted from the bark of various species of the cinnamon tree, and essential cinnamon oil is obtained from the bark or leaves. Active constituents include cinnamaldehyde, eugenol, and coumarin. Cinnamon provides antioxidant, anti-inflammatory, antimicrobial, antiviral, antihypertensive, blood sugar-regulating, and antitumor properties, which may reduce the risk for heart disease and improve brain function. Traditionally, it has also aided digestion and fought infections. Combined with lysozyme, essential oils from Cinnamomum verum and clove ( Syzygium aromaticum ) have been shown to reduce the minimum inhibitory concentrations of gentamicin and imipenem against multidrug-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae , thereby enhancing antibiotic efficacy and modifying resistance. Its use in patients with breast cancer could be promising, but further studies are needed. However, an in vitro study showed that cinnamaldehyde activates receptors that increase the excretion of certain drugs, potentially reducing their effectiveness. The cheaper Asian cassia cinnamon contains larger amounts of coumarin than the more expensive Ceylon cinnamon; in high doses, coumarin can damage the liver and, in combination with anticoagulants, can increase the risk for bleeding. Interactions may occur with painkillers, antidepressants, chemotherapeutic agents, and antidiabetic drugs. Reported side effects include gastrointestinal symptoms, headaches, and skin reactions, such as dermatitis or worsening rosacea. Turmeric Turmeric contains the curcuminoid curcumin, the yellow component of curry powder, masala, and golden milk, prized for its anti-inflammatory and antioxidant properties and, at therapeutic doses, its anticarcinogenic and analgesic effects. Other compounds may also contribute to the observed cognitive benefits. Caution is advised when extrapolating scientific results from laboratory and animal experiments to humans, particularly because the amounts used in these studies are impractical compared with concentrated curcuminoid curcumin extracts. Curcumin interacts with liver enzymes and may affect antidepressants, antihypertensives, chemotherapeutic agents, and certain antibiotics. Its blood-thinning, blood sugar-lowering, and blood pressure-reducing properties can potentiate the effects of anticoagulants, antidiabetics, insulin, and antihypertensives. Concurrent intake of iron-rich foods can reduce curcumin's bioavailability. To ensure adequate absorption, curcumin should be consumed with fats and piperine-rich black or long pepper, as well as with chili, lemon, ginger, honey, or even cinnamon and nutmeg. The preparation methods are crucial: Cooked roots may offer stronger DNA-protective effects, roasting in ghee may benefit the gut microbiome and compound uptake, and oxidation should be avoided. At therapeutic concentrations, curcumin is contraindicated in gallstones, cholestasis, bleeding disorders or anticoagulation, and during pregnancy and breastfeeding. Ginger Ginger is known for its anti-inflammatory, immune-boosting, and antiemetic effects. Some studies suggest blood sugar- and blood lipid-lowering properties, but the extent of interactions with antidiabetic drugs and possible side effects — similar to those of sulfonylureas — requires further research. Ginger is already included in combination products for the treatment of diabetes. Its active constituents, such as gingerol, have blood-thinning effects when consumed regularly, chronically, or in concentrated form, and can increase bleeding risk when taken with anticoagulants. Higher doses can cause gastrointestinal side effects such as mucosal irritation, bloating, and heartburn. Conclusion Laboratory studies have indicated potential drug interactions for these spices, but the findings mainly involve high doses rather than typical culinary use. Caution is advised before starting such supplements, particularly in patients taking anticoagulants, antidiabetics, or chemotherapeutic agents. For most people, these spices are considered safe and combine taste with potential health benefits.

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into a world of global content with local flavor? Download Daily8 app today from your preferred app store and start exploring.
app-storeplay-store