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ClearVue signs NZ distributor for solar glass

ClearVue signs NZ distributor for solar glass

ClearVue Technologies has appointed leading New Zealand glass manufacturer Viridian Glass, to continue the company's solar glass sales push into the Asia Pacific region.
The ASX listed company has struck a five-year manufacturing and distribution agreement that will enable Viridian to exclusively manufacture the range of ClearVue smart solar glazing products. Viridian will also pick up distribution rights for the products within the island nation.
The expansion into the NZ market strengthens the company's push into the Asia Pacific region and will meet the growing demand for energy-efficient building materials. While ClearVue is developing a range of building products, its core innovation is to turn window glass into a solar generating panel.
'This agreement represents a significant step in expanding ClearVue's presence in the region.'
ClearVue Technologies global chief executive officer Martin Deil
The new deal will provide local builders, developers and architects with energy producing products such as solar windows and building envelope 'spandrels' and cladding, to be integrated into their projects, resulting in carbon reduction and increased energy efficiency.
ClearVue Technologies global chief executive officer Martin Deil said: 'This agreement represents a significant step in expanding ClearVue's presence in the region and making our innovative solar glazing solutions more accessible to the New Zealand market. Our partnership aligns with New Zealand's strong commitment to sustainability and net-zero energy building initiatives.'
Viridian Glass is New Zealand's largest glass processor, supplying glazing solutions to both residential and commercial markets. It has a strong focus on energy efficiency and performance.
ClearVue's broader growth plan is to expand its manufacturing and distribution footprint globally. Viridian is the latest industry player to join a growing pipeline of strategic partners, which includes recently-appointed Sinrok Solar Energy in South Korea.
ClearVue's agreement with Sinrok is expected to drive sales of its smart solar glazing products to South Korea's building, construction and greenhouse sectors. The company is adopting a two-prong approach for its entry into South Korea, one of Asia's leading renewable energy-conscious nations.

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Biocurious: Inspired by Neuren, Nyrada aims to change the treatment landscape for brain and heart disorders
Biocurious: Inspired by Neuren, Nyrada aims to change the treatment landscape for brain and heart disorders

News.com.au

time2 hours ago

  • News.com.au

Biocurious: Inspired by Neuren, Nyrada aims to change the treatment landscape for brain and heart disorders

Nyrada is focused on a particular ion pathway to tackle disorders including stroke and traumatic brain injury Preclinical work has shown a significant reduction in secondary brain injury and cardiac damage CEO James Bonnar spent 15 years at Neuren Pharmaceuticals in the company's formative stage Nyrada (ASX:NYR) CEO James Bonnar is too modest to admit it, but he played a key role in developing and commercialising Neuren Pharmaceuticals' (ASX:NEU) neurological drug Daybue. Bonnar was one of the then New Zealand-based Neuren's first employees and spent a decade at the company, which now bears a $1.7 billion market cap. Bonnar seeks to channel Neuren's virtues as Nyrada pursues small molecule treatments for both brain and heart protection. Before Neuren, Bonnar was with Protemix, which worked on a drug for diabetes-related cardiomyopathy. 'This is not my first rodeo." Nyrada's indications of interest include traumatic brain injury (TBI), which Neuren pursued before switching development to the childhood disorder Rett syndrome. 'You learn a lot of lessons along the way, competing in both successful and unsuccessful programs,' Bonnar says. Have a nice TRPC Nyrada's lead drug was called NYR-BI03, but last week the company bestowed the 'proper' name of Xolatryp to reflect the drug's 'advancing development'. The science is based on bodily transient receptor potential canonical (TRPC) ion channels (often pronounced 'tripsy'). These conduits regulate calcium influx into cells. 'Following ischemia or injury, these ion channels are activated and let in calcium into the cell,' Bonnar says. 'That calcium builds up to the extent where they're toxic.' As with Neuren, Nyrada had a spare clinical program in its back pocket. The Delaware-incorporated Nyrada listed in 2020, having spun off from immunology play Noxopharm (ASX:NOX). Nyrada initially focused on oral inhibitors which failed preclinical toxicology studies. 'Fortunately, we had a promising secondary program, which is now the lead program," Bonnar says. Xolatryp blocks TRPC channels to protect key cells in vital organs when under stress. In the case of brain neurons, that could be after ischaemia (a blood clot) and reperfusion (the sudden flow of blood returning to an organ or tissue). Ischemic-reperfusion injury is also a key cause of tissue damage following the restoration of blood flow to the heart post-injury. It's a knock-out! Using a 'knock out' mice model, pioneering work at the University of NSW (Uni NSW) showed the rodents were protected from stroke. The 'knock out' doesn't refer to concussing the critters with a mallet, but genetically modifying and cross breeding them so they no longer express the TRPC channels. 'This confirmed that completely knocking out the channel is safe and for all intents and purposes these mice lived a normal life,' Bonnar says. Over the last 12 months, Nyrada has focused on expanding efficacy data that builds on this 'knock out' mouse work. 'We went through a few iterations of molecules that showed promise, but they weren't target specific,' Bonnar says. Let's get clinical Preclinical work suggests Xolatryp is delivering significant reduction in secondary brain injury and cardiac damage For cardiac reperfusion, rat models showed an 86% reduction in injury (there are no other approved treatments). With ischemic strokes, a mouse study showed 42% protection. The company also ran a neuroprotection study with the Walter Reed Army Institute Research and Uni NSW, deploying a TBI model. Based on follow-up magnetic resonance imaging, this showed a 'statistically significant' neuroprotective benefit. Now for a human study As they say, everything works in mice … or rats. Nyrada's attention now has turned to a phase I healthy volunteer study to appraise dosing safety. The randomised, double blinded effort involves three-hour infusions, compared with 20 hours for the first preclinical study. The study consists of three eight-patient cohorts, six on the active drug and two on the placebo in each group. Bonnar says the trial will guide the company on what indication to pursue in a phase II study. 'In each one, there is first-in-class potential with large markets and unmet need.' The company is hoping to complete the study in September. Later, the company also would like to run a TBI study in the US, given the large addressable population. 'You would struggle to do that in Australia,' Bonnar says. Tackling a barren treatment landscape Bonnar describes Xolatryp as a 'Swiss Army knife' drug candidate, in that it could have broad uses. He says the current TBI treatments only alleviate the symptoms, rather than the condition. 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At the end of March Nyrada had $4.7 million of cash, enough to fund the phase I study. 'We are pretty lean; we work as a virtual company with a low head count.' Bonnar notes Boehringer Ingelheim has developed a TRPC inhibitors for renal fibrosis, while elsewhere work is afoot to develop one for the chronic condition of cardiac hypertrophy. 'But as far as I'm aware, we are the first company to be looking at a TRPC channel blocker in the clinic in our chosen indications.'

Closing Bell: ASX powers to new 50-day high, up 0.63pc
Closing Bell: ASX powers to new 50-day high, up 0.63pc

News.com.au

time14 hours ago

  • News.com.au

Closing Bell: ASX powers to new 50-day high, up 0.63pc

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Health Check: Don't dis-May! ASX biotechs record strong year-on-year share gains
Health Check: Don't dis-May! ASX biotechs record strong year-on-year share gains

News.com.au

time14 hours ago

  • News.com.au

Health Check: Don't dis-May! ASX biotechs record strong year-on-year share gains

Medadvisor and Dimerix lead the valuation gains in a choppy month Emvision and Paradigm open more pivotal trial sites Capital raisings click over MedAdvisor (ASX:MDR) is the ASX hero biotech of an otherwise subdued May, stacking on more than 52% in market capitalisation for the month. The medication compliance group said it had found a probable buyer for its Australian operations, thus spurring the rally. This supersized effort eclipsed Dimerix's (ASX:DXB) 24% surge, on the back of its May 1 news of a US distribution deal for its putative kidney disease drug. The numbers are based on Biotech Daily's top 40 index, which records the performance of the biggest stocks. The newsletter also recorded the Big Four – CSL (ASX:CSL), ResMed (ASX:RMD), ProMedicus (ASX:PME) and Cochlear (ASX:COH) – separately. Overall, the top 40 eased 2.6%, with Avita Medical (ASX:AVH) leading the decliners with a 40% tumble and Imugene (ASX:IMU) shedding 37%. shares lost 6%, translating to $555 million of lost value. Don't dis-May But don't dis-May too much: the sector's still up 9.7% year on year, just eclipsing the overall market's 9.5% increment. The Big Four gained 2.6%, thanks to Pro Medicus's 21% rebound from subdued levels. Investors had to go beyond the top 40 for the best return: pot and psychedelic drug play Incannex Healthcare (ASX:IHL) climbed 300 per cent, albeit having plunged 80% in April. We're doing better than our American friends, with the Nasdaq Biotechnology Index shedding 4.2% for the month. The index is also down 7% over the past 12 months. On trial In trial news, EMvision Medical Devices (ASX:EMV) is poised to activate its third US site in its pivotal trial of its bedside stroke detection device, Emu. The site is at The Mount Sinai Hospital in New York, a recognised leader in stroke research and treatment. The company is activating its second Australian site this week, at Sydney's Liverpool Hospital (a large stroke referral centre). These activations will bring the total of sites activated in the pivotal (validation) trial to five. These include Houston's UTHealth and Memorial Hermann-Texas Medical Centre, Mayo Clinic in Jacksonville and the Royal Melbourne Hospital. The study aims for US Food & Drug Administration (FDA) clearance for Emu, under the new device route. Knees up Paradigm Biopharmaceuticals (ASX:PAR) has activated the first of 11 proposed sites, for the local leg of its phase III knee osteoarthritis trial. Melbourne's Sportsmed Biologic is the first site, with the treatment overseen by prominent sports physician Dr Philip Bloom. The other sites are in 'various stages of start-up and activation'. Meanwhile, 48 sites are in advanced preparation stages. The study is pitched at FDA approval for Paradigm's repurposed drug candidate, to treat the common and debilitating condition. Capital-raising corner While finding a dime in the sector remains difficult, companies are managing decent smaller raisings. Shrugging off its US reimbursement setback, Pacific Edge (ASX:PEB) today upsized its NZ$15 million placement to NZ$16 million, with the board accepting oversubscriptions. A NZ$5 million share purchase plan (SPP) is yet to come. The offer is priced at NZ10 cents a share, a healthy 20% premium to the 20-day weighted average price. The raising is partly to grow sales channels for its non-invasive bladder cancer assay Cxbladder, independent of US Medicare reimbursement. Pacific Edge's Medicare coverage ceased in April, after a code pertaining to genetic oncology testing was excised. Not surpisingly, the company wants to re-gain this funding via legal and other means of suasion. Also today, Recce Pharmaceuticals (ASX:RCE) said it had placed a $7.4 million shortfall from its recent entitlement offer. This takes total proceeds from its capital raising to $15.8 million. The funds will support the synthetic anti-infective outfit's phase III trials, in Indonesia and locally. The Indonesian study treats diabetic foot infections, while the local effort is for acute bacterial skin and skin structure infections. Meanwhile heart device play Cardiex (ASX:CDX) has raised $2.4 million in an insto placement at 4 cents a share, with a $4.1 million rights issue opening on Friday. And OncoSil Medical (ASX:OSL) has raised $6.7 million in a placement and hopes an SPP will reap another $2 million. The price is one-third of a cent, a circa 20% discount. The funds will support the Oncosil's eponymous pancreatic cancer targeted radiation device. Thirty geographies have approved the tool, including Europe and the UK. Best of British biotech Data analytics house Global Data reports that venture financing for UK biopharmaceutical companies doubled in the March quarter, to US$1.1 billion. This is the highest quarterly total since 2021. This foreign investment surge also highlights danger for the Brit 'Growing dependence on US capital and policy-driven cost pressures signal an urgent need to strengthen domestic investment for sustainable growth.'

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